TNSN98082A1 - DERIVES SUBSTITUES EN C - 4 DE 9 - DESOXO - 9a - aza - 9a HOMOERYTHROMYCINE A. - Google Patents

DERIVES SUBSTITUES EN C - 4 DE 9 - DESOXO - 9a - aza - 9a HOMOERYTHROMYCINE A.

Info

Publication number
TNSN98082A1
TNSN98082A1 TNTNSN98082A TNSN98082A TNSN98082A1 TN SN98082 A1 TNSN98082 A1 TN SN98082A1 TN TNSN98082 A TNTNSN98082 A TN TNSN98082A TN SN98082 A TNSN98082 A TN SN98082A TN SN98082 A1 TNSN98082 A1 TN SN98082A1
Authority
TN
Tunisia
Prior art keywords
desoxo
homoerythromycin
aza
substituted derivatives
compounds
Prior art date
Application number
TNTNSN98082A
Other languages
English (en)
French (fr)
Inventor
Scott Bronk Brian
Kaneko Takushi
Vera Yang Bingwei
Alan Glazer Edward
Cheng Hengmiao
Anthony Letavic Michael
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21959336&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TNSN98082(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of TNSN98082A1 publication Critical patent/TNSN98082A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
TNTNSN98082A 1997-06-11 1998-06-10 DERIVES SUBSTITUES EN C - 4 DE 9 - DESOXO - 9a - aza - 9a HOMOERYTHROMYCINE A. TNSN98082A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4934897P 1997-06-11 1997-06-11

Publications (1)

Publication Number Publication Date
TNSN98082A1 true TNSN98082A1 (fr) 2005-03-15

Family

ID=21959336

Family Applications (1)

Application Number Title Priority Date Filing Date
TNTNSN98082A TNSN98082A1 (fr) 1997-06-11 1998-06-10 DERIVES SUBSTITUES EN C - 4 DE 9 - DESOXO - 9a - aza - 9a HOMOERYTHROMYCINE A.

Country Status (49)

Country Link
US (4) US6420536B1 (enExample)
EP (1) EP0988310B9 (enExample)
JP (2) JP3315704B2 (enExample)
KR (1) KR100396168B1 (enExample)
CN (4) CN101691390A (enExample)
AP (1) AP1231A (enExample)
AR (1) AR013086A1 (enExample)
AT (1) ATE251173T1 (enExample)
AU (1) AU749816B2 (enExample)
BG (1) BG64391B1 (enExample)
BR (1) BRPI9810519B8 (enExample)
CA (1) CA2293823C (enExample)
CO (1) CO4950611A1 (enExample)
CZ (1) CZ298556B6 (enExample)
DE (2) DE122004000018I2 (enExample)
DK (1) DK0988310T3 (enExample)
DZ (1) DZ2514A1 (enExample)
EA (1) EA002441B1 (enExample)
EG (1) EG24081A (enExample)
ES (1) ES2205487T3 (enExample)
FR (1) FR04C0013I2 (enExample)
GT (1) GT199800077A (enExample)
HN (1) HN1998000086A (enExample)
HR (1) HRP980314B1 (enExample)
HU (2) HU228005B1 (enExample)
ID (1) ID22992A (enExample)
IL (1) IL132809A0 (enExample)
IS (1) IS1998B (enExample)
LU (1) LU91076I9 (enExample)
MA (1) MA24564A1 (enExample)
ME (1) ME00876B (enExample)
MY (1) MY123354A (enExample)
NL (1) NL300150I2 (enExample)
NO (1) NO316911B1 (enExample)
NZ (2) NZ514871A (enExample)
OA (1) OA11224A (enExample)
PA (1) PA8452201A1 (enExample)
PE (1) PE79699A1 (enExample)
PL (1) PL191601B1 (enExample)
PT (1) PT988310E (enExample)
RS (1) RS49675B (enExample)
SI (1) SI0988310T1 (enExample)
SK (1) SK284171B6 (enExample)
TN (1) TNSN98082A1 (enExample)
TW (1) TW472060B (enExample)
UA (1) UA67744C2 (enExample)
UY (1) UY25040A1 (enExample)
WO (1) WO1998056802A1 (enExample)
ZA (1) ZA985017B (enExample)

