BR112021018236A2 - Bioconjugado de um polissacarídeo de antígeno o4 glicosilado de e. coli covalentemente ligado a uma proteína transportadora, composição, métodos para induzir anticorpos, para vacinar um indivíduo e para produzir um bioconjugado, e, célula hospedeira procariótica recombinante - Google Patents

Bioconjugado de um polissacarídeo de antígeno o4 glicosilado de e. coli covalentemente ligado a uma proteína transportadora, composição, métodos para induzir anticorpos, para vacinar um indivíduo e para produzir um bioconjugado, e, célula hospedeira procariótica recombinante

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Publication number
BR112021018236A2
BR112021018236A2 BR112021018236A BR112021018236A BR112021018236A2 BR 112021018236 A2 BR112021018236 A2 BR 112021018236A2 BR 112021018236 A BR112021018236 A BR 112021018236A BR 112021018236 A BR112021018236 A BR 112021018236A BR 112021018236 A2 BR112021018236 A2 BR 112021018236A2
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BR
Brazil
Prior art keywords
bioconjugate
coli
glycosylated
producing
methods
Prior art date
Application number
BR112021018236A
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English (en)
Inventor
Robert Abbanat Darren
Marleen Weerdenburg Eveline
Theunis Poolman Jan
Jeroen Geurtsen
Cristhina Fae Kellen
Manuela Mally
Paula Carranza Sandmeier Maria
Edward Braun Martin
Thomas Kowarik Michael
Ibarra Yon Patricia
Jan Burghout Pieter
Jochen Kemmler Stefan
Gambillara Fonck Veronica
Original Assignee
Glaxosmithkline Biologicals Sa
Janssen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Glaxosmithkline Biologicals Sa, Janssen Pharmaceuticals Inc filed Critical Glaxosmithkline Biologicals Sa
Publication of BR112021018236A2 publication Critical patent/BR112021018236A2/pt

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • General Health & Medical Sciences (AREA)
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  • Biochemistry (AREA)
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  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Urology & Nephrology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

bioconjugado de um polissacarídeo de antígeno o4 glicosilado de e. coli covalentemente ligado a uma proteína transportadora, composição, métodos para induzir anticorpos, para vacinar um indivíduo e para produzir um bioconjugado, e, célula hospedeira procariótica recombinante. são fornecidos um bioconjugado de um polissacarídeo de antígeno o4 glicosilado de e. coli covalentemente ligado a uma proteína transportadora e composições do mesmo. também são fornecidas células hospedeiras recombinantes para produzir o bioconjugado e métodos para produzir o bioconjugado usando as células hospedeiras recombinantes. as células hospedeiras recombinantes contêm um ácido nucleico que codifica uma glicosiltransferase capaz de modificar o antígeno o4 de e. coli com ramificação de glicose para produzir o polissacarídeo do antígeno o4 glicosilado. bioconjugados de um polissacarídeo de antígeno o4 glicosilado de e. coli descrito neste documento, podem ser usados sozinhos ou em combinação com um ou mais polissacarídeos de antígeno o de e. coli adicionais para induzir anticorpos contra um antígeno glicosilado de e. coli e para vacinar um indivíduo contra e. coli patogênica intestinal (expec).
BR112021018236A 2019-03-18 2020-03-18 Bioconjugado de um polissacarídeo de antígeno o4 glicosilado de e. coli covalentemente ligado a uma proteína transportadora, composição, métodos para induzir anticorpos, para vacinar um indivíduo e para produzir um bioconjugado, e, célula hospedeira procariótica recombinante BR112021018236A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962819746P 2019-03-18 2019-03-18
PCT/US2020/023404 WO2020191082A1 (en) 2019-03-18 2020-03-18 Bioconjugates of e. coli o-antigen polysaccharides, methods of production thereof, and methods of use thereof

Publications (1)

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BR112021018236A2 true BR112021018236A2 (pt) 2021-11-23

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BR112021018236A BR112021018236A2 (pt) 2019-03-18 2020-03-18 Bioconjugado de um polissacarídeo de antígeno o4 glicosilado de e. coli covalentemente ligado a uma proteína transportadora, composição, métodos para induzir anticorpos, para vacinar um indivíduo e para produzir um bioconjugado, e, célula hospedeira procariótica recombinante

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US (2) US11446370B2 (pt)
EP (1) EP3941516A1 (pt)
JP (1) JP7370391B2 (pt)
KR (1) KR102532707B1 (pt)
CN (1) CN113924112A (pt)
AR (1) AR118388A1 (pt)
AU (1) AU2020240072A1 (pt)
BR (1) BR112021018236A2 (pt)
CA (1) CA3134216A1 (pt)
CL (1) CL2021002426A1 (pt)
CO (1) CO2021013823A2 (pt)
CR (1) CR20210522A (pt)
EA (1) EA202192390A1 (pt)
IL (1) IL286394A (pt)
JO (1) JOP20210256A1 (pt)
MA (1) MA55364A (pt)
MX (1) MX2021011445A (pt)
PE (1) PE20212265A1 (pt)
SA (1) SA521430310B1 (pt)
SG (1) SG11202110301TA (pt)
TW (1) TWI751513B (pt)
UY (1) UY38616A (pt)
WO (1) WO2020191082A1 (pt)

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US20200316184A1 (en) 2020-10-08
PE20212265A1 (es) 2021-11-30
TWI751513B (zh) 2022-01-01
IL286394A (en) 2021-10-31
AR118388A1 (es) 2021-09-29
MX2021011445A (es) 2021-10-13
US20230118878A1 (en) 2023-04-20
TW202102255A (zh) 2021-01-16
SA521430310B1 (ar) 2023-12-13
KR20210141586A (ko) 2021-11-23
US11931405B2 (en) 2024-03-19
JP2022533883A (ja) 2022-07-27
CR20210522A (es) 2021-12-17
CA3134216A1 (en) 2020-09-24
KR102532707B1 (ko) 2023-05-12
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