AR013086A1 - Compuestos derivados de 9-desoxo-9a-aza-9a-homoeritromicina a c-4 sustituidos, composiciones que los contienen, metodos para preparar los compuestos, uso de dichos compuestos e intermediarios para su preparacion - Google Patents

Compuestos derivados de 9-desoxo-9a-aza-9a-homoeritromicina a c-4 sustituidos, composiciones que los contienen, metodos para preparar los compuestos, uso de dichos compuestos e intermediarios para su preparacion

Info

Publication number
AR013086A1
AR013086A1 ARP980102706A ARP980102706A AR013086A1 AR 013086 A1 AR013086 A1 AR 013086A1 AR P980102706 A ARP980102706 A AR P980102706A AR P980102706 A ARP980102706 A AR P980102706A AR 013086 A1 AR013086 A1 AR 013086A1
Authority
AR
Argentina
Prior art keywords
compounds
groups
integer ranging
alkynyl
alkenyl
Prior art date
Application number
ARP980102706A
Other languages
English (en)
Spanish (es)
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21959336&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR013086(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of AR013086A1 publication Critical patent/AR013086A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ARP980102706A 1997-06-11 1998-06-09 Compuestos derivados de 9-desoxo-9a-aza-9a-homoeritromicina a c-4 sustituidos, composiciones que los contienen, metodos para preparar los compuestos, uso de dichos compuestos e intermediarios para su preparacion AR013086A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4934897P 1997-06-11 1997-06-11

Publications (1)

Publication Number Publication Date
AR013086A1 true AR013086A1 (es) 2000-12-13

Family

ID=21959336

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980102706A AR013086A1 (es) 1997-06-11 1998-06-09 Compuestos derivados de 9-desoxo-9a-aza-9a-homoeritromicina a c-4 sustituidos, composiciones que los contienen, metodos para preparar los compuestos, uso de dichos compuestos e intermediarios para su preparacion

Country Status (49)

Country Link
US (4) US6420536B1 (enExample)
EP (1) EP0988310B9 (enExample)
JP (2) JP3315704B2 (enExample)
KR (1) KR100396168B1 (enExample)
CN (4) CN1172947C (enExample)
AP (1) AP1231A (enExample)
AR (1) AR013086A1 (enExample)
AT (1) ATE251173T1 (enExample)
AU (1) AU749816B2 (enExample)
BG (1) BG64391B1 (enExample)
BR (1) BRPI9810519B8 (enExample)
CA (1) CA2293823C (enExample)
CO (1) CO4950611A1 (enExample)
CZ (1) CZ298556B6 (enExample)
DE (2) DE122004000018I2 (enExample)
DK (1) DK0988310T3 (enExample)
DZ (1) DZ2514A1 (enExample)
EA (1) EA002441B1 (enExample)
EG (1) EG24081A (enExample)
ES (1) ES2205487T3 (enExample)
FR (1) FR04C0013I2 (enExample)
GT (1) GT199800077A (enExample)
HN (1) HN1998000086A (enExample)
HR (1) HRP980314B1 (enExample)
HU (2) HU228005B1 (enExample)
ID (1) ID22992A (enExample)
IL (1) IL132809A0 (enExample)
IS (1) IS1998B (enExample)
LU (1) LU91076I9 (enExample)
MA (1) MA24564A1 (enExample)
ME (1) ME00876B (enExample)
MY (1) MY123354A (enExample)
NL (1) NL300150I2 (enExample)
NO (1) NO316911B1 (enExample)
NZ (2) NZ500660A (enExample)
OA (1) OA11224A (enExample)
PA (1) PA8452201A1 (enExample)
PE (1) PE79699A1 (enExample)
PL (1) PL191601B1 (enExample)
PT (1) PT988310E (enExample)
RS (1) RS49675B (enExample)
SI (1) SI0988310T1 (enExample)
SK (1) SK284171B6 (enExample)
TN (1) TNSN98082A1 (enExample)
TW (1) TW472060B (enExample)
UA (1) UA67744C2 (enExample)
UY (1) UY25040A1 (enExample)
WO (1) WO1998056802A1 (enExample)
ZA (1) ZA985017B (enExample)