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AU731842B2 (en) * 1997-09-10 2001-04-05 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
EP1779853A3 (en) * 1997-09-10 2010-01-27 Merial Ltd. 9a-azalides as veterinary antimicrobial agents
US6339063B1 (en) 1997-09-10 2002-01-15 Merck & Co., Inc. 9a-azalides as veterinary antimicrobial agents
AP9801420A0 (en) * 1998-01-02 1998-12-31 Pfizer Prod Inc Novel macrolides.
EP1437360A3 (en) * 1998-08-19 2005-04-06 Pfizer Products Inc. C11 Carbamates of macrolide antibacterials
US6043227A (en) * 1998-08-19 2000-03-28 Pfizer Inc. C11 carbamates of macrolide antibacterials
US6100240A (en) * 1998-10-09 2000-08-08 Pfizer Inc Macrolide derivatives
CA2292359C (en) * 1999-01-28 2004-09-28 Pfizer Products Inc. Novel azalides and methods of making same
KR100474229B1 (ko) 1999-05-18 2005-03-08 화이자 프로덕츠 인크. 마크롤라이드계 항생제의 신규 결정형
KR20020016799A (ko) * 1999-05-24 2002-03-06 데이비드 존 우드 13-메틸-에리트로마이신 유도체
US6465437B1 (en) * 1999-06-30 2002-10-15 Pfizer Inc. Diphosphate salt of a 4″-substituted-9-deoxo-9A-AZA-9A- homoerythromycin derivative and its pharmaceutical composition
CA2380455C (en) * 1999-08-24 2009-06-02 Abbott Laboratories 9a-azalides with antibacterial activity
US6764996B1 (en) 1999-08-24 2004-07-20 Abbott Laboratories 9a-azalides with antibacterial activity
US6608033B1 (en) * 1999-08-27 2003-08-19 Pfizer Inc. Treatment or prevention of coccidiosis
BRPI0017013B8 (pt) * 2000-01-27 2022-11-16 Pfizer Prod Inc composição de antibiótico azalídeo e método para sua obtenção
OA12257A (en) * 2000-04-27 2003-11-06 Pfizer Prod Inc the use of azalide antibiotic compositions for treating or preventing a bacterial or protozoal infection in mammals.
BR0209241A (pt) * 2001-04-27 2004-06-15 Pfizer Prod Inc Processo para preparação de derivados de9-deoxo-9a-aza-9a-homoeritromicina a 4-substituida
WO2003011266A2 (en) * 2001-08-01 2003-02-13 Pfizer Products Inc. Azalide antibiotic compositions
CA2529817C (en) 2003-03-10 2013-02-12 Optimer Pharmaceuticals, Inc. Novel antibacterial agents
WO2005030227A1 (en) 2003-09-23 2005-04-07 Enanta Pharmaceuticals, Inc. 9a, 11-3C-BICYCLIC 9a-AZALIDE DERIVATIVES
RU2322241C2 (ru) * 2003-11-21 2008-04-20 Пфайзер Продактс Инк. Применение антибиотиков в качестве адъювантов вакцин
PL1730131T3 (pl) * 2004-03-16 2012-10-31 Boehringer Ingelheim Int Glukopiranozylo-podstawione pochodne benzenu, środki lecznicze zawierające te związki, ich zastosowanie i sposób ich wytwarzania
US20060116336A1 (en) * 2004-03-17 2006-06-01 American Pharmaceutical Partners, Inc. Lyophilized azithromycin formulation
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
US7402568B2 (en) 2004-09-29 2008-07-22 Enanta Pharmaceuticals, Inc. Bicyclic 9a-azalide derivatives
