MX2022015734A - Proteinas de exotoxina a modificadas. - Google Patents
Proteinas de exotoxina a modificadas.Info
- Publication number
- MX2022015734A MX2022015734A MX2022015734A MX2022015734A MX2022015734A MX 2022015734 A MX2022015734 A MX 2022015734A MX 2022015734 A MX2022015734 A MX 2022015734A MX 2022015734 A MX2022015734 A MX 2022015734A MX 2022015734 A MX2022015734 A MX 2022015734A
- Authority
- MX
- Mexico
- Prior art keywords
- modified
- proteins
- antigens
- exotoxin
- relates
- Prior art date
Links
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- OTLLEIBWKHEHGU-UHFFFAOYSA-N 2-[5-[[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy]-3,4-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-4-phosphonooxyhexanedioic acid Chemical class C1=NC=2C(N)=NC=NC=2N1C(C(C1O)O)OC1COC1C(CO)OC(OC(C(O)C(OP(O)(O)=O)C(O)C(O)=O)C(O)=O)C(O)C1O OTLLEIBWKHEHGU-UHFFFAOYSA-N 0.000 title 1
- 239000000427 antigen Substances 0.000 abstract 3
- 102000036639 antigens Human genes 0.000 abstract 3
- 108091007433 antigens Proteins 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 102000035118 modified proteins Human genes 0.000 abstract 2
- 108091005573 modified proteins Proteins 0.000 abstract 2
- 102000014914 Carrier Proteins Human genes 0.000 abstract 1
- 108010078791 Carrier Proteins Proteins 0.000 abstract 1
- 101710082714 Exotoxin A Proteins 0.000 abstract 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1077—Pentosyltransferases (2.4.2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0266—Klebsiella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/21—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pseudomonadaceae (F)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/26—Klebsiella (G)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1081—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/02—Pentosyltransferases (2.4.2)
- C12Y204/02036—NAD(+)--diphthamide ADP-ribosyltransferase (2.4.2.36)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/99—Glycosyltransferases (2.4) transferring other glycosyl groups (2.4.99)
- C12Y204/99019—Undecaprenyl-diphosphooligosaccharide—protein glycotransferase (2.4.99.19)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
La presente invención se relaciona con el campo de las proteínas modificadas, composiciones inmunogénicas y vacunas que comprenden las proteínas modificadas, su fabricación y el uso de tales composiciones en la medicina. Más en particular, se relaciona con una proteína EPA modificada (Exotoxina A de Pseudomonas aeruginosa). La EPA modificada puede utilizarse como una proteína portadora de otros antígenos, en particular de antígenos de sacárido u otros antígenos que carecen de los epítopos de células T.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202063043883P | 2020-06-25 | 2020-06-25 | |
EP20182139 | 2020-06-25 | ||
EP20182138 | 2020-06-25 | ||
PCT/EP2021/066336 WO2021259742A1 (en) | 2020-06-25 | 2021-06-17 | Modified exotoxin a proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2022015734A true MX2022015734A (es) | 2023-01-18 |
Family
ID=76375084
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022015734A MX2022015734A (es) | 2020-06-25 | 2021-06-17 | Proteinas de exotoxina a modificadas. |
MX2022016589A MX2022016589A (es) | 2020-06-25 | 2021-06-17 | O-antigeno de klebsiella pneumoniae. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2022016589A MX2022016589A (es) | 2020-06-25 | 2021-06-17 | O-antigeno de klebsiella pneumoniae. |
Country Status (8)
Country | Link |
---|---|
US (2) | US20230293657A1 (es) |
EP (2) | EP4171624A1 (es) |
JP (2) | JP2023531242A (es) |
CN (2) | CN116209753A (es) |
BR (2) | BR112022023234A2 (es) |
CA (2) | CA3185642A1 (es) |
MX (2) | MX2022015734A (es) |
WO (2) | WO2021259743A2 (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2022249034A1 (en) * | 2021-05-26 | 2022-12-01 | Pfizer Inc. | Recombinant expression of klebsiella pneumoniae o-antigens in escherichia coli |
