MX2009004081A - Metodo para restaurar el efecto de incretina. - Google Patents

Metodo para restaurar el efecto de incretina.

Info

Publication number
MX2009004081A
MX2009004081A MX2009004081A MX2009004081A MX2009004081A MX 2009004081 A MX2009004081 A MX 2009004081A MX 2009004081 A MX2009004081 A MX 2009004081A MX 2009004081 A MX2009004081 A MX 2009004081A MX 2009004081 A MX2009004081 A MX 2009004081A
Authority
MX
Mexico
Prior art keywords
restoring
methods
present
insulin secretion
incretin effect
Prior art date
Application number
MX2009004081A
Other languages
English (en)
Inventor
Anton H Clemens
Original Assignee
Cpd Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cpd Llc filed Critical Cpd Llc
Publication of MX2009004081A publication Critical patent/MX2009004081A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4748—Quinolines; Isoquinolines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se relaciona con métodos para tratar el síndrome metabólico, diabetes mellitus Tipo II, dislipidemia aterogénica y/u obesidad. La presente invención también se relaciona con métodos para restaurar el efecto de incretina, para restaurar el control fisiológico de niveles de glucagón, para restaurar la secreción de insulina de primera fase y restaurar la secreción de insulina dependiente de glucosa fisiológica. Los métodos de la presente invención comprenden la administración de un antagonista ic-receptor selectivo, tal como naltrindol guanidinilatado (GLTI), o derivados farmacéuticamente aceptados de los mismos a un sujeto con necesidad de los mismos.
MX2009004081A 2006-10-20 2007-10-22 Metodo para restaurar el efecto de incretina. MX2009004081A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US86222706P 2006-10-20 2006-10-20
PCT/US2007/082084 WO2008051902A2 (en) 2006-10-20 2007-10-22 Method of restoring the incretin effect

Publications (1)

Publication Number Publication Date
MX2009004081A true MX2009004081A (es) 2009-06-18

Family

ID=39325299

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009004081A MX2009004081A (es) 2006-10-20 2007-10-22 Metodo para restaurar el efecto de incretina.

Country Status (9)

Country Link
US (8) US7893080B2 (es)
EP (2) EP2724722B1 (es)
BR (1) BRPI0718420A2 (es)
CA (1) CA2666846C (es)
ES (1) ES2618500T3 (es)
MX (1) MX2009004081A (es)
PT (1) PT2724722T (es)
SI (1) SI2724722T1 (es)
WO (1) WO2008051902A2 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7893080B2 (en) 2006-10-20 2011-02-22 Neurendo Pharma, Llc Method of restoring the incretin effect
CN102753526B (zh) * 2009-12-07 2014-11-26 佐治亚大学研究基金会 吡啶酮羟基环戊基羧酰胺：具有治疗用途的hiv 整合酶抑制剂
US10034871B2 (en) 2014-11-07 2018-07-31 Regents Of The University Of Minnesota Salts and compositions useful for treating disease

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Also Published As

Publication number Publication date
ES2618500T3 (es) 2017-06-21
US20080108640A1 (en) 2008-05-08
US9987268B2 (en) 2018-06-05
BRPI0718420A2 (pt) 2013-11-12
WO2008051902A3 (en) 2008-07-10
CA2666846A1 (en) 2008-05-02
US20110118293A1 (en) 2011-05-19
EP2083817A2 (en) 2009-08-05
US7893080B2 (en) 2011-02-22
US20130172380A1 (en) 2013-07-04
EP2724722B1 (en) 2016-12-07
EP2724722A1 (en) 2014-04-30
US20140329844A1 (en) 2014-11-06
US20130224176A1 (en) 2013-08-29
CA2666846C (en) 2018-04-10
US20150065535A1 (en) 2015-03-05
US8785469B2 (en) 2014-07-22
SI2724722T1 (sl) 2017-07-31
WO2008051902A2 (en) 2008-05-02
US8445508B2 (en) 2013-05-21
US8829018B2 (en) 2014-09-09
US8399474B2 (en) 2013-03-19
EP2083817A4 (en) 2009-12-23
PT2724722T (pt) 2017-03-14
US20110034501A1 (en) 2011-02-10
US20190134023A1 (en) 2019-05-09

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