NO173785C - Analogifremgangsmaate for fremstilling av farmasoeytisk virksomme kinuklidinderivater samt mellom-produkt for fremstillingen - Google Patents

Analogifremgangsmaate for fremstilling av farmasoeytisk virksomme kinuklidinderivater samt mellom-produkt for fremstillingen

Info

Publication number
NO173785C
NO173785C NO861682A NO861682A NO173785C NO 173785 C NO173785 C NO 173785C NO 861682 A NO861682 A NO 861682A NO 861682 A NO861682 A NO 861682A NO 173785 C NO173785 C NO 173785C
Authority
NO
Norway
Prior art keywords
preparation
pharmaceutically effective
analogous procedure
quinuclidine derivatives
intermediate preparations
Prior art date
Application number
NO861682A
Other languages
English (en)
Other versions
NO861682L (no
NO173785B (no
Inventor
Abraham Fisher
Ishai Karton
Eliahu Heldman
Aharon Levy
Yona Grundfeld
Original Assignee
Israel State
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL75166A external-priority patent/IL75166A/xx
Application filed by Israel State filed Critical Israel State
Publication of NO861682L publication Critical patent/NO861682L/no
Publication of NO173785B publication Critical patent/NO173785B/no
Publication of NO173785C publication Critical patent/NO173785C/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
NO861682A 1985-05-10 1986-04-29 Analogifremgangsmaate for fremstilling av farmasoeytisk virksomme kinuklidinderivater samt mellom-produkt for fremstillingen NO173785C (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL75166A IL75166A (en) 1985-05-10 1985-05-10 2-substituted spiro(1,3-oxathiolane-5,3-quinuclidine)derivatives,their preparation and pharmaceutical compositions containing them and 3-hydroxy-3-mercaptomethylquinuclidine as intermidiate therefor
IL7756886 1986-01-10

Publications (3)

Publication Number Publication Date
NO861682L NO861682L (no) 1986-11-11
NO173785B NO173785B (no) 1993-10-25
NO173785C true NO173785C (no) 1994-02-02

Family

ID=26321442

Family Applications (1)

Application Number Title Priority Date Filing Date
NO861682A NO173785C (no) 1985-05-10 1986-04-29 Analogifremgangsmaate for fremstilling av farmasoeytisk virksomme kinuklidinderivater samt mellom-produkt for fremstillingen

Country Status (9)

Country Link
US (1) US4855290A (no)
EP (1) EP0205247B1 (no)
JP (2) JPH0725767B2 (no)
AT (1) ATE83485T1 (no)
CA (1) CA1311479C (no)
DE (1) DE3687288T2 (no)
DK (1) DK173084B1 (no)
ES (1) ES8703461A1 (no)
NO (1) NO173785C (no)

