EA201490852A1 - Ингибиторы рециркуляции желчных кислот для лечения гиперхолемии и холестатического заболевания печени - Google Patents
Ингибиторы рециркуляции желчных кислот для лечения гиперхолемии и холестатического заболевания печениInfo
- Publication number
- EA201490852A1 EA201490852A1 EA201490852A EA201490852A EA201490852A1 EA 201490852 A1 EA201490852 A1 EA 201490852A1 EA 201490852 A EA201490852 A EA 201490852A EA 201490852 A EA201490852 A EA 201490852A EA 201490852 A1 EA201490852 A1 EA 201490852A1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- liver
- hypercholemia
- alleviating
- treating
- acids
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid
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- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
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- C07C257/10—Compounds containing carboxyl groups, the doubly-bound oxygen atom of a carboxyl group being replaced by a doubly-bound nitrogen atom, this nitrogen atom not being further bound to an oxygen atom, e.g. imino-ethers, amidines with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. amidines
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Abstract
В настоящем документе обеспечены способы лечения или ослабления гиперхолемии или холестатического заболевания печени путем введения индивидууму, нуждающемуся в этом, терапевтически эффективного количества ингибитора апикального натрий-зависимого транспортера желчных кислот (ASBTI) или его фармацевтически приемлемой соли. Кроме того, обеспечены способы лечения или ослабления заболевания печени, понижения уровней желчных кислот в сыворотке крови или желчных кислот в печени, лечения или ослабления прурита, понижения уровней ферментов в печени или понижения уровней билирубина, включающие введение индивидууму, нуждающемуся в этом, терапевтически эффективного количества ASBTI или его фармацевтически приемлемой соли.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US201161553094P | 2011-10-28 | 2011-10-28 | |
US201261607487P | 2012-03-06 | 2012-03-06 | |
PCT/US2012/062303 WO2013063526A1 (en) | 2011-10-28 | 2012-10-26 | Bile acid recycling inhibitors for treatment of hypercholemia and cholestatic liver disease |
Publications (2)
Publication Number | Publication Date |
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EA201490852A1 true EA201490852A1 (ru) | 2014-11-28 |
EA029581B1 EA029581B1 (ru) | 2018-04-30 |
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Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
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EA201490852A EA029581B1 (ru) | 2011-10-28 | 2012-10-26 | Применение ингибиторов рециркуляции желчных кислот для лечения холестатического заболевания печени или прурита |
EA201792541A EA038594B1 (ru) | 2011-10-28 | 2012-10-26 | Ингибиторы рециркуляции желчных кислот для лечения гиперхолемии и холестатического заболевания печени |
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EA201792541A EA038594B1 (ru) | 2011-10-28 | 2012-10-26 | Ингибиторы рециркуляции желчных кислот для лечения гиперхолемии и холестатического заболевания печени |
Country Status (15)
Country | Link |
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US (5) | US20140323412A1 (ru) |
EP (2) | EP3278796A1 (ru) |
JP (4) | JP6217939B2 (ru) |
KR (3) | KR20190135545A (ru) |
CN (2) | CN104023718B (ru) |
AU (3) | AU2012328453B2 (ru) |
BR (1) | BR112014010228B1 (ru) |
CA (1) | CA2852957C (ru) |
EA (2) | EA029581B1 (ru) |
HK (1) | HK1249045A1 (ru) |
IL (2) | IL232149A0 (ru) |
MX (2) | MX363161B (ru) |
SG (3) | SG11201401816SA (ru) |
WO (1) | WO2013063526A1 (ru) |
ZA (1) | ZA201403367B (ru) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX338535B (es) | 2010-11-08 | 2016-04-21 | Albireo Ab | Inhibidores de ibat para el tratamiento de enfermeades hepaticas. |
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