CN1172947C - 4"-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物 - Google Patents

4"-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物 Download PDF

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Publication number
CN1172947C
CN1172947C CNB988059223A CN98805922A CN1172947C CN 1172947 C CN1172947 C CN 1172947C CN B988059223 A CNB988059223 A CN B988059223A CN 98805922 A CN98805922 A CN 98805922A CN 1172947 C CN1172947 C CN 1172947C
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CN
China
Prior art keywords
compound
hydroxyl
alkyl
general formula
hydroxy
Prior art date
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Expired - Lifetime
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CNB988059223A
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English (en)
Chinese (zh)
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CN1259136A (zh
Inventor
Bs
B·S·布罗克
M·A·勒塔威克
ʷ
金子卓史
v
秉薇·V·杨
I
E·A·格拉瑟
程恒淼
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Zoetis LLC
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Pfizer Products Inc
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Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of CN1259136A publication Critical patent/CN1259136A/zh
Application granted granted Critical
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNB988059223A 1997-06-11 1998-05-29 4"-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物 Expired - Lifetime CN1172947C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4934897P 1997-06-11 1997-06-11
US60/049,348 1997-06-11

Related Child Applications (3)

Application Number Title Priority Date Filing Date
CNB2004100491122A Division CN1243766C (zh) 1997-06-11 1998-05-29 4”－取代的－9－脱氧－9a－氮杂－9a－高红霉素a衍生物
CN200910145318A Division CN101691390A (zh) 1997-06-11 1998-05-29 4”-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CN2006100513455A Division CN1793155B (zh) 1997-06-11 1998-05-29 4”-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物

Publications (2)

Publication Number Publication Date
CN1259136A CN1259136A (zh) 2000-07-05
CN1172947C true CN1172947C (zh) 2004-10-27

Family

ID=21959336

Family Applications (4)

Application Number Title Priority Date Filing Date
CNB988059223A Expired - Lifetime CN1172947C (zh) 1997-06-11 1998-05-29 4"-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CN2006100513455A Expired - Lifetime CN1793155B (zh) 1997-06-11 1998-05-29 4”-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CNB2004100491122A Expired - Lifetime CN1243766C (zh) 1997-06-11 1998-05-29 4”－取代的－9－脱氧－9a－氮杂－9a－高红霉素a衍生物
CN200910145318A Pending CN101691390A (zh) 1997-06-11 1998-05-29 4”-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN2006100513455A Expired - Lifetime CN1793155B (zh) 1997-06-11 1998-05-29 4”-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物
CNB2004100491122A Expired - Lifetime CN1243766C (zh) 1997-06-11 1998-05-29 4”－取代的－9－脱氧－9a－氮杂－9a－高红霉素a衍生物
CN200910145318A Pending CN101691390A (zh) 1997-06-11 1998-05-29 4”-取代的-9-脱氧-9a-氮杂-9a-高红霉素a衍生物

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EP (1) EP0988310B9 (enExample)
JP (2) JP3315704B2 (enExample)
KR (1) KR100396168B1 (enExample)
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UY (1) UY25040A1 (enExample)
WO (1) WO1998056802A1 (enExample)
ZA (1) ZA985017B (enExample)

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EP1841437B1 (en) * 2005-01-14 2009-04-29 GlaxoSmithKline istrazivacki centar Zagreb d.o.o. 9a-carbamoyl and thiocarbamoyl azalides with antimalarial activity
JP5698979B2 (ja) * 2007-10-25 2015-04-08 センプラ ファーマシューティカルズ，インコーポレイテッド マクロライド系抗菌剤の調製プロセス
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CN102786569B (zh) * 2012-09-07 2016-12-07 安徽中升药业有限公司 泰拉霉素中间体及其制备方法与泰拉霉素的制备方法
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CN104725446B (zh) * 2015-03-26 2017-10-27 宁夏泰瑞制药股份有限公司 一种从泰拉霉素粗品中分离泰拉霉素a和泰拉霉素b的方法
CN104861018A (zh) * 2015-06-17 2015-08-26 瑞普（天津）生物药业有限公司 一种泰拉菌素的制备方法
CN105646617A (zh) * 2016-01-21 2016-06-08 杭州海尔希畜牧科技有限公司 一种制备泰拉霉素的方法
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CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
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CN111087433B (zh) * 2018-10-23 2023-03-21 湖北美天生物科技股份有限公司 一种泰拉霉素中间体的制备方法

