ES2010775A6 - Procedimiento para la preparacion de derivados fosfatados de 4` -desmetilepipodofilotoxin glucosidos. - Google Patents

Procedimiento para la preparacion de derivados fosfatados de 4` -desmetilepipodofilotoxin glucosidos.

Info

Publication number
ES2010775A6
ES2010775A6 ES8802434A ES8802434A ES2010775A6 ES 2010775 A6 ES2010775 A6 ES 2010775A6 ES 8802434 A ES8802434 A ES 8802434A ES 8802434 A ES8802434 A ES 8802434A ES 2010775 A6 ES2010775 A6 ES 2010775A6
Authority
ES
Spain
Prior art keywords
procedure
aralkyl
compound
glucosidos
desmetilepipodofilotoxin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8802434A
Other languages
English (en)
Spanish (es)
Inventor
Mark G Saulnier
Peter D Senter
John F Kadow
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Co
Original Assignee
Bristol Myers Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Co filed Critical Bristol Myers Co
Publication of ES2010775A6 publication Critical patent/ES2010775A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Cable Accessories (AREA)
ES8802434A 1987-08-04 1988-08-03 Procedimiento para la preparacion de derivados fosfatados de 4` -desmetilepipodofilotoxin glucosidos. Expired ES2010775A6 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (1)

Publication Number Publication Date
ES2010775A6 true ES2010775A6 (es) 1989-12-01

Family

ID=26765636

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8802434A Expired ES2010775A6 (es) 1987-08-04 1988-08-03 Procedimiento para la preparacion de derivados fosfatados de 4` -desmetilepipodofilotoxin glucosidos.

Country Status (34)

Country Link
US (3) US4904768A (OSRAM)
JP (1) JPH0699465B2 (OSRAM)
KR (1) KR900006230B1 (OSRAM)
CN (1) CN1027169C (OSRAM)
AT (1) AT398974B (OSRAM)
BE (1) BE1002982A4 (OSRAM)
CA (1) CA1310637C (OSRAM)
CH (1) CH676716A5 (OSRAM)
CY (1) CY1625A (OSRAM)
CZ (1) CZ286893B6 (OSRAM)
DD (2) DD274423A5 (OSRAM)
DE (1) DE3826562A1 (OSRAM)
DK (2) DK169344B1 (OSRAM)
ES (1) ES2010775A6 (OSRAM)
FI (1) FI87790C (OSRAM)
FR (1) FR2622193B1 (OSRAM)
GB (1) GB2207674B (OSRAM)
GR (1) GR1000490B (OSRAM)
HK (1) HK6392A (OSRAM)
HU (3) HU202547B (OSRAM)
IE (1) IE61040B1 (OSRAM)
IL (1) IL87290A (OSRAM)
IT (1) IT1226825B (OSRAM)
LU (2) LU87290A1 (OSRAM)
MX (1) MX173843B (OSRAM)
MY (1) MY104321A (OSRAM)
NL (2) NL192683C (OSRAM)
NO (4) NO170284C (OSRAM)
NZ (1) NZ225615A (OSRAM)
PT (1) PT88186B (OSRAM)
SE (1) SE502214C2 (OSRAM)
SG (1) SG101291G (OSRAM)
SK (1) SK279325B6 (OSRAM)
YU (3) YU143688A (OSRAM)

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US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (OSRAM) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
CA2085520C (en) * 1991-12-23 1996-07-16 Uday Shankar Gogate Stable hexahydrate of etoposide 4'-phosphate disodium salt
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
FR2725990B1 (fr) * 1994-10-21 1997-01-10 Pf Medicament Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
US5942386A (en) * 1995-06-07 1999-08-24 Thomas Jefferson University Anti-fungal agents and methods of identifying and using the same
DE69729380T2 (de) * 1996-04-01 2005-07-14 Epix Medical, Inc., Cambridge Bioaktivierte diagnostische bilderzeugungskontrastmittel
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
WO1999032499A1 (en) * 1997-12-23 1999-07-01 Korea Research Institute Of Chemical Technology 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE ACETAL DERIVATIVES
EP2266607A3 (en) 1999-10-01 2011-04-20 Immunogen, Inc. Immunoconjugates for treating cancer
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
WO2003035661A1 (en) * 2001-10-26 2003-05-01 Centre National De La Recherche Scientifique Derivatives of etoposide and analogs, and pharmaceutical compositions containing them
JP4827411B2 (ja) 2002-07-15 2011-11-30 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 陰イオン性リン脂質およびアミノリン脂質に結合する選択された抗体およびデュラマイシンペプチド、ならびにウイルス感染の処置におけるそれらの使用
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CN100334090C (zh) * 2005-02-02 2007-08-29 南京医科大学 吡啶类鬼臼毒素化合物及其制备方法和在制备杀虫剂中的应用
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FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
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Also Published As

