EA029581B1 - Применение ингибиторов рециркуляции желчных кислот для лечения холестатического заболевания печени или прурита - Google Patents

Применение ингибиторов рециркуляции желчных кислот для лечения холестатического заболевания печени или прурита Download PDF

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EA029581B1
EA029581B1 EA201490852A EA201490852A EA029581B1 EA 029581 B1 EA029581 B1 EA 029581B1 EA 201490852 A EA201490852 A EA 201490852A EA 201490852 A EA201490852 A EA 201490852A EA 029581 B1 EA029581 B1 EA 029581B1
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alkyl
substituted
bile
implementation
bile acid
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EA201490852A
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English (en)
Russian (ru)
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EA201490852A1 (ru
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Бронислава Гедулин
Майкл Грей
Найэлл О'Доннелл
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ЛУМЕНА ФАРМАСЬЮТИКАЛС ЭлЭлСи
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Publication of EA201490852A1 publication Critical patent/EA201490852A1/ru
Publication of EA029581B1 publication Critical patent/EA029581B1/ru

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
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    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C257/00—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines
    • C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
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    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
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EA201490852A 2011-10-28 2012-10-26 Применение ингибиторов рециркуляции желчных кислот для лечения холестатического заболевания печени или прурита EA029581B1 (ru)

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Application Number Priority Date Filing Date Title
US201161553094P 2011-10-28 2011-10-28
US201261607487P 2012-03-06 2012-03-06
PCT/US2012/062303 WO2013063526A1 (en) 2011-10-28 2012-10-26 Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease

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EA201490852A1 EA201490852A1 (ru) 2014-11-28
EA029581B1 true EA029581B1 (ru) 2018-04-30

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EA201490852A EA029581B1 (ru) 2011-10-28 2012-10-26 Применение ингибиторов рециркуляции желчных кислот для лечения холестатического заболевания печени или прурита
EA201792541A EA038594B1 (ru) 2011-10-28 2012-10-26 Ингибиторы рециркуляции желчных кислот для лечения гиперхолемии и холестатического заболевания печени

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