ES2071288T3 - Vacuna mejorada de conjugado de polisacarido de meningococos. - Google Patents

Vacuna mejorada de conjugado de polisacarido de meningococos.

Info

Publication number
ES2071288T3
ES2071288T3 ES91900142T ES91900142T ES2071288T3 ES 2071288 T3 ES2071288 T3 ES 2071288T3 ES 91900142 T ES91900142 T ES 91900142T ES 91900142 T ES91900142 T ES 91900142T ES 2071288 T3 ES2071288 T3 ES 2071288T3
Authority
ES
Spain
Prior art keywords
reciprovals
coli
antibodies
modified
polysaccharide conjugate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91900142T
Other languages
English (en)
Inventor
Harold J Jennings
Francis Michon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
National Research Council of Canada
Original Assignee
National Research Council of Canada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by National Research Council of Canada filed Critical National Research Council of Canada
Application granted granted Critical
Publication of ES2071288T3 publication Critical patent/ES2071288T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K16/1232—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1217—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

UN POLISACARIDO DEL GRUPO B DE NEISSERIA MENINGITIDIS (GBMP) MODIFICADO PORQUE TIENE GRUPOS DE N-ACETILO CON RESIDUOS DE ACIDO SIALICO SUSTITUIDOS POR GRUPOS DE N-ACILO QUE PRESENTA UNA RESPUESTA INMUNOLOGICA MAYOR AL MISMO. ADEMAS, LA INDUCCION DE LOS ANTICUERPOS QUE REACCIONAN EN CRUZ CON UN MENINGOCOCO DEL GRUPO B NO MODIFICADO Y CON UN POLISACARIDO CAPSULAR DE E. COLI K1 Y OTRAS CELULAS DE LOS TEJIDOS QUE TIENEN UN EPITOPE EN COMUN SE MINIMIZA. LA CONJUGACION DE LOS POLISACARIDOS MODIFICADOS CON UNA PROTEINA FISIOLOGICAMENTE ACEPTABLE COMO POR EJEMPLO TOXOIDES DE TETANOS INDUCE LA PRODUCCION DE ANTICUERPOS PROTECTORES ESPECIFICOS CON NIVELES INSIGNIFICANTES DE ANTICUERPOS REACTIVOS EN CRUZ DE GBMP, PARA ASI CONSEGUIR UNA PROTECCION CONTRA LAS INFECCIONES CAUSADAS POR LOS MENINGOCOCOS DEL GRUPO B Y LA E. COLI K1.
ES91900142T 1989-12-14 1990-12-13 Vacuna mejorada de conjugado de polisacarido de meningococos. Expired - Lifetime ES2071288T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US44819589A 1989-12-14 1989-12-14

Publications (1)

Publication Number Publication Date
ES2071288T3 true ES2071288T3 (es) 1995-06-16

Family

ID=23779371

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91900142T Expired - Lifetime ES2071288T3 (es) 1989-12-14 1990-12-13 Vacuna mejorada de conjugado de polisacarido de meningococos.

Country Status (30)

Country Link
US (3) US5576002A (es)
EP (1) EP0504202B1 (es)
JP (1) JP2637845B2 (es)
KR (1) KR0158436B1 (es)
CN (4) CN1049223C (es)
AR (1) AR243934A1 (es)
AT (1) ATE121947T1 (es)
AU (1) AU641715B2 (es)
BR (1) BR9007917A (es)
CA (1) CA2071811C (es)
CZ (1) CZ283530B6 (es)
DE (1) DE69019164T2 (es)
DK (1) DK0504202T3 (es)
ES (1) ES2071288T3 (es)
FI (2) FI104539B (es)
HR (1) HRP920872A2 (es)
HU (2) HU218146B (es)
IE (1) IE68414B1 (es)
IL (1) IL96676A (es)
IN (1) IN171747B (es)
NO (2) NO305275B1 (es)
NZ (1) NZ236471A (es)
PH (1) PH30305A (es)
PL (2) PL166035B1 (es)
RO (1) RO111416B1 (es)
RU (1) RU2105568C1 (es)
SI (1) SI20008B (es)
WO (1) WO1991008772A1 (es)
YU (1) YU24391A (es)
ZA (1) ZA9010065B (es)

