SI20008B - Improved meningococcal polysaccharide conjugate vaccine - Google Patents

Improved meningococcal polysaccharide conjugate vaccine Download PDF

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Publication number
SI20008B
SI20008B SI9110243A SI9110243A SI20008B SI 20008 B SI20008 B SI 20008B SI 9110243 A SI9110243 A SI 9110243A SI 9110243 A SI9110243 A SI 9110243A SI 20008 B SI20008 B SI 20008B
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SI
Slovenia
Prior art keywords
group
butanoyl
polysaccharide
pentanoyl
modified polysaccharide
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SI9110243A
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English (en)
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SI20008A (sl
Inventor
Harold J Jennings
Francis Michon
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Ca Nat Research Council
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Publication of SI20008A publication Critical patent/SI20008A/sl
Publication of SI20008B publication Critical patent/SI20008B/sl

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K16/1232—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Escherichia (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1217—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Neisseriaceae (F)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Claims (16)

  1. Λ IZBOLJŠANO MENINGOKOKALNO POLISAHARIDNO KONJUGIRANO CEPIVO PATENTNI ZAHTEVKI 1. Modificirani polisaharid skupine B Neisseria Meningitidis, značilen po tem, da ima ostanek sialinske kisline N-acetilnih skupin naravnega polisaharida nadomeščene s C4-C8-acilnimi skupinami, kjer ima modificirani polisaharid povprečno molekulsko maso v obsegu 10.000 do 50.000 Daltonov.
  2. 2. Modificirani polisaharid KI iz ovojnice E. coli, značilen po tem, da ima ostanek sialinske kisline iz N-acetilnih skupin naravnega polisaharida nadomeščene s C4-C8 acilnimi skupinami, kjer ima modificirani polisaharid povprečno molekulsko maso v obsegu 10.000 do 50.000 Daltonov.
  3. 3. Modificiran polisaharid po zahtevku 1 , značilen po tem, da je C4-C8 acilna skupina izbrana iz skupine, ki jo sestavljajo n-butanoil, izobutanoil, n-pentanoil, n-heksanoil, n-heptanoil in n-oktanoil.
  4. 4.Modificirani polisaharid po zahtevku 3, značilen po tem, da je acilna skupina izbrana iz skupine, ki jo sestavljajo n-butanoil, izo-butanoil, n-pentanoil in n- heksanoil. 2 ^ · Modificiran polisaharid po zahtevku 2 , značilen po tem, da je C4-C8 skupina izbrana iz skupine, ki jo sestavljajo n-butanoil, izo-butanoil, n-pentanoil, n-heksanoil, n-heptanoil in n-oktanoil.
  5. 6.Modificirani polisaharid po zahtevku 5, značilen po tem, da je acilna skupina izbrana iz skupine, ki jo sestavljajo n-butanoil, izo-butanoil, n-pentanoil in n-heksanoil. 1 - Polisaharid po zahtevku 1, značilen po tem, da je od 90% do 100% ostanka slatinske kisline N-acetilnih skupin nadomeščeno s C^-Cg-acilnimi skupinami.
  6. 8. Polisaharid po zahtevku 2, značilen po tem, da je od 90% do 100% ostanka sialinske kisline N-acetilnih skupin nadomeščeno s C4-Ce-acilnimi skupinami.
  7. 9. Antigenski konjugat, značilen po tem, da obsega modificirano skupino polisaharida B Neisseria meningitidis, ki ima ostanek sialinske kisline N-acetilne skupine nadomeščen z N-C^-Cg-acilno skupino, konjugiran na imunološko primeren protein, kjer ima modificirani polisaharid povprečno molekulsko maso v obsegu 10.000 do 50.000 Daltonov.
  8. 10. Konjugat po zahtevku 9, značilen po tem, da je acilna skupina izbrana iz skupine, ki jo sestavljajo n-butanoil, izo-butanoil, n-pentanoil, izo-pentanoil, neo-pentanoil, heksanoil, heptanoil in oktanoil.
  9. 11. Konjugat po zahtevku 10, značilen po tem, da je acilna skupina izbrana iz skupine, ki jo sestavljajo n-butanoil, izo-butanoil, n-pentanoil in heksanoil. 3
  10. 12. Konjugat po zahtevku 9, značilen po tem, da je protein izbran iz skupine, ki jo sestavljajo tetanusni toksoid, difteria toksoid, navzkrižno reaktivni material (CRM) in bakterijski proteinski nosilec.
  11. 13. Konjugat po zahtevku 9, značilen po tem, da sta protein in polisaharid povezana kovalentno z vezjo -CH2-NH-protein.
  12. 14. Konjugat po zahtevku 12, značilen po tem, da je CRM CRM197.
  13. 15. Cepivo, značilno po tem, da obsega konjugat po zahtevku 9 in farmacevtsko sprejemljiv injekcijski nosilec.
  14. 16. Cepivo po zahtevku 15, značilno po tem, da nadalje obsega tudi fiziološko sprejemljiv adjuvant.
  15. 17. Cepivo po zahtevku 16, značilno po tem, da je omenjeni adjuvant izbran iz skupine, ki jo sestavljajo aluminijev hidroksid, aluminijev fosfat in aluminijev sulfat.
  16. 18. Gama globulinska frakcija, značilna po tem, da je sposobna pasivno zaščititi proti meningitisu, ki ga povzroča skupina B N. meningitidis in E. coli KI, omenjeno frakcijo pa pridobivamo z imunizacijo sesalcev s cepivom, po zahtevku 17, nakar sledi izločaje gama globulina iz omenjenega sesalca.
SI9110243A 1989-12-14 1990-12-14 Improved meningococcal polysaccharide conjugate vaccine SI20008B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44819589A 1989-12-14 1989-12-14
YU24391A YU24391A (sh) 1989-12-14 1990-12-14 Poboljšana meningokokna polisaharid kon-jugovana vakcina

