EA200000968A1 - Двухфазная система доставки с регулируемым высвобождением для фармацевтических средств с высокой растворимостью и способ - Google Patents

Двухфазная система доставки с регулируемым высвобождением для фармацевтических средств с высокой растворимостью и способ

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Publication number
EA200000968A1
EA200000968A1 EA200000968A EA200000968A EA200000968A1 EA 200000968 A1 EA200000968 A1 EA 200000968A1 EA 200000968 A EA200000968 A EA 200000968A EA 200000968 A EA200000968 A EA 200000968A EA 200000968 A1 EA200000968 A1 EA 200000968A1
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EA
Eurasian Patent Office
Prior art keywords
phase
delivery system
controlled release
release delivery
hydrophobic
Prior art date
Application number
EA200000968A
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English (en)
Other versions
EA003101B1 (ru
Inventor
Питер Тимминз
Эндрю Б. Деннис
Керен А. Вайэс
Original Assignee
Бристол-Майерз Сквибб Компани
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21932435&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200000968(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Бристол-Майерз Сквибб Компани filed Critical Бристол-Майерз Сквибб Компани
Publication of EA200000968A1 publication Critical patent/EA200000968A1/ru
Publication of EA003101B1 publication Critical patent/EA003101B1/ru

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Предложена двухфазная система доставки с регулируемым высвобождением для фармацевтических средств, которые имеют высокую растворимость в воде, таких как HCl-соль антидиабетического метформина, которая обеспечивает лекарственную форму, которая обладает длительным нахождением в желудке и включает в себя (1) внутреннюю твердую фазу в форме частиц, образованную по существу однородными гранулами, содержащими фармацевтическое средство, имеющее высокую растворимость в воде, и один или более чем один гидрофильный полимер, один или более чем один гидрофобный полимер и/или один или более чем один гидрофобный материал, такой как один или более чем один воск, жирный спирт и/или эфир жирной кислоты, и (2) наружную твердую сплошную фазу, в которую заключены и в которой диспергированы вышеупомянутые гранулы внутренней твердой фазы в форме частиц, причем наружная твердая сплошная фаза включает в себя один или более чем один гидрофильный полимер, один или более чем один гидрофобный полимер и/или один или более чем один гидрофобный материал, такой как один или более чем один воск, жирный спирт и/или эфир жирной кислоты, которые можно спрессовать в таблетки или заполнить ими капсулы. Также предложены способы приготовления описанной таким образом двухфазной системы доставки с регулируемым высвобождением и применение такой двухфазной системы доставки с регулируемым высвобождением для лечения диабета.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200000968A 1998-03-19 1999-03-10 Двухфазная система доставки с регулируемым высвобождением для фармацевтических средств с высокой растворимостью и способ лечения диабета с помощью этой системы EA003101B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4444698A 1998-03-19 1998-03-19
PCT/US1999/005233 WO1999047128A1 (en) 1998-03-19 1999-03-10 Biphasic controlled release delivery system for high solubility pharmaceuticals and method

Publications (2)

Publication Number Publication Date
EA200000968A1 true EA200000968A1 (ru) 2001-06-25
EA003101B1 EA003101B1 (ru) 2002-12-26

Family

ID=21932435

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200000968A EA003101B1 (ru) 1998-03-19 1999-03-10 Двухфазная система доставки с регулируемым высвобождением для фармацевтических средств с высокой растворимостью и способ лечения диабета с помощью этой системы

Country Status (14)

Country Link
US (2) US6475521B1 (ru)
EP (2) EP1063973B1 (ru)
JP (1) JP4523153B2 (ru)
KR (1) KR100620935B1 (ru)
CN (1) CN1203846C (ru)
AP (1) AP1224A (ru)
AU (1) AU736951C (ru)
BR (1) BR9908911A (ru)
CA (1) CA2320900C (ru)
EA (1) EA003101B1 (ru)
ID (1) ID26082A (ru)
NZ (1) NZ506202A (ru)
OA (1) OA11484A (ru)
WO (1) WO1999047128A1 (ru)

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EP1063973B1 (en) 2016-11-16
KR20010041958A (ko) 2001-05-25
AP2000001885A0 (en) 2000-09-30
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US6660300B1 (en) 2003-12-09
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CA2320900A1 (en) 1999-09-23
AP1224A (en) 2003-11-14
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EP1063973A4 (en) 2008-11-19
ID26082A (id) 2000-11-23
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US6475521B1 (en) 2002-11-05
AU3182899A (en) 1999-10-11
WO1999047128A1 (en) 1999-09-23
BR9908911A (pt) 2001-10-02
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