AR084158A1 - Formulaciones que mitigan la agregacion inducida por agitacion de composiciones inmunogenicas - Google Patents
Formulaciones que mitigan la agregacion inducida por agitacion de composiciones inmunogenicasInfo
- Publication number
- AR084158A1 AR084158A1 ARP110104542A ARP110104542A AR084158A1 AR 084158 A1 AR084158 A1 AR 084158A1 AR P110104542 A ARP110104542 A AR P110104542A AR P110104542 A ARP110104542 A AR P110104542A AR 084158 A1 AR084158 A1 AR 084158A1
- Authority
- AR
- Argentina
- Prior art keywords
- formulations
- poloxamer
- mitigate
- immunogenic compositions
- agmation
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N25/00—Biocides, pest repellants or attractants, or plant growth regulators, characterised by their forms, or by their non-active ingredients or by their methods of application, e.g. seed treatment or sequential application; Substances for reducing the noxious effect of the active ingredients to organisms other than pests
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/116—Polyvalent bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Toxicology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
Formulaciones que mitigan la agregación inducida por agitación de composiciones inmunogénicas particularmente aquellas que tienen conjugados de polisacárido-proteína. Específicamente, las formulaciones comprenden un poloxámero dentro del intervalo de peso molecular de 1.100 a 17.400 que proporciona ventajas significativas con respecto a tensioactivos usados previamente que incluyen polisorbato 80. En una realización, proporciona una composición inmunogénica multivalente que tiene 15 conjugados de polisacárido-proteína diferentes y un poloxámero. Cada conjugado consiste en un polisacárido capsular preparado a partir de un serotipo diferente de Streptococcus pneumoniae (1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, 22F, 23F o 33F) conjugado a una proteína transportadora, preferentemente CRM197.Reivindicación 2: El poloxámero de la reivindicación 1 que tiene un peso molecular en el intervalo de 7.500 a 15.000.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42196010P | 2010-12-10 | 2010-12-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR084158A1 true AR084158A1 (es) | 2013-04-24 |
Family
ID=46207464
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP110104542A AR084158A1 (es) | 2010-12-10 | 2011-12-05 | Formulaciones que mitigan la agregacion inducida por agitacion de composiciones inmunogenicas |
Country Status (13)
Country | Link |
---|---|
US (1) | US20130273098A1 (es) |
EP (1) | EP2648506A1 (es) |
JP (1) | JP2014502595A (es) |
KR (1) | KR20140005892A (es) |
CN (1) | CN103391714A (es) |
AR (1) | AR084158A1 (es) |
AU (1) | AU2011338723A1 (es) |
BR (1) | BR112013012626A2 (es) |
CA (1) | CA2819366A1 (es) |
MX (1) | MX2013006539A (es) |
RU (1) | RU2013131795A (es) |
TW (1) | TW201304803A (es) |
WO (1) | WO2012078482A1 (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011014487A1 (en) | 2009-07-30 | 2011-02-03 | Merck Sharp & Dohme Corp. | Hepatitis c virus ns3 protease inhibitors |
EP2575870B1 (en) * | 2010-06-04 | 2016-12-07 | Wyeth LLC | Vaccine formulations |
KR102057217B1 (ko) | 2012-06-20 | 2020-01-22 | 에스케이바이오사이언스 주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
MX363511B (es) * | 2012-08-16 | 2019-03-26 | Pfizer | Proceso de glucoconjugación y composiciones. |
CN103623401A (zh) * | 2012-08-23 | 2014-03-12 | 北京科兴中维生物技术有限公司 | 多价肺炎球菌荚膜多糖-蛋白质共轭组合物及其制备方法 |
KR20140075196A (ko) | 2012-12-11 | 2014-06-19 | 에스케이케미칼주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
MX365331B (es) | 2013-01-17 | 2019-05-29 | Arsanis Biosciences Gmbh | Anticuerpo específico contra e. coli mdr. |
