EA201690209A1 - Состав в форме капельной микропилюли и способ его получения - Google Patents

Состав в форме капельной микропилюли и способ его получения

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Publication number
EA201690209A1
EA201690209A1 EA201690209A EA201690209A EA201690209A1 EA 201690209 A1 EA201690209 A1 EA 201690209A1 EA 201690209 A EA201690209 A EA 201690209A EA 201690209 A EA201690209 A EA 201690209A EA 201690209 A1 EA201690209 A1 EA 201690209A1
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EA
Eurasian Patent Office
Prior art keywords
drug
drip
droplet
liquid
stage
Prior art date
Application number
EA201690209A
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English (en)
Other versions
EA034240B1 (ru
Inventor
Сицзюнь Янь
Найфэн У
Кайцзин Янь
Сяобин Сунь
Шуньнань Чжан
Чжэнлян Е
Хай'оу Дун
Хунбо Чжан
Вэньшэн Чжан
Лихун Чжоу
Чэньмин Ли
Цун Чэнь
Сяофэн Лю
Шицин Ван
Чаншэн Жун
Юнфэн Чжен
Лицзюнь Фань
Original Assignee
Тасли Фармасьютикал Груп Ко., Лтд.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Priority claimed from CN201310291465.2A external-priority patent/CN104274416B/zh
Priority claimed from CN201310290966.9A external-priority patent/CN104274319A/zh
Priority claimed from CN201310290967.3A external-priority patent/CN104274517B/zh
Application filed by Тасли Фармасьютикал Груп Ко., Лтд. filed Critical Тасли Фармасьютикал Груп Ко., Лтд.
Publication of EA201690209A1 publication Critical patent/EA201690209A1/ru
Publication of EA034240B1 publication Critical patent/EA034240B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • A61J3/06—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of pills, lozenges or dragees
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
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    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
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    • A61K9/2022—Organic macromolecular compounds
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    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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    • A61K9/5015—Organic compounds, e.g. fats, sugars
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    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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    • A61K9/5005—Wall or coating material
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    • A61K9/5005—Wall or coating material
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    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Medicinal Preparation (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Настоящее изобретение относится к способу получения капельной пилюли средств традиционной китайской медицины и капельной микропилюле средств традиционной китайской медицины, полученной с помощью данного способа, и, в частности, настоящее изобретение относится к способу получения капельной микропилюли с высоким уровнем содержания лекарственного средства, простым способом получения и высокой скоростью производства, и капельной микропилюле, полученной с помощью данного способа. В частности, применяемый способ получения капельной пилюли включает следующие стадии: (1) стадию плавления материала: термическое плавление лекарственного препарата и матрицы капельной пилюли с получением жидкости с расплавленным лекарственным препаратом; (2) стадию капельного выливания: подача жидкости с расплавленным лекарственным препаратом в капельницу и получение капель лекарственного препарата из жидкости с расплавленным лекарственным препаратом посредством вибрационного капельного выливания; и (3) стадию конденсации: охлаждение капель лекарственного препарата с помощью охлаждающего газа с получением капельных микропилюль.
EA201690209A 2013-07-11 2014-07-11 Средство традиционной китайской медицины в форме капельной микропилюли и способ его получения EA034240B1 (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN201310291465.2A CN104274416B (zh) 2013-07-11 2013-07-11 一种振动滴制微滴丸的方法
CN201310290966.9A CN104274319A (zh) 2013-07-11 2013-07-11 一种振动滴制滴丸的方法
CN201310290967.3A CN104274517B (zh) 2013-07-11 2013-07-11 振动法制备芪参益气微滴丸
CN201310290968 2013-07-11
PCT/CN2014/082104 WO2015003661A1 (zh) 2013-07-11 2014-07-11 一种中药微滴丸的制备方法以及由所述方法制得的中药微滴丸

Publications (2)

Publication Number Publication Date
EA201690209A1 true EA201690209A1 (ru) 2016-08-31
EA034240B1 EA034240B1 (ru) 2020-01-21

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EA201690209A EA034240B1 (ru) 2013-07-11 2014-07-11 Средство традиционной китайской медицины в форме капельной микропилюли и способ его получения

Country Status (16)

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US (2) US20160151293A1 (ru)
EP (1) EP3020395B1 (ru)
JP (1) JP6371841B2 (ru)
KR (1) KR102342819B1 (ru)
AU (1) AU2014289765B2 (ru)
CA (1) CA2916423C (ru)
DK (1) DK3020395T3 (ru)
EA (1) EA034240B1 (ru)
ES (1) ES2869918T3 (ru)
GE (1) GEP20186901B (ru)
HK (1) HK1221156A1 (ru)
HU (1) HUE054609T2 (ru)
MX (1) MX2015017651A (ru)
TW (1) TWI653991B (ru)
UA (1) UA119750C2 (ru)
WO (1) WO2015003661A1 (ru)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104418744B (zh) 2013-08-29 2017-03-01 天士力制药集团股份有限公司 一种新的丹酚酸化合物t、其制备方法和用途
CN107782798B (zh) * 2016-08-24 2021-09-21 天士力医药集团股份有限公司 一种应用双波长uplc检测芪参益气滴丸的方法
CN106344410B (zh) * 2016-09-21 2023-03-14 吉林省农业机械研究院 一种具有二次加药装置的中药煎煮系统及中药煎煮方法
CN113218480B (zh) * 2020-04-14 2022-10-11 浙江大学 一种滴丸丸重表征方法

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