GB1524747A - Polypeptide - Google Patents
PolypeptideInfo
- Publication number
- GB1524747A GB1524747A GB19327/76A GB1932776A GB1524747A GB 1524747 A GB1524747 A GB 1524747A GB 19327/76 A GB19327/76 A GB 19327/76A GB 1932776 A GB1932776 A GB 1932776A GB 1524747 A GB1524747 A GB 1524747A
- Authority
- GB
- United Kingdom
- Prior art keywords
- tyr
- leu
- pro
- arg
- azgly
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06086—Dipeptides with the first amino acid being basic
- C07K5/06095—Arg-amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/13—Luteinizing hormone-releasing hormone; related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Pharmacology & Pharmacy (AREA)
- Reproductive Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Fodder In General (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (44)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB19327/76A GB1524747A (en) | 1976-05-11 | 1976-05-11 | Polypeptide |
| IE808/77A IE44426B1 (en) | 1976-05-11 | 1977-04-20 | Polypeptide |
| ZA00772433A ZA772433B (en) | 1976-05-11 | 1977-04-22 | Polypeptide |
| US05/790,003 US4100274A (en) | 1976-05-11 | 1977-04-22 | Polypeptide |
| NZ183931A NZ183931A (en) | 1976-05-11 | 1977-04-26 | Polypeptide analogues of luteinising harmone releasing factor (lh-rf);pharmaceutical veterinary compositions |
| CA277,003A CA1101844A (en) | 1976-05-11 | 1977-04-26 | Polypeptide |
| AU24681/77A AU508025B2 (en) | 1976-05-11 | 1977-04-28 | Polypeptide |
| HU77IE777A HU179990B (en) | 1976-05-11 | 1977-05-04 | Process for preparing polypeptides |
| PL1977212706A PL108860B1 (en) | 1976-05-11 | 1977-05-05 | Method of producing polypeptides |
| IL52014A IL52014A (en) | 1976-05-11 | 1977-05-05 | Polypeptides having luliberin agonist properties |
| PL1977197889A PL104362B1 (pl) | 1976-05-11 | 1977-05-05 | Sposob wytwarzania polipeptydow |
| DE2720245A DE2720245C2 (de) | 1976-05-11 | 1977-05-05 | Peptide, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Zusammensetzungen |
| CS772980A CS199673B2 (en) | 1976-05-11 | 1977-05-05 | Method of producing polypeptides |
| YU1172/77A YU40672B (en) | 1976-05-11 | 1977-05-09 | Process for obtaining a polypeptide of the formula glu-his-trp-ser-tyr-a-b-argo-pro-e-f |
| CH578677A CH627151A5 (cg-RX-API-DMAC10.html) | 1976-05-11 | 1977-05-09 | |
| NL7705130A NL191793C (nl) | 1976-05-11 | 1977-05-10 | Werkwijze voor de bereiding van een polypeptide, en van een farmaceutisch of veterinair preparaat. |
| FI771480A FI64139C (fi) | 1976-05-11 | 1977-05-10 | Polypeptid med inverkan pao djurens fortplantning |
| NO771644A NO147304C (no) | 1976-05-11 | 1977-05-10 | Polypeptid som har evnen til aa regulere og/eller oeke fruktbarheten hos dyr og/eller aa bedre ufruktbarhet hos menn og kvinner |
| FR7714262A FR2351092A1 (fr) | 1976-05-11 | 1977-05-10 | Polypeptides ayant une activite agoniste de la luliberine |
| BE177448A BE854467A (fr) | 1976-05-11 | 1977-05-10 | Polypeptides |
| SE7705432A SE437837B (sv) | 1976-05-11 | 1977-05-10 | Polypeptid for att kontrollera och/eller forbettra reproduktionen hos djur jemte veteriner komposition innehallande nemnda polypeptid som aktiv bestandsdel |
| JP5418677A JPS52136172A (en) | 1976-05-11 | 1977-05-11 | Polypeptide* its preparation and medical and veterinary compositions having rulibeline synergistic effect |
