CN101711792B8 - 一种治疗冠心病的滴丸及其制备方法 - Google Patents
一种治疗冠心病的滴丸及其制备方法 Download PDFInfo
- Publication number
- CN101711792B8 CN101711792B8 CN200910179090.4A CN200910179090A CN101711792B8 CN 101711792 B8 CN101711792 B8 CN 101711792B8 CN 200910179090 A CN200910179090 A CN 200910179090A CN 101711792 B8 CN101711792 B8 CN 101711792B8
- Authority
- CN
- China
- Prior art keywords
- weight percentage
- percentage content
- dripping pill
- heart disease
- plasticizing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000006187 pill Substances 0.000 title abstract 4
- 208000029078 coronary artery disease Diseases 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 abstract 3
- 239000000463 material Substances 0.000 abstract 3
- 239000011159 matrix material Substances 0.000 abstract 3
- KMZHZAAOEWVPSE-UHFFFAOYSA-N 2,3-dihydroxypropyl acetate Chemical compound CC(=O)OCC(O)CO KMZHZAAOEWVPSE-UHFFFAOYSA-N 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Natural products OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 abstract 1
- 229920000858 Cyclodextrin Polymers 0.000 abstract 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- 239000004375 Dextrin Substances 0.000 abstract 1
- 229920001353 Dextrin Polymers 0.000 abstract 1
- PYGXAGIECVVIOZ-UHFFFAOYSA-N Dibutyl decanedioate Chemical compound CCCCOC(=O)CCCCCCCCC(=O)OCCCC PYGXAGIECVVIOZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000004386 Erythritol Substances 0.000 abstract 1
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 abstract 1
- 240000007472 Leucaena leucocephala Species 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- 235000003143 Panax notoginseng Nutrition 0.000 abstract 1
- 241000180649 Panax notoginseng Species 0.000 abstract 1
- 239000002202 Polyethylene glycol Substances 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 abstract 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 abstract 1
- 239000000783 alginic acid Substances 0.000 abstract 1
- 235000010443 alginic acid Nutrition 0.000 abstract 1
- 229920000615 alginic acid Polymers 0.000 abstract 1
- 229960001126 alginic acid Drugs 0.000 abstract 1
- 150000004781 alginic acids Chemical class 0.000 abstract 1
- 239000001768 carboxy methyl cellulose Substances 0.000 abstract 1
- 239000004359 castor oil Substances 0.000 abstract 1
- 235000019438 castor oil Nutrition 0.000 abstract 1
- -1 citric acid ester Chemical class 0.000 abstract 1
- 239000003240 coconut oil Substances 0.000 abstract 1
- 235000019864 coconut oil Nutrition 0.000 abstract 1
- 239000000306 component Substances 0.000 abstract 1
- 235000019425 dextrin Nutrition 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 235000019414 erythritol Nutrition 0.000 abstract 1
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 abstract 1
- 229940009714 erythritol Drugs 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 235000011187 glycerol Nutrition 0.000 abstract 1
- 229960005150 glycerol Drugs 0.000 abstract 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 abstract 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 1
- 239000000832 lactitol Substances 0.000 abstract 1
- 235000010448 lactitol Nutrition 0.000 abstract 1
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 abstract 1
- 229960003451 lactitol Drugs 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- 229960001855 mannitol Drugs 0.000 abstract 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 abstract 1
- 229920000609 methyl cellulose Polymers 0.000 abstract 1
- 239000001923 methylcellulose Substances 0.000 abstract 1
- 235000010981 methylcellulose Nutrition 0.000 abstract 1
- 231100000956 nontoxicity Toxicity 0.000 abstract 1
- 229920001223 polyethylene glycol Polymers 0.000 abstract 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 abstract 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 abstract 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000000811 xylitol Substances 0.000 abstract 1
- 235000010447 xylitol Nutrition 0.000 abstract 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 abstract 1
- 229960002675 xylitol Drugs 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200910179090.4A CN101711792B8 (zh) | 2008-10-06 | 2009-09-30 | 一种治疗冠心病的滴丸及其制备方法 |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN200810152009.9 | 2008-10-06 | ||
CN200810152009 | 2008-10-06 | ||
CN200910179090.4A CN101711792B8 (zh) | 2008-10-06 | 2009-09-30 | 一种治疗冠心病的滴丸及其制备方法 |
Publications (3)
Publication Number | Publication Date |
---|---|
CN101711792A CN101711792A (zh) | 2010-05-26 |
CN101711792B CN101711792B (zh) | 2012-08-22 |
CN101711792B8 true CN101711792B8 (zh) | 2020-12-22 |
Family
ID=42416040