CN104069488A (zh) * | 2013-03-29 | 2014-10-01 | 北京科兴中维生物技术有限公司 | 多价肺炎球菌荚膜多糖-蛋白质共轭组合物及其制备方法 |
IL296681B2 (en) * | 2014-01-21 | 2024-09-01 | Pfizer | Immunogenic preparations including conjugated capsular saccharide antigens and their uses |
HUE055553T2 (hu) * | 2014-01-21 | 2021-12-28 | Pfizer | Streptococcus pneumoniae kapszulás poliszacharidok és azok konjugátumai |
US11160855B2 (en) * | 2014-01-21 | 2021-11-02 | Pfizer Inc. | Immunogenic compositions comprising conjugated capsular saccharide antigens and uses thereof |
EP3957321A3 (en) * | 2014-01-21 | 2022-07-13 | Pfizer Inc. | Streptococcus pneumoniae capsular polysaccharides and conjugates thereof |
AU2015220723C1 (en) | 2014-02-24 | 2018-04-05 | Glaxosmithkline Biologicals Sa | Novel polysaccharide and uses thereof |
TN2017000126A1 (en) * | 2014-10-09 | 2018-10-19 | Msd Wellcome Trust Hilleman Laboratories Pvt Ltd | An improved process of conjugation and novel synthetic oligosaccharide- protein conjugates obtained thereof |
CA2988366C (en) * | 2015-06-08 | 2021-12-07 | Serum Institute Of India Private Ltd. | Methods for improving the adsorption of polysaccharide-protein conjugates and multivalent vaccine formulation obtained thereof. |
PE20240927A1 (es) | 2015-07-21 | 2024-04-30 | Pfizer | Composiciones inmunogenas que comprenden antigenos de sacarido capsular conjugados, kits que las comprenden y sus usos |
TWI715617B (zh) | 2015-08-24 | 2021-01-11 | 比利時商葛蘭素史密斯克藍生物品公司 | 對抗腸道外病原性大腸桿菌之免疫保護之方法及組合物 |
AR109621A1 (es) | 2016-10-24 | 2018-12-26 | Janssen Pharmaceuticals Inc | Formulaciones de vacunas contra glucoconjugados de expec |
US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
KR20190103256A (ko) | 2016-12-30 | 2019-09-04 | 수트로박스, 인코포레이티드 | 비자연 아미노산을 갖는 폴리펩타이드-항원 접합체 |
US11197921B2 (en) | 2017-01-31 | 2021-12-14 | Merck Sharp & Dohme Corp. | Methods for making polysaccharide-protein conjugates |
KR102650073B1 (ko) | 2017-01-31 | 2024-03-20 | 머크 샤프 앤드 돔 엘엘씨 | 스트렙토코커스 뉴모니아 혈청형 19f 유래의 협막 다당류 단백질 접합체의 제조 방법 |
WO2018156468A1 (en) * | 2017-02-24 | 2018-08-30 | Merck Sharp & Dohme Corp. | Pneumococcal conjugate vaccine formulations |
US11219680B2 (en) | 2017-02-24 | 2022-01-11 | Merck Sharp & Dohme Corp. | Polysaccharide-protein conjugates utilizing diphtheria toxin fragment B as a carrier |
EP3589314A4 (en) | 2017-02-24 | 2021-04-21 | Merck Sharp & Dohme Corp. | INCREASED IMMUNOGENICITY OF STREPTOCOCCUS PNEUMONIAE POLYSACCHARIDE PROTEIN CONJUGATES |
KR20200040812A (ko) * | 2017-08-16 | 2020-04-20 | 머크 샤프 앤드 돔 코포레이션 | 폐렴구균 접합체 백신 제제 |
CA3074703A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
AU2018328036B2 (en) * | 2017-09-07 | 2024-03-07 | Merck Sharp & Dohme Llc | Pneumococcal polysaccharides and their use in immunogenic polysaccharide-carrier protein conjugates |
WO2019050816A1 (en) | 2017-09-07 | 2019-03-14 | Merck Sharp & Dohme Corp. | ANTI-PNEUMOCOCCAL POLYSACCHARIDES AND THEIR USE IN IMMUNOGENIC CONJUGATES POLYSACCHARIDE-PROTEIN CARRIER |
US20200325020A1 (en) * | 2017-10-25 | 2020-10-15 | Merck Sharp & Dohme Corp. | Adjuvanted vaccines |
CN117982633A (zh) | 2017-12-06 | 2024-05-07 | 默沙东有限责任公司 | 包含肺炎链球菌多糖蛋白缀合物的组合物及其使用方法 |
BR112020020802A2 (pt) * | 2018-04-13 | 2021-01-12 | Genentech, Inc. | Composições farmacêuticas, composições farmacêuticas produzidas por liofilização, composições líquidas, composição farmacêutica compreendendo um imunoconjugado anti-cd79b, frasco de vidro, composição líquida compreendendo um imunoconjugado anti-cd79b, composições farmacêuticas liofilizadas, composição liofilizada, composições farmacêuticas líquidas, método para tratar um distúrbio proliferativo |
