SK284171B9 - Derivát 4''-substituovaného-9-deoxo-9a-aza-9a-homoerytromycínu A, spôsob a medziprodukty na jeho prípravu, jeho použitie a farmaceutická kompozícia s jeho obsahom - Google Patents

Derivát 4''-substituovaného-9-deoxo-9a-aza-9a-homoerytromycínu A, spôsob a medziprodukty na jeho prípravu, jeho použitie a farmaceutická kompozícia s jeho obsahom

Info

Publication number
SK284171B9
SK284171B9 SK168399A SK168399A SK284171B9 SK 284171 B9 SK284171 B9 SK 284171B9 SK 168399 A SK168399 A SK 168399A SK 168399 A SK168399 A SK 168399A SK 284171 B9 SK284171 B9 SK 284171B9
Authority
SK
Slovakia
Prior art keywords
homoerythromycin
deoxo
aza
intermediates
derivative
Prior art date
Application number
SK168399A
Other languages
English (en)
Slovak (sk)
Other versions
SK284171B6 (sk
SK168399A3 (en
Inventor
Brian Scott Bronk
Michael Anthony Letavic
Takushi Kaneko
Bingwei Vera Yang
Edward Alan Glazer
Hengmiao Cheng
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21959336&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SK284171(B9) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of SK168399A3 publication Critical patent/SK168399A3/sk
Publication of SK284171B6 publication Critical patent/SK284171B6/sk
Publication of SK284171B9 publication Critical patent/SK284171B9/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
SK168399A 1997-06-11 1998-05-29 Derivát 4''-substituovaného-9-deoxo-9a-aza-9a-homoerytromycínu A, spôsob a medziprodukty na jeho prípravu, jeho použitie a farmaceutická kompozícia s jeho obsahom SK284171B9 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4934897P 1997-06-11 1997-06-11
PCT/IB1998/000839 WO1998056802A1 (en) 1997-06-11 1998-05-29 4'-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives

Publications (3)

Publication Number Publication Date
SK168399A3 SK168399A3 (en) 2000-11-07
SK284171B6 SK284171B6 (sk) 2004-10-05
SK284171B9 true SK284171B9 (sk) 2005-03-04

Family

ID=21959336

Family Applications (1)

Application Number Title Priority Date Filing Date
SK168399A SK284171B9 (sk) 1997-06-11 1998-05-29 Derivát 4''-substituovaného-9-deoxo-9a-aza-9a-homoerytromycínu A, spôsob a medziprodukty na jeho prípravu, jeho použitie a farmaceutická kompozícia s jeho obsahom

Country Status (49)

Country Link
US (4) US6420536B1 (enExample)
EP (1) EP0988310B9 (enExample)
JP (2) JP3315704B2 (enExample)
KR (1) KR100396168B1 (enExample)
CN (4) CN1243766C (enExample)
AP (1) AP1231A (enExample)
AR (1) AR013086A1 (enExample)
AT (1) ATE251173T1 (enExample)
AU (1) AU749816B2 (enExample)
BG (1) BG64391B1 (enExample)
BR (1) BRPI9810519B8 (enExample)
CA (1) CA2293823C (enExample)
CO (1) CO4950611A1 (enExample)
CZ (1) CZ298556B6 (enExample)
DE (2) DE122004000018I2 (enExample)
DK (1) DK0988310T3 (enExample)
DZ (1) DZ2514A1 (enExample)
EA (1) EA002441B1 (enExample)
EG (1) EG24081A (enExample)
ES (1) ES2205487T3 (enExample)
FR (1) FR04C0013I2 (enExample)
GT (1) GT199800077A (enExample)
HN (1) HN1998000086A (enExample)
HR (1) HRP980314B1 (enExample)
HU (2) HU228005B1 (enExample)
ID (1) ID22992A (enExample)
IL (1) IL132809A0 (enExample)
IS (1) IS1998B (enExample)
LU (1) LU91076I9 (enExample)
MA (1) MA24564A1 (enExample)
ME (1) ME00876B (enExample)
MY (1) MY123354A (enExample)
NL (1) NL300150I2 (enExample)
NO (1) NO316911B1 (enExample)
NZ (2) NZ500660A (enExample)
OA (1) OA11224A (enExample)
PA (1) PA8452201A1 (enExample)
PE (1) PE79699A1 (enExample)
PL (1) PL191601B1 (enExample)
PT (1) PT988310E (enExample)
RS (1) RS49675B (enExample)
SI (1) SI0988310T1 (enExample)
SK (1) SK284171B9 (enExample)
TN (1) TNSN98082A1 (enExample)
TW (1) TW472060B (enExample)
UA (1) UA67744C2 (enExample)
UY (1) UY25040A1 (enExample)
WO (1) WO1998056802A1 (enExample)
ZA (1) ZA985017B (enExample)

