DK173084B1 - Quinuclidinderivater, fremgangsmåde til fremstilling heraf samt farmaceutisk præparat indeholdende disse - Google Patents

Quinuclidinderivater, fremgangsmåde til fremstilling heraf samt farmaceutisk præparat indeholdende disse Download PDF

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Publication number
DK173084B1
DK173084B1 DK198601966A DK196686A DK173084B1 DK 173084 B1 DK173084 B1 DK 173084B1 DK 198601966 A DK198601966 A DK 198601966A DK 196686 A DK196686 A DK 196686A DK 173084 B1 DK173084 B1 DK 173084B1
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DK
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Prior art keywords
group
af102b
pharmaceutical composition
af64a
rats
Prior art date
Application number
DK198601966A
Other languages
Danish (da)
English (en)
Other versions
DK196686A (da
DK196686D0 (da
Inventor
Abraham Fisher
Ishai Karton
Eliahu Heldman
Aharon Levy
Yona Grunfeld
Original Assignee
Israel State
Israel Inst For Biolog Res S O
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IL75166A external-priority patent/IL75166A/xx
Application filed by Israel State, Israel Inst For Biolog Res S O filed Critical Israel State
Publication of DK196686D0 publication Critical patent/DK196686D0/da
Publication of DK196686A publication Critical patent/DK196686A/da
Application granted granted Critical
Publication of DK173084B1 publication Critical patent/DK173084B1/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK198601966A 1985-05-10 1986-04-29 Quinuclidinderivater, fremgangsmåde til fremstilling heraf samt farmaceutisk præparat indeholdende disse DK173084B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
IL7516685 1985-05-10
IL75166A IL75166A (en) 1985-05-10 1985-05-10 2-substituted spiro(1,3-oxathiolane-5,3-quinuclidine)derivatives,their preparation and pharmaceutical compositions containing them and 3-hydroxy-3-mercaptomethylquinuclidine as intermidiate therefor
IL7756886 1986-01-10
IL7756886 1986-01-10

Publications (3)

Publication Number Publication Date
DK196686D0 DK196686D0 (da) 1986-04-29
DK196686A DK196686A (da) 1986-11-11
DK173084B1 true DK173084B1 (da) 1999-12-27

Family

ID=26321442

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198601966A DK173084B1 (da) 1985-05-10 1986-04-29 Quinuclidinderivater, fremgangsmåde til fremstilling heraf samt farmaceutisk præparat indeholdende disse

Country Status (9)

Country Link
US (1) US4855290A (no)
EP (1) EP0205247B1 (no)
JP (2) JPH0725767B2 (no)
AT (1) ATE83485T1 (no)
CA (1) CA1311479C (no)
DE (1) DE3687288T2 (no)
DK (1) DK173084B1 (no)
ES (1) ES8703461A1 (no)
NO (1) NO173785C (no)

