FI109767B - Förfarande för tillverkning av vaccinsammansättning - Google Patents

Förfarande för tillverkning av vaccinsammansättning Download PDF

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Publication number
FI109767B
FI109767B FI946064A FI946064A FI109767B FI 109767 B FI109767 B FI 109767B FI 946064 A FI946064 A FI 946064A FI 946064 A FI946064 A FI 946064A FI 109767 B FI109767 B FI 109767B
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FI
Finland
Prior art keywords
mpl
antigen
cells
virus
rts
Prior art date
Application number
FI946064A
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English (en)
Finnish (fi)
Other versions
FI946064A0 (sv
FI946064A (sv
Inventor
Nathalie Marie- Garcon-Johnson
Jean-Paul Prieels
Moncef Slaoui
Pietro Pala
Original Assignee
Smithkline Beecham Biolog
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9213559A external-priority patent/GB9213559D0/en
Priority claimed from GB929226283A external-priority patent/GB9226283D0/en
Priority claimed from GB939304056A external-priority patent/GB9304056D0/en
Application filed by Smithkline Beecham Biolog filed Critical Smithkline Beecham Biolog
Publication of FI946064A0 publication Critical patent/FI946064A0/sv
Publication of FI946064A publication Critical patent/FI946064A/sv
Application granted granted Critical
Publication of FI109767B publication Critical patent/FI109767B/sv

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A61K39/292—Serum hepatitis virus, hepatitis B virus, e.g. Australia antigen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/002—Protozoa antigens
    • A61K39/015—Hemosporidia antigens, e.g. Plasmodium antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/245—Herpetoviridae, e.g. herpes simplex virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/29—Hepatitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55572—Lipopolysaccharides; Lipid A; Monophosphoryl lipid A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55577—Saponins; Quil A; QS21; ISCOMS
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16611—Simplexvirus, e.g. human herpesvirus 1, 2
    • C12N2710/16634—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2730/00—Reverse transcribing DNA viruses
    • C12N2730/00011—Details
    • C12N2730/10011—Hepadnaviridae
    • C12N2730/10111—Orthohepadnavirus, e.g. hepatitis B virus
    • C12N2730/10134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Claims (6)

1. Förfarande för tillverkning av en vaccinsairtmansättning, 5 kännetecknat av att ur barken till Quillaja saponaria molina renas QS21 medelst HPLC och denna blandas med en 3-0-deacylerad monofosforyllipid A (3D-MPL).
2. Förfarande enligt patentkrav 1, kännetecknat av att QS21 | och 3D-MPL blandas med en antigen eller en antigensamman- I 10 sättning.
3. Förfarande enligt patentkrav 2, kännetecknat av att an-tigenen eller antigensammansättningen härrör frän människans immunbristvirus, kattens immunbristvirus, herpes simplex virustyp 1, herpes simplex virustyp 2, människans cytomegalo- 15 virus, hepatit A, B, C eller E virus, respiratory syncytial virus, människans papillomavirus, influensavirus, Salmonella. Neisseria. Borrelia. Chlamydia. Bordetella. Plasmodium eller Toxoplasma.
4. Förfarande enligt patentkrav 2, kännetecknat av att anti- 20 genen är en tumörantigen. «II*
5. Förfarande enligt patentkrav 1, kännetecknat av att ett • iti! förhällande QS21:3D-MPL om 1:10-10:1 används. I I » * ♦ * *1^
6. Förfarande enligt patentkrav 5, kännetecknat av att ett 'li) förhällande QS21:3D-MPL om 1-1:2,5 används. * · · i » t * · » * » » t · • · » * < • · I * * * * f · » I * ! t I » I I > » I I » 1 I l » i III I t t % * » I » I · I
FI946064A 1992-06-25 1994-12-23 Förfarande för tillverkning av vaccinsammansättning FI109767B (sv)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
GB9213559 1992-06-25
GB9213559A GB9213559D0 (en) 1992-06-25 1992-06-25 Vaccines
GB929226283A GB9226283D0 (en) 1992-12-17 1992-12-17 Vaccines
GB9226283 1992-12-17
GB939304056A GB9304056D0 (en) 1993-03-01 1993-03-01 Vaccines
GB9304056 1993-03-01
EP9301524 1993-06-15
PCT/EP1993/001524 WO1994000153A1 (en) 1992-06-25 1993-06-15 Vaccine composition containing adjuvants

Publications (3)

Publication Number Publication Date
FI946064A0 FI946064A0 (sv) 1994-12-23
FI946064A FI946064A (sv) 1995-02-22
FI109767B true FI109767B (sv) 2002-10-15

Family

ID=27266263

Family Applications (1)

Application Number Title Priority Date Filing Date
FI946064A FI109767B (sv) 1992-06-25 1994-12-23 Förfarande för tillverkning av vaccinsammansättning

Country Status (31)

Country Link
US (2) US5750110A (sv)
EP (2) EP0671948B1 (sv)
JP (1) JP3755890B2 (sv)
KR (1) KR100278157B1 (sv)
CN (1) CN1122530C (sv)
AP (1) AP408A (sv)
AT (2) ATE156710T1 (sv)
AU (1) AU661404B2 (sv)
CA (1) CA2138997C (sv)
CZ (1) CZ282235B6 (sv)
DE (2) DE69327599T2 (sv)
DK (2) DK0761231T3 (sv)
ES (2) ES2143716T3 (sv)
FI (1) FI109767B (sv)
GR (2) GR3025184T3 (sv)
HK (2) HK1010097A1 (sv)
HU (1) HU219808B (sv)
IL (1) IL106109A (sv)
MA (1) MA22911A1 (sv)
MX (1) MX9303773A (sv)
MY (1) MY109278A (sv)
NO (1) NO317546B1 (sv)
NZ (1) NZ253137A (sv)
PL (1) PL170980B1 (sv)
PT (1) PT761231E (sv)
RU (1) RU2118164C1 (sv)
SG (2) SG90042A1 (sv)
SI (1) SI9300335B (sv)
SK (1) SK279188B6 (sv)
UA (1) UA40597C2 (sv)
WO (1) WO1994000153A1 (sv)

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