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US5106831A (en) * 1987-08-13 1992-04-21 State Of Israel, Represented By The Prime Minister's Office, Israel Institute For Biological Research Pharmaceutical composition comprising a spiro oxathiolon/quinuclidine and method of treating senile dementia
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US4876260A (en) * 1987-10-28 1989-10-24 State Of Israel, Israel Institute Of Biological Research Oxathiolanes
US4900830A (en) * 1987-10-28 1990-02-13 Israel Institute For Biological Research Process for labelling sulfur-containing compounds
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IL97726A (en) * 1990-04-10 1994-12-29 Israel Inst Biolog Res Pharmaceutical preparations containing compounds with bridged and unbridged heterocyclic groups connected via spiro-atop with oxazoline and thiazoline groups, and sharp compounds
US5852029A (en) * 1990-04-10 1998-12-22 Israel Institute For Biological Research Aza spiro compounds acting on the cholinergic system with muscarinic agonist activity
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
US5268687A (en) * 1990-07-30 1993-12-07 Spectrum Sciences B.V. Laser scanning apparatus
JP2761973B2 (ja) * 1990-08-28 1998-06-04 雪印乳業株式会社 粉砕容易なシス‐２‐メチルスピロ（１，３‐オキサチオラン‐５，３′）キヌクリジン塩酸塩１／２水和物の製造方法
JP2683783B2 (ja) * 1992-07-10 1997-12-03 雪印乳業株式会社 シェーグレン症候群治療剤
JPH06239861A (ja) * 1993-02-17 1994-08-30 Kanegafuchi Chem Ind Co Ltd 二環式含チッ素化合物
JP2983141B2 (ja) * 1993-10-06 1999-11-29 株式会社三和化学研究所 新規化合物及び該化合物を有効成分とする脳機能改善剤
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JP2852608B2 (ja) * 1994-06-27 1999-02-03 雪印乳業株式会社 口腔乾燥症治療剤
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WO1998030243A1 (en) * 1997-01-08 1998-07-16 Warner-Lambert Company Acetylcholinesterase inhibitors in combination with muscarinic agonists for the treatment of alzheimer's disease
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
JP4447685B2 (ja) * 1999-01-14 2010-04-07 第一三共株式会社 皮膚乾燥症治療剤
CA2360326C (en) * 1999-02-09 2011-04-05 Uab Research Foundation Use of 4-amino pyridine for treatment of peripheral neuropathies
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
US6433168B1 (en) 1999-07-26 2002-08-13 Sumika Fine Chemicals Co., Ltd. Highly pure phenothiazine compound, production method thereof, production method of intermediate therefor, and hydrate and novel crystal as starting materials for the intermediate
KR100998804B1 (ko) * 2002-05-03 2010-12-06 이스라엘 인스티튜트 포 바이올로지컬 리서치 중추 및 말초 신경계 장애의 치료를 위한 방법 및 조성물,및 그에 유용한 신규 화합물
US7514567B2 (en) * 2003-07-08 2009-04-07 Astrazeneca Ab Oxazolidinone nicotinic acetylcholine receptor agonists
US20050192321A1 (en) * 2003-09-15 2005-09-01 Meythaler Jay M. Treatment of neuropathy with rapid release aminopyridine
WO2006013914A1 (ja) * 2004-08-06 2006-02-09 Daiichi Pharmaceutical Co., Ltd. 口腔粘膜投与剤
KR20070090922A (ko) * 2004-12-15 2007-09-06 아스트라제네카 아베 니코틴성 아세틸콜린 수용체 리간드
EP2258358A3 (en) 2005-08-26 2011-09-07 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
US7678363B2 (en) * 2005-08-26 2010-03-16 Braincells Inc Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
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US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
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EP2167071B1 (en) * 2007-06-13 2020-03-18 Wayne State University Board Of Governors A baclofen solution for low-volume therapeutic delivery
WO2008157308A2 (en) * 2007-06-13 2008-12-24 Wayne State University Board Of Governors A zwitterion solution for low-volume therapeutic delivery
US8143400B2 (en) * 2008-01-10 2012-03-27 Apotex Pharmachem Inc. Process for the preparation and purification of cis-2-methylspiro(1,3-oxathiolane-5,3′)quiniclidine hydrochloride
EP2100598A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
US9034891B2 (en) 2009-01-26 2015-05-19 Israel Institute For Biological Research Bicyclic heterocyclic spiro compounds
EP2389383B1 (en) 2009-01-26 2019-04-24 Israel Institute For Biological Research Bicyclic heterocyclic spiro compounds
WO2010099217A1 (en) 2009-02-25 2010-09-02 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
JP5452165B2 (ja) * 2009-10-23 2014-03-26 第一ファインケミカル株式会社 キヌクリジン類の製造法
US8450487B2 (en) * 2010-06-08 2013-05-28 Apicore, Llc Process for the preparation of cis-2-methylspiro (1,3-oxathiolane 5-3′) quinuclidine
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CN104892619A (zh) * 2015-06-26 2015-09-09 大道隆达（北京）医药科技发展有限公司 一种药物中间体的制备方法
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Also Published As

Publication number Publication date
DK196686A (da) 1986-11-11
EP0205247A2 (en) 1986-12-17
ATE83485T1 (de) 1993-01-15
CA1311479C (en) 1992-12-15
EP0205247B1 (en) 1992-12-16
JPH0725767B2 (ja) 1995-03-22
US4855290A (en) 1989-08-08
DE3687288D1 (de) 1993-01-28
EP0205247A3 (en) 1988-02-03
ES8703461A1 (es) 1987-03-01
DK173084B1 (da) 1999-12-27
JPS61280497A (ja) 1986-12-11
NO861682L (no) 1986-11-11
DK196686D0 (da) 1986-04-29
ES554280A0 (es) 1987-03-01
NO173785B (no) 1993-10-25
JPH07223953A (ja) 1995-08-22
DE3687288T2 (de) 1993-04-15

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