ES2573259T3 - Solubilización de polisacárido capsular y vacunas de combinación - Google Patents

Solubilización de polisacárido capsular y vacunas de combinación Download PDF

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Publication number
ES2573259T3
ES2573259T3 ES09075006.8T ES09075006T ES2573259T3 ES 2573259 T3 ES2573259 T3 ES 2573259T3 ES 09075006 T ES09075006 T ES 09075006T ES 2573259 T3 ES2573259 T3 ES 2573259T3
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ES
Spain
Prior art keywords
polysaccharide
solubilization
capsular polysaccharide
combination vaccines
carrier protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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ES09075006.8T
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English (en)
Inventor
Paolo Costantino
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GlaxoSmithKline Biologicals SA
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GlaxoSmithKline Biologicals SA
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Application filed by GlaxoSmithKline Biologicals SA filed Critical GlaxoSmithKline Biologicals SA
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Publication of ES2573259T3 publication Critical patent/ES2573259T3/es
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
    • A23J1/04—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from fish or other sea animals
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23J—PROTEIN COMPOSITIONS FOR FOODSTUFFS; WORKING-UP PROTEINS FOR FOODSTUFFS; PHOSPHATIDE COMPOSITIONS FOR FOODSTUFFS
    • A23J1/00—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites
    • A23J1/20—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey
    • A23J1/205—Obtaining protein compositions for foodstuffs; Bulk opening of eggs and separation of yolks from whites from milk, e.g. casein; from whey from whey, e.g. lactalbumine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/22—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Neisseriaceae (F)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/285—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Pasteurellaceae (F), e.g. Haemophilus influenza
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09F—NATURAL RESINS; FRENCH POLISH; DRYING-OILS; DRIERS (SICCATIVES); TURPENTINE
    • C09F1/00—Obtaining purification, or chemical modification of natural resins, e.g. oleo-resins
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09G—POLISHING COMPOSITIONS; SKI WAXES
    • C09G1/00—Polishing compositions
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S424/00—Drug, bio-affecting and body treating compositions
    • Y10S424/831—Drug, bio-affecting and body treating compositions involving capsular polysaccharide of bacterium, e.g. polyribosyl ribitol phosphate

Abstract

Un procedimiento para purificar y conjugar un polisacárido capsular bacteriano de Haemophilus influenzae tipo B a una proteína vehículo de toxoide diftérico CRM197, que comprende purificar el polisacárido, que comprende las etapas de (a) precipitación del polisacárido usando uno o más detergentes catiónicos incluyendo bromuro de cetiltrimetilamonio, seguido por (b) solubilización del polisacárido precipitado usando etanol a una concentración final entre el 75 % y el 95 %, después (c) tratamiento del polisacárido solubilizado obtenido en la etapa (b) para retirar los contaminantes, que comprende filtración por tamaño y/o ultrafiltración, activación o funcionalización del polisacárido, y conjugación del polisacárido a la proteína vehículo.
ES09075006.8T 2001-06-20 2002-06-20 Solubilización de polisacárido capsular y vacunas de combinación Expired - Lifetime ES2573259T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0115176 2001-06-20
GBGB0115176.0A GB0115176D0 (en) 2001-06-20 2001-06-20 Capular polysaccharide solubilisation and combination vaccines

Publications (1)

Publication Number Publication Date
ES2573259T3 true ES2573259T3 (es) 2016-06-06

Family

ID=9917070

Family Applications (9)

Application Number Title Priority Date Filing Date
ES09075010.0T Expired - Lifetime ES2670219T3 (es) 2001-06-20 2002-06-20 Disolución de polisacáridos capsulares y vacunas de combinación
ES10007477T Expired - Lifetime ES2387592T5 (es) 2001-06-20 2002-06-20 Vacunas combinadas contra Neisseria meningitidis
ES02755452T Expired - Lifetime ES2261705T5 (es) 2001-06-20 2002-06-20 Solubilización de polisacáridos capsulares
ES10179806.4T Expired - Lifetime ES2539134T3 (es) 2001-06-20 2002-06-20 Vacunas combinadas contra Neisseria meningitidis
ES09075005.0T Expired - Lifetime ES2603275T3 (es) 2001-06-20 2002-06-20 Solubilización de polisacárido capsular y vacunas de combinación
ES09075009.2T Expired - Lifetime ES2670196T3 (es) 2001-06-20 2002-06-20 Disolución de polisacáridos capsulares y vacunas de combinación
ES10179797.5T Expired - Lifetime ES2662015T3 (es) 2001-06-20 2002-06-20 Purificación de polisacáridos capsulares bacterianos
ES06075175T Expired - Lifetime ES2347458T3 (es) 2001-06-20 2002-06-20 Vacunas combinadas contra neisseria meningitidis.
ES09075006.8T Expired - Lifetime ES2573259T3 (es) 2001-06-20 2002-06-20 Solubilización de polisacárido capsular y vacunas de combinación

Family Applications Before (8)

Application Number Title Priority Date Filing Date
ES09075010.0T Expired - Lifetime ES2670219T3 (es) 2001-06-20 2002-06-20 Disolución de polisacáridos capsulares y vacunas de combinación
ES10007477T Expired - Lifetime ES2387592T5 (es) 2001-06-20 2002-06-20 Vacunas combinadas contra Neisseria meningitidis
ES02755452T Expired - Lifetime ES2261705T5 (es) 2001-06-20 2002-06-20 Solubilización de polisacáridos capsulares
ES10179806.4T Expired - Lifetime ES2539134T3 (es) 2001-06-20 2002-06-20 Vacunas combinadas contra Neisseria meningitidis
ES09075005.0T Expired - Lifetime ES2603275T3 (es) 2001-06-20 2002-06-20 Solubilización de polisacárido capsular y vacunas de combinación
ES09075009.2T Expired - Lifetime ES2670196T3 (es) 2001-06-20 2002-06-20 Disolución de polisacáridos capsulares y vacunas de combinación
ES10179797.5T Expired - Lifetime ES2662015T3 (es) 2001-06-20 2002-06-20 Purificación de polisacáridos capsulares bacterianos
ES06075175T Expired - Lifetime ES2347458T3 (es) 2001-06-20 2002-06-20 Vacunas combinadas contra neisseria meningitidis.

Country Status (23)

Country Link
US (9) US8753651B2 (es)
EP (10) EP2229954B1 (es)
JP (4) JP5075317B2 (es)
CN (4) CN101524533A (es)
AT (3) ATE556718T1 (es)
AU (3) AU2002321716B2 (es)
BE (4) BE2010C033I2 (es)
BR (2) BRPI0210590B8 (es)
CA (3) CA2450203C (es)
CY (6) CY1110820T1 (es)
DE (6) DE122010000042I1 (es)
DK (6) DK2189165T3 (es)
ES (9) ES2670219T3 (es)
FR (4) FR10C0042I1 (es)
GB (1) GB0115176D0 (es)
LU (4) LU91732I2 (es)
MX (1) MXPA03011462A (es)
NL (3) NL300458I2 (es)
NZ (2) NZ529881A (es)
PT (6) PT2277536T (es)
RU (2) RU2381814C2 (es)
TR (2) TR201808055T4 (es)
WO (1) WO2003007985A2 (es)

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