CZ286893B6 - 4' -fosfátu epipodofyllotoxinglukosidů, způsob jejich výroby a farmaceutický prostředek s jejich obsahem - Google Patents

4' -fosfátu epipodofyllotoxinglukosidů, způsob jejich výroby a farmaceutický prostředek s jejich obsahem Download PDF

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Publication number
CZ286893B6
CZ286893B6 CS19885412A CS541288A CZ286893B6 CZ 286893 B6 CZ286893 B6 CZ 286893B6 CS 19885412 A CS19885412 A CS 19885412A CS 541288 A CS541288 A CS 541288A CZ 286893 B6 CZ286893 B6 CZ 286893B6
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CZ
Czechia
Prior art keywords
carbon atoms
group
formula
phosphate
phosphate derivatives
Prior art date
Application number
CS19885412A
Other languages
Czech (cs)
English (en)
Inventor
Mark G. Saulnier
Peter D. Senter
John F. Kadow
Original Assignee
Bristol-Myers Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Company filed Critical Bristol-Myers Company
Publication of CZ541288A3 publication Critical patent/CZ541288A3/cs
Publication of CZ286893B6 publication Critical patent/CZ286893B6/cs

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Cable Accessories (AREA)
CS19885412A 1987-08-04 1988-08-02 4' -fosfátu epipodofyllotoxinglukosidů, způsob jejich výroby a farmaceutický prostředek s jejich obsahem CZ286893B6 (cs)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (2)

Publication Number Publication Date
CZ541288A3 CZ541288A3 (cs) 1999-12-15
CZ286893B6 true CZ286893B6 (cs) 2000-07-12

Family

ID=26765636

Family Applications (1)

Application Number Title Priority Date Filing Date
CS19885412A CZ286893B6 (cs) 1987-08-04 1988-08-02 4' -fosfátu epipodofyllotoxinglukosidů, způsob jejich výroby a farmaceutický prostředek s jejich obsahem

Country Status (34)

Country Link
US (3) US4904768A (OSRAM)
JP (1) JPH0699465B2 (OSRAM)
KR (1) KR900006230B1 (OSRAM)
CN (1) CN1027169C (OSRAM)
AT (1) AT398974B (OSRAM)
BE (1) BE1002982A4 (OSRAM)
CA (1) CA1310637C (OSRAM)
CH (1) CH676716A5 (OSRAM)
CY (1) CY1625A (OSRAM)
CZ (1) CZ286893B6 (OSRAM)
DD (2) DD299067A5 (OSRAM)
DE (1) DE3826562A1 (OSRAM)
DK (2) DK169344B1 (OSRAM)
ES (1) ES2010775A6 (OSRAM)
FI (1) FI87790C (OSRAM)
FR (1) FR2622193B1 (OSRAM)
GB (1) GB2207674B (OSRAM)
GR (1) GR1000490B (OSRAM)
HK (1) HK6392A (OSRAM)
HU (3) HU202547B (OSRAM)
IE (1) IE61040B1 (OSRAM)
IL (1) IL87290A (OSRAM)
IT (1) IT1226825B (OSRAM)
LU (2) LU87290A1 (OSRAM)
MX (1) MX173843B (OSRAM)
MY (1) MY104321A (OSRAM)
NL (2) NL192683C (OSRAM)
NO (4) NO170284C (OSRAM)
NZ (1) NZ225615A (OSRAM)
PT (1) PT88186B (OSRAM)
SE (1) SE502214C2 (OSRAM)
SG (1) SG101291G (OSRAM)
SK (1) SK279325B6 (OSRAM)
YU (3) YU143688A (OSRAM)

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US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (OSRAM) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
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US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
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US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
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WO1999032499A1 (en) * 1997-12-23 1999-07-01 Korea Research Institute Of Chemical Technology 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE ACETAL DERIVATIVES
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US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
WO2003035661A1 (en) * 2001-10-26 2003-05-01 Centre National De La Recherche Scientifique Derivatives of etoposide and analogs, and pharmaceutical compositions containing them
CN104001181B (zh) 2002-07-15 2017-05-10 得克萨斯大学体系董事会 与阴离子磷脂和氨基磷脂结合的选定抗体及其治疗和诊断用途
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CN100334090C (zh) * 2005-02-02 2007-08-29 南京医科大学 吡啶类鬼臼毒素化合物及其制备方法和在制备杀虫剂中的应用
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FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
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Also Published As