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EP0504202B1 (en) * 1989-12-14 1995-05-03 National Research Council Of Canada Improved meningococcal polysaccharide conjugate vaccine
KR100293017B1 (ko) * 1992-09-24 2001-09-17 루시에 라포인테-쇼우, 카르타 커티 케이 그룹b스트렙토코쿠스ii형및v형다당류-단백질결합백신
US5439808A (en) * 1993-07-23 1995-08-08 North American Vaccine, Inc. Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis
US6153406A (en) * 1993-07-23 2000-11-28 North American Vaccine, Inc. Method for the high level expression, purification and refolding of the outer membrane protein P2 from Haemophilus influenzae type B
US5679654A (en) * 1994-09-02 1997-10-21 Brigham & Women's Hospital, Inc. Capsular polysaccharide immunomodulator
US5700787A (en) * 1994-09-02 1997-12-23 Brigham & Women's Hospital, Inc. Capsular polysaccharide immunomodulator
US5747287A (en) * 1995-04-28 1998-05-05 North American Vaccine, Inc. Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis
US6284884B1 (en) 1995-06-07 2001-09-04 North American Vaccine, Inc. Antigenic group B streptococcus type II and type III polysaccharide fragments having a 2,5-anhydro-D-mannose terminal structure and conjugate vaccine thereof
ATE400295T1 (de) * 1995-06-07 2008-07-15 Glaxosmithkline Biolog Sa Vakzine mit einem polysaccharide antigen- trägerprotein konjugat und freiem trägerprotein
US5811102A (en) 1995-06-07 1998-09-22 National Research Council Of Canada Modified meningococcal polysaccharide conjugate vaccines
ZA97248B (en) * 1996-01-18 1997-07-18 Rohm & Haas Method for identifying and quantifying polymers utilizing immunoassay techniques
WO1998008874A1 (en) 1996-08-27 1998-03-05 Chiron Corporation Monoclonal antibodies that define unique meningococcal b epitopes and their use in the preparation of vaccine compositions
WO1998008543A1 (en) † 1996-08-27 1998-03-05 Chiron Corporation Neisseria meningitidis serogroup b glycoconjugates and methods of using the same
US6426074B1 (en) * 1997-03-19 2002-07-30 The Brigham And Women's Hospital Inc. Group B Streptococcus vaccine
JP2002506448A (ja) 1997-06-24 2002-02-26 カイロン コーポレイション 抗髄膜炎菌ワクチン組成物を使用して成体を免疫する方法
ATE421527T1 (de) 1997-08-27 2009-02-15 Novartis Vaccines & Diagnostic Molekular-mimetika von meningokokkus b epitopen
ES2346022T3 (es) 1997-12-23 2010-10-07 Baxter Healthcare S.A. Procedimiento para la extraccion y el aislamiento de polisacaridos capsulares bacterianos para su uso como vacunas o ligandos a proteinas como vacunas de conjugados.
DE69941574D1 (de) * 1998-08-19 2009-12-03 Baxter Healthcare Sa Immunogenes beta-propionamido-gebundenes polysaccharid-protein konjugat geeignet als impfstoff und hergestellt bei verwendung von n-acryloyliertem polysaccharid
US6436653B1 (en) 1998-12-15 2002-08-20 Exiqon A/S Method for introduction of reporter groups into bacterial lipopolysaccharide-derived carbohydrates and the subsequent coupling of such derivatives onto solid surfaces
US7083777B1 (en) * 1999-04-02 2006-08-01 The Brigham And Women's Hospital, Inc. Immunomodulating polymers
US6518037B2 (en) * 1999-11-12 2003-02-11 University Of Iowa Research Foundation Two-component system that controls bacterial membrane synthesis
GB9928196D0 (en) * 1999-11-29 2000-01-26 Chiron Spa Combinations of B, C and other antigens
SV2003000753A (es) 2000-12-05 2003-06-16 Brigham & Womens Hospital Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico
AU2002252638A1 (en) 2001-04-17 2002-10-28 Children's Hospital Oakland Research Institute Molecular mimetics of meningococcal b epitopes which elicit functionally active antibodies
GB0115176D0 (en) * 2001-06-20 2001-08-15 Chiron Spa Capular polysaccharide solubilisation and combination vaccines
GB0121591D0 (en) * 2001-09-06 2001-10-24 Chiron Spa Hybrid and tandem expression of neisserial proteins
AR045702A1 (es) 2001-10-03 2005-11-09 Chiron Corp Composiciones de adyuvantes.
DE60325565D1 (de) * 2002-03-26 2009-02-12 Novartis Vaccines & Diagnostic Modifizierte saccharide mit verbesserter stabilität in wasser
EP1638581A2 (en) * 2003-03-31 2006-03-29 The Brigham And Women's Hospital, Inc. Zwitterionic immunomodulators for the treatment of asthma and allergy
US7731967B2 (en) 2003-04-30 2010-06-08 Novartis Vaccines And Diagnostics, Inc. Compositions for inducing immune responses
EP1654290B1 (en) 2003-08-12 2019-03-13 Lipoxen Technologies Limited Sialic acid derivatives for protein derivatisation and conjugation
KR20070060069A (ko) 2004-06-23 2007-06-12 칠드런즈 하스피틀 앤드 리써치 센터 앳 오클랜드 다당류 유도체 및 면역반응의 유도에서의 용도
US8148335B2 (en) 2004-06-23 2012-04-03 Children's Hospital & Research Center Oakland De-N-acetyl sialic acid antigens, antibodies thereto, and methods of use in cancer therapy
GB0428394D0 (en) * 2004-12-24 2005-02-02 Chiron Srl Saccharide conjugate vaccines
PT1896065E (pt) 2005-06-27 2011-08-31 Glaxosmithkline Biolog Sa Processo para a preparação de vacinas
US8206726B2 (en) 2006-02-06 2012-06-26 The Brigham And Women's Hospital, Inc. Zwitterionic polysaccharides for promotion of immune system maturation and health
GB0611914D0 (en) 2006-06-15 2006-07-26 Teti Giuseppe Peptides that mimic non-human cross-reactive protective epitopes of the group Bmeningococcal capsulsar polysaccharide
EP1872791A1 (en) * 2006-06-30 2008-01-02 Institut Pasteur Use of bacterial polysaccharides for biofilm inhibition
AU2008265767B2 (en) * 2007-06-20 2014-11-13 Pfizer Ireland Pharmaceuticals Modified polysaccharides for conjugate vaccines
EP3067048B1 (en) 2007-12-07 2018-02-14 GlaxoSmithKline Biologicals SA Compositions for inducing immune responses
WO2010083477A2 (en) 2009-01-16 2010-07-22 University Of Maryland, Baltimore Broad spectrum vaccine against non-typhoidal salmonella
WO2013009945A1 (en) 2011-07-12 2013-01-17 The Brigham And Women's Hospital, Inc. Lipid-containing psa compositions, methods of isolation and methods of use thereof
EP2752403A1 (de) * 2013-01-08 2014-07-09 Sika Technology AG Amin für emissionsarme Epoxidharz-Produkte
WO2017031431A1 (en) 2015-08-19 2017-02-23 President And Fellows Of Harvard College Lipidated psa compositions and methods
EP3484441A4 (en) 2016-07-15 2020-03-18 President and Fellows of Harvard College GLYCOLIPID COMPOSITIONS AND METHODS OF USE
MX2019009011A (es) * 2017-01-31 2019-09-26 Pfizer Composiciones de neisseria meningitidis y metodos respectivos.

