PE20090879A1 - DERIVADOS 9-DESOXO-9a-METIL-9a-AZA-9a-HOMOERITROMICINA A COMO AGENTES ANTIMALARICOS - Google Patents

DERIVADOS 9-DESOXO-9a-METIL-9a-AZA-9a-HOMOERITROMICINA A COMO AGENTES ANTIMALARICOS

Info

Publication number
PE20090879A1
PE20090879A1 PE2008001268A PE2008001268A PE20090879A1 PE 20090879 A1 PE20090879 A1 PE 20090879A1 PE 2008001268 A PE2008001268 A PE 2008001268A PE 2008001268 A PE2008001268 A PE 2008001268A PE 20090879 A1 PE20090879 A1 PE 20090879A1
Authority
PE
Peru
Prior art keywords
homoerithromycin
deoxo
aza
methyl
amino
Prior art date
Application number
PE2008001268A
Other languages
English (en)
Inventor
Sulejman Alihodzic
Mihaela Peric
Dijana Pesic
Original Assignee
Glaxosmithkline Zagreb
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Zagreb filed Critical Glaxosmithkline Zagreb
Publication of PE20090879A1 publication Critical patent/PE20090879A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

REFERIDA A UN DERIVADO DE ERITROMICINA DE FORMULA (I), DONDE R1 ES H O UN GRUPO ALFA-L-CLADINOSILDE FORMULA (a); R2 ES -(CH2)a-X-(CH2)b-(NH)c-A; R3 ES H O -C(O)ALQUILO C1-C3 O R3 Y R4 JUNTOS FORMAN UN GRUPO CARBONATO CICLICO DE FORMULA (b): R4 ES H O R3 Y R4 JUNTOS FORMAN UN GRUPO CARBONATO CICLICO DE FORMULA (b); X ES N(R5), NHC(O) O C(O)NH; R5 ES H O ALQUILO C1-C3; A ES UN GRUPO DE FORMULA (c) O (d)R6 ES H O HALOGENO; a ES UN NUMERO ENTERO DE 2 A 6; b ES UN NUMERO ENTERO DE 0 A 6; c ES 0 O 1, CON LA CONDICION DE QUE CUANDO c ES 1 ENTONCES b ES UN NUMERO ENTERO DE 1 A 6. SON COMPUESTOS PREFERIDOS: 2'-O-[3-({4-[(7-CLORO-4-QUINOLINIL)AMINO]BUTANOIL}AMINO)PROPIL]-9-DESOXO-9a-METIL-9a-AZA-9a-HOMOERITROMICINA A, 2'-O-[3-({4-[(7-CLORO-4-QUINOLINIL)AMINO]BUTANOIL}AMINO)PROPIL]-3-O-DECLADINOSIL-9-DESOXO-9a-METIL-9a-AZA-9a-HOMOERITROMICINA A, 2'-O-{3-[(7-CLORO-4-QUINOLINIL)AMINO]PROPIL}-9-DESOXO-9a-METIL-9a-AZA-9a-HOMOERITROMICINA A, ENTRE OTROS. TAMBIEN ESTA REFERIDA A UNA COMPOSICION FARMACEUTICA Y A UN PROCEDIMIENTO DE PREPARACION. DICHOS COMPUESTOS SON UTILES EN EL TRATAMIENTO DE LA MALARIA
PE2008001268A 2007-07-30 2008-07-25 DERIVADOS 9-DESOXO-9a-METIL-9a-AZA-9a-HOMOERITROMICINA A COMO AGENTES ANTIMALARICOS PE20090879A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95264907P 2007-07-30 2007-07-30

Publications (1)

Publication Number Publication Date
PE20090879A1 true PE20090879A1 (es) 2009-07-25

Family

ID=39874927

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2008001268A PE20090879A1 (es) 2007-07-30 2008-07-25 DERIVADOS 9-DESOXO-9a-METIL-9a-AZA-9a-HOMOERITROMICINA A COMO AGENTES ANTIMALARICOS

Country Status (10)

Country Link
US (1) US20090036388A1 (es)
EP (1) EP2183265A1 (es)
JP (1) JP2010534709A (es)
CN (1) CN101809026A (es)
AR (1) AR067718A1 (es)
CL (1) CL2008002223A1 (es)
PE (1) PE20090879A1 (es)
TW (1) TW200922943A (es)
UY (1) UY31252A1 (es)
WO (1) WO2009016142A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010086350A1 (en) 2009-01-30 2010-08-05 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 9-deoxo- 9a-methyl- 9a- aza- 9a-h0m0erythr0mycin a derivatives for the treatment of neutrophil dominated inflammatory diseases
WO2010086351A1 (en) * 2009-01-30 2010-08-05 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 3'-n-substituted 9-deoxo-9a-methyl-9a-aza-homoerythromycin having antimalarial activity
WO2011131749A1 (en) 2010-04-23 2011-10-27 Glaxo Group Limited New 14 and 15 membered macrolides for the treatment of neutrophil dominated inflammatory diseases
WO2021204423A1 (en) 2020-04-05 2021-10-14 University of Zagreb School of Medicine Use of 15-membered azalides as active agents in the treatment of viral infections

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6407074B1 (en) * 1997-06-11 2002-06-18 Pfizer Inc C-4″-substituted macrolide derivatives
ATE429921T1 (de) * 2005-01-14 2009-05-15 Glaxosmithkline Zagreb 9a-carbamoyl- und thiocarbamoylazalide mit antimalariawirkung
ATE465741T1 (de) * 2005-01-14 2010-05-15 Glaxosmithkline Zagreb 9a-carbamoyl-y-aminopropyl- und 9a-thiocarbamoyl- y-aminopropyl-azalide mit antimalaria-aktivität

Also Published As

Publication number Publication date
UY31252A1 (es) 2009-03-02
CN101809026A (zh) 2010-08-18
AR067718A1 (es) 2009-10-21
WO2009016142A1 (en) 2009-02-05
JP2010534709A (ja) 2010-11-11
EP2183265A1 (en) 2010-05-12
TW200922943A (en) 2009-06-01
US20090036388A1 (en) 2009-02-05
CL2008002223A1 (es) 2009-08-07

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