DE602006006546D1 - 9a-carbamoyl- und thiocarbamoylazalide mit antimalariawirkung - Google Patents
9a-carbamoyl- und thiocarbamoylazalide mit antimalariawirkungInfo
- Publication number
- DE602006006546D1 DE602006006546D1 DE602006006546T DE602006006546T DE602006006546D1 DE 602006006546 D1 DE602006006546 D1 DE 602006006546D1 DE 602006006546 T DE602006006546 T DE 602006006546T DE 602006006546 T DE602006006546 T DE 602006006546T DE 602006006546 D1 DE602006006546 D1 DE 602006006546D1
- Authority
- DE
- Germany
- Prior art keywords
- carbamoyl
- thiocarbamoylazalides
- antimalaria
- effect
- azalides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000000078 anti-malarial effect Effects 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 201000004792 malaria Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- -1 thiocarbamoyl Chemical group 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US64435005P | 2005-01-14 | 2005-01-14 | |
PCT/IB2006/001189 WO2006087642A2 (en) | 2005-01-14 | 2006-01-12 | 9a-carbamoyl and thiocarbamoyl azalides with antimalarial activity |
Publications (1)
Publication Number | Publication Date |
---|---|
DE602006006546D1 true DE602006006546D1 (de) | 2009-06-10 |
Family
ID=36916829
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE602006006546T Active DE602006006546D1 (de) | 2005-01-14 | 2006-01-12 | 9a-carbamoyl- und thiocarbamoylazalide mit antimalariawirkung |
Country Status (7)
Country | Link |
---|---|
US (1) | US20080227730A1 (de) |
EP (1) | EP1841437B1 (de) |
JP (1) | JP2008526948A (de) |
AT (1) | ATE429921T1 (de) |
DE (1) | DE602006006546D1 (de) |
ES (1) | ES2326002T3 (de) |
WO (1) | WO2006087642A2 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2552682T3 (es) | 2003-03-10 | 2015-12-01 | Merck Sharp & Dohme Corp. | Agentes antibacterianos novedosos |
US20090105301A1 (en) * | 2006-05-03 | 2009-04-23 | Sulejman Alihodzic | 9a-substituted azalides for the treatment of malaria |
PE20090879A1 (es) * | 2007-07-30 | 2009-07-25 | Glaxosmithkline Zagreb | DERIVADOS 9-DESOXO-9a-METIL-9a-AZA-9a-HOMOERITROMICINA A COMO AGENTES ANTIMALARICOS |
WO2009055557A1 (en) | 2007-10-25 | 2009-04-30 | Cempra Pharmaceuticals, Inc. | Process for the preparation of macrolide antibacterial agents |
WO2010048601A1 (en) | 2008-10-24 | 2010-04-29 | Cempra Pharmaceuticals, Inc. | Biodefenses using triazole-containing macrolides |
US9937194B1 (en) | 2009-06-12 | 2018-04-10 | Cempra Pharmaceuticals, Inc. | Compounds and methods for treating inflammatory diseases |
AU2010292010B2 (en) * | 2009-09-10 | 2016-01-07 | Cempra Pharmaceuticals, Inc. | Methods for treating malaria, tuberculosis and MAC diseases |
RU2608390C2 (ru) | 2010-05-20 | 2017-01-18 | Семпра Фармасьютикалз, Инк. | Способы получения макролидов и кетолидов, и промежуточных соединений для их получения |
JP6042334B2 (ja) | 2010-09-10 | 2016-12-14 | センプラ ファーマシューティカルズ,インコーポレイテッド | 疾患治療のための水素結合形成フルオロケトライド |
RU2658050C2 (ru) | 2012-03-27 | 2018-06-19 | Семпра Фармасьютикалз, Инк. | Парентеральные составы для введения макролидных антибиотиков |
US9861616B2 (en) | 2013-03-14 | 2018-01-09 | Cempra Pharmaceuticals, Inc. | Methods for treating respiratory diseases and formulations therefor |
CN105188712A (zh) | 2013-03-15 | 2015-12-23 | 森普拉制药公司 | 用于制备大环内酯抗菌剂的收敛方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
HRP931480B1 (en) * | 1993-12-08 | 1997-08-31 | Sour Pliva | 9a-N-(N'-CARBAMONYL) and 9a-N-(N'-THIOCARBAMONYL) DERIVATES OF 9-DEOXO-9a-HOMOERYTHROMYCIN A |
HN1998000086A (es) * | 1997-06-11 | 1999-03-08 | Pfizer Prod Inc | Derivados de 9 - desofo - 9 aza - 9a - homoeritromicina a - c - 4 sustituidos. |
EP1032574B1 (de) * | 1998-09-30 | 2007-06-13 | Walter Reed Army Institute of Research | Indolo¬2,1-b|quinazolin-6,12-dione antimalaria derivate und methoden zur behandlung von malaria |
US6239113B1 (en) * | 1999-03-31 | 2001-05-29 | Insite Vision, Incorporated | Topical treatment or prevention of ocular infections |
HRP990130B1 (en) * | 1999-05-03 | 2004-06-30 | Pliva D D | HALOGEN DERIVATIVES 9a-N-(N'-ARYLCARBAMOYL)- AND 9a-N-(N'-ARYLTHIOCARBAMOYL)-9-DEOXO-9a-AZA-9a OF HOMOERYTHROMYCIN A |
HRP20010146B1 (en) * | 2001-02-28 | 2005-10-31 | Pliva D.D. | 9a-N-(N'-(PHENYLSULFONYL)CARBAMOYL) DERIVATIVES OF 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMYCIN A AND OF 5-O-DESOSAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHRONOLIDE A |
MXPA03009786A (es) * | 2001-04-27 | 2004-01-29 | Pfizer Prod Inc | Procedimiento para preparar derivados de 9-desoxo-9a-aza-9a-homoeritromicina a 4"-sustituidos. |
HRP20020885B1 (en) * | 2002-11-11 | 2007-05-31 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | SUBSTITUTED 9a-N-{N'-[4-(SULFONYL)PHENYLCARBAMOYL]}DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHROMYCIN A AND 5-O-DESOZAMINYL-9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERITHRONOLIDE A |
HRP20030381B1 (en) * | 2003-05-14 | 2007-05-31 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 3-DECLADINOZYL 9a-N-CARBAMOYL AND 9a-N-THIOCARBAMOYL DERIVATIVES 9-DEOXO-9-DIHYDRO-9a-AZA-9a-HOMOERYTHROMICYNE A |
-
2006
- 2006-01-12 JP JP2007550877A patent/JP2008526948A/ja active Pending
- 2006-01-12 ES ES06744666T patent/ES2326002T3/es active Active
- 2006-01-12 WO PCT/IB2006/001189 patent/WO2006087642A2/en active Application Filing
- 2006-01-12 EP EP06744666A patent/EP1841437B1/de active Active
- 2006-01-12 US US11/813,869 patent/US20080227730A1/en not_active Abandoned
- 2006-01-12 AT AT06744666T patent/ATE429921T1/de not_active IP Right Cessation
- 2006-01-12 DE DE602006006546T patent/DE602006006546D1/de active Active
Also Published As
Publication number | Publication date |
---|---|
EP1841437B1 (de) | 2009-04-29 |
ATE429921T1 (de) | 2009-05-15 |
WO2006087642A2 (en) | 2006-08-24 |
ES2326002T3 (es) | 2009-09-28 |
WO2006087642A3 (en) | 2007-01-04 |
US20080227730A1 (en) | 2008-09-18 |
JP2008526948A (ja) | 2008-07-24 |
EP1841437A2 (de) | 2007-10-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition |