LU93189I2 - Ixekizumab et ses dérivés pharmaceutiquement acceptables (TALTZ) - Google Patents

Ixekizumab et ses dérivés pharmaceutiquement acceptables (TALTZ) Download PDF

Info

Publication number
LU93189I2
LU93189I2 LU93189C LU93189C LU93189I2 LU 93189 I2 LU93189 I2 LU 93189I2 LU 93189 C LU93189 C LU 93189C LU 93189 C LU93189 C LU 93189C LU 93189 I2 LU93189 I2 LU 93189I2
Authority
LU
Luxembourg
Prior art keywords
taltz
ixekizumab
pharmaceutically acceptable
acceptable derivatives
derivatives
Prior art date
Application number
LU93189C
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of LU93189I2 publication Critical patent/LU93189I2/fr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244Interleukins [IL]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/06Antipsoriatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Neurosurgery (AREA)
  • Urology & Nephrology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
LU93189C 2005-12-13 2016-08-31 Ixekizumab et ses dérivés pharmaceutiquement acceptables (TALTZ) LU93189I2 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74995305P 2005-12-13 2005-12-13
US80194806P 2006-05-19 2006-05-19
PCT/US2006/061586 WO2007070750A1 (fr) 2005-12-13 2006-12-05 Anticorps anti-il-17

Publications (1)

Publication Number Publication Date
LU93189I2 true LU93189I2 (fr) 2016-10-31

Family

ID=38008638

Family Applications (1)

Application Number Title Priority Date Filing Date
LU93189C LU93189I2 (fr) 2005-12-13 2016-08-31 Ixekizumab et ses dérivés pharmaceutiquement acceptables (TALTZ)

Country Status (24)

Country Link
US (2) US7838638B2 (fr)
EP (4) EP1963368B3 (fr)
JP (1) JP5063612B2 (fr)
KR (1) KR101158959B1 (fr)
CN (1) CN101326195B9 (fr)
AU (1) AU2006325860B2 (fr)
BR (1) BRPI0619792B1 (fr)
CA (1) CA2631938C (fr)
CY (3) CY1113097T1 (fr)
DK (2) DK2481753T3 (fr)
EA (1) EA014298B1 (fr)
ES (2) ES2672221T3 (fr)
HK (1) HK1120275A1 (fr)
HR (2) HRP20120606T4 (fr)
HU (2) HUE039353T2 (fr)
IL (1) IL191217A (fr)
LT (2) LT2481753T (fr)
LU (1) LU93189I2 (fr)
NO (2) NO340827B1 (fr)
PL (2) PL2481753T3 (fr)
PT (2) PT1963368E (fr)
RS (2) RS57255B1 (fr)
SI (2) SI1963368T1 (fr)
WO (1) WO2007070750A1 (fr)

Families Citing this family (122)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1687026B1 (fr) 2003-11-21 2008-05-14 UCB Pharma, S.A. Methode de traitement de la sclerose en plaques par inhibition de l'activite d'il-17
PT1963368E (pt) * 2005-12-13 2012-09-14 Lilly Co Eli Anticorpos anti-il-17
US7790163B2 (en) 2006-03-10 2010-09-07 Zymogenetics, Inc. Antibodies that bind both IL-17A and IL-17F and methods of using the same
EP2377887A1 (fr) 2006-03-10 2011-10-19 Zymogenetics Inc Anticorps liant l'IL-17A et l'IL-17F et leurs procédés d'utilisation
US7910703B2 (en) 2006-03-10 2011-03-22 Zymogenetics, Inc. Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use
TW200815469A (en) * 2006-06-23 2008-04-01 Astrazeneca Ab Compounds
GB0612928D0 (en) * 2006-06-29 2006-08-09 Ucb Sa Biological products
CN101646690B (zh) * 2006-08-11 2013-10-23 默沙东公司 抗il-17a抗体
GB0620729D0 (en) 2006-10-18 2006-11-29 Ucb Sa Biological products
CN103275216B (zh) 2007-03-12 2015-05-06 艾斯巴技术-诺华有限责任公司 单链抗体的基于序列的工程改造和最优化
KR101530723B1 (ko) 2007-06-25 2015-06-22 에스바테크 - 어 노바티스 컴파니 엘엘씨 단일 쇄 항체의 서열에 기초한 공학처리 및 최적화
CN101849001B (zh) * 2007-06-25 2014-07-16 艾斯巴技术-诺华有限责任公司 修饰抗体的方法和具有改善的功能性质的修饰抗体
WO2009026412A1 (fr) * 2007-08-21 2009-02-26 Children's Medical Center Corporation Traitement de l'hyperréactivité des voies aériennes
WO2009082624A2 (fr) * 2007-12-10 2009-07-02 Zymogenetics, Inc. Antagonistes de il-17a, il-17f et il-23 et procédés d'utilisation de ceux-ci
GB0807413D0 (en) 2008-04-23 2008-05-28 Ucb Pharma Sa Biological products
US20090317400A1 (en) 2008-05-05 2009-12-24 Krzysztof Masternak Anti-IL 17A/IL-17F Cross-Reactive Antibodies and Methods of Use Thereof
WO2010034443A1 (fr) * 2008-09-29 2010-04-01 F. Hoffmann-La Roche Ag Anticorps contre l'il 17 humaine et utilisations associees
SG2014010573A (en) * 2008-11-12 2014-04-28 Merck Sharp & Dohme ßGI-IGG INTRON FOR ENHANCED ANTI-IGF1 R EXPRESSION
US8211434B2 (en) 2008-11-26 2012-07-03 Allergan, Inc. KLK-13 antibody inhibitor for treating dry eye
WO2010062858A1 (fr) * 2008-11-26 2010-06-03 Allergan, Inc. Anticorps inhibiteur d’il-17 pour traiter la sécheresse oculaire
BRPI1013688A8 (pt) * 2009-03-05 2017-02-14 Abbott Lab Proteínas de ligação de il-17.
MX2011011729A (es) 2009-05-05 2012-04-10 Novimmune Sa Anticuerpo anti il-17f y metodos de uso de los mismos.
CN102905727B (zh) 2009-10-30 2016-12-07 詹森生物科技公司 Il-17a拮抗剂
JO3417B1 (ar) 2010-01-08 2019-10-20 Regeneron Pharma الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r
WO2011123813A2 (fr) 2010-04-02 2011-10-06 Amunix Operating Inc. Protéines de fusion liantes, conjugués protéines de fusion liantes-médicaments, conjugués xten-médicaments et procédés pour les préparer et les utiliser
WO2011141823A2 (fr) * 2010-05-14 2011-11-17 Orega Biotech Méthodes de traitement et/ou de prévention de troubles de prolifération cellulaire à l'aide d'antagonistes de il-17
AU2011285922B2 (en) * 2010-08-05 2016-06-16 Anaptysbio, Inc. Antibodies directed against IL-17
TW201302793A (zh) * 2010-09-03 2013-01-16 Glaxo Group Ltd 新穎之抗原結合蛋白
ES2660770T3 (es) * 2010-10-08 2018-03-26 Novartis Ag Métodos para el tratamiento de psoriasis usando antagonistas de IL-17
US10208349B2 (en) 2011-01-07 2019-02-19 Ucb Biopharma Sprl Lipocalin 2 as a biomarker for IL-17 inhibitor therapy efficacy
GB201100282D0 (en) 2011-01-07 2011-02-23 Ucb Pharma Sa Biological methods
LT2663577T (lt) 2011-01-14 2017-07-25 Ucb Biopharma Sprl Antikūnas, surišantis il-17a ir il-17f
