SI20008B - Improved meningococcal polysaccharide conjugate vaccine - Google Patents
Improved meningococcal polysaccharide conjugate vaccine Download PDFInfo
- Publication number
- SI20008B SI20008B SI9110243A SI9110243A SI20008B SI 20008 B SI20008 B SI 20008B SI 9110243 A SI9110243 A SI 9110243A SI 9110243 A SI9110243 A SI 9110243A SI 20008 B SI20008 B SI 20008B
- Authority
- SI
- Slovenia
- Prior art keywords
- group
- butanoyl
- polysaccharide
- pentanoyl
- modified polysaccharide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K16/1232—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Escherichia (G)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0258—Escherichia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1217—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Neisseriaceae (F)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Claims (16)
- Λ IZBOLJŠANO MENINGOKOKALNO POLISAHARIDNO KONJUGIRANO CEPIVO PATENTNI ZAHTEVKI 1. Modificirani polisaharid skupine B Neisseria Meningitidis, značilen po tem, da ima ostanek sialinske kisline N-acetilnih skupin naravnega polisaharida nadomeščene s C4-C8-acilnimi skupinami, kjer ima modificirani polisaharid povprečno molekulsko maso v obsegu 10.000 do 50.000 Daltonov.
- 2. Modificirani polisaharid KI iz ovojnice E. coli, značilen po tem, da ima ostanek sialinske kisline iz N-acetilnih skupin naravnega polisaharida nadomeščene s C4-C8 acilnimi skupinami, kjer ima modificirani polisaharid povprečno molekulsko maso v obsegu 10.000 do 50.000 Daltonov.
- 3. Modificiran polisaharid po zahtevku 1 , značilen po tem, da je C4-C8 acilna skupina izbrana iz skupine, ki jo sestavljajo n-butanoil, izobutanoil, n-pentanoil, n-heksanoil, n-heptanoil in n-oktanoil.
- 4.Modificirani polisaharid po zahtevku 3, značilen po tem, da je acilna skupina izbrana iz skupine, ki jo sestavljajo n-butanoil, izo-butanoil, n-pentanoil in n- heksanoil. 2 ^ · Modificiran polisaharid po zahtevku 2 , značilen po tem, da je C4-C8 skupina izbrana iz skupine, ki jo sestavljajo n-butanoil, izo-butanoil, n-pentanoil, n-heksanoil, n-heptanoil in n-oktanoil.
- 6.Modificirani polisaharid po zahtevku 5, značilen po tem, da je acilna skupina izbrana iz skupine, ki jo sestavljajo n-butanoil, izo-butanoil, n-pentanoil in n-heksanoil. 1 - Polisaharid po zahtevku 1, značilen po tem, da je od 90% do 100% ostanka slatinske kisline N-acetilnih skupin nadomeščeno s C^-Cg-acilnimi skupinami.
- 8. Polisaharid po zahtevku 2, značilen po tem, da je od 90% do 100% ostanka sialinske kisline N-acetilnih skupin nadomeščeno s C4-Ce-acilnimi skupinami.
- 9. Antigenski konjugat, značilen po tem, da obsega modificirano skupino polisaharida B Neisseria meningitidis, ki ima ostanek sialinske kisline N-acetilne skupine nadomeščen z N-C^-Cg-acilno skupino, konjugiran na imunološko primeren protein, kjer ima modificirani polisaharid povprečno molekulsko maso v obsegu 10.000 do 50.000 Daltonov.
- 10. Konjugat po zahtevku 9, značilen po tem, da je acilna skupina izbrana iz skupine, ki jo sestavljajo n-butanoil, izo-butanoil, n-pentanoil, izo-pentanoil, neo-pentanoil, heksanoil, heptanoil in oktanoil.