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EP1779853A3 (en) * 1997-09-10 2010-01-27 Merial Ltd. 9a-azalides as veterinary antimicrobial agents
AU731842B2 (en) * 1997-09-10 2001-04-05 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
US6339063B1 (en) 1997-09-10 2002-01-15 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
CA2292359C (en) * 1999-01-28 2004-09-28 Pfizer Products Inc. Novel azalides and methods of making same
PL353316A1 (en) * 1999-05-18 2003-11-17 Pfizer Products Inc. Novel crystalline forms of a macrolide antibiotic
CZ20013733A3 (cs) * 1999-05-24 2002-11-13 Pfizer Products Inc. Deriváty 13-methylerythromycinu
US6465437B1 (en) 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
PT1206476E (pt) * 1999-08-24 2006-05-31 Abbott Lab 9a-azalidos com actividade antibacteriana
US6608033B1 (en) * 1999-08-27 2003-08-19 Pfizer Inc. Treatment or prevention of coccidiosis
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CN1297564C (zh) 2001-04-27 2007-01-31 辉瑞产品公司 4″－取代－9－脱氧－9a－氮杂－9a－高红霉素A衍生物的制备方法
WO2003011266A2 (en) * 2001-08-01 2003-02-13 Pfizer Products Inc. Azalide antibiotic compositions
EP2772254A3 (en) 2003-03-10 2015-03-11 Optimer Pharmaceuticals, Inc. Novel Antibacterial Agents
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KR100785601B1 (ko) * 2003-11-21 2007-12-14 화이자 프로덕츠 인크. 백신 아쥬반트로서의 항생제의 용도
EA011158B1 (ru) * 2004-03-16 2009-02-27 Бёрингер Ингельхайм Интернациональ Гмбх Замещённые глюкопиранозилом бензольные производные, содержащие эти соединения лекарственные средства, их применение и способ их получения
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
US7767797B1 (en) * 2004-09-30 2010-08-03 Synovo Gmbh Macrocyclic compounds and methods of use thereof
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
EP1841437B1 (en) * 2005-01-14 2009-04-29 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. 9a-carbamoyl and thiocarbamoyl azalides with antimalarial activity
JP5698979B2 (ja) * 2007-10-25 2015-04-08 センプラ ファーマシューティカルズ，インコーポレイテッド マクロライド系抗菌剤の調製プロセス
EP2358379B1 (en) 2008-10-24 2015-12-16 Cempra Pharmaceuticals, Inc. Biodefenses using triazole-containing macrolides
US9937194B1 (en) * 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
EP2475253B1 (en) 2009-09-10 2016-10-26 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and mac diseases
AU2011232627B2 (en) 2010-03-22 2016-03-17 Cempra Pharmaceuticals, Inc. Crystalline forms of a macrolide, and uses therefor
RU2608390C2 (ru) 2010-05-20 2017-01-18 Семпра Фармасьютикалз, Инк. Способы получения макролидов и кетолидов, и промежуточных соединений для их получения
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ES2532455T3 (es) * 2010-09-20 2015-03-27 Novartis Tiergesundheit Ag Nuevo procedimiento de preparación de 9-desoxo-9a-aza-9a-homoeritromicina modificada en el C-4'' del anillo de cladinosa por un grupo epóxido
AU2011313862A1 (en) * 2010-10-10 2013-05-30 Synovo Gmbh Anti-inflammatory macrolides
CN102993250B (zh) * 2011-07-06 2016-02-10 洛阳惠中兽药有限公司 C-3取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
WO2013013834A1 (en) 2011-07-27 2013-01-31 Farma Grs, D.O.O. New crystalline forms of tulathromycin
JP6208742B2 (ja) 2012-03-27 2017-10-04 センプラ ファーマシューティカルズ，インコーポレイテッド マクロライド抗生物質を投与するための非経口製剤
CN102786569B (zh) * 2012-09-07 2016-12-07 安徽中升药业有限公司 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法
US9861616B2 (en) 2013-03-14 2018-01-09 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
US9751908B2 (en) 2013-03-15 2017-09-05 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
SI3027634T1 (sl) * 2013-07-31 2018-10-30 Farma Grs, D.O.O. Proces za pripravo tulatromicina
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
CN104861018A (zh) * 2015-06-17 2015-08-26 瑞普（天津）生物药业有限公司 一种泰拉菌素的制备方法
CN105646617A (zh) * 2016-01-21 2016-06-08 杭州海尔希畜牧科技有限公司 一种制备泰拉霉素的方法
FR3048612B1 (fr) * 2016-03-14 2020-10-02 Septeos Tulathromycine potentialisee
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN108003207B (zh) 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
CN111087433B (zh) * 2018-10-23 2023-03-21 湖北美天生物科技股份有限公司 一种泰拉霉素中间体的制备方法

