DK2365750T3 - Benzoxazol-kinaseinhibitorer og fremgangsmåder til anvendelse deraf - Google Patents

Benzoxazol-kinaseinhibitorer og fremgangsmåder til anvendelse deraf Download PDF

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Publication number
DK2365750T3
DK2365750T3 DK09823947.8T DK09823947T DK2365750T3 DK 2365750 T3 DK2365750 T3 DK 2365750T3 DK 09823947 T DK09823947 T DK 09823947T DK 2365750 T3 DK2365750 T3 DK 2365750T3
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compound
cancer
compounds
use according
cell
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DK09823947.8T
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Pingda Ren
Yi Liu
Liansheng Li
Katrina Chan
Troy Edward Wilson
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Intellikine Llc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07—ORGANIC CHEMISTRY
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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
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    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
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  • Veterinary Medicine (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Nutrition Science (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Claims (18)

1. Forbindelse af følgende struktur:
eller et farmaceutisk acceptabelt salt deraf.
2. Farmaceutisk sammensætning omfattende en terapeutisk effektiv mængde af forbindelsen eller det farmaceutisk acceptable salt ifølge krav 1, og en farmaceutisk acceptabel bærer.
3. Forbindelse eller farmaceutisk acceptabelt salt ifølge krav 1 til anvendelse ved behandlingen af cancer.
4. Farmaceutisk sammensætning ifølge krav 2 til anvendelse ved behandlingen af cancer.
5. Forbindelsen eller det farmaceutisk acceptable salt til anvendelse ifølge krav 3, eller farmaceutisk sammensætning til anvendelse ifølge krav 4, hvor canceren er fibrosarcom, pankreascancer, nyrecancer, levercancer, melanom, nasopharyngeal cancer, gastrisk cancer, ovariecancer, leukæmi, myelom, brystcancer, prostatacancer, colorektal cancer, lungecancer, glioblastom, livmodercancer, blærecancer, mesotheliom, hovedcancer, halscancer og cervical cancer.
6. Forbindelse eller farmaceutisk acceptabelt salt til anvendelse ifølge krav 3, eller farmaceutisk sammensætning til anvendelse ifølge krav 4, hvor canceren er nyrecancer.
7. Forbindelse eller farmaceutisk acceptabelt salt til anvendelse ifølge krav 3, eller farmaceutisk sammensætning til anvendelse ifølge krav 4, hvor canceren er nyrecellecarcinom.
8. Forbindelse eller farmaceutisk acceptabelt salt til anvendelse ifølge krav 3, eller farmaceutisk sammensætning til anvendelse ifølge krav 4, hvor canceren er brystcancer.
9. Forbindelse eller farmaceutisk acceptabelt salt til anvendelse ifølge krav 3, eller farmaceutisk sammensætning til anvendelse ifølge krav 4, hvor canceren er livmodercancer.
10. Forbindelse eller farmaceutisk acceptabelt salt til anvendelse ifølge krav 3, eller farmaceutisk sammensætning til anvendelse ifølge krav 4, hvor cancer er blærecancer.
11. Forbindelse eller farmaceutisk acceptabelt salt til anvendelse ifølge krav 3, eller farmaceutisk sammensætning til anvendelse ifølge krav 4, hvor canceren er colorektal cancer.
12. Forbindelse eller farmaceutisk acceptabelt salt til anvendelse ifølge krav 3, eller farmaceutisk sammensætning til anvendelse ifølge krav 4, hvor canceren er lungecancer.
13. Forbindelse eller farmaceutisk acceptabelt salt til anvendelse ifølge krav 3, eller farmaceutisk sammensætning til anvendelse ifølge krav 4, hvor canceren er ikke-småcellet lungecancer.
14. Forbindelse eller farmaceutisk acceptabelt salt til anvendelse ifølge krav 3, eller farmaceutisk sammensætning til anvendelse ifølge krav 4, hvor canceren er småcellet lungecancer.
15. Forbindelse eller farmaceutisk acceptabelt salt til anvendelse ifølge krav 3, eller farmaceutisk sammensætning til anvendelse ifølge krav 4, hvor canceren er glioblastom.
16. Forbindelse eller farmaceutisk acceptabelt salt til anvendelse ifølge krav 3, eller farmaceutisk sammensætning til anvendelse ifølge krav 4, hvor canceren er en gynækologisk cancer.
17. Forbindelse eller farmaceutisk acceptabelt salt til anvendelse ifølge krav 3, eller farmaceutisk sammensætning til anvendelse ifølge krav 4, hvor canceren er cervical cancer.
18. Forbindelse eller farmaceutisk acceptabelt salt til anvendelse ifølge krav 3, eller farmaceutisk sammensætning til anvendelse ifølge krav 4, hvor canceren er gastrisk cancer.
DK09823947.8T 2008-11-03 2009-11-02 Benzoxazol-kinaseinhibitorer og fremgangsmåder til anvendelse deraf DK2365750T3 (da)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US19820008P 2008-11-03 2008-11-03
US20192308P 2008-12-16 2008-12-16
US21426109P 2009-04-20 2009-04-20
US23065509P 2009-07-31 2009-07-31
US12/586,309 US8476282B2 (en) 2008-11-03 2009-09-17 Benzoxazole kinase inhibitors and methods of use
US12/586,241 US8476431B2 (en) 2008-11-03 2009-09-17 Benzoxazole kinase inhibitors and methods of use
PCT/US2009/005959 WO2010051043A1 (en) 2008-11-03 2009-11-02 Benzoxazole kinase inhibitors and methods of use

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DK2365750T3 true DK2365750T3 (da) 2016-08-29

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US (6) US8476431B2 (da)
EP (2) EP2365750B1 (da)
JP (8) JP5897333B2 (da)
KR (2) KR101737192B1 (da)
CN (2) CN102271513B (da)
AU (1) AU2009310364B2 (da)
BR (1) BRPI0920500B1 (da)
CA (1) CA2741898C (da)
CY (1) CY1117913T1 (da)
DK (1) DK2365750T3 (da)
ES (1) ES2588197T3 (da)
HK (1) HK1162855A1 (da)
HR (1) HRP20161074T1 (da)
HU (1) HUE029906T2 (da)
IL (3) IL212586A (da)
LT (1) LT2365750T (da)
MX (3) MX2011004523A (da)
MY (2) MY182533A (da)
NZ (2) NZ609221A (da)
PL (1) PL2365750T3 (da)
PT (1) PT2365750T (da)
SG (2) SG10201501702WA (da)
SI (1) SI2365750T1 (da)
SM (1) SMT201600278B (da)
WO (2) WO2010051043A1 (da)
ZA (1) ZA201103270B (da)

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