| ES458691A ES458691A1 (es) | 1976-05-11 | 1977-05-11 | Procedimiento para preparar polipeptidos. |
| AT0335877A AT379400B (de) | 1976-05-11 | 1977-05-11 | Verfahren zur herstellung eines neuen polypeptids |
| DK207977A DK149596C (da) | 1976-05-11 | 1977-05-11 | Lh-rh-analoge nona- eller decapeptider, syreadditionssalte deraf og veterinaert middel til anvendelse til regulering og/eller forbedring af dyrs reproduktion |
| SU772480485A SU910116A3 (ru) | 1976-05-11 | 1977-05-11 | Способ получени полипептидов или их солей |
| DD77198869A DD136738A5 (de) | 1976-05-11 | 1977-05-11 | Verfahren zur herstellung neuer polypeptide |
| CS79207A CS199674B2 (cs) | 1976-05-11 | 1979-01-09 | Způsob výroby polypeptidů |
| AT0217979A AT365562B (de) | 1976-05-11 | 1979-03-23 | Verfahren zur herstellung eines neuen polypeptids |
| SE8007763A SE437993B (sv) | 1976-05-11 | 1980-11-05 | Sett att framstella en polypeptid med luliberin-agonist-egenskaper |
| CH447281A CH629475A5 (de) | 1976-05-11 | 1981-07-07 | Verfahren zur herstellung von polypeptiden. |
| NO822984A NO149586C (no) | 1976-05-11 | 1982-09-03 | Analogifremgangsmaate for fremstilling av terapeutisk aktive polypeptider |
| FI830601A FI75579C (fi) | 1976-05-11 | 1983-02-23 | Foerfarande foer framstaellning av terapeutiskt anvaendbar polypeptid. |
| DK469983A DK149272C (da) | 1976-05-11 | 1983-10-12 | Analogifremgangsmaade til fremstilling af lhrh-analoge nona- eller decapeptider eller farmaceutisk anvendelige syreadditionssalte deraf |
| AT328684A AT379601B (de) | 1976-05-11 | 1984-10-15 | Verfahren zur herstellung eines neuen polypeptids |
| AT328384A AT379818B (de) | 1976-05-11 | 1984-10-15 | Verfahren zur herstellung eines neuen polypeptids |
| AT327984A AT379595B (de) | 1976-05-11 | 1984-10-15 | Verfahren zur herstellung eines neuen polypeptids |
| AT328584A AT379600B (de) | 1976-05-11 | 1984-10-15 | Verfahren zur herstellung eines neuen polypeptids |
| AT328184A AT379597B (de) | 1976-05-11 | 1984-10-15 | Verfahren zur herstellung eines neuen polypeptids |
| AT328484A AT379599B (de) | 1976-05-11 | 1984-10-15 | Verfahren zur herstellung eines neuen polypeptids |
| AT328284A AT379598B (de) | 1976-05-11 | 1984-10-15 | Verfahren zur herstellung eines neuen polypeptids |
| AT328084A AT379596B (de) | 1976-05-11 | 1984-10-15 | Verfahren zur herstellung eines neuen polypeptids |
| BG098123A BG60740B2 (bg) | 1976-05-11 | 1993-09-24 | Полипептид |
| NL970002C NL970002I2 (nl) | 1976-05-11 | 1997-01-15 | Werkwijze voor de bereiding van een polypeptide, en van een farmaceutisch of veterinair preparaat. |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB19327/76A GB1524747A (en) | 1976-05-11 | 1976-05-11 | Polypeptide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1524747A true GB1524747A (en) | 1978-09-13 |
Family
ID=10127509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB19327/76A Expired GB1524747A (en) | 1976-05-11 | 1976-05-11 | Polypeptide |
Country Status (27)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6897289B1 (en) | 1999-05-20 | 2005-05-24 | Lipotec, S.A. | Peptide synthesis procedure in solid phase |
Families Citing this family (138)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4234571A (en) * | 1979-06-11 | 1980-11-18 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone |
