EA002441B1 - 4"- замещенные производные 9-дезоксо-9а-аза-9а-гомоэритромицина а - Google Patents

4"- замещенные производные 9-дезоксо-9а-аза-9а-гомоэритромицина а Download PDF

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Publication number
EA002441B1
EA002441B1 EA199901015A EA199901015A EA002441B1 EA 002441 B1 EA002441 B1 EA 002441B1 EA 199901015 A EA199901015 A EA 199901015A EA 199901015 A EA199901015 A EA 199901015A EA 002441 B1 EA002441 B1 EA 002441B1
Authority
EA
Eurasian Patent Office
Prior art keywords
hydroxy
compound
alkyl
formula
groups
Prior art date
Application number
EA199901015A
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English (en)
Russian (ru)
Other versions
EA199901015A1 (ru
Inventor
Брайан Скотт Бронк
Майкл Энтони Литейвик
Такуши Канеко
Бингуэй Виэра Янг
Эдвард Алан Глейзер
Хенгмяо Ченг
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21959336&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA002441(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA199901015A1 publication Critical patent/EA199901015A1/ru
Publication of EA002441B1 publication Critical patent/EA002441B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
EA199901015A 1997-06-11 1998-05-29 4"- замещенные производные 9-дезоксо-9а-аза-9а-гомоэритромицина а EA002441B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4934897P 1997-06-11 1997-06-11
PCT/IB1998/000839 WO1998056802A1 (en) 1997-06-11 1998-05-29 4'-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives

Publications (2)

Publication Number Publication Date
EA199901015A1 EA199901015A1 (ru) 2000-06-26
EA002441B1 true EA002441B1 (ru) 2002-04-25

Family

ID=21959336

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199901015A EA002441B1 (ru) 1997-06-11 1998-05-29 4"- замещенные производные 9-дезоксо-9а-аза-9а-гомоэритромицина а

Country Status (49)

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US (4) US6420536B1 (enExample)
EP (1) EP0988310B9 (enExample)
JP (2) JP3315704B2 (enExample)
KR (1) KR100396168B1 (enExample)
CN (4) CN1793155B (enExample)
AP (1) AP1231A (enExample)
AR (1) AR013086A1 (enExample)
AT (1) ATE251173T1 (enExample)
AU (1) AU749816B2 (enExample)
BG (1) BG64391B1 (enExample)
BR (1) BRPI9810519B8 (enExample)
CA (1) CA2293823C (enExample)
CO (1) CO4950611A1 (enExample)
CZ (1) CZ298556B6 (enExample)
DE (2) DE122004000018I2 (enExample)
DK (1) DK0988310T3 (enExample)
DZ (1) DZ2514A1 (enExample)
EA (1) EA002441B1 (enExample)
EG (1) EG24081A (enExample)
ES (1) ES2205487T3 (enExample)
FR (1) FR04C0013I2 (enExample)
GT (1) GT199800077A (enExample)
HN (1) HN1998000086A (enExample)
HR (1) HRP980314B1 (enExample)
HU (2) HU228005B1 (enExample)
ID (1) ID22992A (enExample)
IL (1) IL132809A0 (enExample)
IS (1) IS1998B (enExample)
LU (1) LU91076I9 (enExample)
MA (1) MA24564A1 (enExample)
ME (1) ME00876B (enExample)
MY (1) MY123354A (enExample)
NL (1) NL300150I2 (enExample)
NO (1) NO316911B1 (enExample)
NZ (2) NZ514871A (enExample)
OA (1) OA11224A (enExample)
PA (1) PA8452201A1 (enExample)
PE (1) PE79699A1 (enExample)
PL (1) PL191601B1 (enExample)
PT (1) PT988310E (enExample)
RS (1) RS49675B (enExample)
SI (1) SI0988310T1 (enExample)
SK (1) SK284171B9 (enExample)
TN (1) TNSN98082A1 (enExample)
TW (1) TW472060B (enExample)
UA (1) UA67744C2 (enExample)
UY (1) UY25040A1 (enExample)
WO (1) WO1998056802A1 (enExample)
ZA (1) ZA985017B (enExample)