- 11. Konjugat po zahtevku 10, značilen po tem, da je acilna skupina izbrana iz skupine, ki jo sestavljajo n-butanoil, izo-butanoil, n-pentanoil in heksanoil. 3
- 12. Konjugat po zahtevku 9, značilen po tem, da je protein izbran iz skupine, ki jo sestavljajo tetanusni toksoid, difteria toksoid, navzkrižno reaktivni material (CRM) in bakterijski proteinski nosilec.
- 13. Konjugat po zahtevku 9, značilen po tem, da sta protein in polisaharid povezana kovalentno z vezjo -CH2-NH-protein.
- 14. Konjugat po zahtevku 12, značilen po tem, da je CRM CRM197.
- 15. Cepivo, značilno po tem, da obsega konjugat po zahtevku 9 in farmacevtsko sprejemljiv injekcijski nosilec.
- 16. Cepivo po zahtevku 15, značilno po tem, da nadalje obsega tudi fiziološko sprejemljiv adjuvant.
- 17. Cepivo po zahtevku 16, značilno po tem, da je omenjeni adjuvant izbran iz skupine, ki jo sestavljajo aluminijev hidroksid, aluminijev fosfat in aluminijev sulfat.
- 18. Gama globulinska frakcija, značilna po tem, da je sposobna pasivno zaščititi proti meningitisu, ki ga povzroča skupina B N. meningitidis in E. coli KI, omenjeno frakcijo pa pridobivamo z imunizacijo sesalcev s cepivom, po zahtevku 17, nakar sledi izločaje gama globulina iz omenjenega sesalca.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44819589A | 1989-12-14 | 1989-12-14 | |
| YU24391A YU24391A (sh) | 1989-12-14 | 1990-12-14 | Poboljšana meningokokna polisaharid kon-jugovana vakcina |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| SI20008A SI20008A (sl) | 2000-02-29 |
| SI20008B true SI20008B (en) | 2001-02-28 |
Family
ID=23779371
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI9110243A SI20008B (en) | 1989-12-14 | 1990-12-14 | Improved meningococcal polysaccharide conjugate vaccine |
Country Status (30)
| Country | Link |
|---|---|
| US (3) | US5576002A (sl) |
| EP (1) | EP0504202B1 (sl) |
| JP (1) | JP2637845B2 (sl) |
| KR (1) | KR0158436B1 (sl) |
| CN (4) | CN1049223C (sl) |
| AR (1) | AR243934A1 (sl) |
| AT (1) | ATE121947T1 (sl) |
| AU (1) | AU641715B2 (sl) |
| BR (1) | BR9007917A (sl) |
| CA (1) | CA2071811C (sl) |
| CZ (1) | CZ283530B6 (sl) |
| DE (1) | DE69019164T2 (sl) |
| DK (1) | DK0504202T3 (sl) |
| ES (1) | ES2071288T3 (sl) |
| FI (2) | FI104539B (sl) |
| HR (1) | HRP920872A2 (sl) |
| HU (2) | HU218146B (sl) |
| IE (1) | IE68414B1 (sl) |
| IL (1) | IL96676A (sl) |
| IN (1) | IN171747B (sl) |
| NO (2) | NO305275B1 (sl) |
| NZ (1) | NZ236471A (sl) |
| PH (1) | PH30305A (sl) |
| PL (2) | PL166659B1 (sl) |
| RO (1) | RO111416B1 (sl) |
| RU (1) | RU2105568C1 (sl) |
| SI (1) | SI20008B (sl) |
| WO (1) | WO1991008772A1 (sl) |
| YU (1) | YU24391A (sl) |
| ZA (1) | ZA9010065B (sl) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5648241A (en) * | 1989-09-15 | 1997-07-15 | The General Hospital Corporation | Conjugate vaccine against group B streptococcus |
| RU2105568C1 (ru) * | 1989-12-14 | 1998-02-27 | Нэшнл Рисерч Каунсл Оф Канада | Полисахарид neisseria meningitidis с модифицированной группой b, конъюгированный антиген, вакцина против менингита группы b и способ индукции ответа антител к менингиту группы b |