US7767797B1 (en) * 2004-09-30 2010-08-03 Synovo Gmbh Macrocyclic compounds and methods of use thereof
US7271155B2 (en) 2005-01-07 2007-09-18 Enanta Pharmaceuticals, Inc. 9A, 11-2C-bicyclic 9a-azalide derivatives
US20080227730A1 (en) * 2005-01-14 2008-09-18 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 9A-Carbamoyl and Thiocarbamoyl Azalides With Antimalarial Activity
AU2008316830B2 (en) * 2007-10-25 2016-03-17 Cempra Pharmaceuticals, Inc. Process for the preparation of macrolide antibacterial agents
WO2010048600A1 (en) * 2008-10-24 2010-04-29 Cempra Pharmaceuticals, Inc. Methods for treating resistant diseases using triazole containing macrolides
US9937194B1 (en) * 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
US9480679B2 (en) 2009-09-10 2016-11-01 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
HRP20160168T1 (hr) 2010-03-22 2016-03-25 Cempra Pharmaceuticals Inc Kristalne forme makrolida i njihova uporaba
EP2571506B1 (en) 2010-05-20 2017-05-10 Cempra Pharmaceuticals, Inc. Processes for preparing macrolides and ketolides and intermediates therefor
KR20130120458A (ko) 2010-09-10 2013-11-04 셈프라 파마슈티컬스, 인크. 질환을 치료하기 위한 수소결합 형성 플루오로 케토라이드
EP2619214B1 (en) 2010-09-20 2014-12-24 Novartis AG Novel process for the preparation of 9-deoxo-9a-aza-9a-homoerythromycin a modified in the c-4'' of the cladinose ring by an epoxide group
MX2013004013A (es) * 2010-10-10 2013-09-26 Synovo Gmbh Macrolidos antiinflamatorios.
CN102993250B (zh) * 2011-07-06 2016-02-10 洛阳惠中兽药有限公司 C-3取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
EP2736915A1 (en) 2011-07-27 2014-06-04 Farma GRS, d.o.o. New crystalline forms of tulathromycin
WO2013148891A1 (en) 2012-03-27 2013-10-03 Cempra Pharmaceuticals, Inc. Parenteral formulations for administering macrolide antibiotics
CN102786569B (zh) * 2012-09-07 2016-12-07 安徽中升药业有限公司 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法
EP2968801B1 (en) 2013-03-14 2018-09-26 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
MX356772B (es) 2013-03-15 2018-06-13 Cempra Pharmaceuticals Inc Procesos convergentes para la preparacion de agentes antibacterianos macrolidos.
EP3027634B1 (en) * 2013-07-31 2018-03-21 Farma GRS, d.o.o. Process for preparation of tulathromycin
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
CN104861018A (zh) * 2015-06-17 2015-08-26 瑞普（天津）生物药业有限公司 一种泰拉菌素的制备方法
CN105646617A (zh) * 2016-01-21 2016-06-08 杭州海尔希畜牧科技有限公司 一种制备泰拉霉素的方法
FR3048612B1 (fr) * 2016-03-14 2020-10-02 Septeos Tulathromycine potentialisee
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN108003207B (zh) * 2017-12-19 2019-05-10 海门慧聚药业有限公司 制备泰拉霉素的方法
CN111087433B (zh) * 2018-10-23 2023-03-21 湖北美天生物科技股份有限公司 一种泰拉霉素中间体的制备方法

