ES458691A1 - Procedimiento para preparar polipeptidos. - Google Patents

Procedimiento para preparar polipeptidos.

Info

Publication number
ES458691A1
ES458691A1 ES458691A ES458691A ES458691A1 ES 458691 A1 ES458691 A1 ES 458691A1 ES 458691 A ES458691 A ES 458691A ES 458691 A ES458691 A ES 458691A ES 458691 A1 ES458691 A1 ES 458691A1
Authority
ES
Spain
Prior art keywords
luliberin
polypeptide
tyr
phe
analogues
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES458691A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of ES458691A1 publication Critical patent/ES458691A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • C07K5/06095—Arg-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/13—Luteinizing hormone-releasing hormone; related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Reproductive Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Fodder In General (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

Esta invención se relaciona con un procedimiento para preparar un polipéptido que posee propiedades agonistas de luliberina, siendo la luliberina el nombre trivial internacionalmente aprobado para LH-RF (factor de liberación de hormona luteinizante) (J. Biol. Chem., 1975, 250, 3215). Es sabido que la sustitución de alpha-aza-amino-ácidos en las posiciones 6 ó 10 de luliberina produce compuestos que son menos potentes que la molécula principal en su capacidad para liberar hormona luteinizante (LH) de la glándula pituitaria. Se ha encontrado ahora que la sustitución de azaglicina en la posición 10 en combinación con la sustitución de varios D-alpha-amino-ácidos en la posición 6 de luliberina o la sustitución de azaglicina o azalanina en la posición 6 en combinación con el remplazamiento de la amida glicínica terminal por un radical etilamina en la luliberina, produce compuestos que son más activos que la luliberina en su capacidad para liberar hormona luteilizante.
ES458691A 1976-05-11 1977-05-11 Procedimiento para preparar polipeptidos. Expired ES458691A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB19327/76A GB1524747A (en) 1976-05-11 1976-05-11 Polypeptide

Publications (1)

Publication Number Publication Date
ES458691A1 true ES458691A1 (es) 1978-08-16

Family

ID=10127509

Family Applications (1)

Application Number Title Priority Date Filing Date
ES458691A Expired ES458691A1 (es) 1976-05-11 1977-05-11 Procedimiento para preparar polipeptidos.

Country Status (27)

Country Link
US (1) US4100274A (es)
JP (1) JPS52136172A (es)
AT (2) AT379400B (es)
AU (1) AU508025B2 (es)
BE (1) BE854467A (es)
BG (1) BG60740B2 (es)
CA (1) CA1101844A (es)
CH (2) CH627151A5 (es)
CS (1) CS199673B2 (es)
DD (1) DD136738A5 (es)
DE (1) DE2720245C2 (es)
DK (1) DK149596C (es)
ES (1) ES458691A1 (es)
FI (1) FI64139C (es)
FR (1) FR2351092A1 (es)
GB (1) GB1524747A (es)
HU (1) HU179990B (es)
IE (1) IE44426B1 (es)
IL (1) IL52014A (es)
NL (2) NL191793C (es)
NO (2) NO147304C (es)
NZ (1) NZ183931A (es)
PL (2) PL104362B1 (es)
SE (2) SE437837B (es)
SU (1) SU910116A3 (es)
YU (1) YU40672B (es)
ZA (1) ZA772433B (es)

Families Citing this family (136)

* Cited by examiner, † Cited by third party
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JP7254076B2 (ja) 2017-11-19 2023-04-07 サンシャイン・レイク・ファーマ・カンパニー・リミテッド 置換ヘテロアリール化合物及び使用方法
JP7021356B2 (ja) 2017-12-21 2022-02-16 ヘフェイ インスティテューツ オブ フィジカル サイエンス， チャイニーズ アカデミー オブ サイエンシーズ ピリミジン誘導体系キナーゼ阻害剤類
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SE437993B (sv) 1985-03-25
US4100274A (en) 1978-07-11
YU117277A (en) 1983-02-28
HU179990B (en) 1983-01-28
NL191793B (nl) 1996-04-01
NO771644L (no) 1977-11-14
FI64139C (fi) 1983-10-10
PL197889A1 (pl) 1978-02-13
IE44426L (en) 1977-11-11
DK149596B (da) 1986-08-04
FR2351092B1 (es) 1980-02-22
IL52014A0 (en) 1977-07-31
AT365562B (de) 1982-01-25
NL7705130A (nl) 1977-11-15
PL104362B1 (pl) 1979-08-31
DK207977A (da) 1977-11-12
DK149596C (da) 1987-01-05
IL52014A (en) 1979-11-30
FR2351092A1 (fr) 1977-12-09
JPS6113480B2 (es) 1986-04-14
NO149586C (no) 1984-05-16
CH627151A5 (es) 1981-12-31
CS199673B2 (en) 1980-07-31
ATA335877A (de) 1985-05-15
GB1524747A (en) 1978-09-13
CA1101844A (en) 1981-05-26
AU508025B2 (en) 1980-03-06
JPS52136172A (en) 1977-11-14
NO147304B (no) 1982-12-06
FI771480A (es) 1977-11-12
SE437837B (sv) 1985-03-18
BG60740B2 (bg) 1996-01-31
DD136738A5 (de) 1979-07-25
YU40672B (en) 1986-04-30
CH629475A5 (de) 1982-04-30
AU2468177A (en) 1978-11-02
DE2720245A1 (de) 1977-11-24
NO149586B (no) 1984-02-06
SE7705432L (sv) 1977-11-12
ATA217979A (de) 1981-06-15
SE8007763L (sv) 1980-11-05
NO822984L (no) 1977-11-14
NL970002I1 (nl) 1997-03-03
BE854467A (fr) 1977-11-10
NL970002I2 (nl) 1997-05-01
IE44426B1 (en) 1981-11-18
SU910116A3 (ru) 1982-02-28
FI64139B (fi) 1983-06-30
NO147304C (no) 1983-03-16
PL108860B1 (en) 1980-05-31
AT379400B (de) 1985-12-27
ZA772433B (en) 1978-03-29
NL191793C (nl) 1996-08-02
DE2720245C2 (de) 1986-09-25
NZ183931A (en) 1979-03-16

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