HK6392A - Podophyllotoxin derivatives - Google Patents

Podophyllotoxin derivatives Download PDF

Info

Publication number
HK6392A
HK6392A HK63/92A HK6392A HK6392A HK 6392 A HK6392 A HK 6392A HK 63/92 A HK63/92 A HK 63/92A HK 6392 A HK6392 A HK 6392A HK 6392 A HK6392 A HK 6392A
Authority
HK
Hong Kong
Prior art keywords
substd
alkyl
opt
aralkyl
cycloalkyl
Prior art date
Application number
HK63/92A
Other languages
English (en)
Inventor
G Saulnier Mark
D Senter Peter
F Kadow John
Original Assignee
Bristol-Myers Squibb Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company
Publication of HK6392A publication Critical patent/HK6392A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Mechanical Coupling Of Light Guides (AREA)
  • Cable Accessories (AREA)
HK63/92A 1987-08-04 1992-01-16 Podophyllotoxin derivatives HK6392A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8149387A 1987-08-04 1987-08-04
US07/199,731 US4904768A (en) 1987-08-04 1988-05-27 Epipodophyllotoxin glucoside 4'-phosphate derivatives

Publications (1)

Publication Number Publication Date
HK6392A true HK6392A (en) 1992-01-17

Family

ID=26765636

Family Applications (1)

Application Number Title Priority Date Filing Date
HK63/92A HK6392A (en) 1987-08-04 1992-01-16 Podophyllotoxin derivatives

Country Status (34)

