MX2016014807A - Singenes de alfa(1,2)fucosiltransferasa para su utilizacion en la produccion de oligosacaridos fucosilados. - Google Patents

Singenes de alfa(1,2)fucosiltransferasa para su utilizacion en la produccion de oligosacaridos fucosilados.

Info

Publication number
MX2016014807A
MX2016014807A MX2016014807A MX2016014807A MX2016014807A MX 2016014807 A MX2016014807 A MX 2016014807A MX 2016014807 A MX2016014807 A MX 2016014807A MX 2016014807 A MX2016014807 A MX 2016014807A MX 2016014807 A MX2016014807 A MX 2016014807A
Authority
MX
Mexico
Prior art keywords
alpha
production
fucosylated oligosaccharides
syngenes
fucosyltransferase
Prior art date
Application number
MX2016014807A
Other languages
English (en)
Inventor
M Mccoy John
Ian HEIDTMAN Matthew
Merighi Massimo
Original Assignee
Glycosyn LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glycosyn LLC filed Critical Glycosyn LLC
Publication of MX2016014807A publication Critical patent/MX2016014807A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1048—Glycosyltransferases (2.4)
    • C12N9/1051—Hexosyltransferases (2.4.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/18—Preparation of compounds containing saccharide radicals produced by the action of a glycosyl transferase, e.g. alpha-, beta- or gamma-cyclodextrins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01069—Galactoside 2-alpha-L-fucosyltransferase (2.4.1.69)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01086—Glucosaminylgalactosylglucosylceramide beta-galactosyltransferase (2.4.1.86)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y204/00—Glycosyltransferases (2.4)
    • C12Y204/01—Hexosyltransferases (2.4.1)
    • C12Y204/01149—N-Acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase (2.4.1.149)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

La invención proporciona composiciones y métodos para la modificación de E. coli y otras cepas bacterias hospederas de producción para producir oligosacáridos fucosilados y el uso de los mismos en la prevención o tratamiento de infecciones.
MX2016014807A 2014-05-15 2015-05-14 Singenes de alfa(1,2)fucosiltransferasa para su utilizacion en la produccion de oligosacaridos fucosilados. MX2016014807A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461993742P 2014-05-15 2014-05-15
PCT/US2015/030823 WO2015175801A1 (en) 2014-05-15 2015-05-14 Alpha (1,2) fucosyltransferase syngenes for use in the production of fucosylated oligosaccharides

Publications (1)

Publication Number Publication Date
MX2016014807A true MX2016014807A (es) 2017-05-10

Family

ID=54480689

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016014807A MX2016014807A (es) 2014-05-15 2015-05-14 Singenes de alfa(1,2)fucosiltransferasa para su utilizacion en la produccion de oligosacaridos fucosilados.

Country Status (12)

Country Link
US (2) US11046984B2 (es)
EP (2) EP4293033A3 (es)
JP (3) JP2017515455A (es)
KR (2) KR20230113650A (es)
CN (1) CN106795484B (es)
AU (1) AU2015259088B2 (es)
CA (1) CA2945661C (es)
ES (1) ES2962258T3 (es)
MX (1) MX2016014807A (es)
NZ (1) NZ722185A (es)
SG (2) SG11201609366TA (es)
WO (1) WO2015175801A1 (es)