TWI589299B (zh) 2011-10-11 2017-07-01 再生元醫藥公司 用於治療類風濕性關節炎之組成物及其使用方法
US9943594B2 (en) 2011-10-11 2018-04-17 Sanofi Biotechnology Methods for the treatment of rheumatoid arthritis
CA2856252A1 (fr) 2011-11-21 2013-05-30 Novartis Ag Procedes de traitement du rhumatisme psoriasique (psa) utilisant des antagonistes d'il-17 et des alleles repondeurs ou non repondeurs a psa
WO2013116682A1 (fr) 2012-02-02 2013-08-08 Ensemble Therapeutics Corporation Composés macrocycliques pour une modulation d'il-17
BR112014021308B1 (pt) * 2012-03-07 2022-08-30 Eli Lilly And Company Formulações farmacêuticas de anticorpos
BR112014025768A2 (pt) 2012-04-20 2017-07-04 Novartis Ag métodos de tratamento de espondilite anquilosante usando antagonistas de il-17
AR090626A1 (es) 2012-04-20 2014-11-26 Lilly Co Eli Anticuerpos anti-baff-anti-il-17 biespecificos
UY34815A (es) 2012-05-22 2013-11-29 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware Anticuerpos biespecíficos y sus métodos de uso
US9676847B2 (en) 2012-06-25 2017-06-13 Orega Biotech IL-17 antagonist antibodies
WO2014066726A2 (fr) 2012-10-26 2014-05-01 Ensemble Therapeutics Corporation Composés pour la modulation d'il-17
RU2015125343A (ru) * 2012-11-29 2017-01-11 БАЙЕР ХелсКер ЛЛСи Гуманизированные моноклональные антитела против активированного белка с и их применение
CU24300B1 (es) * 2013-02-08 2017-12-08 Novartis Ag Anticuerpos anti-il-17a útiles en el tratamiento de trastornos autoinmunes e inflamatorios
TW201444867A (zh) * 2013-03-08 2014-12-01 Lilly Co Eli 抗tnf-抗il-17雙特異性抗體
WO2014155278A2 (fr) 2013-03-26 2014-10-02 Novartis Ag Méthodes de traitement de maladies auto-immunes à l'aide d'antagonistes de l'il -17
US9700485B2 (en) 2013-04-24 2017-07-11 Corning Incorporated Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients
US20150004133A1 (en) * 2013-06-07 2015-01-01 The Regents Of The University Of California Compositions And Methods For Treating Steatohepatitis, Liver Fibrosis, and Hepatocellular Carcinoma (HCC)
US9603882B2 (en) 2013-08-13 2017-03-28 Industrial Technology Research Institute Method for modulating Th17 cells and method for treating a disease related to modulation of Th17 cells
JP6255099B2 (ja) 2013-08-15 2017-12-27 ノバルティス アーゲー Il−17アンタゴニストを使用して汎発性膿疱性乾癬(gpp)を処置する方法
CA2929662C (fr) 2013-11-18 2023-05-02 Shanghai Hengrui Pharmaceutical Co., Ltd. Conjugue de il-17a et utilisations associees
US11421025B2 (en) 2013-12-27 2022-08-23 Osaka University Treatment of IL-17A diseases
RU2016129959A (ru) * 2013-12-30 2018-02-02 Эпимаб Биотерепьютикс Инк. Иммуноглобулин с тандемным расположением fab-фрагментов и его применение
KR20160124165A (ko) 2014-02-21 2016-10-26 제넨테크, 인크. 항-il-13/il-17 이중특이적 항체 및 그의 용도
RU2577228C2 (ru) * 2014-03-14 2016-03-10 Закрытое Акционерное Общество "Биокад" Анти-il-17-антитела, способ их получения и способ применения
TWI713453B (zh) 2014-06-23 2020-12-21 美商健生生物科技公司 干擾素α及ω抗體拮抗劑
PT3191120T (pt) 2014-09-10 2024-07-16 Novartis Ag Utilização de antagonistas de il-17 para inibir a progressão de danos estruturais em doentes com artrite psoriática
MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
CR20170143A (es) 2014-10-14 2017-06-19 Dana Farber Cancer Inst Inc Moléculas de anticuerpo que se unen a pd-l1 y usos de las mismas
US10934335B2 (en) 2015-01-12 2021-03-02 Affibody Ab IL-17A-binding polypeptides
CN107407677B (zh) 2015-01-28 2020-07-17 豪夫迈·罗氏有限公司 多发性硬化的基因表达标志和治疗