Country Link
US (3) US4904768A (OSRAM)
JP (1) JPH0699465B2 (OSRAM)
KR (1) KR900006230B1 (OSRAM)
CN (1) CN1027169C (OSRAM)
AT (1) AT398974B (OSRAM)
BE (1) BE1002982A4 (OSRAM)
CA (1) CA1310637C (OSRAM)
CH (1) CH676716A5 (OSRAM)
CY (1) CY1625A (OSRAM)
CZ (1) CZ286893B6 (OSRAM)
DD (2) DD274423A5 (OSRAM)
DE (1) DE3826562A1 (OSRAM)
DK (2) DK169344B1 (OSRAM)
ES (1) ES2010775A6 (OSRAM)
FI (1) FI87790C (OSRAM)
FR (1) FR2622193B1 (OSRAM)
GB (1) GB2207674B (OSRAM)
GR (1) GR1000490B (OSRAM)
HK (1) HK6392A (OSRAM)
HU (3) HU202547B (OSRAM)
IE (1) IE61040B1 (OSRAM)
IL (1) IL87290A (OSRAM)
IT (1) IT1226825B (OSRAM)
LU (2) LU87290A1 (OSRAM)
MX (1) MX173843B (OSRAM)
MY (1) MY104321A (OSRAM)
NL (2) NL192683C (OSRAM)
NO (4) NO170284C (OSRAM)
NZ (1) NZ225615A (OSRAM)
PT (1) PT88186B (OSRAM)
SE (1) SE502214C2 (OSRAM)
SG (1) SG101291G (OSRAM)
SK (1) SK279325B6 (OSRAM)
YU (3) YU143688A (OSRAM)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5191071A (en) * 1987-08-21 1993-03-02 Novo Nordisk A/S Monoesters of glycosides and a process for enzymatic preparation thereof
US4965348A (en) * 1989-05-19 1990-10-23 Bristol-Myers Company Dimeric epipodophyllotoxin glucoside derivatives
US5036055A (en) * 1989-06-07 1991-07-30 Bristol-Myers Company Acylated derivatives of etoposide
US5066645A (en) * 1989-09-01 1991-11-19 Bristol-Myers Company Epipodophyllotoxin altroside derivatives
US6610299B1 (en) 1989-10-19 2003-08-26 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US7241595B2 (en) 1989-10-20 2007-07-10 Sanofi-Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US6475486B1 (en) 1990-10-18 2002-11-05 Aventis Pharma Deutschland Gmbh Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates
US5552154A (en) 1989-11-06 1996-09-03 The Stehlin Foundation For Cancer Research Method for treating cancer with water-insoluble s-camptothecin of the closed lactone ring form and derivatives thereof
US5034380A (en) * 1989-11-20 1991-07-23 Bristol-Myers Squibb Company Alkoxymethylidene epipodophyllotoxin glucosides
US5081234A (en) * 1990-04-30 1992-01-14 Bristol-Myers Squibb Co. 4'-demethylepipodophyllotoxin glycosides
US4997931A (en) * 1990-06-11 1991-03-05 Bristol-Myers Squibb Company Epipodophyllotoxin glycosides
TW260671B (OSRAM) * 1991-04-29 1995-10-21 Bristol Myers Squibb Co
IT1250692B (it) * 1991-07-23 1995-04-21 Procedimento per la preparazione di demetilepipodofillotossina- beta-d-glucosidi.
US5648474A (en) * 1991-10-08 1997-07-15 Bristol-Myers Squibb Crystalline etoposide 4'-phosphate diethanolate
CA2085520C (en) * 1991-12-23 1996-07-16 Uday Shankar Gogate Stable hexahydrate of etoposide 4'-phosphate disodium salt
US6080751A (en) * 1992-01-14 2000-06-27 The Stehlin Foundation For Cancer Research Method for treating pancreatic cancer in humans with water-insoluble S-camptothecin of the closed lactone ring form and derivatives thereof
JP3061476B2 (ja) * 1992-04-24 2000-07-10 日本化薬株式会社 エトポシド燐酸エステルの製造法
US5459248A (en) * 1993-11-04 1995-10-17 Bristol-Myers Squibb Company Process of preparing etoposide phosphate and etoposide
FR2725990B1 (fr) * 1994-10-21 1997-01-10 Pf Medicament Derives hydrosolubles d'epipodophyllotoxine, leur procede de preparation, leur utilisation a titre de medicament, et leur utilisation destinee aux traitements anticancereux
US5942386A (en) * 1995-06-07 1999-08-24 Thomas Jefferson University Anti-fungal agents and methods of identifying and using the same
DE69729380T2 (de) * 1996-04-01 2005-07-14 Epix Medical, Inc., Cambridge Bioaktivierte diagnostische bilderzeugungskontrastmittel
US6207673B1 (en) 1997-03-12 2001-03-27 The University Of North Carolina At Chapel Hill Covalent conjugates of topoisomerase I and topoisomerase II inhibitors
WO1999032499A1 (en) * 1997-12-23 1999-07-01 Korea Research Institute Of Chemical Technology 4'-O-DEMETHYL-EPIPODOPHYLLOTOXIN-β-D-GLUCOSIDE ACETAL DERIVATIVES
EP2266607A3 (en) 1999-10-01 2011-04-20 Immunogen, Inc. Immunoconjugates for treating cancer
US6624317B1 (en) 2000-09-25 2003-09-23 The University Of North Carolina At Chapel Hill Taxoid conjugates as antimitotic and antitumor agents
US6506739B1 (en) 2001-05-01 2003-01-14 Telik, Inc. Bis-(N,N'-bis-(2-haloethyl)amino)phosphoramidates as antitumor agents