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AU731842B2 (en) * 1997-09-10 2001-04-05 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
CA2292359C (en) * 1999-01-28 2004-09-28 Pfizer Products Inc. Novel azalides and methods of making same
DE60038610T2 (de) * 1999-05-18 2009-06-25 Pfizer Products Inc., Groton Neue kristalline formen eines makrolidantibiotikums
EE200100613A (et) * 1999-05-24 2003-02-17 Pfizer Products Inc. 13-metüülerütromütsiini derivaadid
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CA2380455C (en) * 1999-08-24 2009-06-02 Abbott Laboratories 9a-azalides with antibacterial activity
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ATE243703T1 (de) * 2000-01-27 2003-07-15 Pfizer Prod Inc Antibiotische azalid-zusammensetzungen
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BRPI0416205A (pt) * 2003-11-21 2006-12-26 Pfizer Prod Inc uso de antibióticos como adjuvantes de vacina
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US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
US20080227730A1 (en) * 2005-01-14 2008-09-18 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 9A-Carbamoyl and Thiocarbamoyl Azalides With Antimalarial Activity
AU2008316830B2 (en) 2007-10-25 2016-03-17 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
CN107854477A (zh) 2008-10-24 2018-03-30 森普拉制药公司 使用含三唑的大环内酯治疗抗性疾病的方法
US9937194B1 (en) * 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US9480679B2 (en) 2009-09-10 2016-11-01 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
HRP20160168T1 (hr) 2010-03-22 2016-03-25 Cempra Pharmaceuticals Inc Kristalne forme makrolida i njihova uporaba
BR112012029586A2 (pt) 2010-05-20 2016-08-02 Cempra Pharmaceuticals Inc processos para preparar macrolídeos e cetolídeos e intermediários dos mesmos
KR20130120458A (ko) 2010-09-10 2013-11-04 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
US8940880B2 (en) * 2010-09-20 2015-01-27 Novartis Ag Process for the preparation of 9-deoxo-9a-homoerythromycin A, modified in the C-4″ of the cladinose ring by an epoxide group
US9145436B2 (en) * 2010-10-10 2015-09-29 Michael W. Burnet Anti-inflammatory macrolides
CN102993250B (zh) * 2011-07-06 2016-02-10 洛阳惠中兽药有限公司 C-3取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
EP2736915A1 (en) 2011-07-27 2014-06-04 Farma GRS, d.o.o. New crystalline forms of tulathromycin
WO2013148891A1 (en) 2012-03-27 2013-10-03 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
CN102786569B (zh) * 2012-09-07 2016-12-07 安徽中升药业有限公司 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法
WO2014152326A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
AU2014233240B2 (en) 2013-03-15 2018-08-09 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents
EP3027634B1 (en) * 2013-07-31 2018-03-21 Farma GRS, d.o.o. Process for preparation of tulathromycin
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
CN104861018A (zh) * 2015-06-17 2015-08-26 瑞普（天津）生物药业有限公司 一种泰拉菌素的制备方法
CN105646617A (zh) * 2016-01-21 2016-06-08 杭州海尔希畜牧科技有限公司 一种制备泰拉霉素的方法
FR3048612B1 (fr) * 2016-03-14 2020-10-02 Septeos Tulathromycine potentialisee
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN108003207B (zh) 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
CN111087433B (zh) * 2018-10-23 2023-03-21 湖北美天生物科技股份有限公司 一种泰拉霉素中间体的制备方法

