DK2184071T3 - Kapselformige polysaccharidopløsnings- og kombinationsvacciner - Google Patents
Kapselformige polysaccharidopløsnings- og kombinationsvacciner Download PDFInfo
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- DK2184071T3 DK2184071T3 DK09075005.0T DK09075005T DK2184071T3 DK 2184071 T3 DK2184071 T3 DK 2184071T3 DK 09075005 T DK09075005 T DK 09075005T DK 2184071 T3 DK2184071 T3 DK 2184071T3
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- Prior art keywords
- saccharide
- polysaccharide
- vol
- serogroup
- capsular
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
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- C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
- C09F—NATURAL RESINS; FRENCH POLISH; DRYING-OILS; OIL DRYING AGENTS, i.e. SICCATIVES; TURPENTINE
- C09F1/00—Obtaining purification, or chemical modification of natural resins, e.g. oleo-resins
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- C09G—POLISHING COMPOSITIONS; SKI WAXES
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/831—Drug, bio-affecting and body treating compositions involving capsular polysaccharide of bacterium, e.g. polyribosyl ribitol phosphate
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Claims (13)
1. Fremgangsmåde til oprensning og konjugering af et bakterielt kapselformigt poly-saccharid til et bærerprotein og derefter at blande det konjugerede polysaccharid med yderligere kapselformigt saccharid for at tilvejebringe en blanding, omfattende: at oprense polysaccharidet, omfattende trinnene af (a) bundfældning af polysaccha-ridet ved anvendelse af én eller flere kationiske detergenter, efterfulgt af (b) opløsning af det bundfældede polysaccharid ved anvendelse afen alkohol, konjugering af polysaccharidet til et bærerprotein, hvor bærerproteinet er et bakterielt toksin eller toxoid, og at blande kapselformigt saccharid fra Neisseria nieningitidis for at tilvejebringe en blanding omfattende kapselformige saccharider fra serogruppe Y og én eller begge af se-rogrupperne C og W135, hvor: forholdet (vægt/vægt) af MenY-saccharid:MenW135-saccharid er større end 1 og/eller forholdet (vægt/vægt) af MenY-saccharid:MenC-saccharid mindre end 1; og de kapselformige saccharider er konjugeret til bærerprotein(er), hvor det bakterielle kapselformige polysaccharid er fra Neisseria meningitidis, eller fra Haemophilus influenza, eller fra Streptococcus pneumoniae.
2. Fremgangsmåde ifølge krav 1, hvor det/de kationisk(e) detergent(er) omfatter et cetyltrimethylammoniumsalt, et tetrabutylammoniumsalt, et myristyltrimethylammonium-salt og/eller hexadimethrinbromid.
3. Fremgangsmåde ifølge krav 1 eller krav 2, hvor alkoholen der anvendes i trin (b) omfatter ethanol, og hvor ethanolen har en endelig koncentration på mellem 50% og 95%.
4. Fremgangsmåde ifølge et hvilket som helst foregående krav, hvor polysaccharidet tilvejebragt i trin (b) derefter bundfældes.
5. Fremgangsmåde ifølge krav 4, hvor bundfældning er ved tilsætning af calcium- eller natriumsalte.
6. Fremgangsmåde ifølge et hvilket som helst foregående krav, hvor saccharidet aktiveres forud for konjugering
7. Fremgangsmåde ifølge krav 6, hvor aktivering involverer en cyanylerende reagens.
8. Fremgangsmåde ifølge et hvilket som helst foregående krav, hvor konjugering er med en linker.
9. Fremgangsmåde ifølge et hvilket som helst foregående krav, hvor det konjugerede saccharid har et saccharid:protein forhold (vægt/vægt) mellem 0,5:1 og 5:1.
10. Fremgangsmåde ifølge et hvilket som helst foregående krav, hvor bærerproteinet er difteritoxoid eller tetanustoksoid.
11. Fremgangsmåde ifølge et hvilket som helst foregående krav, hvor, efter konjugering, frie og konjugerede saccharider er adskilte.
12. Fremgangsmåde ifølge krav 11, hvor adskillelsen anvender hydrofobisk kromato grafi, tangentiel ultrafiltrering, eller diafiltrering.
13. Fremgangsmåde ifølge et hvilket som helst foregående krav, yderligere omfattende trin af vaccineformulering omfattende at blande saccharidantigen(et/erne) med et adjuvans, som er en aluminiumphosphat og/eller en aluminiumhydroxid.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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GBGB0115176.0A GB0115176D0 (en) | 2001-06-20 | 2001-06-20 | Capular polysaccharide solubilisation and combination vaccines |
EP06075175A EP1741442B1 (en) | 2001-06-20 | 2002-06-20 | Neisseria meningitidis combination vaccines |
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DK2184071T3 true DK2184071T3 (da) | 2016-11-07 |
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Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
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DK02755452.6T DK1401489T4 (da) | 2001-06-20 | 2002-06-20 | Solubilisering af kapselpolysaccharid |
DK10007477.2T DK2263688T4 (da) | 2001-06-20 | 2002-06-20 | Kombinationsvacciner mod neisseria meningitidis |
DK10179797.5T DK2277536T3 (da) | 2001-06-20 | 2002-06-20 | Oprensning af bakterielle kapselpolysaccharider |
DK09075006.8T DK2189165T3 (da) | 2001-06-20 | 2002-06-20 | Kapselpolysaccharidsolubilisering og kombinationsvacciner |
DK09075005.0T DK2184071T3 (da) | 2001-06-20 | 2002-06-20 | Kapselformige polysaccharidopløsnings- og kombinationsvacciner |
DK06075175.7T DK1741442T3 (da) | 2001-06-20 | 2002-06-20 | Neisseria meningitidis-kombinationavacciner |
Family Applications Before (4)
Application Number | Title | Priority Date | Filing Date |
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DK02755452.6T DK1401489T4 (da) | 2001-06-20 | 2002-06-20 | Solubilisering af kapselpolysaccharid |
DK10007477.2T DK2263688T4 (da) | 2001-06-20 | 2002-06-20 | Kombinationsvacciner mod neisseria meningitidis |
DK10179797.5T DK2277536T3 (da) | 2001-06-20 | 2002-06-20 | Oprensning af bakterielle kapselpolysaccharider |
DK09075006.8T DK2189165T3 (da) | 2001-06-20 | 2002-06-20 | Kapselpolysaccharidsolubilisering og kombinationsvacciner |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
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DK06075175.7T DK1741442T3 (da) | 2001-06-20 | 2002-06-20 | Neisseria meningitidis-kombinationavacciner |
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US (9) | US8753651B2 (da) |
EP (10) | EP2277537B1 (da) |
JP (4) | JP5075317B2 (da) |
CN (4) | CN100482273C (da) |
AT (3) | ATE474594T1 (da) |
AU (3) | AU2002321716B2 (da) |
BE (4) | BE2010C031I2 (da) |
BR (2) | BR122019009186B8 (da) |
CA (3) | CA2730856C (da) |
CY (6) | CY1110820T1 (da) |
DE (6) | DE60210456T3 (da) |
DK (6) | DK1401489T4 (da) |
ES (9) | ES2261705T5 (da) |
FR (4) | FR10C0044I1 (da) |
GB (1) | GB0115176D0 (da) |
LU (4) | LU91732I2 (da) |
MX (1) | MXPA03011462A (da) |
NL (3) | NL300458I2 (da) |
NZ (2) | NZ529881A (da) |
PT (6) | PT1741442E (da) |
RU (2) | RU2381814C2 (da) |
TR (2) | TR201808055T4 (da) |
WO (1) | WO2003007985A2 (da) |
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