| JP4163251B2 (ja) * | 1992-09-24 | 2008-10-08 | ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド | グループbストレプトコッカス・タイプ▲ii▼およびタイプ▲v▼多糖−蛋白質接合ワクチン |
| US6153406A (en) * | 1993-07-23 | 2000-11-28 | North American Vaccine, Inc. | Method for the high level expression, purification and refolding of the outer membrane protein P2 from Haemophilus influenzae type B |
| US5439808A (en) * | 1993-07-23 | 1995-08-08 | North American Vaccine, Inc. | Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis |
| US5679654A (en) * | 1994-09-02 | 1997-10-21 | Brigham & Women's Hospital, Inc. | Capsular polysaccharide immunomodulator |
| US5700787A (en) * | 1994-09-02 | 1997-12-23 | Brigham & Women's Hospital, Inc. | Capsular polysaccharide immunomodulator |
| US5747287A (en) * | 1995-04-28 | 1998-05-05 | North American Vaccine, Inc. | Method for the high level expression, purification and refolding of the outer membrane group B porin proteins from Neisseria meningitidis |
| US5811102A (en) * | 1995-06-07 | 1998-09-22 | National Research Council Of Canada | Modified meningococcal polysaccharide conjugate vaccines |
| US6284884B1 (en) | 1995-06-07 | 2001-09-04 | North American Vaccine, Inc. | Antigenic group B streptococcus type II and type III polysaccharide fragments having a 2,5-anhydro-D-mannose terminal structure and conjugate vaccine thereof |
| WO1996040242A1 (en) * | 1995-06-07 | 1996-12-19 | Smithkline Beecham Biologicals S.A. | Vaccine comprising a polysaccharide antigen-carrier protein conjugate and free carrier protein |
| ZA97248B (en) * | 1996-01-18 | 1997-07-18 | Rohm & Haas | Method for identifying and quantifying polymers utilizing immunoassay techniques |
| ATE252602T1 (de) * | 1996-08-27 | 2003-11-15 | Chiron Corp | Meningokokkus b-epitop ausbildende monoklonale antikoerper und deren verwendung zur herstellung von impfstoffzusammenstellungen |
| ATE208629T1 (de) | 1996-08-27 | 2001-11-15 | Chiron Corp | Neisseria meningitidis serogruppe b glykokonjugate und verfahren zu deren verwendung |
| US6426074B1 (en) | 1997-03-19 | 2002-07-30 | The Brigham And Women's Hospital Inc. | Group B Streptococcus vaccine |
| WO1998058670A1 (en) | 1997-06-24 | 1998-12-30 | Chiron Corporation | Methods of immunizing adults using anti-meningococcal vaccine compositions |
| ATE505478T1 (de) | 1997-08-27 | 2011-04-15 | Novartis Vaccines & Diagnostic | Molekular-mimetika von meningokokkalen b epitopen |
| CA2316975C (en) | 1997-12-23 | 2009-03-24 | North American Vaccine, Inc. | Procedures for the extraction and isolation of bacterial capsular polysaccharides for use as vaccines or linked to proteins as conjugate vaccines |
| PL346645A1 (en) * | 1998-08-19 | 2002-02-25 | North American Vaccine | IMMUNOGENIC β-PROPIONAMIDO-LINKED POLYSACCHARIDE PROTEIN CONJUGATE USEFUL AS A VACCINE PRODUCED USING AN N-ACRYLOYLATED POLYSACCHARIDE |
| CA2340692A1 (en) * | 1998-08-19 | 2000-03-02 | North American Vaccine, Inc. | Immunogenic .beta.-propionamido-linked polysaccharide protein conjugate useful as a vaccine produced using an n-acryloylated polysaccharide |
| US6436653B1 (en) | 1998-12-15 | 2002-08-20 | Exiqon A/S | Method for introduction of reporter groups into bacterial lipopolysaccharide-derived carbohydrates and the subsequent coupling of such derivatives onto solid surfaces |