Publication number Publication date
DE3826562C2 (OSRAM) 1993-04-08
CH676716A5 (OSRAM) 1991-02-28
FR2622193B1 (fr) 1993-12-17
NO920277D0 (no) 1992-01-22
MY104321A (en) 1994-03-31
DD274423A5 (de) 1989-12-20
HU211960A9 (en) 1996-01-29
JPH01100188A (ja) 1989-04-18
NO170284C (no) 1992-09-30
MX173843B (es) 1994-03-30
HU905862D0 (en) 1991-03-28
FI87790C (fi) 1993-02-25
IT8821535A0 (it) 1988-07-28
DK11992D0 (da) 1992-01-31
SK541288A3 (en) 1998-10-07
CN1061225A (zh) 1992-05-20
GB8818462D0 (en) 1988-09-07
DK434088D0 (da) 1988-08-03
SE502214C2 (sv) 1995-09-18
NO883299D0 (no) 1988-07-26
NL192683C (nl) 1997-12-02
AT398974B (de) 1995-02-27
CN1027169C (zh) 1994-12-28
JPH0699465B2 (ja) 1994-12-07
HK6392A (en) 1992-01-17
SK279325B6 (sk) 1998-10-07
DK169344B1 (da) 1994-10-10
SG101291G (en) 1992-01-17
NO920277L (no) 1989-02-24
LU90138I2 (fr) 1997-11-26
HUT47303A (en) 1989-02-28
CY1625A (en) 1992-07-10
NZ225615A (en) 1991-06-25
NO883299L (no) 1989-02-24
FI87790B (fi) 1992-11-13
NO920665L (no) 1989-02-24
NO172440B (no) 1993-04-13
DK434088A (da) 1989-02-05
GB2207674B (en) 1991-09-11
DE3826562A1 (de) 1989-02-16
KR900006230B1 (ko) 1990-08-27
NL970042I1 (nl) 1998-03-02
PT88186B (pt) 1995-07-03
NO172440C (no) 1993-07-21
NL8801934A (nl) 1989-03-01
SE8802815D0 (sv) 1988-08-03
MX9202851A (es) 1992-06-30
YU10490A (en) 1990-06-30
IL87290A (en) 1993-01-31
NO1998002I1 (no) 1998-01-14
HU208147B (en) 1993-08-30
DK11992A (da) 1992-01-31
FR2622193A1 (fr) 1989-04-28
AU610619B2 (en) 1991-05-23
FI883596A7 (fi) 1989-02-05
NO170284B (no) 1992-06-22
AU2030688A (en) 1989-06-08
KR890003790A (ko) 1989-04-18
ES2010775A6 (es) 1989-12-01
DD299067A5 (de) 1992-03-26
CZ541288A3 (cs) 1999-12-15
GB2207674A (en) 1989-02-08
YU10390A (en) 1990-06-30
BE1002982A4 (fr) 1991-10-15
GR1000490B (el) 1992-07-30
NL192683B (OSRAM) 1997-08-01
IT1226825B (it) 1991-02-19
PT88186A (pt) 1989-06-30
HU202547B (en) 1991-03-28
ATA195588A (de) 1994-07-15
US4904768A (en) 1990-02-27
LU87290A1 (fr) 1990-02-07
IE882378L (en) 1989-02-04
FI883596A0 (fi) 1988-08-01
IL87290A0 (en) 1989-01-31
SE8802815L (sv) 1989-02-05
NO920665D0 (no) 1992-02-20
NL970042I2 (OSRAM) 2005-06-01
USRE35524E (en) 1997-06-03
IE61040B1 (en) 1994-09-07
US5041424A (en) 1991-08-20
CA1310637C (en) 1992-11-24
GR880100512A (en) 1989-05-25
YU143688A (en) 1990-04-30

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MK4A Patent expired

Effective date: 20080802