CN106336459B (zh) * 2015-07-13 2020-12-08 三生国健药业(上海)股份有限公司 抗人白细胞介素-17a单克隆抗体、其制备方法和应用
BR112017025264A2 (pt) 2015-07-16 2018-08-07 Lilly Co Eli tratamento de prurido
PT3317301T (pt) 2015-07-29 2021-07-09 Novartis Ag Terapias de associação compreendendo moléculas de anticorpo contra lag-3
US20180207273A1 (en) 2015-07-29 2018-07-26 Novartis Ag Combination therapies comprising antibody molecules to tim-3
WO2017019896A1 (fr) 2015-07-29 2017-02-02 Novartis Ag Traitements combinés comprenant des molécules d'anticorps qui se lient à pd-1
WO2017087391A1 (fr) 2015-11-17 2017-05-26 Bayer Healthcare, Llc Épitope d'anticorps monoclonaux humanisés optimisés dirigés contre la protéine c activée et leurs utilisations
AU2016369537B2 (en) 2015-12-17 2024-03-14 Novartis Ag Antibody molecules to PD-1 and uses thereof
AU2017214692B2 (en) 2016-02-06 2021-11-04 Epimab Biotherapeutics, Inc. Fabs-in-tandem immunoglobulin and uses thereof
CN107488227A (zh) * 2016-06-12 2017-12-19 三生国健药业(上海)股份有限公司 抗人白细胞介素‑17a单克隆抗体、其制备方法和应用
WO2017221174A1 (fr) 2016-06-22 2017-12-28 Novartis Ag Méthodes de traitement du vitiligo à l'aide d'anticorps de l'interleukine-17 (il -17)
CN109476733A (zh) 2016-07-19 2019-03-15 诺华股份有限公司 使用il-17拮抗剂治疗新发斑块型银屑病的方法
PE20191075A1 (es) 2016-09-14 2019-08-20 Beijing hanmi pharm co ltd Anticuerpo que se une especificamente a il-17a y fragmento funcional del mismo
WO2018096467A1 (fr) 2016-11-28 2018-05-31 Novartis Ag Méthodes de traitement de l'acné à l'aide d'antagonistes de l'interleukine-17 (il -17)
JP6995127B2 (ja) 2017-02-10 2022-02-04 ジェネンテック, インコーポレイテッド 抗トリプターゼ抗体、その組成物、及びその使用
WO2018158741A1 (fr) 2017-03-03 2018-09-07 Novartis Ag Modification de la maladie du psoriasis suite à un traitement à long terme avec un antagoniste de l'il-17
CN110582512B (zh) * 2017-03-10 2022-08-30 苏州鑫康合生物医药科技有限公司 针对il-17a和il-17f二者的单克隆抗体及其用途
WO2018170488A1 (fr) * 2017-03-17 2018-09-20 Gilead Sciences, Inc. Procédé de purification d'un anticorps
US10676522B2 (en) 2017-05-05 2020-06-09 Novartis Ag Methods of selectively treating asthma using IL-17 antagonists
US11299540B2 (en) 2017-06-18 2022-04-12 Kindred Biosciences, Inc. IL17A antibodies and antagonists for veterinary use
WO2019027828A1 (fr) 2017-08-04 2019-02-07 Eli Lilly And Company Schéma posologique d'anticorps anti-il-17
JP7212675B2 (ja) 2017-08-23 2023-01-25 イーライ リリー アンド カンパニー 性器乾癬の治療
AU2018361975A1 (en) 2017-11-02 2020-05-07 Novartis Ag Method of treating tendinopathy using interleukin-17 (IL-17) antagonists
KR102048475B1 (ko) * 2017-11-10 2019-11-26 주식회사 와이바이오로직스 IL-17A (Interleukin-17A)에 특이적으로 결합하는 항체 및 이의 용도
CN110914304B (zh) * 2017-11-10 2022-07-26 江苏恒瑞医药股份有限公司 Cd96抗体、其抗原结合片段及医药用途
US20200277369A1 (en) 2017-11-20 2020-09-03 Novartis Ag Method of treating hidradentitis suppurativa with il-17 antagonists
WO2019108900A1 (fr) 2017-11-30 2019-06-06 Novartis Ag Récepteur d'antigène chimérique ciblant le bcma et ses utilisations
US11619832B2 (en) * 2018-03-08 2023-04-04 Coopervision International Limited Identification of contact lens wearers predisposed to contact lens discomfort
JP7368453B2 (ja) 2018-05-03 2023-10-24 シャンハイ エピムアブ バイオセラピューティクス カンパニー リミテッド Pd-1およびlag-3に対する高親和性抗体ならびにそれらから作製された二重特異性結合タンパク質
WO2019218298A1 (fr) * 2018-05-17 2019-11-21 江苏荃信生物医药有限公司 Anticorps monoclonal anti-interleukine 17a humaine et son application
US11492409B2 (en) 2018-06-01 2022-11-08 Novartis Ag Binding molecules against BCMA and uses thereof