| US7083777B1 (en) * | 1999-04-02 | 2006-08-01 | The Brigham And Women's Hospital, Inc. | Immunomodulating polymers |
| US6518037B2 (en) * | 1999-11-12 | 2003-02-11 | University Of Iowa Research Foundation | Two-component system that controls bacterial membrane synthesis |
| GB9928196D0 (en) * | 1999-11-29 | 2000-01-26 | Chiron Spa | Combinations of B, C and other antigens |
| GB0011108D0 (en) * | 2000-05-08 | 2000-06-28 | Microscience Ltd | Virulence gene and protein and their use |
| SV2003000753A (es) | 2000-12-05 | 2003-06-16 | Brigham & Womens Hospital | Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico |
| CN1306956C (zh) | 2001-04-17 | 2007-03-28 | 希龙公司 | 诱导功能活性抗体的脑膜炎球菌b抗原表位的分子模拟物 |
| GB0115176D0 (en) * | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
| GB0121591D0 (en) * | 2001-09-06 | 2001-10-24 | Chiron Spa | Hybrid and tandem expression of neisserial proteins |
| AR045702A1 (es) | 2001-10-03 | 2005-11-09 | Chiron Corp | Composiciones de adyuvantes. |
| MXPA04009339A (es) * | 2002-03-26 | 2005-01-25 | Chiron Srl | Sacaridos modificados que tienen estabilidad mejorada en agua. |
| WO2003094960A2 (en) * | 2002-05-14 | 2003-11-20 | Chiron Srl | Mucosal combination vaccines for bacterial meningitis |
| RU2364418C2 (ru) * | 2002-08-02 | 2009-08-20 | ГлаксоСмитКлайн Байолоджикалз с.а. | ВАКЦИННЫЕ КОМПОЗИЦИИ, СОДЕРЖАЩИЕ ЛИПОПОЛИСАХАРИДЫ ИММУНОТИПА L2 И/ИЛИ L3, ПРОИСХОДЯЩИЕ ИЗ ШТАММА NEISSERIA MENINGITIDIS IgtB- |
| GB0227346D0 (en) * | 2002-11-22 | 2002-12-31 | Chiron Spa | 741 |
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| US7731967B2 (en) | 2003-04-30 | 2010-06-08 | Novartis Vaccines And Diagnostics, Inc. | Compositions for inducing immune responses |
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| KR20070060069A (ko) | 2004-06-23 | 2007-06-12 | 칠드런즈 하스피틀 앤드 리써치 센터 앳 오클랜드 | 다당류 유도체 및 면역반응의 유도에서의 용도 |
| US8148335B2 (en) | 2004-06-23 | 2012-04-03 | Children's Hospital & Research Center Oakland | De-N-acetyl sialic acid antigens, antibodies thereto, and methods of use in cancer therapy |
| GB0428394D0 (en) * | 2004-12-24 | 2005-02-02 | Chiron Srl | Saccharide conjugate vaccines |
| PL2878307T3 (pl) | 2005-06-27 | 2020-01-31 | Glaxosmithkline Biologicals S.A. | Kompozycja immunogenna |
| US8206726B2 (en) | 2006-02-06 | 2012-06-26 | The Brigham And Women's Hospital, Inc. | Zwitterionic polysaccharides for promotion of immune system maturation and health |
| GB0611914D0 (en) | 2006-06-15 | 2006-07-26 | Teti Giuseppe | Peptides that mimic non-human cross-reactive protective epitopes of the group Bmeningococcal capsulsar polysaccharide |
| EP1872791A1 (en) * | 2006-06-30 | 2008-01-02 | Institut Pasteur | Use of bacterial polysaccharides for biofilm inhibition |
| EP2170391B1 (en) * | 2007-06-20 | 2017-01-18 | Pfizer Ireland Pharmaceuticals | Modified polysaccharides for conjugate vaccines |
| EP3067048B1 (en) | 2007-12-07 | 2018-02-14 | GlaxoSmithKline Biologicals SA | Compositions for inducing immune responses |
| WO2010083477A2 (en) | 2009-01-16 | 2010-07-22 | University Of Maryland, Baltimore | Broad spectrum vaccine against non-typhoidal salmonella |