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US4981858A (en) * 1987-08-13 1991-01-01 State Of Israel, Represented By The Prime Minister's Office, Israel Institute For Biological Research Optical isomers
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IL97726A (en) * 1990-04-10 1994-12-29 Israel Inst Biolog Res Pharmaceutical preparations containing compounds with bridged and unbridged heterocyclic groups connected via spiro-atop with oxazoline and thiazoline groups, and sharp compounds
US5407938A (en) * 1990-04-10 1995-04-18 Israel Institute For Biological Research Certain 1-methyl-piperidine-4-spiro-4'-(1'-3'-oxazolines) and corresponding -(1',3' thiazolines)
US5534520A (en) * 1990-04-10 1996-07-09 Fisher; Abraham Spiro compounds containing five-membered rings
US5268687A (en) * 1990-07-30 1993-12-07 Spectrum Sciences B.V. Laser scanning apparatus
JP2761973B2 (ja) * 1990-08-28 1998-06-04 雪印乳業株式会社 粉砕容易なシス‐２‐メチルスピロ（１，３‐オキサチオラン‐５，３′）キヌクリジン塩酸塩１／２水和物の製造方法
JP2683783B2 (ja) * 1992-07-10 1997-12-03 雪印乳業株式会社 シェーグレン症候群治療剤
JPH06239861A (ja) * 1993-02-17 1994-08-30 Kanegafuchi Chem Ind Co Ltd 二環式含チッ素化合物
JP2983141B2 (ja) * 1993-10-06 1999-11-29 株式会社三和化学研究所 新規化合物及び該化合物を有効成分とする脳機能改善剤
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JP2852608B2 (ja) * 1994-06-27 1999-02-03 雪印乳業株式会社 口腔乾燥症治療剤
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AU5716898A (en) * 1997-01-08 1998-08-03 Warner-Lambert Company Acetylcholinesterase inhibitors in combination with muscarinic agonists for the treatment of alzheimer's disease
US6528529B1 (en) 1998-03-31 2003-03-04 Acadia Pharmaceuticals Inc. Compounds with activity on muscarinic receptors
JP4447685B2 (ja) * 1999-01-14 2010-04-07 第一三共株式会社 皮膚乾燥症治療剤
WO2000047210A1 (en) * 1999-02-09 2000-08-17 Uab Research Foundation Use of 4-amino pyridine for treatment of peripheral neuropathies
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
US6433168B1 (en) 1999-07-26 2002-08-13 Sumika Fine Chemicals Co., Ltd. Highly pure phenothiazine compound, production method thereof, production method of intermediate therefor, and hydrate and novel crystal as starting materials for the intermediate
AU2003223093B2 (en) * 2002-05-03 2010-02-04 Israel Institute For Biological Research Methods and compositions for treatment of central and peripheral nervous system disorders and novel compounds useful therefor
MXPA06000231A (es) * 2003-07-08 2006-04-11 Astrazeneca Ab Derivados espiro '1-azabiciclo'2.2.2!octan-3,5'-oxazolidin-2'-ona! con afinidad a la alfa7 del receptor nicotinico para acetilcolina.
US20050192321A1 (en) * 2003-09-15 2005-09-01 Meythaler Jay M. Treatment of neuropathy with rapid release aminopyridine
WO2006013914A1 (ja) * 2004-08-06 2006-02-09 Daiichi Pharmaceutical Co., Ltd. 口腔粘膜投与剤
CA2591430A1 (en) * 2004-12-15 2006-06-22 Astrazeneca Ab Nicotinic acetylcholine receptor ligands
EP2258357A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis with acetylcholinesterase inhibitor
JP2009506069A (ja) * 2005-08-26 2009-02-12 ブレインセルス，インコーポレイティド ムスカリン性受容体調節による神経発生
AU2006304787A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by PDE inhibition
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
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AU2010207486B2 (en) * 2009-01-26 2013-03-07 Israel Institute For Biological Research Bicyclic heterocyclic spiro compounds
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
JP5452165B2 (ja) * 2009-10-23 2014-03-26 第一ファインケミカル株式会社 キヌクリジン類の製造法
US8450487B2 (en) * 2010-06-08 2013-05-28 Apicore, Llc Process for the preparation of cis-2-methylspiro (1,3-oxathiolane 5-3′) quinuclidine
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CN104892619A (zh) * 2015-06-26 2015-09-09 大道隆达（北京）医药科技发展有限公司 一种药物中间体的制备方法
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Also Published As

Publication number Publication date
US4855290A (en) 1989-08-08
JPS61280497A (ja) 1986-12-11
EP0205247B1 (en) 1992-12-16
DK196686A (da) 1986-11-11
DK196686D0 (da) 1986-04-29
NO861682L (no) 1986-11-11
JPH07223953A (ja) 1995-08-22
ES8703461A1 (es) 1987-03-01
ES554280A0 (es) 1987-03-01
DE3687288T2 (de) 1993-04-15
JPH0725767B2 (ja) 1995-03-22
EP0205247A3 (en) 1988-02-03
EP0205247A2 (en) 1986-12-17
DE3687288D1 (de) 1993-01-28
CA1311479C (en) 1992-12-15
ATE83485T1 (de) 1993-01-15
NO173785C (no) 1994-02-02
NO173785B (no) 1993-10-25

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