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Also Published As

Publication number Publication date
FR04C0013I1 (enExample) 2004-06-11
HUP0002209A2 (hu) 2000-12-28
YU58699A (enExample) 2002-08-12
HRP980314A2 (en) 1999-04-30
CZ298556B6 (cs) 2007-11-07
US20040180842A1 (en) 2004-09-16
PL337505A1 (en) 2000-08-28
AU7347598A (en) 1998-12-30
SK284171B6 (sk) 2004-10-05
CN1259136A (zh) 2000-07-05
ME00876B (me) 2012-06-20
RS49675B (sr) 2007-11-15
TNSN98082A1 (fr) 2005-03-15
BRPI9810519A (pt) 2000-09-19
DE122004000018I2 (de) 2011-01-13
ID22992A (id) 1999-12-23
HK1088014A1 (zh) 2006-10-27
EP0988310B9 (en) 2006-03-08
HUS1200028I1 (hu) 2016-08-29
LU91076I9 (en) 2018-07-02
FR04C0013I2 (enExample) 2005-10-21
BRPI9810519B8 (pt) 2022-11-16
AP9801255A0 (en) 1998-06-30
CA2293823C (en) 2004-02-17
US6777393B2 (en) 2004-08-17
KR20010013632A (ko) 2001-02-26
PA8452201A1 (es) 2000-05-24
UA67744C2 (uk) 2004-07-15
CN101691390A (zh) 2010-04-07
NO996106L (no) 2000-02-10
HN1998000086A (es) 1999-03-08
US20020061858A1 (en) 2002-05-23
CN1172947C (zh) 2004-10-27
LU91076I2 (fr) 2004-07-05
PL191601B1 (pl) 2006-06-30
JP2002316933A (ja) 2002-10-31
CA2293823A1 (en) 1998-12-17
SK168399A3 (en) 2000-11-07
NL300150I1 (nl) 2004-08-02
UY25040A1 (es) 2000-09-29
IS5252A (is) 1999-11-16
AP1231A (en) 2003-12-11
DE122004000018I1 (de) 2004-09-30
EA002441B1 (ru) 2002-04-25
EG24081A (en) 2008-05-11
CO4950611A1 (es) 2000-09-01
HRP980314B1 (en) 2004-04-30
HK1028048A1 (en) 2001-02-02
BRPI9810519B1 (pt) 2012-02-22
NZ514871A (en) 2003-08-29
BG103945A (en) 2000-07-31
HUP0002209A3 (en) 2003-05-28
US6420536B1 (en) 2002-07-16
CN1793155A (zh) 2006-06-28
AU749816B2 (en) 2002-07-04
CN1793155B (zh) 2010-05-12
DE69818665T2 (de) 2004-04-29
GT199800077A (es) 1999-12-02
SI0988310T1 (en) 2004-02-29
JP3315704B2 (ja) 2002-08-19
PT988310E (pt) 2003-12-31
NO316911B1 (no) 2004-06-21
DE69818665D1 (de) 2003-11-06
EA199901015A1 (ru) 2000-06-26
NO996106D0 (no) 1999-12-10
EP0988310B1 (en) 2003-10-01
MY123354A (en) 2006-05-31
CN1566129A (zh) 2005-01-19
ATE251173T1 (de) 2003-10-15
US6936592B2 (en) 2005-08-30
KR100396168B1 (ko) 2003-08-27
OA11224A (en) 2003-07-16
IL132809A0 (en) 2001-03-19
US20040023896A1 (en) 2004-02-05
CN1243766C (zh) 2006-03-01
HK1068893A1 (en) 2005-07-29
ES2205487T3 (es) 2004-05-01
JP2000514098A (ja) 2000-10-24
IS1998B (is) 2005-03-15
MA24564A1 (fr) 1998-12-31
PE79699A1 (es) 1999-08-25
BG64391B1 (bg) 2004-12-30
CZ442199A3 (cs) 2000-07-12
ZA985017B (en) 1999-12-17
TW472060B (en) 2002-01-11
WO1998056802A1 (en) 1998-12-17
NZ500660A (en) 2002-03-01
HU228005B1 (en) 2012-08-28
NL300150I2 (nl) 2004-09-01
EP0988310A1 (en) 2000-03-29
DK0988310T3 (da) 2003-12-15
DZ2514A1 (fr) 2003-02-01

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