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Also Published As

Publication number Publication date
NO922316D0 (no) 1992-06-12
NO973311D0 (no) 1997-07-17
SI20008B (en) 2001-02-28
EP0504202B1 (en) 1995-05-03
HRP920872A2 (en) 1997-06-30
JPH05505392A (ja) 1993-08-12
DK0504202T3 (da) 1995-10-02
CN1100656A (zh) 1995-03-29
ATE121947T1 (de) 1995-05-15
US5902586A (en) 1999-05-11
IE68414B1 (en) 1996-06-12
AR243934A1 (es) 1993-09-30
YU24391A (sh) 1995-12-04
HUT64480A (en) 1994-01-28
WO1991008772A1 (en) 1991-06-27
IL96676A0 (en) 1991-09-16
IL96676A (en) 1996-09-12
NZ236471A (en) 1992-10-28
CZ628490A3 (en) 1997-12-17
PL166035B1 (pl) 1995-03-31
PH30305A (en) 1997-02-20
HU218146B (hu) 2000-06-28
NO922316L (no) 1992-08-14
KR0158436B1 (ko) 1998-12-01
NO307835B1 (no) 2000-06-05
NO973311L (no) 1992-08-14
RU2105568C1 (ru) 1998-02-27
CN1049223C (zh) 2000-02-09
DE69019164D1 (de) 1995-06-08
SI20008A (sl) 2000-02-29
CN1036504C (zh) 1997-11-26
IE904513A1 (en) 1991-06-19
CN1100428A (zh) 1995-03-22
FI104539B (fi) 2000-02-29
CN1055541A (zh) 1991-10-23
US5683699A (en) 1997-11-04
CN1072506C (zh) 2001-10-10
CN1036522C (zh) 1997-11-26
FI19991917A (fi) 1999-09-09
NO305275B1 (no) 1999-05-03
DE69019164T2 (de) 1995-09-07
IN171747B (es) 1992-12-26
CA2071811C (en) 2003-11-04
HU9201966D0 (en) 1992-10-28
JP2637845B2 (ja) 1997-08-06
PL166659B1 (pl) 1995-06-30
AU641715B2 (en) 1993-09-30
ZA9010065B (en) 1992-02-26
EP0504202A1 (en) 1992-09-23
CN1096516A (zh) 1994-12-21
AU6898791A (en) 1991-07-18
PL288271A1 (en) 1991-12-16
FI922737A0 (fi) 1992-06-12
RO111416B1 (ro) 1996-10-31
BR9007917A (pt) 1992-10-20
CA2071811A1 (en) 1991-06-15
CZ283530B6 (cs) 1998-04-15
US5576002A (en) 1996-11-19

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