Publications (2)

Publication Number Publication Date
SI20008A SI20008A (sl) 2000-02-29
SI20008B true SI20008B (en) 2001-02-28

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ID=23779371

Family Applications (1)

Application Number Title Priority Date Filing Date
SI9110243A SI20008B (en) 1989-12-14 1990-12-14 Improved meningococcal polysaccharide conjugate vaccine

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US (3) US5576002A (sl)
EP (1) EP0504202B1 (sl)
JP (1) JP2637845B2 (sl)
KR (1) KR0158436B1 (sl)
CN (4) CN1049223C (sl)
AR (1) AR243934A1 (sl)
AT (1) ATE121947T1 (sl)
AU (1) AU641715B2 (sl)
BR (1) BR9007917A (sl)
CA (1) CA2071811C (sl)
CZ (1) CZ283530B6 (sl)
DE (1) DE69019164T2 (sl)
DK (1) DK0504202T3 (sl)
ES (1) ES2071288T3 (sl)
FI (2) FI104539B (sl)
HR (1) HRP920872A2 (sl)
HU (2) HU218146B (sl)
IE (1) IE68414B1 (sl)
IL (1) IL96676A (sl)
IN (1) IN171747B (sl)
NO (2) NO305275B1 (sl)
NZ (1) NZ236471A (sl)
PH (1) PH30305A (sl)
PL (2) PL166659B1 (sl)
RO (1) RO111416B1 (sl)
RU (1) RU2105568C1 (sl)
SI (1) SI20008B (sl)
WO (1) WO1991008772A1 (sl)
YU (1) YU24391A (sl)
ZA (1) ZA9010065B (sl)

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US5683699A (en) 1997-11-04
CZ628490A3 (en) 1997-12-17
RO111416B1 (ro) 1996-10-31
ZA9010065B (en) 1992-02-26
PL166659B1 (pl) 1995-06-30
YU24391A (sh) 1995-12-04
CN1072506C (zh) 2001-10-10
CN1049223C (zh) 2000-02-09
NO973311L (no) 1992-08-14
BR9007917A (pt) 1992-10-20
FI922737A0 (fi) 1992-06-12
PL288271A1 (en) 1991-12-16
IL96676A (en) 1996-09-12
NO973311D0 (no) 1997-07-17
IL96676A0 (en) 1991-09-16
WO1991008772A1 (en) 1991-06-27
US5576002A (en) 1996-11-19
CN1096516A (zh) 1994-12-21
CN1055541A (zh) 1991-10-23
DE69019164T2 (de) 1995-09-07
DE69019164D1 (de) 1995-06-08
IE68414B1 (en) 1996-06-12
CZ283530B6 (cs) 1998-04-15
CA2071811C (en) 2003-11-04
IE904513A1 (en) 1991-06-19
DK0504202T3 (da) 1995-10-02
NO922316D0 (no) 1992-06-12
EP0504202B1 (en) 1995-05-03
CN1036504C (zh) 1997-11-26
PL166035B1 (pl) 1995-03-31
JP2637845B2 (ja) 1997-08-06
CN1100428A (zh) 1995-03-22
AR243934A1 (es) 1993-09-30
FI104539B (fi) 2000-02-29
AU6898791A (en) 1991-07-18
FI19991917L (fi) 1999-09-09
ATE121947T1 (de) 1995-05-15
NZ236471A (en) 1992-10-28
US5902586A (en) 1999-05-11
NO307835B1 (no) 2000-06-05
FI19991917A7 (fi) 1999-09-09
HU9201966D0 (en) 1992-10-28
HUT64480A (en) 1994-01-28
PH30305A (en) 1997-02-20
SI20008A (sl) 2000-02-29
ES2071288T3 (es) 1995-06-16
IN171747B (sl) 1992-12-26
HU218146B (hu) 2000-06-28
KR0158436B1 (ko) 1998-12-01
NO922316L (no) 1992-08-14
AU641715B2 (en) 1993-09-30
NO305275B1 (no) 1999-05-03
JPH05505392A (ja) 1993-08-12
RU2105568C1 (ru) 1998-02-27
CA2071811A1 (en) 1991-06-15
CN1100656A (zh) 1995-03-29
EP0504202A1 (en) 1992-09-23
HRP920872A2 (en) 1997-06-30
CN1036522C (zh) 1997-11-26

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