MX2016011055A - Nuevo polisacarido y usos del mismo. - Google Patents
Nuevo polisacarido y usos del mismo.Info
- Publication number
- MX2016011055A MX2016011055A MX2016011055A MX2016011055A MX2016011055A MX 2016011055 A MX2016011055 A MX 2016011055A MX 2016011055 A MX2016011055 A MX 2016011055A MX 2016011055 A MX2016011055 A MX 2016011055A MX 2016011055 A MX2016011055 A MX 2016011055A
- Authority
- MX
- Mexico
- Prior art keywords
- bioconjugates
- compositions
- host cells
- novel polysaccharide
- polysaccharide
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0066—Isolation or extraction of proteoglycans from organs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6087—Polysaccharides; Lipopolysaccharides [LPS]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
La presente invención se refiere a un nuevo polisacárido O de E. coli, O258. También se proporcionan en la presente células hospederas procarióticas que comprende enzimas (por ejemplo, glicosiltransferasas) usadas en la producción de O25B. Las células hospederas proporcionadas en la presente producen bioconjugados de O25B, en donde tales bioconjugados comprenden O25B ligado a una proteína portadora. Además, proporcionadas en la presente están composiciones, por ejemplo, composiciones farmacéuticas, que comprenden O25B y/o bioconjugados que comprenden O258. Tales composiciones pueden ser usadas como vacunas contra la infección con ExPEC, y pueden comprender, además, uno o más bioconjugados adicionales.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201461943710P | 2014-02-24 | 2014-02-24 | |
PCT/EP2015/053739 WO2015124769A1 (en) | 2014-02-24 | 2015-02-23 | Novel polysaccharide and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016011055A true MX2016011055A (es) | 2017-10-24 |
Family
ID=52589386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016011055A MX2016011055A (es) | 2014-02-24 | 2015-02-23 | Nuevo polisacarido y usos del mismo. |
Country Status (19)
Country | Link |
---|---|
US (5) | US9700612B2 (es) |
EP (1) | EP3110441B1 (es) |
JP (2) | JP6276427B2 (es) |
KR (1) | KR101855142B1 (es) |
CN (1) | CN106535927B (es) |
AR (1) | AR100859A1 (es) |
AU (1) | AU2015220723C1 (es) |
BR (1) | BR112016019341A2 (es) |
CA (1) | CA2940547C (es) |
CL (1) | CL2016002123A1 (es) |
EA (1) | EA035991B9 (es) |
IL (1) | IL247344B (es) |
LT (1) | LT3110441T (es) |
MX (1) | MX2016011055A (es) |
NZ (1) | NZ723328A (es) |
PH (1) | PH12016501671A1 (es) |
SG (1) | SG11201606889PA (es) |
TW (1) | TWI639439B (es) |
WO (1) | WO2015124769A1 (es) |
Families Citing this family (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2718051T3 (es) | 2013-01-17 | 2019-06-27 | Arsanis Biosciences Gmbh | Antígeno específico de E. coli MDR |
CA2940547C (en) | 2014-02-24 | 2021-01-05 | Glycovaxyn Ag | Novel polysaccharide and uses thereof |
US10722580B2 (en) * | 2015-05-13 | 2020-07-28 | University Of Washington | Compositions and methods for treatment and prevention of uropathogenic E. coli infection |
TWI715617B (zh) * | 2015-08-24 | 2021-01-11 | 比利時商葛蘭素史密斯克藍生物品公司 | 對抗腸道外病原性大腸桿菌之免疫保護之方法及組合物 |
AR109621A1 (es) * | 2016-10-24 | 2018-12-26 | Janssen Pharmaceuticals Inc | Formulaciones de vacunas contra glucoconjugados de expec |
GB201711637D0 (en) * | 2017-07-19 | 2017-08-30 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
US20190275134A1 (en) | 2018-03-12 | 2019-09-12 | Janssen Pharmaceuticals, Inc | Vaccines against urinary tract infections |
CN108531439B (zh) * | 2018-04-16 | 2020-04-07 | 南京工业大学 | 一种大肠杆菌基因工程菌及其构建方法与应用 |
US11260119B2 (en) | 2018-08-24 | 2022-03-01 | Pfizer Inc. | Escherichia coli compositions and methods thereof |