GB201810327D0 (en) 2018-06-22 2018-08-08 Bicycletx Ltd Peptide ligands for binding to IL-17
MX2021002422A (es) 2018-08-29 2021-07-15 Regeneron Pharma Métodos y composiciones para el tratamiento de sujetos que padecen artritis reumatoide.
US20220033486A1 (en) 2018-09-25 2022-02-03 Inserm (Institut National De La Santè Et De La Recherch Médicale) Use of antagonists of th17 cytokines for the treatment of bronchial remodeling in patients suffering from allergic asthma
GB201820316D0 (en) 2018-12-13 2019-01-30 Bicyclerd Ltd Bicyclic peptide ligands specific for IL-17
CN109369806B (zh) * 2019-01-14 2019-04-19 迈威(上海)生物科技有限公司 苏金单抗制品中半胱氨酸化变异体的去除方法
CN113631574A (zh) 2019-01-31 2021-11-09 努玛治疗有限公司 对TNFα和IL-17A具有特异性的多特异性抗体、靶向IL-17A的抗体及其使用方法
EP3689907A1 (fr) 2019-01-31 2020-08-05 Numab Therapeutics AG Anticorps dirigés contre il-17a et leurs procédés d'utilisation
CA3128212A1 (fr) 2019-01-31 2020-08-06 Sanofi Biotechnology Anticorps anti-recepteur de l'il6 pour traiter l'arthrite idiopathique juvenile
BR112021015034A2 (pt) 2019-02-18 2021-10-05 Eli Lilly And Company Formulação de anticorpo terapêutico
KR102400401B1 (ko) * 2019-05-22 2022-05-24 (주)셀인바이오 항염증 펩타이드 및 항염증 조성물
EP4036113A4 (fr) 2019-07-26 2023-01-18 Sinocelltech Ltd. Anticorps anti-il17a humanisé et son utilisation
CN114127108A (zh) 2019-07-30 2022-03-01 江苏恒瑞医药股份有限公司 Il-17拮抗剂治疗自身免疫疾病的方法
WO2021053591A1 (fr) 2019-09-20 2021-03-25 Novartis Ag Méthodes de traitement de maladies auto-immunes à l'aide d'antagonistes de l'interleukine-17 (il-17)
JP7551744B2 (ja) 2019-10-15 2024-09-17 イーライ リリー アンド カンパニー 組換え操作された、リパーゼ/エステラーゼ欠損哺乳動物細胞株
US20230009657A1 (en) 2019-11-19 2023-01-12 Novartis Ag Methods of treating lupus nephritis using interleukin-17 (il-17) antagonists
WO2021111377A2 (fr) 2019-12-06 2021-06-10 Novartis Ag Procédés de traitement de lichen plan à l'aide d'antagonistes de l'interleukine 17 (il-17)
GB201918557D0 (en) 2019-12-16 2020-01-29 Bicycle Tx Ltd Bicyclic peptide ligands specific for IL-17
US20230021419A1 (en) 2019-12-16 2023-01-26 Bicycletx Limited Bicyclic peptide ligands specific for il-17
GB201918558D0 (en) 2019-12-16 2020-01-29 Bicycle Tx Ltd Bicyclic peptide ligands specific for IL-17
GB201918559D0 (en) 2019-12-16 2020-01-29 Bicycle Tx Ltd Bicyclic peptide ligands specific for IL-17
GB201919062D0 (en) * 2019-12-20 2020-02-05 Ucb Biopharma Sprl Antibody
EP4157828A1 (fr) 2020-05-27 2023-04-05 Sanofi Modulateurs de il-17a
EP4157827A1 (fr) 2020-05-27 2023-04-05 Sanofi Modulateurs de il-17a
IL298882A (en) 2020-06-23 2023-02-01 Novartis Ag Methods for treating thyroid eye disease and Graves' orbitopathy using interleukin-17 (IL-17) antagonists
WO2022097060A1 (fr) 2020-11-06 2022-05-12 Novartis Ag Molécules de liaison à cd19 et utilisations associées
CN115746132B (zh) * 2021-09-03 2023-09-08 三优生物医药(上海)有限公司 抗il-17a抗体及其用途
IT202100023816A1 (it) * 2021-09-16 2023-03-16 Takis S R L Anticorpo contro SARS-CoV-2 e suoi usi in campo medico.
CN113896793B (zh) * 2021-09-30 2023-05-26 港科鹏禾生物(苏州)有限公司 一种抗人il-17rc的单克隆抗体及其应用
WO2023223211A1 (fr) 2022-05-16 2023-11-23 Novartis Ag Méthodes de traitement de l'artérite à cellules géantes à l'aide d'antagonistes de l'interleukine-17 (il-17)
WO2023223263A1 (fr) 2022-05-18 2023-11-23 Novartis Ag Procédés de traitement sélectif de la tendinopathie à l'aide d'antagonistes de l'interleukine-17 (il-17)
WO2024121427A1 (fr) 2022-12-09 2024-06-13 Sanofi Composés thérapeutiques

