EA202192390A1 - Биоконъюгаты полисахаридных о-антигенов e.coli, способы их получения и способы их применения - Google Patents

Биоконъюгаты полисахаридных о-антигенов e.coli, способы их получения и способы их применения

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Publication number
EA202192390A1
EA202192390A1 EA202192390A EA202192390A EA202192390A1 EA 202192390 A1 EA202192390 A1 EA 202192390A1 EA 202192390 A EA202192390 A EA 202192390A EA 202192390 A EA202192390 A EA 202192390A EA 202192390 A1 EA202192390 A1 EA 202192390A1
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Prior art keywords
coli
methods
antigen
polysaccharide
glycosylated
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EA202192390A
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English (en)
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Ерун Гёртсен
Ян Тёнис Пулман
Келлен Кристина Фа
Питер Ян Бюргаут
Эвелине Марлен Верденбург
Патрисиа Ибарра Ион
Даррен Роберт Аббанат
Стэфан Йохен Кеммлер
Михель Томас Коварик
Мануэла Малли
Вероника Гамбиллара Фонк
Мартин Эдвард Браун
Мария Паула Карранза Сандмейер
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Янссен Фармасьютикалз, Инк.
Глаксосмитклайн Байолоджикалс С.А.
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Application filed by Янссен Фармасьютикалз, Инк., Глаксосмитклайн Байолоджикалс С.А. filed Critical Янссен Фармасьютикалз, Инк.
Publication of EA202192390A1 publication Critical patent/EA202192390A1/ru

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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
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    • C12N9/10—Transferases (2.)
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    • C12N9/1051—Hexosyltransferases (2.4.1)
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    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
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Abstract

Предложен биоконъюгат гликозилированного полисахаридного антигена O4 E.coli, ковалентно связанного с белком-носителем и его композиции. Также предложены рекомбинантные клетки-хозяева для продуцирования биоконъюгата и способы продуцирования биоконъюгата с применением рекомбинантных клеток-хозяев. Рекомбинантные клетки-хозяева содержат нуклеиновую кислоту, кодирующую глюкозилтрансферазу, которая способна модифицировать антиген O4 E.coli отвлетвлениями глюкозы для получения гликозилированного полисахаридного антигена O4. Биоконъюгаты гликозилированного полисахаридного антигена O4 E.coli, предложенные в данном документе, могут применяться в отдельности или в комбинации с одним или несколькими дополнительными полисахаридными O-антигенами E.coli для индукции антител против гликозилированного антигена E.coli и для вакцинации субъекта против внекишечной патогенной E.coli (ExPEC).
EA202192390A 2019-03-18 2020-03-18 Биоконъюгаты полисахаридных о-антигенов e.coli, способы их получения и способы их применения EA202192390A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962819746P 2019-03-18 2019-03-18
PCT/US2020/023404 WO2020191082A1 (en) 2019-03-18 2020-03-18 Bioconjugates of e. coli o-antigen polysaccharides, methods of production thereof, and methods of use thereof

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EA202192390A1 true EA202192390A1 (ru) 2021-12-03

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US (2) US11446370B2 (ru)
EP (1) EP3941516A1 (ru)
JP (1) JP7370391B2 (ru)
KR (1) KR102532707B1 (ru)
CN (1) CN113924112A (ru)
AR (1) AR118388A1 (ru)
AU (1) AU2020240072A1 (ru)
BR (1) BR112021018236A2 (ru)
CA (1) CA3134216A1 (ru)
CL (1) CL2021002426A1 (ru)
CO (1) CO2021013823A2 (ru)
CR (1) CR20210522A (ru)
EA (1) EA202192390A1 (ru)
IL (1) IL286394A (ru)
JO (1) JOP20210256A1 (ru)
MA (1) MA55364A (ru)
MX (1) MX2021011445A (ru)
PE (1) PE20212265A1 (ru)
SG (1) SG11202110301TA (ru)
TW (1) TWI751513B (ru)
UY (1) UY38616A (ru)
WO (1) WO2020191082A1 (ru)

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CO2021013823A2 (es) 2022-03-29
US20230118878A1 (en) 2023-04-20
JOP20210256A1 (ar) 2023-01-30
SG11202110301TA (en) 2021-10-28
US20200316184A1 (en) 2020-10-08
CN113924112A (zh) 2022-01-11
CL2021002426A1 (es) 2022-04-29
KR20210141586A (ko) 2021-11-23
AU2020240072A1 (en) 2021-10-28
US11446370B2 (en) 2022-09-20
MA55364A (fr) 2022-01-26
UY38616A (es) 2020-09-30
AR118388A1 (es) 2021-09-29
CA3134216A1 (en) 2020-09-24
BR112021018236A2 (pt) 2021-11-23
IL286394A (en) 2021-10-31
MX2021011445A (es) 2021-10-13
JP2022533883A (ja) 2022-07-27
EP3941516A1 (en) 2022-01-26
KR102532707B1 (ko) 2023-05-12
WO2020191082A9 (en) 2020-11-05
TW202102255A (zh) 2021-01-16
PE20212265A1 (es) 2021-11-30
WO2020191082A1 (en) 2020-09-24
US11931405B2 (en) 2024-03-19
CR20210522A (es) 2021-12-17
JP7370391B2 (ja) 2023-10-27
TWI751513B (zh) 2022-01-01

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