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN200910179090.4A Active CN101711792B8 (zh) | 2008-10-06 | 2009-09-30 | 一种治疗冠心病的滴丸及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101711792B8 (zh) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104147111A (zh) * | 2013-05-14 | 2014-11-19 | 天士力制药集团股份有限公司 | 复方丹参滴丸治疗氧化应激损伤 |
HUE054609T2 (hu) * | 2013-07-11 | 2021-09-28 | Tasly Pharmaceutical Group Co | Elkészítési eljárás hagyományos kínai gyógyszer mikrocsepp pilulához, és a hagyományos kínai gyógyszer mikrocsepp pilula, amely ennek az eljárásnak az alkalmazásával van elkészítve |
CN204147279U (zh) * | 2013-07-11 | 2015-02-11 | 天士力制药集团股份有限公司 | 气冷滴丸生产线 |
EP3020408B1 (en) | 2013-07-11 | 2022-01-12 | Tasly Pharmaceutical Group Co., Ltd. | Traditional chinese medicine composition, and preparation and application thereof |
USRE49050E1 (en) | 2013-07-11 | 2022-04-26 | Tasly Pharmaceutical Group Co., Ltd. | Traditional Chinese medicine composition, and preparation and application thereof |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1348815A (zh) * | 2001-11-09 | 2002-05-15 | 天津天士力制药股份有限公司 | 一种预防和治疗冠心病心绞痛的药物及其制备方法和其它用途 |
-
2009
- 2009-09-30 CN CN200910179090.4A patent/CN101711792B8/zh active Active
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1348815A (zh) * | 2001-11-09 | 2002-05-15 | 天津天士力制药股份有限公司 | 一种预防和治疗冠心病心绞痛的药物及其制备方法和其它用途 |
Also Published As
Publication number | Publication date |
---|---|
CN101711792A (zh) | 2010-05-26 |
CN101711792B (zh) | 2012-08-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101711792B8 (zh) | 一种治疗冠心病的滴丸及其制备方法 | |
JP6598841B2 (ja) | ツーピース硬カプセル用の耐酸性バンド溶液 | |
CN102036654B (zh) | 稳定的非典型抗精神病制剂 | |
CN102300570B (zh) | 用于治疗肝炎的水飞蓟宾组分 | |
CN102065847A (zh) | 含有血管紧张素-ⅱ受体阻断剂的药物制剂 | |
CN101652141A (zh) | 他克莫司的调节释放剂型 | |
JP2010540554A5 (zh) | ||
CA2554588A1 (en) | Method of preparing low-crystallinity oltipraz or amorphous oltipraz | |
WO2010092450A8 (en) | Stable pharmaceutical composition for atherosclerosis | |
JP2015509909A5 (zh) | ||
CN101257893A (zh) | 文拉法辛盐酸盐的控释药物组合物及其制备方法 | |
JP2007529564A5 (zh) | ||
JP2020535162A5 (zh) | ||
CA2936709A1 (en) | Composition of oily, pungent and odoriferous substances and a process of preparation thereof | |
JP2015514797A5 (zh) | ||
JP2006316009A (ja) | 口腔内貼付剤及びその製造方法 | |
CN101674850B (zh) | 狭花天竺葵和肾叶天竺葵的干提取物 | |
JP6441811B2 (ja) | 複合体形成用組成物、そこから形成された複合体、及びそれを含む経口摂取用組成物 | |
CN103169685B (zh) | 一种丁苯酞控释制剂及其制备方法 | |
US20220193018A1 (en) | Omega-3 compositions and methods relating thereto | |
CN107281150A (zh) | 一种降血脂的辛伐他汀缓释片及其制备方法 | |
US20230270678A1 (en) | Pharmaceutical compositions for improved delivery of therapeutic lipophilic actives | |
DE112006000873T5 (de) | Zusammensetzungen mit modifizierter Freisetzung, umfassend ein Fluorcytidin-Derivate zur Behandlung von Krebs | |
CN104887639B (zh) | 盐酸曲美他嗪单层渗透泵控释片及制备方法 | |
JP2022553653A (ja) | 高親油性生理活性物質の放出制御製剤 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1142271 Country of ref document: HK |
|
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C56 | Change in the name or address of the patentee |
Owner name: TASLY PHARMACEUTICAL GROUP CO., LTD. Free format text: FORMER NAME: TIANJIN TASLY PHARM. CO., LTD. |
|
CP01 | Change in the name or title of a patent holder |
Address after: 300410 Tianjin City Hedong District of Beichen Puji Road No. 2 city of the modern Chinese Medicine Patentee after: Tasly Pharmaceutical Group Co., Ltd. Address before: 300410 Tianjin City Hedong District of Beichen Puji Road No. 2 city of the modern Chinese Medicine Patentee before: Tianjin Tianshili Pharmaceutical Co., Ltd. |
|
REG | Reference to a national code |
Ref country code: HK Ref legal event code: WD Ref document number: 1142271 Country of ref document: HK |
|
CP01 | Change in the name or title of a patent holder | ||
CP01 | Change in the name or title of a patent holder |
Address after: 300410 Tianjin City Hedong District of Beichen Puji Road No. 2 city of the modern Chinese Medicine Patentee after: Tasly Pharmaceutical Group Limited by Share Ltd Address before: 300410 Tianjin City Hedong District of Beichen Puji Road No. 2 city of the modern Chinese Medicine Patentee before: Tasly Pharmaceutical Group Co., Ltd. |
|
CI03 | Correction of invention patent |
Correction item: Inventor Correct: Chen Jianming|Yan Xijun|Zhu Yonghong|Gao Baoan|Zhang Shunnan|Dong Haiou|Zhang Jizhong|Li Wei|Yan Xinjiang|Zhao Ying False: Chen Jianming|Yan Xijun|Zhu Yonghong|Gao Baoan|Zhang Shunnan|Dong Haiou|Zhang Jizhong|Li Wei|Yanxinjiang|Zhao Ying Number: 34 Page: The title page Volume: 28 Correction item: Inventor Correct: Chen Jianming|Yan Xijun|Zhu Yonghong|Gao Baoan|Zhang Shunnan|Dong Haiou|Zhang Jizhong|Li Wei|Yan Xinjiang|Zhao Ying False: Chen Jianming|Yan Xijun|Zhu Yonghong|Gao Baoan|Zhang Shunnan|Dong Haiou|Zhang Jizhong|Li Wei|Yanxinjiang|Zhao Ying Number: 34 Volume: 28 |
|
CI03 | Correction of invention patent |