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225A (en) 1847-08-07 Latch
US539A (en) 1837-12-26 Standard measurer for taking measure for coats
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5807715A (en) 1984-08-27 1998-09-15 The Board Of Trustees Of The Leland Stanford Junior University Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
ATE352612T1 (de) 1990-08-29 2007-02-15 Pharming Intellectual Pty Bv Homologe rekombination in säugetier-zellen
US5814318A (en) 1990-08-29 1998-09-29 Genpharm International Inc. Transgenic non-human animals for producing heterologous antibodies
US5789650A (en) 1990-08-29 1998-08-04 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US5770429A (en) 1990-08-29 1998-06-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5625126A (en) 1990-08-29 1997-04-29 Genpharm International, Inc. Transgenic non-human animals for producing heterologous antibodies
ATE158021T1 (de) 1990-08-29 1997-09-15 Genpharm Int Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper
US5661016A (en) 1990-08-29 1997-08-26 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5633425A (en) 1990-08-29 1997-05-27 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US6284471B1 (en) 1991-03-18 2001-09-04 New York University Medical Center Anti-TNFa antibodies and assays employing anti-TNFa antibodies
WO1994004679A1 (fr) 1991-06-14 1994-03-03 Genentech, Inc. Procede pour fabriquer des anticorps humanises
AU2515992A (en) 1991-08-20 1993-03-16 Genpharm International, Inc. Gene targeting in animal cells using isogenic dna constructs
WO1993016177A1 (fr) 1992-02-11 1993-08-19 Cell Genesys, Inc. Homogeneisation de ciblages de genes
US6274711B1 (en) * 1993-06-14 2001-08-14 Inserm, Institut National De La Sante Et De La Recherche Medicale Purified mammalian CTLA-8 antigens and related reagents
US6562333B1 (en) 1993-06-14 2003-05-13 Schering Corporation Purified mammalian CTLA-8 antigens and related reagents
US5625825A (en) 1993-10-21 1997-04-29 Lsi Logic Corporation Random number generating apparatus for an interface unit of a carrier sense with multiple access and collision detect (CSMA/CD) ethernet data network
US5698762A (en) 1994-12-09 1997-12-16 Dauerman; Leonard Microwave-assisted pyrolysis of waste polyaromatic hydrocarbons
DE69636868T2 (de) 1995-08-29 2007-10-25 Kirin Beer Kabushiki Kaisha Chimäres tier und methode zu dessen herstellung
GB0312481D0 (en) * 2003-05-30 2003-07-09 Celltech R&D Ltd Antibodies
EP1644416A4 (fr) 2003-06-30 2007-08-29 Centocor Inc Proteines derivees de l'immunoglobuline anti-cible et genetiquement modifiees, compositions, procedes et utilisations
EP1687026B1 (fr) 2003-11-21 2008-05-14 UCB Pharma, S.A. Methode de traitement de la sclerose en plaques par inhibition de l'activite d'il-17
GB0417487D0 (en) * 2004-08-05 2004-09-08 Novartis Ag Organic compound
GB0425569D0 (en) * 2004-11-19 2004-12-22 Celltech R&D Ltd Biological products
PT1963368E (pt) 2005-12-13 2012-09-14 Lilly Co Eli Anticorpos anti-il-17