Publication number Publication date
KR900006230B1 (ko) 1990-08-27
PT88186B (pt) 1995-07-03
USRE35524E (en) 1997-06-03
SG101291G (en) 1992-01-17
GB2207674A (en) 1989-02-08
NL192683B (OSRAM) 1997-08-01
CZ286893B6 (cs) 2000-07-12
NO920277D0 (no) 1992-01-22
MY104321A (en) 1994-03-31
GB2207674B (en) 1991-09-11
FI87790B (fi) 1992-11-13
CA1310637C (en) 1992-11-24
NO883299D0 (no) 1988-07-26
CH676716A5 (OSRAM) 1991-02-28
NL970042I1 (nl) 1998-03-02
NO170284B (no) 1992-06-22
IL87290A0 (en) 1989-01-31
SE8802815D0 (sv) 1988-08-03
YU10390A (en) 1990-06-30
GR880100512A (en) 1989-05-25
DD274423A5 (de) 1989-12-20
DD299067A5 (de) 1992-03-26
DK169344B1 (da) 1994-10-10
US4904768A (en) 1990-02-27
FR2622193A1 (fr) 1989-04-28
SE8802815L (sv) 1989-02-05
NZ225615A (en) 1991-06-25
CZ541288A3 (cs) 1999-12-15
HU202547B (en) 1991-03-28
YU10490A (en) 1990-06-30
SK541288A3 (en) 1998-10-07
SK279325B6 (sk) 1998-10-07
NO1998002I1 (no) 1998-01-14
CN1027169C (zh) 1994-12-28
YU143688A (en) 1990-04-30
IT8821535A0 (it) 1988-07-28
NL192683C (nl) 1997-12-02
DK434088D0 (da) 1988-08-03
CN1061225A (zh) 1992-05-20
KR890003790A (ko) 1989-04-18
FI87790C (fi) 1993-02-25
SE502214C2 (sv) 1995-09-18
LU90138I2 (fr) 1997-11-26
NO920665L (no) 1989-02-24
MX9202851A (es) 1992-06-30
NO920665D0 (no) 1992-02-20
IE61040B1 (en) 1994-09-07
JPH0699465B2 (ja) 1994-12-07
HK6392A (en) 1992-01-17
FR2622193B1 (fr) 1993-12-17
HU211960A9 (en) 1996-01-29
NO170284C (no) 1992-09-30
DK11992D0 (da) 1992-01-31
ATA195588A (de) 1994-07-15
PT88186A (pt) 1989-06-30
AU2030688A (en) 1989-06-08
NL970042I2 (OSRAM) 2005-06-01
IL87290A (en) 1993-01-31
FI883596A0 (fi) 1988-08-01
AT398974B (de) 1995-02-27
HUT47303A (en) 1989-02-28
DK11992A (da) 1992-01-31
FI883596A7 (fi) 1989-02-05
CY1625A (en) 1992-07-10
MX173843B (es) 1994-03-30
DE3826562C2 (OSRAM) 1993-04-08
NO172440B (no) 1993-04-13
DE3826562A1 (de) 1989-02-16
GB8818462D0 (en) 1988-09-07
AU610619B2 (en) 1991-05-23
JPH01100188A (ja) 1989-04-18
BE1002982A4 (fr) 1991-10-15
US5041424A (en) 1991-08-20
LU87290A1 (fr) 1990-02-07
NO172440C (no) 1993-07-21
NO883299L (no) 1989-02-24
HU905862D0 (en) 1991-03-28
IT1226825B (it) 1991-02-19
HU208147B (en) 1993-08-30
NO920277L (no) 1989-02-24
NL8801934A (nl) 1989-03-01
GR1000490B (el) 1992-07-30
DK434088A (da) 1989-02-05
IE882378L (en) 1989-02-04

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