| DE3411224A1 (de) * | 1984-03-27 | 1985-10-10 | Hoechst Ag, 6230 Frankfurt | Verfahren zur racematarmen herstellung von peptidzwischenprodukten der gonadorelin- und gonadorelinanaloga-synthese und neue zwischenprodukte bei diesem verfahren |
| US4760053A (en) * | 1984-08-02 | 1988-07-26 | Fernand Labrie | Combination therapy for selected sex steroid dependent cancers |
| US4666885A (en) * | 1985-02-08 | 1987-05-19 | Fernand Labrie | Combination therapy for treatment of female breast cancer |
| US4705778A (en) * | 1985-10-22 | 1987-11-10 | Sri International | Orally active LHRH analogs |
| JPH0284272U (cg-RX-API-DMAC10.html) * | 1988-12-20 | 1990-06-29 | ||
| JP2672677B2 (ja) * | 1989-02-09 | 1997-11-05 | タツプ・フアーマシユーテイカルズ・インコーポレイテツド | Lhrh同族体 |
| US5372996A (en) * | 1989-03-10 | 1994-12-13 | Endorecherche, Inc. | Method of treatment of androgen-related diseases |
| EP0462189B1 (en) * | 1989-03-10 | 1995-09-27 | Endorecherche Inc. | Combination therapy for treatment of estrogen sensitive diseases |
| CA2063378A1 (en) * | 1989-07-07 | 1991-01-08 | Fernand Labrie | Androgen derivatives for use in the inhibition of sex steroid activity |
| ATE230994T1 (de) * | 1989-07-07 | 2003-02-15 | Endorech Inc | Methode zur behandlung androgenbedingter krankheiten |
| GB9112859D0 (en) * | 1991-06-14 | 1991-07-31 | Ici Plc | Peptide process |
| HUT71514A (en) * | 1992-05-21 | 1995-12-28 | Endorecherche Inc | Inhibitors of testosterone 5 alfa-reductase activity and pharmaceutical compositions containing the same |
| US6413536B1 (en) | 1995-06-07 | 2002-07-02 | Southern Biosystems, Inc. | High viscosity liquid controlled delivery system and medical or surgical device |
| US7833543B2 (en) * | 1995-06-07 | 2010-11-16 | Durect Corporation | High viscosity liquid controlled delivery system and medical or surgical device |
| CA2192773C (en) | 1995-12-15 | 2008-09-23 | Hiroaki Okada | Production of sustained-release preparation for injection |
| CA2192782C (en) | 1995-12-15 | 2008-10-14 | Nobuyuki Takechi | Production of microspheres |
| US6448031B1 (en) | 1996-06-13 | 2002-09-10 | Itoham Foods Inc. | Process for producing LH-RH derivatives |
| US6051558A (en) * | 1997-05-28 | 2000-04-18 | Southern Biosystems, Inc. | Compositions suitable for controlled release of the hormone GnRH and its analogs |
| US20060025328A1 (en) * | 1997-05-28 | 2006-02-02 | Burns Patrick J | Compositions suitable for controlled release of the hormone GnRH and its analogs |
| US6242421B1 (en) | 1997-11-06 | 2001-06-05 | Richard Lloyd Bowen | Methods for preventing and treating Alzheimer's disease |
| US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US20040265285A1 (en) * | 1999-04-15 | 2004-12-30 | Monash University | Normalization of defective T cell responsiveness through manipulation of thymic regeneration |
| US20070274946A1 (en) * | 1999-04-15 | 2007-11-29 | Norwood Immunoloty, Ltd. | Tolerance to Graft Prior to Thymic Reactivation |
| US20040259803A1 (en) * | 1999-04-15 | 2004-12-23 | Monash University | Disease prevention by reactivation of the thymus |
| US20040241842A1 (en) * | 1999-04-15 | 2004-12-02 | Monash University | Stimulation of thymus for vaccination development |
| US20050020524A1 (en) * | 1999-04-15 | 2005-01-27 | Monash University | Hematopoietic stem cell gene therapy |
| US20040258672A1 (en) * | 1999-04-15 | 2004-12-23 | Monash University | Graft acceptance through manipulation of thymic regeneration |