Also Published As

Publication number Publication date
HUE039353T2 (hu) 2018-12-28
ES2389780T3 (es) 2012-10-31
DK1963368T6 (da) 2020-06-29
US20080269467A1 (en) 2008-10-30
EP1963368B3 (fr) 2020-06-10
JP5063612B2 (ja) 2012-10-31
SI2481753T1 (en) 2018-06-29
HK1120275A1 (en) 2009-03-27
WO2007070750A1 (fr) 2007-06-21
KR20080068122A (ko) 2008-07-22
EA200870050A1 (ru) 2009-12-30
DK1963368T3 (da) 2012-08-06
EP2481753A1 (fr) 2012-08-01
US20110027290A1 (en) 2011-02-03
NO20082905L (no) 2008-09-03
ES2672221T3 (es) 2018-06-13
AU2006325860B2 (en) 2011-09-22
EP1963368B1 (fr) 2012-07-18
RS52509B (en) 2013-04-30
LT2481753T (lt) 2018-05-25
JP2009519348A (ja) 2009-05-14
CY2016030I2 (el) 2016-12-14
RS52509B2 (sr) 2020-09-30
CY2016030I1 (el) 2016-12-14
HRP20120606T1 (en) 2012-10-31
HUS1600037I1 (hu) 2016-10-28
NO340827B1 (no) 2017-06-26
US8110191B2 (en) 2012-02-07
ES2389780T7 (es) 2021-01-14
NO2017044I2 (no) 2017-08-18
EP3366702B1 (fr) 2023-08-09
BRPI0619792A2 (pt) 2011-10-18
EA014298B1 (ru) 2010-10-29
PT2481753T (pt) 2018-07-13
KR101158959B1 (ko) 2012-07-09
CN101326195B (zh) 2012-01-11
EP3808769A1 (fr) 2021-04-21
HRP20120606T4 (hr) 2020-08-07
NO2017044I1 (no) 2017-08-18
PT1963368E (pt) 2012-09-14
EP2481753B1 (fr) 2018-04-18
PL2481753T3 (pl) 2018-09-28
EP1963368A1 (fr) 2008-09-03
SI1963368T1 (sl) 2012-11-30
LTPA2016026I1 (lt) 2016-09-26
AU2006325860A1 (en) 2007-06-21
CY1113097T1 (el) 2016-04-13
CY1120365T1 (el) 2019-07-10
US7838638B2 (en) 2010-11-23
BRPI0619792B1 (pt) 2021-09-28
CA2631938C (fr) 2014-05-20
LTC1963368I2 (lt) 2018-01-10
HRP20180941T1 (hr) 2018-08-10
DK2481753T3 (en) 2018-06-18
EP3366702A1 (fr) 2018-08-29
CN101326195B9 (zh) 2022-11-11
PL1963368T6 (pl) 2021-02-08
RS57255B1 (sr) 2018-08-31
CA2631938A1 (fr) 2007-06-21
PL1963368T3 (pl) 2012-11-30
CN101326195A (zh) 2008-12-17
IL191217A (en) 2015-10-29