WO2003035661A1 (en) * 2001-10-26 2003-05-01 Centre National De La Recherche Scientifique Derivatives of etoposide and analogs, and pharmaceutical compositions containing them
JP4827411B2 (ja) 2002-07-15 2011-11-30 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム 陰イオン性リン脂質およびアミノリン脂質に結合する選択された抗体およびデュラマイシンペプチド、ならびにウイルス感染の処置におけるそれらの使用
DK1583562T3 (da) * 2003-01-06 2011-09-19 Angiochem Inc Angiopep-1, beslægtede forbindelser og anvendelser deraf
CN100334090C (zh) * 2005-02-02 2007-08-29 南京医科大学 吡啶类鬼臼毒素化合物及其制备方法和在制备杀虫剂中的应用
US20090016959A1 (en) * 2005-02-18 2009-01-15 Richard Beliveau Delivery of antibodies to the central nervous system
PT2360258E (pt) * 2005-02-18 2015-01-13 Angiochem Inc Moléculas para transportar um composto através da barreira hematoencefálica
DK2233156T3 (da) 2005-07-15 2013-08-05 Angiochem Inc Anvendelse af aprotininpolypeptider som bærere i farmaceutiske konjugater
CN100410266C (zh) * 2006-01-11 2008-08-13 重庆华邦制药股份有限公司 鬼臼毒素磷酸酯衍生物的合成方法
JO2660B1 (en) 2006-01-20 2012-06-17 نوفارتيس ايه جي Pi-3 inhibitors and methods of use
PE20070978A1 (es) * 2006-02-14 2007-11-15 Novartis Ag COMPUESTOS HETEROCICLICOS COMO INHIBIDORES DE FOSFATIDILINOSITOL 3-QUINASAS (PI3Ks)
TW200808739A (en) * 2006-04-06 2008-02-16 Novartis Vaccines & Diagnostic Quinazolines for PDK1 inhibition
GB0625283D0 (en) * 2006-12-19 2007-01-24 Cyclacel Ltd Combination
US9365634B2 (en) * 2007-05-29 2016-06-14 Angiochem Inc. Aprotinin-like polypeptides for delivering agents conjugated thereto to tissues
WO2009036106A1 (en) * 2007-09-13 2009-03-19 Bristol-Myers Squibb Company Cytotoxic xanthone compounds
CN101918030B (zh) 2007-11-09 2015-10-14 派瑞格恩医药公司 抗vegf抗体的组合物和方法
US8940771B2 (en) 2007-12-20 2015-01-27 Novartis Ag Organic compounds
BRPI0910557A2 (pt) * 2008-04-18 2015-09-29 Angiochem Inc composições farmacêuticas de paclitaxel, análogos de paclitaxel ou conjugados de paclitaxel e métodos relacionados de preparação e uso.
RU2011118056A (ru) 2008-10-15 2012-11-27 Ангиокем Инк. Конъюгаты агонистов glp-1 и их применение
RU2531591C2 (ru) 2008-10-15 2014-10-20 Ангиокем Инк. Конъюгаты этопозида и доксорубицина для доставки лекарственных средств
CN102307904A (zh) * 2008-12-05 2012-01-04 安吉奥开米公司 神经降压素或神经降压素类似物的缀合物及其用途
AU2009327267A1 (en) 2008-12-17 2011-07-14 Angiochem, Inc. Membrane type-1 matrix metalloprotein inhibitors and uses thereof
CA2759129C (en) 2009-04-20 2018-12-11 Angiochem Inc. Treatment of ovarian cancer using an anticancer agent conjugated to an angiopep-2 analog
US8293753B2 (en) 2009-07-02 2012-10-23 Novartis Ag Substituted 2-carboxamide cycloamino ureas
US9161988B2 (en) 2009-07-02 2015-10-20 Angiochem Inc. Multimeric peptide conjugates and uses thereof
MX2012009059A (es) 2010-02-22 2012-09-07 Hoffmann La Roche Compuestos inhibidores de fosfoinositida 3-cinasa delta (pi3k) pirido [3,2-d]pirimidina y metodos de uso.
US9586954B2 (en) 2010-06-22 2017-03-07 Demerx, Inc. N-substituted noribogaine prodrugs
AR082418A1 (es) 2010-08-02 2012-12-05 Novartis Ag Formas cristalinas de 1-(4-metil-5-[2-(2,2,2-trifluoro-1,1-dimetil-etil)-piridin-4-il]-tiazol-2-il)-amida de 2-amida del acido (s)-pirrolidin-1,2-dicarboxilico
EP2670753B1 (en) 2011-01-31 2016-10-19 Novartis AG Novel heterocyclic derivatives
US9617274B1 (en) 2011-08-26 2017-04-11 Demerx, Inc. Synthetic noribogaine
PH12014500912A1 (en) 2011-10-28 2014-06-09 Novartis Ag Novel purine derivatives and their use in the treatment of disease
JP2015500833A (ja) * 2011-12-09 2015-01-08 デメレックス， インコーポレイテッド ノルイボガインのリン酸エステル
SG10201608469RA (en) 2012-05-16 2016-11-29 Novartis Ag Dosage regimen for a pi-3 kinase inhibitor
JP2016508979A (ja) 2012-12-20 2016-03-24 デメレックス， インコーポレイテッド 置換ノルイボガイン
PL3076969T3 (pl) 2013-12-06 2022-01-17 Novartis Ag Schemat dawkowania selektywnego inhibitora 3-kinazy fosfatydynozytolu alfa-izoformy
DK3307326T3 (da) 2015-06-15 2020-10-19 Angiochem Inc Fremgangsmåder til behandling af leptomeningeal karcinomatose
MX2018005298A (es) 2015-11-02 2018-06-22 Novartis Ag Regimen de dosificacion para un inhibidor de fosfatidilinositol 3-quinasa.
WO2018060833A1 (en) 2016-09-27 2018-04-05 Novartis Ag Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
KR102378151B1 (ko) 2020-05-11 2022-03-24 주식회사 제이앤씨사이언스 베타-아포피크로포도필린의 신규한 유도체