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JP6129821B2 (ja) 2011-05-13 2017-05-17 グリコシン リミテッド ライアビリティー カンパニー プレバイオティクスとしての、精製された２’−フコシルラクトース、３−フコシルラクトース、およびラクトジフコテトラオースの使用
US9029136B2 (en) * 2012-07-25 2015-05-12 Glycosyn LLC Alpha (1,2) fucosyltransferases suitable for use in the production of fucosylated oligosaccharides
US9758803B2 (en) 2013-03-14 2017-09-12 Glycosyn LLC Microorganisms and methods for producing sialylated and N-acetylglucosamine-containing oligosaccharides
EP4293033A3 (en) 2014-05-15 2024-04-10 Glycosyn LLC Alpha (1,2) fucosyltransferase syngenes for use in the production of fucosylated oligosaccharides
WO2017101958A1 (en) 2015-12-18 2017-06-22 Glycom A/S Fermentative production of oligosaccharides
WO2017106864A1 (en) * 2015-12-18 2017-06-22 The Regents Of The University Of California Te2ft enzyme for enzymatic synthesis of alpha1-2-fucosides
CN106190937B9 (zh) * 2016-07-18 2020-12-01 南开大学 一种构建重组大肠杆菌生物合成2’-岩藻乳糖的方法
ES2928859T3 (es) * 2017-03-17 2022-11-23 Chr Hansen Hmo Gmbh Un método para inhibir la isomerización de un sacárido reductor tras el tratamiento térmico
KR101953375B1 (ko) * 2017-11-20 2019-02-28 고려대학교 산학협력단 다양하고 신규한 퓨코실 올리고당의 제조법 및 이의 용도
CN109402020B (zh) * 2018-11-30 2020-08-04 江南大学 一株高产精氨酸氨肽酶的瑞士乳杆菌及其应用
CN109735479B (zh) * 2019-01-30 2022-04-01 光明乳业股份有限公司 一种合成2’-岩藻糖基乳糖的重组枯草芽孢杆菌及其构建方法与应用
SG11202109537WA (en) * 2019-03-04 2021-09-29 Celloryx AG Chloride-inducible prokaryotic expression system
WO2020246585A1 (ja) 2019-06-05 2020-12-10 森永乳業株式会社 栄養組成物
KR20220116243A (ko) 2019-12-17 2022-08-22 인바이오스 엔.브이. 락토오스 전환 알파-1,2-푸코실트랜스퍼라제 효소
CN111218488B (zh) * 2020-02-10 2022-11-15 中国科学院上海高等研究院 一种利用大肠杆菌生产2’-岩藻糖基乳糖的方法
CN111471605B (zh) * 2020-03-17 2022-03-08 山东大学 一株高产岩藻糖基乳糖的酿酒酵母工程菌株及其应用
CN111471606B (zh) * 2020-03-17 2022-03-08 山东大学 一株优化的高产岩藻糖基乳糖的酿酒酵母菌株及其应用
EP3954769A1 (en) * 2020-08-10 2022-02-16 Inbiose N.V. Production of oligosaccharide mixtures by a cell
WO2021231751A1 (en) 2020-05-13 2021-11-18 Glycosyn LLC Fucosylated oligosaccharides for prevention of coronavirus infection
JP2023526271A (ja) 2020-05-13 2023-06-21 グリコシン リミテッド ライアビリティー カンパニー コロナウイルスによって誘導される炎症の防止および処置のための２’－フコシルラクトース
EP4192973A2 (en) * 2020-08-10 2023-06-14 Inbiose N.V. Production of galactosylated di- and oligosaccharides
JP2023537880A (ja) * 2020-08-19 2023-09-06 コナゲン インコーポレイテッド ２－フコシルラクトースの生合成産生
KR20220096752A (ko) 2020-12-31 2022-07-07 주식회사 삼양사 푸코오스 전이효소를 발현하는 재조합 미생물 및 이를 이용한 2’-푸코실락토오스 제조방법
KR102633804B1 (ko) * 2020-12-31 2024-02-05 주식회사 삼양사 재조합 바실러스 속 미생물 및 이를 이용한 모유올리고당 제조방법
WO2023182970A1 (en) * 2021-02-19 2023-09-28 The Regents Of The University Of California Methods for production of fucosylated oligosaccharides in recombinant cell culture
KR20240035566A (ko) * 2021-07-16 2024-03-15 인바이오스 엔.브이. 락토-n-바이오스 전환 푸코실트랜스퍼라제
CN116676288A (zh) * 2021-09-30 2023-09-01 中南大学 α-1,2-岩藻糖基转移酶突变体及其应用
CN113832092B (zh) * 2021-10-20 2023-10-03 江南大学 一种提高乳酰-n-岩藻五糖产量的基因工程菌及其生产方法
CN116286919A (zh) * 2021-12-03 2023-06-23 虹摹生物科技(上海)有限公司 基因工程菌及利用其制备岩藻糖基化寡糖的方法
KR20240017427A (ko) * 2022-07-29 2024-02-08 주식회사 진켐 3-푸코실락토스 생산용 유전자 조작 미생물 및 이를 이용한 방법

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EP4293033A3 (en) 2014-05-15 2024-04-10 Glycosyn LLC Alpha (1,2) fucosyltransferase syngenes for use in the production of fucosylated oligosaccharides

Also Published As

Publication number Publication date
KR20230113650A (ko) 2023-07-31
JP2017515455A (ja) 2017-06-15
EP4293033A3 (en) 2024-04-10
SG11201609366TA (en) 2016-12-29
NZ722185A (en) 2023-12-22
CN106795484B (zh) 2022-09-09
CA2945661A1 (en) 2015-11-19
EP4293033A2 (en) 2023-12-20
EP3083938A1 (en) 2016-10-26
ES2962258T3 (es) 2024-03-18
EP3083938C0 (en) 2023-11-08
EP3083938A4 (en) 2017-05-31
US11643675B2 (en) 2023-05-09
CA2945661C (en) 2023-10-17
JP2022173457A (ja) 2022-11-18
JP2020188761A (ja) 2020-11-26
CN106795484A (zh) 2017-05-31
US20220056497A1 (en) 2022-02-24
WO2015175801A1 (en) 2015-11-19
AU2015259088A1 (en) 2016-08-04
WO2015175801A9 (en) 2016-10-20
EP3083938B1 (en) 2023-11-08
AU2015259088A2 (en) 2018-06-28
SG10202010599TA (en) 2020-11-27
US11046984B2 (en) 2021-06-29
AU2015259088B2 (en) 2021-11-11
US20170081353A1 (en) 2017-03-23
KR20170035835A (ko) 2017-03-31

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