CA3134216A1 (en) | 2019-03-18 | 2020-09-24 | Janssen Pharmaceuticals, Inc. | Bioconjugates of e. coli o-antigen polysaccharides, methods of production thereof, and methods of use thereof |
CA3134045A1 (en) | 2019-03-18 | 2020-09-24 | Janssen Pharmaceuticals, Inc. | Methods of producing bioconjugates of e. coli o-antigen polysaccharides, compositions thereof, and methods of use thereof |
CN110018253A (zh) * | 2019-04-15 | 2019-07-16 | 艾美卫信生物药业(浙江)有限公司 | 一种生物制品中游离蛋白含量的高效液相测定方法 |
CN111855826B (zh) * | 2019-04-24 | 2022-09-16 | 岛津企业管理(中国)有限公司 | 破伤风类毒素或白喉类毒素的监测方法 |
GB201908528D0 (en) * | 2019-06-13 | 2019-07-31 | Univ Dundee | Rhamnose-polysaccharides |
BR112022013720A2 (pt) | 2020-01-16 | 2022-10-11 | Janssen Pharmaceuticals Inc | Mutante fimh, composições com o mesmo e seu uso |
JP2023530154A (ja) | 2020-06-18 | 2023-07-13 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 赤痢菌4価(Shigella4V)バイオコンジュゲート |
CA3185642A1 (en) | 2020-06-25 | 2021-12-30 | Glaxosmithkline Biologicals Sa | Modified exotoxin a proteins |
AU2021342797B2 (en) | 2020-09-17 | 2024-02-08 | Janssen Pharmaceuticals, Inc. | Multivalent vaccine compositions and uses thereof |
US20230349913A1 (en) * | 2020-11-30 | 2023-11-02 | Janssen Pharmaceuticals, Inc. | Analytical method for glycogonjugates using a capillary-based immunoassay system |
EP4277921A1 (en) | 2021-01-12 | 2023-11-22 | Janssen Pharmaceuticals, Inc. | Fimh mutants, compositions therewith and use thereof |
WO2022178020A1 (en) | 2021-02-16 | 2022-08-25 | Duke University | Vaccine compositions and methods for the treatment and prevention of urinary tract infections |
BR112023019874A2 (pt) | 2021-04-01 | 2023-11-07 | Janssen Pharmaceuticals Inc | Produção de bioconjugados de e. coli o18 |
WO2022214620A1 (en) | 2021-04-08 | 2022-10-13 | Janssen Pharmaceuticals, Inc. | Process for bioconjugate production |
WO2023118033A1 (en) | 2021-12-22 | 2023-06-29 | Glaxosmithkline Biologicals Sa | Vaccine |
US20230222313A1 (en) * | 2022-01-12 | 2023-07-13 | Dell Products L.P. | Polysaccharide archival storage |
CN114150005B (zh) * | 2022-02-09 | 2022-04-22 | 广州恩宝生物医药科技有限公司 | 用于预防SARS-CoV-2奥密克戎株的腺病毒载体疫苗 |
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US3700612A (en) | 1971-06-23 | 1972-10-24 | Tenneco Chem | Aqueous surface-coating compositions containing hydroxyalkyl ethers of galactomannan gums as thickeners |
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US5370872A (en) | 1991-08-12 | 1994-12-06 | Swiss Serum And Vaccine Institute Berne | Escherichia coliO-polysaccharide-protein conjugate vaccine |
ES2258214T3 (es) | 2002-03-07 | 2006-08-16 | Eidgenossische Technische Hochschule Zurich | Sistema y procedimiento para la produccion de proteinas glucosiladas recombinantes en un huesped procariotico. |
KR101524636B1 (ko) | 2005-05-11 | 2015-06-03 | 에테하 취리히 | 원핵 세포로부터의 재조합 n-글리코실화 단백질 |
CA2646539A1 (en) | 2006-03-23 | 2007-09-27 | Novartis Ag | Imidazoquinoxaline compounds as immunomodulators |
CA2646891A1 (en) | 2006-03-23 | 2007-09-27 | Novartis Ag | Immunopotentiating compounds |
JP5647899B2 (ja) | 2008-01-08 | 2015-01-07 | ラツィオファルム ゲーエムベーハーratiopharm GmbH | オリゴサッカリルトランスフェラーゼを使用するポリペプチドの複合糖質化 |
SI2257307T1 (sl) * | 2008-02-20 | 2018-09-28 | Glaxosmithkline Biologicals S.A. | Biokonjugati, izdelani iz rekombinantnih N-glikoziliranih proteinov iz prokariontskih celic |
PT2501406T (pt) | 2009-11-19 | 2018-02-21 | Glaxosmithkline Biologicals Sa | Sistema de biossíntese que produz polissacáridos imunogénicos em células procariotas |
WO2012078482A1 (en) | 2010-12-10 | 2012-06-14 | Merck Sharp & Dohme Corp. | Novel formulations which mitigate agitation-induced aggregation of immunogenic compositions |
JP2014526449A (ja) * | 2011-09-06 | 2014-10-06 | グリコヴァキシン アーゲー | 原核細胞において製造されるバイオコンジュゲートワクチン |