| WO2013009945A1 (en) | 2011-07-12 | 2013-01-17 | The Brigham And Women's Hospital, Inc. | Lipid-containing psa compositions, methods of isolation and methods of use thereof |
| EP2752403A1 (de) * | 2013-01-08 | 2014-07-09 | Sika Technology AG | Amin für emissionsarme Epoxidharz-Produkte |
| CA2997211A1 (en) | 2015-08-19 | 2017-02-23 | President And Fellows Of Harvard College | Lipidated psa compositions and methods |
| CA3030974A1 (en) | 2016-07-15 | 2018-01-18 | President And Fellows Of Harvard College | Glycolipid compositions and methods of use |
| SG10202111092UA (en) * | 2017-01-31 | 2021-11-29 | Pfizer | Neisseria meningitidis compositions and methods thereof |
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| US4356170A (en) * | 1981-05-27 | 1982-10-26 | Canadian Patents & Development Ltd. | Immunogenic polysaccharide-protein conjugates |
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| US4727136A (en) * | 1985-10-01 | 1988-02-23 | Canadian Patents And Development Ltd. | Modified meningococcal group B polysaccharide for conjugate vaccine |
| RU2105568C1 (ru) * | 1989-12-14 | 1998-02-27 | Нэшнл Рисерч Каунсл Оф Канада | Полисахарид neisseria meningitidis с модифицированной группой b, конъюгированный антиген, вакцина против менингита группы b и способ индукции ответа антител к менингиту группы b |
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1990
- 1990-12-13 RU SU5052391A patent/RU2105568C1/ru active
- 1990-12-13 DK DK91900142.0T patent/DK0504202T3/da active
- 1990-12-13 AU AU68987/91A patent/AU641715B2/en not_active Ceased
- 1990-12-13 ES ES91900142T patent/ES2071288T3/es not_active Expired - Lifetime
- 1990-12-13 CA CA002071811A patent/CA2071811C/en not_active Expired - Fee Related
- 1990-12-13 KR KR1019920701403A patent/KR0158436B1/ko not_active Expired - Fee Related
- 1990-12-13 WO PCT/CA1990/000437 patent/WO1991008772A1/en not_active Ceased
- 1990-12-13 AT AT91900142T patent/ATE121947T1/de not_active IP Right Cessation
- 1990-12-13 DE DE69019164T patent/DE69019164T2/de not_active Expired - Fee Related
- 1990-12-13 RO RO92-0789A patent/RO111416B1/ro unknown
- 1990-12-13 HU HU9201966A patent/HU218146B/hu unknown
- 1990-12-13 EP EP91900142A patent/EP0504202B1/en not_active Expired - Lifetime
- 1990-12-13 BR BR909007917A patent/BR9007917A/pt not_active Application Discontinuation
- 1990-12-13 HU HU9201966A patent/HU9201966D0/hu unknown
- 1990-12-13 JP JP3500908A patent/JP2637845B2/ja not_active Expired - Fee Related
- 1990-12-14 AR AR90318627A patent/AR243934A1/es active
- 1990-12-14 PL PL90302476A patent/PL166659B1/pl not_active IP Right Cessation
- 1990-12-14 CZ CS906284A patent/CZ283530B6/cs unknown
- 1990-12-14 SI SI9110243A patent/SI20008B/sl not_active IP Right Cessation
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1992
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1993
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1994
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1995
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1997
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1999
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Effective date: 20090910 |