WO2023118033A1 (en) * | 2021-12-22 | 2023-06-29 | Glaxosmithkline Biologicals Sa | Vaccine |
WO2024089001A1 (en) * | 2022-10-24 | 2024-05-02 | Idorsia Pharmaceuticals Ltd | Vaccine against klebsiella pneumoniae |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0027888B1 (en) | 1979-09-21 | 1986-04-16 | Hitachi, Ltd. | Semiconductor switch |
US4673574A (en) | 1981-08-31 | 1987-06-16 | Anderson Porter W | Immunogenic conjugates |
US4695624A (en) | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
IT1187753B (it) | 1985-07-05 | 1987-12-23 | Sclavo Spa | Coniugati glicoproteici ad attivita' immunogenica trivalente |
US5057540A (en) | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
US4912094B1 (en) | 1988-06-29 | 1994-02-15 | Ribi Immunochem Research Inc. | Modified lipopolysaccharides and process of preparation |
US5153312A (en) | 1990-09-28 | 1992-10-06 | American Cyanamid Company | Oligosaccharide conjugate vaccines |
NZ249704A (en) | 1992-02-11 | 1996-11-26 | Jackson H M Found Military Med | A two carrier immunogenic construct comprising a 70+ kd molecule conjugated to at least 1 t-dependent antigen, preparation, compositions containing the construct |
ATE254475T1 (de) | 1993-09-22 | 2003-12-15 | Jackson H M Found Military Med | Verfahren zur aktivierung von löslichem kohlenhydraten durch verwendung von neuen cyanylierungsreagenzien, zur herstellung von immunogenischen konstrukten |
ES2200059T3 (es) | 1995-03-22 | 2004-03-01 | Henry M. Jackson Foundation For The Advancement Of Military Medicine | Produccion de construcciones inmunogenicas usando carbohidratos solubles activados mediante reactivos cianilados organicos. |
CA2477794C (en) | 2002-03-07 | 2013-08-20 | Eidgenoessische Technische Hochschule Zuerich | System and method for the production of recombinant glycosylated proteins in a prokaryotic host |
US20070184072A1 (en) | 2005-04-08 | 2007-08-09 | Wyeth | Multivalent pneumococcal polysaccharide-protein conjugate composition |
EP2853600B1 (en) | 2005-05-11 | 2018-09-19 | ETH Zürich | Recombinant N-glycosylated proteins from procaryotic cells |
EP3427749A1 (en) | 2008-02-20 | 2019-01-16 | GlaxoSmithKline Biologicals SA | Bioconjugates made from recombinant n-glycosylated proteins from procaryotic cells |
WO2011006261A1 (en) | 2009-07-17 | 2011-01-20 | Ocean Harvest Technology (Canada) Inc. | Natural and sustainable seaweed formula that replaces synthetic additives in fish feed |
WO2011062615A1 (en) | 2009-11-19 | 2011-05-26 | Glycovaxyn Ag | Biosynthetic system that produces immunogenic polysaccharides in prokaryotic cells |
EP2566507B1 (en) * | 2010-05-06 | 2017-11-22 | GlaxoSmithKline Biologicals SA | Capsular gram-positive bacteria bioconjugate vaccines |
US20150238596A1 (en) | 2012-09-10 | 2015-08-27 | Glycovaxyn Ag | Bioconjugates comprising modified antigens and uses thereof |
CA2887133C (en) | 2012-10-12 | 2022-05-03 | Glycovaxyn Ag | Methods of host cell modification |
SG11201503308XA (en) | 2012-11-07 | 2015-05-28 | Glycovaxyn Ag | PRODUCTION OF RECOMBINANT VACCINE IN <i>E. COLI</i> BY ENZYMATIC CONJUGATION |
EP3055416B1 (en) | 2013-10-11 | 2020-01-22 | GlaxoSmithKline Biologicals S.A. | Methods of host cell modification |
FI3110441T3 (fi) | 2014-02-24 | 2024-05-06 | Glaxosmithkline Biologicals S A | Uusi polysakkaridi ja sen käyttöjä |
EP3177325B1 (en) | 2014-08-08 | 2020-04-01 | GlaxoSmithKline Biologicals S.A. | Modified host cells and hybrid oligosaccharides for use in bioconjugate production |
TWI715617B (zh) | 2015-08-24 | 2021-01-11 | 比利時商葛蘭素史密斯克藍生物品公司 | 對抗腸道外病原性大腸桿菌之免疫保護之方法及組合物 |
GB201712678D0 (en) | 2017-08-07 | 2017-09-20 | Glaxosmithkline Biologicals Sa | Process for the manipulation of nucleic acids |
EP3492481A1 (en) * | 2017-11-30 | 2019-06-05 | Vaxxilon AG | Vaccine against klebsiella pneumoniae |
-
2021
- 2021-06-17 EP EP21731533.2A patent/EP4171624A1/en active Pending