| AUPR074500A0 (en) * | 2000-10-13 | 2000-11-09 | Monash University | Treatment of t cell disorders |
| AR023940A1 (es) | 2000-05-03 | 2002-09-04 | Eriochem Sa | Procedimiento para la produccion de microcapsulas de liberacion prolongada de peptidos solubles en agua |
| DE10032256C2 (de) * | 2000-07-03 | 2003-06-05 | Infineon Technologies Ag | Chip-ID-Register-Anordnung |
| US20060088512A1 (en) * | 2001-10-15 | 2006-04-27 | Monash University | Treatment of T cell disorders |
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| US20060287282A1 (en) * | 2001-06-25 | 2006-12-21 | Steiner Mitchell S | Compositions comprising a SARM ad GnRH agonist or a GnRH antagonist, and methods of use thereof |
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| CA2507522C (en) * | 2002-12-13 | 2015-02-24 | Durect Corporation | Oral drug delivery system |
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| US20080279812A1 (en) * | 2003-12-05 | 2008-11-13 | Norwood Immunology, Ltd. | Disease Prevention and Vaccination Prior to Thymic Reactivation |
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| WO2012175520A1 (en) | 2011-06-20 | 2012-12-27 | Novartis Ag | Hydroxy substituted isoquinolinone derivatives |
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| CA3203561A1 (en) | 2021-01-12 | 2022-07-21 | Adrian Neil Verity | Sustained release drug delivery systems and related methods |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4005063A (en) * | 1973-10-11 | 1977-01-25 | Abbott Laboratories | [Des-gly]10 -GnRH nonapeptide anide analogs in position 6 having ovulation-inducing activity |
| US3914412A (en) * | 1973-10-11 | 1975-10-21 | Abbott Lab | {8 Des{13 Gly{9 {0 10 -Gn{13 RH nonapeptide amide analogs in position 6 having ovulation-inducing activity |
| US3901872A (en) * | 1974-03-13 | 1975-08-26 | American Home Prod | P-glu-his-trp-ser-tyr-d-pgl-leu-arg-pro-gly-nh' 2 'and intermediates |
| JPS50142563A (cg-RX-API-DMAC10.html) * | 1974-04-26 | 1975-11-17 | ||
| US3896104A (en) * | 1974-05-22 | 1975-07-22 | American Home Prod | P-glu-his-trp-ser-tyr-d-lys-leu-arg-pro-gly-nh' 2 'and intermediates |
| DE2438350C3 (de) * | 1974-08-09 | 1979-06-13 | Hoechst Ag, 6000 Frankfurt | Peptide mit starker LH-RH/FSH-RH-Wirkung, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
| US3971737A (en) * | 1975-03-24 | 1976-07-27 | American Home Products Corporation | [2-Methyl-Ala6 ]LRH |
| US4024121A (en) * | 1976-01-27 | 1977-05-17 | Schally Andrew Victor | (Pyro)-Glu-His-Trp-D-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHR and intermediates |
| US4010125A (en) * | 1975-06-12 | 1977-03-01 | Schally Andrew Victor | [D-Trp6 ]-LH-RH and intermediates therefor |
| US4018726A (en) * | 1975-06-12 | 1977-04-19 | Andrew Victor Schally | [D-Phe6 ]-LH-RH and intermediates therefor |
| US3992530A (en) * | 1975-12-08 | 1976-11-16 | American Home Products Corporation | [D-2-(1,4-Cyclohexadienyl)gly]6 -des-gly10 -lrh nonapeptide amides |
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- 1977-05-05 DE DE2720245A patent/DE2720245C2/de not_active Expired
- 1977-05-05 IL IL52014A patent/IL52014A/xx unknown
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6897289B1 (en) | 1999-05-20 | 2005-05-24 | Lipotec, S.A. | Peptide synthesis procedure in solid phase |
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