US9932598B2 (en) | 2012-08-02 | 2018-04-03 | The Regents Of The University Of California | Metabolic engineering of microbial organisms |
BR112015004817A2 (pt) | 2012-09-10 | 2017-07-04 | Glycovaxyn Ag | bioconjugados compreendendo antígenos modificados e seus usos |
EP3527663B1 (en) | 2012-10-12 | 2021-12-01 | GlaxoSmithKline Biologicals SA | Methods of host cell modification |
US10287330B2 (en) | 2012-12-27 | 2019-05-14 | Glaxosmithkline Biologicals S.A. | Methods and compositions relating to CRM197 |
ES2718051T3 (es) * | 2013-01-17 | 2019-06-27 | Arsanis Biosciences Gmbh | Antígeno específico de E. coli MDR |
EA201690529A1 (ru) | 2013-10-11 | 2016-11-30 | Гликоваксин Аг | Способы модификации клетки-хозяина |
CN106536551B (zh) | 2014-02-06 | 2021-04-16 | X4制药(奥地利)有限责任公司 | 大肠杆菌特异性抗体序列 |
CA2940547C (en) | 2014-02-24 | 2021-01-05 | Glycovaxyn Ag | Novel polysaccharide and uses thereof |
BE1022998B1 (fr) | 2014-12-30 | 2016-10-28 | Glycovaxyn Ag | Compositions et procédés de glycosylation de protéines |
TWI715617B (zh) | 2015-08-24 | 2021-01-11 | 比利時商葛蘭素史密斯克藍生物品公司 | 對抗腸道外病原性大腸桿菌之免疫保護之方法及組合物 |
AR109621A1 (es) | 2016-10-24 | 2018-12-26 | Janssen Pharmaceuticals Inc | Formulaciones de vacunas contra glucoconjugados de expec |
GB201711635D0 (en) | 2017-07-19 | 2017-08-30 | Glaxosmithkline Biologicals Sa | Immunogenic composition |
CA3134045A1 (en) | 2019-03-18 | 2020-09-24 | Janssen Pharmaceuticals, Inc. | Methods of producing bioconjugates of e. coli o-antigen polysaccharides, compositions thereof, and methods of use thereof |
CA3134216A1 (en) | 2019-03-18 | 2020-09-24 | Janssen Pharmaceuticals, Inc. | Bioconjugates of e. coli o-antigen polysaccharides, methods of production thereof, and methods of use thereof |
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2015
- 2015-02-23 CA CA2940547A patent/CA2940547C/en active Active
- 2015-02-23 EP EP15706459.3A patent/EP3110441B1/en active Active
- 2015-02-23 SG SG11201606889PA patent/SG11201606889PA/en unknown
- 2015-02-23 AR ARP150100534A patent/AR100859A1/es unknown
- 2015-02-23 BR BR112016019341A patent/BR112016019341A2/pt active IP Right Grant
- 2015-02-23 MX MX2016011055A patent/MX2016011055A/es unknown
- 2015-02-23 WO PCT/EP2015/053739 patent/WO2015124769A1/en active Application Filing
- 2015-02-23 LT LTEPPCT/EP2015/053739T patent/LT3110441T/lt unknown
- 2015-02-23 NZ NZ723328A patent/NZ723328A/en unknown
- 2015-02-23 CN CN201580020077.8A patent/CN106535927B/zh active Active
- 2015-02-23 AU AU2015220723A patent/AU2015220723C1/en active Active
- 2015-02-23 EA EA201691478A patent/EA035991B9/ru unknown
- 2015-02-23 JP JP2016570184A patent/JP6276427B2/ja active Active
- 2015-02-23 KR KR1020167026424A patent/KR101855142B1/ko active IP Right Grant
- 2015-02-23 US US14/628,844 patent/US9700612B2/en active Active
- 2015-02-24 TW TW104105953A patent/TWI639439B/zh active
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2016
- 2016-08-18 IL IL247344A patent/IL247344B/en active IP Right Grant
- 2016-08-23 PH PH12016501671A patent/PH12016501671A1/en unknown
- 2016-08-23 CL CL2016002123A patent/CL2016002123A1/es unknown
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2017
- 2017-07-07 US US15/643,788 patent/US10441647B2/en active Active
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2018
- 2018-01-11 JP JP2018002276A patent/JP6771499B2/ja active Active
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2019
- 2019-10-11 US US16/599,900 patent/US10940192B2/en active Active
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2021
- 2021-02-02 US US17/165,333 patent/US11738076B2/en active Active
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2023
- 2023-04-24 US US18/305,948 patent/US20230364214A1/en active Pending
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