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Also Published As

Publication number Publication date
NO996106D0 (no) 1999-12-10
EG24081A (en) 2008-05-11
US6936592B2 (en) 2005-08-30
TNSN98082A1 (fr) 2005-03-15
EP0988310B1 (en) 2003-10-01
PE79699A1 (es) 1999-08-25
ATE251173T1 (de) 2003-10-15
HN1998000086A (es) 1999-03-08
CN1566129A (zh) 2005-01-19
DE69818665T2 (de) 2004-04-29
YU58699A (enExample) 2002-08-12
KR100396168B1 (ko) 2003-08-27
NL300150I1 (nl) 2004-08-02
DZ2514A1 (fr) 2003-02-01
UY25040A1 (es) 2000-09-29
US6777393B2 (en) 2004-08-17
ME00876B (me) 2012-06-20
HK1068893A1 (en) 2005-07-29
WO1998056802A1 (en) 1998-12-17
FR04C0013I1 (enExample) 2004-06-11
AP1231A (en) 2003-12-11
DE122004000018I1 (de) 2004-09-30
US6420536B1 (en) 2002-07-16
BG64391B1 (bg) 2004-12-30
ZA985017B (en) 1999-12-17
NZ500660A (en) 2002-03-01
US20040180842A1 (en) 2004-09-16
CA2293823A1 (en) 1998-12-17
CN101691390A (zh) 2010-04-07
JP3315704B2 (ja) 2002-08-19
MY123354A (en) 2006-05-31
KR20010013632A (ko) 2001-02-26
HRP980314B1 (en) 2004-04-30
NL300150I2 (nl) 2004-09-01
HUP0002209A3 (en) 2003-05-28
IL132809A0 (en) 2001-03-19
NZ514871A (en) 2003-08-29
PT988310E (pt) 2003-12-31
LU91076I2 (fr) 2004-07-05
FR04C0013I2 (enExample) 2005-10-21
CN1172947C (zh) 2004-10-27
HUP0002209A2 (hu) 2000-12-28
CZ442199A3 (cs) 2000-07-12
CN1793155B (zh) 2010-05-12
PA8452201A1 (es) 2000-05-24
HU228005B1 (en) 2012-08-28
GT199800077A (es) 1999-12-02
NO316911B1 (no) 2004-06-21
SK284171B6 (sk) 2004-10-05
AU7347598A (en) 1998-12-30
HK1028048A1 (en) 2001-02-02
AP9801255A0 (en) 1998-06-30
SI0988310T1 (en) 2004-02-29
BRPI9810519B8 (pt) 2022-11-16
TW472060B (en) 2002-01-11
DK0988310T3 (da) 2003-12-15
MA24564A1 (fr) 1998-12-31
HUS1200028I1 (hu) 2016-08-29
RS49675B (sr) 2007-11-15
SK168399A3 (en) 2000-11-07
IS1998B (is) 2005-03-15
BG103945A (bg) 2000-07-31
CZ298556B6 (cs) 2007-11-07
US20020061858A1 (en) 2002-05-23
NO996106L (no) 2000-02-10
PL337505A1 (en) 2000-08-28
HK1088014A1 (zh) 2006-10-27
LU91076I9 (en) 2018-07-02
UA67744C2 (uk) 2004-07-15
JP2002316933A (ja) 2002-10-31
CN1259136A (zh) 2000-07-05
EA199901015A1 (ru) 2000-06-26
ID22992A (id) 1999-12-23
DE69818665D1 (de) 2003-11-06
CN1793155A (zh) 2006-06-28
CA2293823C (en) 2004-02-17
EP0988310A1 (en) 2000-03-29
US20040023896A1 (en) 2004-02-05
DE122004000018I2 (de) 2011-01-13
BRPI9810519B1 (pt) 2012-02-22
IS5252A (is) 1999-11-16
BRPI9810519A (pt) 2000-09-19
CN1243766C (zh) 2006-03-01
AU749816B2 (en) 2002-07-04
JP2000514098A (ja) 2000-10-24
ES2205487T3 (es) 2004-05-01
CO4950611A1 (es) 2000-09-01
OA11224A (en) 2003-07-16
AR013086A1 (es) 2000-12-13
EP0988310B9 (en) 2006-03-08
EA002441B1 (ru) 2002-04-25
HRP980314A2 (en) 1999-04-30
PL191601B1 (pl) 2006-06-30

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