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AU731842B2 (en) * 1997-09-10 2001-04-05 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
US6339063B1 (en) 1997-09-10 2002-01-15 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
EP1779853A3 (en) * 1997-09-10 2010-01-27 Merial Ltd. 9a-azalides as veterinary antimicrobial agents
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
CA2411293A1 (en) * 1999-01-28 2000-07-28 Pfizer Products Inc. Novel azalides and methods of making same
HUP0201341A3 (en) * 1999-05-18 2003-03-28 Pfizer Prod Inc Novel crystalline forms of a macrolide antibiotic, process for its preparation and pharmaceutical compositions containing it
TR200103395T2 (tr) * 1999-05-24 2002-04-22 Pfizer Products Inc. 13-metil eritromisin türevleri.
US6465437B1 (en) * 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
CA2380455C (en) * 1999-08-24 2009-06-02 Abbott Laboratories 9a-azalides with antibacterial activity
US6608033B1 (en) * 1999-08-27 2003-08-19 Pfizer Inc. Treatment or prevention of coccidiosis
BRPI0017013B1 (pt) * 2000-01-27 2015-07-14 Zoetis P Llc Composição de antibiótico azalídeo e método para sua obtenção
AP2002002652A0 (en) * 2000-04-27 2002-12-31 Pfizer Prod Inc The use of azalide antibiotic composition for treating or preventing a bacterial or protozoal infection in mammals.
CN1297564C (zh) * 2001-04-27 2007-01-31 辉瑞产品公司 4″－取代－9－脱氧－9a－氮杂－9a－高红霉素A衍生物的制备方法
WO2003011266A2 (en) * 2001-08-01 2003-02-13 Pfizer Products Inc. Azalide antibiotic compositions
EP3738591A3 (en) 2003-03-10 2021-03-24 Merck Sharp & Dohme Corp. Novel antibacterial agents
US7276487B2 (en) 2003-09-23 2007-10-02 Enanta Pharmaceuticals, Inc. 9a, 11-3C-bicyclic 9a-azalide derivatives
CN1882360A (zh) * 2003-11-21 2006-12-20 辉瑞产品公司 抗生素作为疫苗佐剂的用途
CA2557801C (en) * 2004-03-16 2013-06-25 Boehringer Ingelheim International Gmbh Glucopyranosyl-substituted benzol derivatives, drugs containing said compounds, the use thereof and method for the production thereof
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
US7767797B1 (en) * 2004-09-30 2010-08-03 Synovo Gmbh Macrocyclic compounds and methods of use thereof
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
EP1841437B1 (en) * 2005-01-14 2009-04-29 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. 9a-carbamoyl and thiocarbamoyl azalides with antimalarial activity
CN101917850B (zh) 2007-10-25 2016-01-13 森普拉制药公司 大环内酯类抗菌剂的制备方法
DK2358379T3 (en) * 2008-10-24 2016-03-07 Cempra Pharmaceuticals Inc BIOFORSVAR USING TRIAZOLHOLDIGE macrolides
US9937194B1 (en) * 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
EP2475253B1 (en) 2009-09-10 2016-10-26 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
BR112012023950A2 (pt) 2010-03-22 2016-07-05 Cempra Pharmaceuticals Inc formas cristalinas de um macrolídeo, e usos dos mesmos
PL2571506T3 (pl) 2010-05-20 2017-10-31 Cempra Pharmaceuticals Inc Sposoby sporządzania makrolidów i ketolidów oraz ich produktów pośrednich
US9815863B2 (en) 2010-09-10 2017-11-14 Cempra Pharmaceuticals, Inc. Hydrogen bond forming fluoro ketolides for treating diseases
US8940880B2 (en) * 2010-09-20 2015-01-27 Novartis Ag Process for the preparation of 9-deoxo-9a-homoerythromycin A, modified in the C-4″ of the cladinose ring by an epoxide group
US9145436B2 (en) * 2010-10-10 2015-09-29 Michael W. Burnet Anti-inflammatory macrolides
CN102993250B (zh) * 2011-07-06 2016-02-10 洛阳惠中兽药有限公司 C-3取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
WO2013013834A1 (en) 2011-07-27 2013-01-31 Farma Grs, D.O.O. New crystalline forms of tulathromycin
MX2014011537A (es) 2012-03-27 2015-02-10 Cempra Pharmaceuticals Inc Formulaciones parenterales para la administracion de antibioticos macrolidos.
CN102786569B (zh) * 2012-09-07 2016-12-07 安徽中升药业有限公司 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法
WO2014152326A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
BR112015023670A2 (pt) 2013-03-15 2017-07-18 Cempra Pharmaceuticals Inc processo para preparar um composto
SI3027634T1 (sl) * 2013-07-31 2018-10-30 Farma Grs, D.O.O. Proces za pripravo tulatromicina
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
CN104861018A (zh) * 2015-06-17 2015-08-26 瑞普（天津）生物药业有限公司 一种泰拉菌素的制备方法
CN105646617A (zh) * 2016-01-21 2016-06-08 杭州海尔希畜牧科技有限公司 一种制备泰拉霉素的方法
FR3048612B1 (fr) 2016-03-14 2020-10-02 Septeos Tulathromycine potentialisee
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN108003207B (zh) * 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
CN111087433B (zh) * 2018-10-23 2023-03-21 湖北美天生物科技股份有限公司 一种泰拉霉素中间体的制备方法

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US4512982A (en) * 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
EP0508699A1 (en) * 1991-04-04 1992-10-14 Merck & Co. Inc. 9-Deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and 8a-positions
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin

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UA70972C2 (uk) 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків

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US4512982A (en) * 1984-04-13 1985-04-23 Pfizer Inc. 9α-Aza-9α-homoerythromycin compounds, pharmaceutical composition and therapeutic method
EP0508699A1 (en) * 1991-04-04 1992-10-14 Merck & Co. Inc. 9-Deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and 8a-positions
EP0549040A1 (en) * 1991-12-20 1993-06-30 Merck & Co. Inc. Methods of making 4" derivatives of 9-deoxo-8a-aza-8a-alkyl-8a-homoerythromycin A
US5441939A (en) * 1994-03-04 1995-08-15 Pfizer Inc. 3"-desmethoxy derivatives of erythromycin and azithromycin

Also Published As

Publication number Publication date
CN101691390A (zh) 2010-04-07
HUP0002209A2 (hu) 2000-12-28
AR013086A1 (es) 2000-12-13
US20020061858A1 (en) 2002-05-23
BRPI9810519A (pt) 2000-09-19
JP2000514098A (ja) 2000-10-24
CN1566129A (zh) 2005-01-19
ME00876B (me) 2012-06-20
PA8452201A1 (es) 2000-05-24
UY25040A1 (es) 2000-09-29
OA11224A (en) 2003-07-16
PL191601B1 (pl) 2006-06-30
NZ514871A (en) 2003-08-29
LU91076I9 (en) 2018-07-02
MA24564A1 (fr) 1998-12-31
US6936592B2 (en) 2005-08-30
IS1998B (is) 2005-03-15
GT199800077A (es) 1999-12-02
AU749816B2 (en) 2002-07-04
EP0988310B9 (en) 2006-03-08
BRPI9810519B1 (pt) 2012-02-22
PE79699A1 (es) 1999-08-25
EP0988310B1 (en) 2003-10-01
HUS1200028I1 (hu) 2016-08-29
DE69818665T2 (de) 2004-04-29
ES2205487T3 (es) 2004-05-01
NO316911B1 (no) 2004-06-21
KR100396168B1 (ko) 2003-08-27
EP0988310A1 (en) 2000-03-29
LU91076I2 (fr) 2004-07-05
SI0988310T1 (en) 2004-02-29
AU7347598A (en) 1998-12-30
US20040180842A1 (en) 2004-09-16
JP2002316933A (ja) 2002-10-31
US6777393B2 (en) 2004-08-17
HUP0002209A3 (en) 2003-05-28
SK284171B9 (sk) 2005-03-04
UA67744C2 (uk) 2004-07-15
AP1231A (en) 2003-12-11
US6420536B1 (en) 2002-07-16
PL337505A1 (en) 2000-08-28
WO1998056802A1 (en) 1998-12-17
CA2293823A1 (en) 1998-12-17
DE122004000018I1 (de) 2004-09-30
DK0988310T3 (da) 2003-12-15
PT988310E (pt) 2003-12-31
CZ298556B6 (cs) 2007-11-07
DE69818665D1 (de) 2003-11-06
BRPI9810519B8 (pt) 2022-11-16
NZ500660A (en) 2002-03-01
AP9801255A0 (en) 1998-06-30
US20040023896A1 (en) 2004-02-05
RS49675B (sr) 2007-11-15
DE122004000018I2 (de) 2011-01-13
HK1028048A1 (en) 2001-02-02
CN1243766C (zh) 2006-03-01
SK284171B6 (sk) 2004-10-05
NO996106D0 (no) 1999-12-10
NL300150I2 (nl) 2004-09-01
JP3315704B2 (ja) 2002-08-19
TNSN98082A1 (fr) 2005-03-15
HK1068893A1 (en) 2005-07-29
HU228005B1 (en) 2012-08-28
YU58699A (enExample) 2002-08-12
BG103945A (bg) 2000-07-31
ZA985017B (en) 1999-12-17
CN1793155B (zh) 2010-05-12
BG64391B1 (bg) 2004-12-30
CA2293823C (en) 2004-02-17
NO996106L (no) 2000-02-10
ID22992A (id) 1999-12-23
HRP980314B1 (en) 2004-04-30
CO4950611A1 (es) 2000-09-01
CZ442199A3 (cs) 2000-07-12
IL132809A0 (en) 2001-03-19
EA199901015A1 (ru) 2000-06-26
ATE251173T1 (de) 2003-10-15
SK168399A3 (en) 2000-11-07
TW472060B (en) 2002-01-11
FR04C0013I2 (enExample) 2005-10-21
HK1088014A1 (zh) 2006-10-27
HRP980314A2 (en) 1999-04-30
FR04C0013I1 (enExample) 2004-06-11
KR20010013632A (ko) 2001-02-26
EG24081A (en) 2008-05-11
HN1998000086A (es) 1999-03-08
IS5252A (is) 1999-11-16
CN1259136A (zh) 2000-07-05
DZ2514A1 (fr) 2003-02-01
NL300150I1 (nl) 2004-08-02
CN1793155A (zh) 2006-06-28
CN1172947C (zh) 2004-10-27
MY123354A (en) 2006-05-31

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