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1171314A (fr) * 1955-05-13 1959-01-23 Sandoz Ag Produits de condensation de glucosides avec des composés carbonyliques et leur préparation
NL6613143A (OSRAM) * 1965-09-21 1967-03-22
CH464957A (de) * 1965-12-14 1968-11-15 Sandoz Ag Verfahren zur Herstellung eines neuen Glucosids
CH481913A (de) * 1966-12-13 1969-11-30 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
CH514578A (de) * 1968-02-27 1971-10-31 Sandoz Ag Verfahren zur Herstellung von Glucosiden
CH543502A (de) * 1970-11-20 1973-10-31 Sandoz Ag Verfahren zur Herstellung neuer Glucoside
GB1395820A (en) * 1971-06-05 1975-05-29 Villax I Preparation of 21-inorganic esters of corticosteroids and salts thereof
CH589668A5 (en) * 1973-06-07 1977-07-15 Sandoz Ag Cytostatic (4')-demethyl substd. epipodophyllotoxin - prepd. from the corresp. glucopyranoside with (3)-thiophene-carboxaldehyde
FR2397425A1 (fr) * 1977-07-11 1979-02-09 Rhone Poulenc Ind Nouveaux derives de la daunorubicine, leur preparation et les compositions qui les contiennent
EP0111058B1 (en) * 1982-11-26 1987-11-04 Nippon Kayaku Kabushiki Kaisha Process for producing 4'-demethyl-epipodophyllotoxin-beta-d-ethylidene-glucoside and acyl-derivative thereof
US4567253A (en) * 1984-02-03 1986-01-28 Tony Durst 2-Substituted derivatives of podophyllotoxin and etoposide
JPS60208910A (ja) * 1984-03-31 1985-10-21 Green Cross Corp:The 水難溶性薬物・リン脂質複合体の製造方法
JPS60246393A (ja) * 1984-05-22 1985-12-06 Nippon Kayaku Co Ltd エトポシドの新規製造法
US4739046A (en) * 1985-08-19 1988-04-19 Luzio Nicholas R Di Soluble phosphorylated glucan
IL77334A (en) * 1985-12-16 1991-04-15 Univ Bar Ilan Synthesis of 9-epipodophyllotoxin glucoside derivatives and some novel intermediates therefor
US4916217A (en) * 1987-01-08 1990-04-10 Bristol-Myers Company Phosphorus containing derivatives of epipodophyllotoxin
JPS63192793A (ja) * 1987-02-06 1988-08-10 Nippon Kayaku Co Ltd ４′−デメチル−エピポドフイロトキシン誘導体の新規エステル
US4874851A (en) * 1987-07-01 1989-10-17 Bristol-Meyers Company 3',4'-dinitrogen substituted epipodophyllotoxin glucoside derivatives

