AR118388A1 - Bioconjugados de antígenos-polisacáridos de e. coli, métodos de producción y métodos de utilización de los mismos - Google Patents

Bioconjugados de antígenos-polisacáridos de e. coli, métodos de producción y métodos de utilización de los mismos

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Publication number
AR118388A1
AR118388A1 ARP200100746A ARP200100746A AR118388A1 AR 118388 A1 AR118388 A1 AR 118388A1 AR P200100746 A ARP200100746 A AR P200100746A AR P200100746 A ARP200100746 A AR P200100746A AR 118388 A1 AR118388 A1 AR 118388A1
Authority
AR
Argentina
Prior art keywords
coli
antigen
glycosylated
methods
bioconjugates
Prior art date
Application number
ARP200100746A
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English (en)
Original Assignee
Janssen Pharmaceuticals Inc
Glaxosmithkline Biologicals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceuticals Inc, Glaxosmithkline Biologicals Sa filed Critical Janssen Pharmaceuticals Inc
Publication of AR118388A1 publication Critical patent/AR118388A1/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

Se proporciona un bioconjunto de un polisacárido de antígeno O4 glicosilado de E. coli unido covalentemente a una proteína portadora, y sus composiciones. También se proporcionan células huéspedes recombinantes para producir el bioconjugado, y métodos para producir el bioconjugado usando las células huéspedes recombinantes. Las células huéspedes recombinantes contienen un ácido nucleico que codifica un glicosil transferasa capaz de modificar el antígeno O4 de E. coli ramificado de glucosa para producir el polisacárido de antígeno O4 glicosilado. Los bioconjugados de un polisacárido de antígeno O4 glicosilado de E. coli descritos en este documento pueden usarse solos o en combinación con uno o más polisacáridos de antígeno O de E. coli adicionales, para inducir anticuerpos contra un antígeno glicosilado de E. coli y para vacunar a un sujeto contra E. coli patógena extra intestinal (ExPEC).
ARP200100746A 2019-03-18 2020-03-18 Bioconjugados de antígenos-polisacáridos de e. coli, métodos de producción y métodos de utilización de los mismos AR118388A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962819746P 2019-03-18 2019-03-18

Publications (1)

Publication Number Publication Date
AR118388A1 true AR118388A1 (es) 2021-09-29

Family

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Family Applications (1)

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ARP200100746A AR118388A1 (es) 2019-03-18 2020-03-18 Bioconjugados de antígenos-polisacáridos de e. coli, métodos de producción y métodos de utilización de los mismos

Country Status (23)

Country Link
US (3) US11446370B2 (es)
EP (1) EP3941516A1 (es)
JP (1) JP7370391B2 (es)
KR (1) KR102532707B1 (es)
CN (1) CN113924112A (es)
AR (1) AR118388A1 (es)
AU (1) AU2020240072A1 (es)
BR (1) BR112021018236A2 (es)
CA (1) CA3134216A1 (es)
CL (1) CL2021002426A1 (es)
CO (1) CO2021013823A2 (es)
CR (1) CR20210522A (es)
EA (1) EA202192390A1 (es)
IL (1) IL286394A (es)
JO (1) JOP20210256A1 (es)
MA (1) MA55364A (es)
MX (1) MX2021011445A (es)
PE (1) PE20212265A1 (es)
SA (1) SA521430310B1 (es)
SG (1) SG11202110301TA (es)
TW (1) TWI751513B (es)
UY (1) UY38616A (es)
WO (1) WO2020191082A1 (es)

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Publication number Publication date
TWI751513B (zh) 2022-01-01
EP3941516A1 (en) 2022-01-26
BR112021018236A2 (pt) 2021-11-23
KR102532707B1 (ko) 2023-05-12
WO2020191082A1 (en) 2020-09-24
CA3134216A1 (en) 2020-09-24
PE20212265A1 (es) 2021-11-30
AU2020240072A1 (en) 2021-10-28
MX2021011445A (es) 2021-10-13
US20200316184A1 (en) 2020-10-08
IL286394A (en) 2021-10-31
JP7370391B2 (ja) 2023-10-27
UY38616A (es) 2020-09-30
US11446370B2 (en) 2022-09-20
US20230118878A1 (en) 2023-04-20
MA55364A (fr) 2022-01-26
TW202102255A (zh) 2021-01-16
JOP20210256A1 (ar) 2023-01-30
JP2022533883A (ja) 2022-07-27
EA202192390A1 (ru) 2021-12-03
CN113924112A (zh) 2022-01-11
SA521430310B1 (ar) 2023-12-13
CR20210522A (es) 2021-12-17
US11931405B2 (en) 2024-03-19
KR20210141586A (ko) 2021-11-23
CO2021013823A2 (es) 2022-03-29
CL2021002426A1 (es) 2022-04-29
WO2020191082A9 (en) 2020-11-05
SG11202110301TA (en) 2021-10-28
US20240316172A1 (en) 2024-09-26

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