EP3787673A4 (en) | 2018-04-30 | 2022-04-27 | Merck Sharp & Dohme Corp. | METHODS FOR PRODUCING CAPSULAR CARRIER PROTEIN-POLYSACCHARIDE CONJUGATES OF STREPTOCOCCUS PNEUMONIAE |
WO2019212844A1 (en) | 2018-04-30 | 2019-11-07 | Merck Sharp & Dohme Corp. | Methods for providing a homogenous solution of lyophilized mutant diptheria toxin in dimethylsulfoxide |
SG11202106541WA (en) | 2018-12-19 | 2021-07-29 | Merck Sharp & Dohme | Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof |
US11446370B2 (en) | 2019-03-18 | 2022-09-20 | Janssen Pharmaceuticals, Inc. | Bioconjugates of E. coli o-antigen polysaccharides, methods of production thereof, and methods of use thereof |
JP2022525773A (ja) | 2019-03-18 | 2022-05-19 | ヤンセン ファーマシューティカルズ,インコーポレーテッド | 大腸菌o抗原多糖のバイオコンジュゲートを製造する方法、その組成物およびその使用方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE360640T1 (de) * | 2000-08-08 | 2007-05-15 | St Jude Childrens Res Hospital | Gruppe-b streptococcus polypeptide, nukleinsäure, therapeutische zusammensetzungen und impfstoffe davon |
ES2564241T3 (es) * | 2005-12-02 | 2016-03-21 | Glaxosmithkline Biologicals Sa | Nanopartículas para su uso en composiciones inmunogénicas |
AU2006330858A1 (en) * | 2005-12-21 | 2007-07-05 | Wyeth | Protein formulations with reduced viscosity and uses thereof |
TW200806315A (en) * | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
AU2008259423A1 (en) * | 2007-06-04 | 2008-12-11 | Novartis Ag | Formulation of meningitis vaccines |
JP5555623B2 (ja) * | 2007-06-20 | 2014-07-23 | バクスター・インターナショナル・インコーポレイテッド | コンジュゲートワクチン用修飾多糖 |
US8962026B2 (en) * | 2008-09-26 | 2015-02-24 | The Regents Of The University Of Michigan | Nanoemulsion therapeutic compositions and methods of using the same |
-
2011
- 2011-12-05 KR KR1020137014672A patent/KR20140005892A/ko not_active Application Discontinuation
- 2011-12-05 BR BR112013012626A patent/BR112013012626A2/pt not_active IP Right Cessation
- 2011-12-05 MX MX2013006539A patent/MX2013006539A/es not_active Application Discontinuation
- 2011-12-05 JP JP2013543230A patent/JP2014502595A/ja active Pending
- 2011-12-05 AR ARP110104542A patent/AR084158A1/es unknown
- 2011-12-05 WO PCT/US2011/063215 patent/WO2012078482A1/en active Application Filing
- 2011-12-05 RU RU2013131795/15A patent/RU2013131795A/ru not_active Application Discontinuation
- 2011-12-05 CA CA2819366A patent/CA2819366A1/en not_active Abandoned
- 2011-12-05 US US13/992,844 patent/US20130273098A1/en not_active Abandoned
- 2011-12-05 EP EP11846964.2A patent/EP2648506A1/en not_active Withdrawn
- 2011-12-05 AU AU2011338723A patent/AU2011338723A1/en not_active Abandoned
- 2011-12-05 CN CN2011800595990A patent/CN103391714A/zh active Pending
- 2011-12-06 TW TW100144929A patent/TW201304803A/zh unknown
Also Published As
Publication number | Publication date |
---|---|
CA2819366A1 (en) | 2012-06-14 |
MX2013006539A (es) | 2013-07-22 |
US20130273098A1 (en) | 2013-10-17 |
TW201304803A (zh) | 2013-02-01 |
BR112013012626A2 (pt) | 2016-07-19 |
EP2648506A1 (en) | 2013-10-16 |
WO2012078482A1 (en) | 2012-06-14 |
CN103391714A (zh) | 2013-11-13 |
AU2011338723A1 (en) | 2013-05-30 |
JP2014502595A (ja) | 2014-02-03 |
KR20140005892A (ko) | 2014-01-15 |
RU2013131795A (ru) | 2015-01-20 |
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TH160962A (th) | "องค์ประกอบมัลติวาเลนท์ นิวโมคอกคัสโพลีแซคคาไรด์-โปรตีน คอนจูเกต" | |
AR093161A1 (es) | Composicion de conjugados polisacarido-proteina neumococicos multivalente | |
TH160962B (th) | "องค์ประกอบมัลติวาเลนท์ นิวโมคอกคัสโพลีแซคคาไรด์-โปรตีน คอนจูเกต" | |
TH128171B (th) | องค์ประกอบวัคซีนคอนจูเกต 15-วาเลนท์ นิวโมคอคคอล โพลีแซคคาไรด์-โปรตีน |
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