- 2021-06-17 CN CN202180044800.1A patent/CN116209753A/zh active Pending
- 2021-06-17 WO PCT/EP2021/066343 patent/WO2021259743A2/en unknown
- 2021-06-17 BR BR112022023234A patent/BR112022023234A2/pt unknown
- 2021-06-17 EP EP21731535.7A patent/EP4171625A2/en active Pending
- 2021-06-17 MX MX2022015734A patent/MX2022015734A/es unknown
- 2021-06-17 BR BR112022024267A patent/BR112022024267A2/pt unknown
- 2021-06-17 CN CN202180045684.5A patent/CN115996749A/zh active Pending
- 2021-06-17 CA CA3185642A patent/CA3185642A1/en active Pending
- 2021-06-17 JP JP2022579677A patent/JP2023531242A/ja active Pending
- 2021-06-17 MX MX2022016589A patent/MX2022016589A/es unknown
- 2021-06-17 US US18/001,525 patent/US20230293657A1/en active Pending
- 2021-06-17 WO PCT/EP2021/066336 patent/WO2021259742A1/en unknown
- 2021-06-17 CA CA3185639A patent/CA3185639A1/en active Pending
- 2021-06-17 JP JP2022580015A patent/JP2023531059A/ja active Pending
- 2021-06-17 US US18/001,498 patent/US20230226175A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
WO2021259743A2 (en) | 2021-12-30 |
JP2023531242A (ja) | 2023-07-21 |
WO2021259743A3 (en) | 2022-04-21 |
EP4171625A2 (en) | 2023-05-03 |
CA3185639A1 (en) | 2021-12-30 |
CA3185642A1 (en) | 2021-12-30 |
MX2022016589A (es) | 2023-02-01 |
US20230226175A1 (en) | 2023-07-20 |
US20230293657A1 (en) | 2023-09-21 |
BR112022023234A2 (pt) | 2023-01-03 |
WO2021259742A1 (en) | 2021-12-30 |
JP2023531059A (ja) | 2023-07-20 |
CN115996749A (zh) | 2023-04-21 |
BR112022024267A2 (pt) | 2023-01-17 |
EP4171624A1 (en) | 2023-05-03 |
CN116209753A (zh) | 2023-06-02 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2022015734A (es) | Proteinas de exotoxina a modificadas. | |
CY1123909T1 (el) | Σταθεροποιημενα σκευασματα που περιεχουν αντισωματα κατα του υποδοχεα της ιντερλευκινης-6 (il-6r) | |
WO2018075857A8 (en) | Novel cd47 monoclonal antibodies and uses thereof | |
CY1123657T1 (el) | Σταθερη φαρμακοτεχνικη μορφη anti-ifnar1 | |
AU2017297757A1 (en) | Novel antibodies specifically binding to zika virus epitopes and uses thereof | |
MX2010003574A (es) | Anticuerpos il-23. | |
EA035991B9 (ru) | Новый полисахарид и его применения | |
WO2019224716A3 (en) | Antibodies specific for gucy2c and uses thereof | |
AR081809A1 (es) | Composiciones farmaceuticas que comprenden un polipeptido que comprende al menos un motivo cxxc y antigenos heterologos y usos de las mismas | |
UA97095C2 (ru) | Противораковая вакцина, которая содержит опухолевоассоциированный пептид, который связывается с молекулами лейкоцитарного антигена человека (hla) класса i или ii, и ее применение в производстве лекарственного средства | |
EA201300322A1 (ru) | Композиция опухолеассоциированных пептидов и относящаяся к ним противораковая вакцина | |
NZ711567A (en) | Antibody formulations | |
EA201992570A1 (ru) | Составы на основе человеческих антител к rankl, а также способы их применения | |
EP4249064A3 (en) | Novel fusion protein specific for cd137 and pd-l1 | |
CR10555A (es) | Vacunas para malaria | |
EA201692279A1 (ru) | Способ уменьшения иммуногенности белка и пептида | |
DK2054431T3 (da) | Konformere af bakterielle adhæsiner | |
WO2009042895A3 (en) | Reagents for inducing an immune response | |
MX2020002181A (es) | Anticuerpos multiespecificos que se unen especificamente a los epitopos del virus del zika y usos de los mismos. | |
MX2020009935A (es) | Formulaciones acuosas y estables de anticuerpos anti-tau. | |
MX2021011137A (es) | Formulaciones estabilizadas que contienen anticuerpos anti-il-33. | |
Tinker et al. | Immunogenicity of a West Nile virus DIII-cholera toxin A2/B chimera after intranasal delivery | |
MX2022012545A (es) | Peptidos y combinaciones de peptidos para usar en la inmunoterapia contra una infeccion por sars-cov-2 (covid-19). | |
MX2021007047A (es) | Formulaciones de anticuerpos. | |
ZA202205813B (en) | Trpv1 epitopes and antibodies |