BR112018068865A2 - plataforma e vacinas de antígeno de fusão multiepítopo de ponta de adesina e seu uso no tratamento de diarreia enterotoxigênica - Google Patents
plataforma e vacinas de antígeno de fusão multiepítopo de ponta de adesina e seu uso no tratamento de diarreia enterotoxigênicaInfo
- Publication number
- BR112018068865A2 BR112018068865A2 BR112018068865A BR112018068865A BR112018068865A2 BR 112018068865 A2 BR112018068865 A2 BR 112018068865A2 BR 112018068865 A BR112018068865 A BR 112018068865A BR 112018068865 A BR112018068865 A BR 112018068865A BR 112018068865 A2 BR112018068865 A2 BR 112018068865A2
- Authority
- BR
- Brazil
- Prior art keywords
- adhesin
- mefa
- vaccines
- subunit
- treatment
- Prior art date
Links
- 108010037896 heparin-binding hemagglutinin Proteins 0.000 title abstract 5
- 206010012735 Diarrhoea Diseases 0.000 title abstract 2
- 230000000688 enterotoxigenic effect Effects 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 239000000427 antigen Substances 0.000 title 1
- 102000036639 antigens Human genes 0.000 title 1
- 108091007433 antigens Proteins 0.000 title 1
- 230000004927 fusion Effects 0.000 title 1
- 241000588724 Escherichia coli Species 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
a presente invenção refere-se a vacinas e constructos de mefa contra escherichia coli enterotoxigênica (etec). métodos para redução da incidência de diarreia associada com etec são também providos. os mefas de ponta de adesina representativos e o mefa-ii cfa de subunidade principal representativo providos na descrição têm uma estrutura de ponta de adesina ou cfa de subunidade principal com uma ou mais pontas de adesina, subunidade de adesina ou epítopos de subunidade estrutural principal incorporados na estrutura. os mefas de ponta de adesina e o mefa-ii cfa providos previnem vantajosamente a molécula etec de se ligar ao intestino.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662310417P | 2016-03-18 | 2016-03-18 | |
| PCT/US2017/023183 WO2017161366A1 (en) | 2016-03-18 | 2017-03-20 | Adhesin tip multiepitope fusion antigen platform and vaccines and their use in the treatment of enterotoxigenic diarrhea |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112018068865A2 true BR112018068865A2 (pt) | 2019-01-22 |
Family
ID=59850522
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112018068865A BR112018068865A2 (pt) | 2016-03-18 | 2017-03-20 | plataforma e vacinas de antígeno de fusão multiepítopo de ponta de adesina e seu uso no tratamento de diarreia enterotoxigênica |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US10987414B2 (pt) |
| EP (1) | EP3430028A1 (pt) |
| JP (1) | JP2019512504A (pt) |
| CN (1) | CN109311947A (pt) |
| AU (1) | AU2017233078A1 (pt) |
| BR (1) | BR112018068865A2 (pt) |
| CA (1) | CA3017809A1 (pt) |
| WO (1) | WO2017161366A1 (pt) |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10646560B2 (en) | 2013-12-17 | 2020-05-12 | The John Hopkins University | Multiepitope fusion antigens and vaccines and their use in treatment of enterotoxigenic diarrhea |
-
2017
- 2017-03-20 US US16/085,884 patent/US10987414B2/en active Active
- 2017-03-20 CN CN201780030566.0A patent/CN109311947A/zh active Pending
- 2017-03-20 WO PCT/US2017/023183 patent/WO2017161366A1/en active Application Filing
- 2017-03-20 CA CA3017809A patent/CA3017809A1/en not_active Abandoned
- 2017-03-20 BR BR112018068865A patent/BR112018068865A2/pt not_active IP Right Cessation
- 2017-03-20 EP EP17767698.8A patent/EP3430028A1/en not_active Withdrawn
- 2017-03-20 JP JP2018548784A patent/JP2019512504A/ja active Pending
- 2017-03-20 AU AU2017233078A patent/AU2017233078A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US10987414B2 (en) | 2021-04-27 |
| CN109311947A (zh) | 2019-02-05 |
| CA3017809A1 (en) | 2017-09-21 |
| AU2017233078A1 (en) | 2018-10-25 |
| WO2017161366A1 (en) | 2017-09-21 |
| US20190091318A1 (en) | 2019-03-28 |
| JP2019512504A (ja) | 2019-05-16 |
| EP3430028A1 (en) | 2019-01-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 3A ANUIDADE. |
|
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2560 DE 28/01/2020. |
|
| B350 | Update of information on the portal [chapter 15.35 patent gazette] |