Similar Documents

Publication Publication Date Title
LU93189I2 (fr) Ixekizumab et ses dérivés pharmaceutiquement acceptables (TALTZ)
LU93096I2 (fr) Evolocumab et ses dérivés pharmaceutiquement acceptables (repatha)
LU93093I2 (fr) Nécitumumab et ses dérivés pharmaceutiquement acceptables (portrazza)
LU92326I2 (fr) Canakinumab et ses dérivés pharmaceutiquement acceptables (ILARIS)
LU92871I2 (fr) Fumarate de diméthyle et ses dérivés pharmaceutiquement acceptables (tecfidera)
LUC00127I1 (fr) Dacomitinib et ses derives pharmaceutiquement accepatbles ( vizimpro )
LU92517I2 (fr) Delamanide et ses dérivés pharmaceutiquement acceptables
LU92513I2 (fr) Sofosbuvir et ses dérivés pharmaceutiquement acceptables (solvaldi)
CY2022001I2 (el) Παραγωγα του uk-2a
LU92336I2 (fr) Trastuzumab emtansine et ses dérivés pharmaceutiquement acceptables (KADCYLA)
LU92419I2 (fr) Riociguat et ses dérivés pharmaceutiquement acceptables (ADEMPAS®)
LU91883I2 (fr) Pradofloxacin et ses dérivés pharmaceutiquement acceptables (VERAFLOX®)
IS8578A (is) 3- karbamoýl - 2- pýridón afleiður
DK1725553T3 (da) Tetrahydropyridoindolderivater
CY2014011I1 (el) Χορηγηση αναστολεων διπεπτιδυλοπεπτιδασης
ATE553079T1 (de) Heteroarylphenylharnstoffderivat
ATE417830T1 (de) Sulfonylbenzimidazolderivate
MA29039B1 (fr) Dibenzylamines et derives
NO20075628L (no) Farmasøytiske formuleringer
DK3421471T3 (da) Purin- og deazapurinderivater som farmaceutiske forbindelser
DK1940467T3 (da) Lægemiddelsammensætning med langvarig frigivelse
DK2783682T3 (da) Farmaceutisk sammensætning omfattende pimobendan
DK1732892T3 (da) Tetrahydrocarbazoler og derivater
LU92634I2 (fr) Flutémétamol (18f) et ses dérivés pharmaceutiquement acceptables (vizamyl)
BRPI0611025A2 (pt) composto, uso de um composto, e, composição farmacêuticamente aceitável