Also Published As

Publication number Publication date
KR900006230B1 (ko) 1990-08-27
PT88186B (pt) 1995-07-03
USRE35524E (en) 1997-06-03
SG101291G (en) 1992-01-17
GB2207674A (en) 1989-02-08
NL192683B (OSRAM) 1997-08-01
CZ286893B6 (cs) 2000-07-12
NO920277D0 (no) 1992-01-22
MY104321A (en) 1994-03-31
GB2207674B (en) 1991-09-11
FI87790B (fi) 1992-11-13
CA1310637C (en) 1992-11-24
NO883299D0 (no) 1988-07-26
CH676716A5 (OSRAM) 1991-02-28
NL970042I1 (nl) 1998-03-02
NO170284B (no) 1992-06-22
IL87290A0 (en) 1989-01-31
SE8802815D0 (sv) 1988-08-03
YU10390A (en) 1990-06-30
GR880100512A (en) 1989-05-25
DD274423A5 (de) 1989-12-20
DD299067A5 (de) 1992-03-26
DK169344B1 (da) 1994-10-10
US4904768A (en) 1990-02-27
FR2622193A1 (fr) 1989-04-28
SE8802815L (sv) 1989-02-05
NZ225615A (en) 1991-06-25
CZ541288A3 (cs) 1999-12-15
HU202547B (en) 1991-03-28
YU10490A (en) 1990-06-30
SK541288A3 (en) 1998-10-07
SK279325B6 (sk) 1998-10-07
NO1998002I1 (no) 1998-01-14
CN1027169C (zh) 1994-12-28
YU143688A (en) 1990-04-30
IT8821535A0 (it) 1988-07-28
NL192683C (nl) 1997-12-02
DK434088D0 (da) 1988-08-03
CN1061225A (zh) 1992-05-20
KR890003790A (ko) 1989-04-18
FI87790C (fi) 1993-02-25
SE502214C2 (sv) 1995-09-18
LU90138I2 (fr) 1997-11-26
ES2010775A6 (es) 1989-12-01
NO920665L (no) 1989-02-24
MX9202851A (es) 1992-06-30
NO920665D0 (no) 1992-02-20
IE61040B1 (en) 1994-09-07
JPH0699465B2 (ja) 1994-12-07
FR2622193B1 (fr) 1993-12-17
HU211960A9 (en) 1996-01-29
NO170284C (no) 1992-09-30
DK11992D0 (da) 1992-01-31
ATA195588A (de) 1994-07-15
PT88186A (pt) 1989-06-30
AU2030688A (en) 1989-06-08
NL970042I2 (OSRAM) 2005-06-01
IL87290A (en) 1993-01-31
FI883596A0 (fi) 1988-08-01
AT398974B (de) 1995-02-27
HUT47303A (en) 1989-02-28
DK11992A (da) 1992-01-31
FI883596A7 (fi) 1989-02-05
CY1625A (en) 1992-07-10
MX173843B (es) 1994-03-30
DE3826562C2 (OSRAM) 1993-04-08
NO172440B (no) 1993-04-13
DE3826562A1 (de) 1989-02-16
GB8818462D0 (en) 1988-09-07
AU610619B2 (en) 1991-05-23
JPH01100188A (ja) 1989-04-18
BE1002982A4 (fr) 1991-10-15
US5041424A (en) 1991-08-20
LU87290A1 (fr) 1990-02-07
NO172440C (no) 1993-07-21
NO883299L (no) 1989-02-24
HU905862D0 (en) 1991-03-28
IT1226825B (it) 1991-02-19
HU208147B (en) 1993-08-30
NO920277L (no) 1989-02-24
NL8801934A (nl) 1989-03-01
GR1000490B (el) 1992-07-30
DK434088A (da) 1989-02-05
IE882378L (en) 1989-02-04

Similar Documents

Publication Publication Date Title
HK6392A (en) Podophyllotoxin derivatives
ZA883602B (en) Medicament
ES8604516A1 (es) Un derivado de dihidropiridina
TW430661B (en) Benzenesulfonamide derivative and process for preparing thereof
PT1061940E (pt) Utilizacao de foliestatina para a producao de um medicamento para o tratamento de disturbios relacionados com os musculos
NO932650D0 (no) Forbedringer vedroerende benzotiofener
AU5945686A (en) Isoxazole and furan derivatives, their preparation and use as antiviral agents
GB2208861B (en) 1,4-dihydropyridines, their preparation and medicinal use
ES2042534T3 (es) Un proceso para la preparacion de una preparacion topica en forma de un hidrogel.
IE863381L (en) Antibiotics
ES2091766T3 (es) Uso de n-butil-desoxinojirimicina para el tratamiento de herpes.
AU3256789A (en) Topical preparation for treating otopathy
NZ218789A (en) Antibiotic a-40926 derivatives
EP0333154A3 (en) Process for the preparation of cephem derivatives and intermediates therefor
GR3002480T3 (en) Condom
NZ322202A (en) Aminocycloalkylpyrrolidine derivatives and salts thereof with antibacterial activity
SE9300758L (sv) Förfarande för framställning av kavulansyrasalter
EP0342587A3 (en) Thienotriazolodiazepine compounds and pharmaceutical uses thereof
AU4714589A (en) 4,5,6,7-tetrahydrobenzimidazole derivatives
FI950422A0 (fi) Uusia 3-fenyylisulfonyyli-3,7-diatsabisyklo(3,3,1)nonaani-yhdisteitä sisältävät lääkeaineet
MD1744F2 (ro) Săruri ale acidului clavulanic şi procedeu de obţinere a lor
DE69627519D1 (de) Sesquiterpen-derivate mit antiviraler aktivität
ATE71380T1 (de) Aminoacylderivate von 4,9-dihydro-10h-pyrido(3,2b>thieno(3,2-e>(1,4>diazepinonen und 4,9-dihydro10h-pyrido(3,2-b>thieno(3,4-e>(1,4>diazepinonen ihre herstellung und diese enthaltende pharmazeutische zubereitungen.
IT8521446A0 (it) Nuovi sali della 6-metil-2-amino-4-idrossi-5,6,7,8-t etraidropteridina ad attivita'antiamnesica.
IT1307328B1 (it) Composti indolici

Legal Events

Date Code Title Description
PF Patent in force
PE Patent expired

Effective date: 20080802