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UA70972C2 (uk) 1998-11-20 2004-11-15 Пфайзер Продактс Інк. 13-членні азаліди і їх застосування як антибіотиків

Also Published As

Publication number Publication date
JP2000514098A (ja) 2000-10-24
TW472060B (en) 2002-01-11
HUP0002209A2 (hu) 2000-12-28
EP0988310A1 (en) 2000-03-29
EP0988310B1 (en) 2003-10-01
HU228005B1 (en) 2012-08-28
ES2205487T3 (es) 2004-05-01
AR013086A1 (es) 2000-12-13
CN1566129A (zh) 2005-01-19
HK1068893A1 (en) 2005-07-29
KR20010013632A (ko) 2001-02-26
PL337505A1 (en) 2000-08-28
HK1088014A1 (zh) 2006-10-27
CN1793155A (zh) 2006-06-28
LU91076I2 (fr) 2004-07-05
AU7347598A (en) 1998-12-30
CN1172947C (zh) 2004-10-27
HK1028048A1 (en) 2001-02-02
ME00876B (me) 2012-06-20
IL132809A0 (en) 2001-03-19
GT199800077A (es) 1999-12-02
AP1231A (en) 2003-12-11
DK0988310T3 (da) 2003-12-15
CN1243766C (zh) 2006-03-01
MA24564A1 (fr) 1998-12-31
CA2293823C (en) 2004-02-17
CZ298556B6 (cs) 2007-11-07
ID22992A (id) 1999-12-23
NZ500660A (en) 2002-03-01
BG103945A (en) 2000-07-31
PL191601B1 (pl) 2006-06-30
SI0988310T1 (en) 2004-02-29
FR04C0013I1 (enExample) 2004-06-11
HRP980314A2 (en) 1999-04-30
CA2293823A1 (en) 1998-12-17
OA11224A (en) 2003-07-16
EP0988310B9 (en) 2006-03-08
EG24081A (en) 2008-05-11
US20040023896A1 (en) 2004-02-05
US6936592B2 (en) 2005-08-30
BRPI9810519B1 (pt) 2012-02-22
NZ514871A (en) 2003-08-29
JP3315704B2 (ja) 2002-08-19
PE79699A1 (es) 1999-08-25
AP9801255A0 (en) 1998-06-30
BRPI9810519A (pt) 2000-09-19
IS1998B (is) 2005-03-15
SK168399A3 (en) 2000-11-07
PT988310E (pt) 2003-12-31
PA8452201A1 (es) 2000-05-24
HN1998000086A (es) 1999-03-08
RS49675B (sr) 2007-11-15
NO996106D0 (no) 1999-12-10
CZ442199A3 (cs) 2000-07-12
NO996106L (no) 2000-02-10
EA002441B1 (ru) 2002-04-25
US20040180842A1 (en) 2004-09-16
NL300150I1 (nl) 2004-08-02
UY25040A1 (es) 2000-09-29
HUP0002209A3 (en) 2003-05-28
NL300150I2 (nl) 2004-09-01
KR100396168B1 (ko) 2003-08-27
EA199901015A1 (ru) 2000-06-26
CN1793155B (zh) 2010-05-12
HUS1200028I1 (hu) 2016-08-29
HRP980314B1 (en) 2004-04-30
US20020061858A1 (en) 2002-05-23
MY123354A (en) 2006-05-31
SK284171B6 (sk) 2004-10-05
JP2002316933A (ja) 2002-10-31
LU91076I9 (en) 2018-07-02
ATE251173T1 (de) 2003-10-15
DZ2514A1 (fr) 2003-02-01
DE122004000018I2 (de) 2011-01-13
DE69818665D1 (de) 2003-11-06
DE69818665T2 (de) 2004-04-29
CN1259136A (zh) 2000-07-05
ZA985017B (en) 1999-12-17
CN101691390A (zh) 2010-04-07
US6777393B2 (en) 2004-08-17
NO316911B1 (no) 2004-06-21
UA67744C2 (uk) 2004-07-15
BRPI9810519B8 (pt) 2022-11-16
US6420536B1 (en) 2002-07-16
YU58699A (enExample) 2002-08-12
BG64391B1 (bg) 2004-12-30
WO1998056802A1 (en) 1998-12-17
IS5252A (is) 1999-11-16
FR04C0013I2 (enExample) 2005-10-21
DE122004000018I1 (de) 2004-09-30
CO4950611A1 (es) 2000-09-01
AU749816B2 (en) 2002-07-04

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