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FR04C0013I1 (enExample) 2004-06-11
HUP0002209A2 (hu) 2000-12-28
YU58699A (enExample) 2002-08-12
HRP980314A2 (en) 1999-04-30
CZ298556B6 (cs) 2007-11-07
US20040180842A1 (en) 2004-09-16
PL337505A1 (en) 2000-08-28
AU7347598A (en) 1998-12-30
SK284171B6 (sk) 2004-10-05
CN1259136A (zh) 2000-07-05
ME00876B (me) 2012-06-20
RS49675B (sr) 2007-11-15
TNSN98082A1 (fr) 2005-03-15
BRPI9810519A (pt) 2000-09-19
DE122004000018I2 (de) 2011-01-13
ID22992A (id) 1999-12-23
HK1088014A1 (zh) 2006-10-27
EP0988310B9 (en) 2006-03-08
HUS1200028I1 (hu) 2016-08-29
LU91076I9 (en) 2018-07-02
FR04C0013I2 (enExample) 2005-10-21
BRPI9810519B8 (pt) 2022-11-16
AP9801255A0 (en) 1998-06-30
CA2293823C (en) 2004-02-17
US6777393B2 (en) 2004-08-17
KR20010013632A (ko) 2001-02-26
PA8452201A1 (es) 2000-05-24
UA67744C2 (uk) 2004-07-15
CN101691390A (zh) 2010-04-07
NO996106L (no) 2000-02-10
HN1998000086A (es) 1999-03-08
US20020061858A1 (en) 2002-05-23
LU91076I2 (fr) 2004-07-05
PL191601B1 (pl) 2006-06-30
JP2002316933A (ja) 2002-10-31
CA2293823A1 (en) 1998-12-17
SK168399A3 (en) 2000-11-07
NL300150I1 (nl) 2004-08-02
UY25040A1 (es) 2000-09-29
IS5252A (is) 1999-11-16
AP1231A (en) 2003-12-11
DE122004000018I1 (de) 2004-09-30
EA002441B1 (ru) 2002-04-25
EG24081A (en) 2008-05-11
CO4950611A1 (es) 2000-09-01
HRP980314B1 (en) 2004-04-30
HK1028048A1 (en) 2001-02-02
AR013086A1 (es) 2000-12-13
BRPI9810519B1 (pt) 2012-02-22
NZ514871A (en) 2003-08-29
BG103945A (en) 2000-07-31
HUP0002209A3 (en) 2003-05-28
US6420536B1 (en) 2002-07-16
CN1793155A (zh) 2006-06-28
AU749816B2 (en) 2002-07-04
CN1793155B (zh) 2010-05-12
DE69818665T2 (de) 2004-04-29
GT199800077A (es) 1999-12-02
SI0988310T1 (en) 2004-02-29
JP3315704B2 (ja) 2002-08-19
PT988310E (pt) 2003-12-31
NO316911B1 (no) 2004-06-21
DE69818665D1 (de) 2003-11-06
EA199901015A1 (ru) 2000-06-26
NO996106D0 (no) 1999-12-10
EP0988310B1 (en) 2003-10-01
MY123354A (en) 2006-05-31
CN1566129A (zh) 2005-01-19
ATE251173T1 (de) 2003-10-15
US6936592B2 (en) 2005-08-30
KR100396168B1 (ko) 2003-08-27
OA11224A (en) 2003-07-16
IL132809A0 (en) 2001-03-19
US20040023896A1 (en) 2004-02-05
CN1243766C (zh) 2006-03-01
HK1068893A1 (en) 2005-07-29
ES2205487T3 (es) 2004-05-01
JP2000514098A (ja) 2000-10-24
IS1998B (is) 2005-03-15
MA24564A1 (fr) 1998-12-31
PE79699A1 (es) 1999-08-25
BG64391B1 (bg) 2004-12-30
CZ442199A3 (cs) 2000-07-12
ZA985017B (en) 1999-12-17
TW472060B (en) 2002-01-11
WO1998056802A1 (en) 1998-12-17
NZ500660A (en) 2002-03-01
HU228005B1 (en) 2012-08-28
NL300150I2 (nl) 2004-09-01
EP0988310A1 (en) 2000-03-29
DK0988310T3 (da) 2003-12-15
DZ2514A1 (fr) 2003-02-01

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