ES2000140A6 - Procedimiento para preparar vacunas conjugadas no toxicas contra infecciones por bacterias gram-negativas - Google Patents

Procedimiento para preparar vacunas conjugadas no toxicas contra infecciones por bacterias gram-negativas

Info

Publication number
ES2000140A6
ES2000140A6 ES8601006A ES8601006A ES2000140A6 ES 2000140 A6 ES2000140 A6 ES 2000140A6 ES 8601006 A ES8601006 A ES 8601006A ES 8601006 A ES8601006 A ES 8601006A ES 2000140 A6 ES2000140 A6 ES 2000140A6
Authority
ES
Spain
Prior art keywords
toxin
polysaccharide
preparation
methods
conjugate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8601006A
Other languages
English (en)
Inventor
Stanley J Cryz
Emil Fuerer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cilag GmbH International
Original Assignee
Schweiz Serum und Impfinstitut und Institut zur Erforschung der Infektionskrankheiten
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schweiz Serum und Impfinstitut und Institut zur Erforschung der Infektionskrankheiten filed Critical Schweiz Serum und Impfinstitut und Institut zur Erforschung der Infektionskrankheiten
Publication of ES2000140A6 publication Critical patent/ES2000140A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0258—Escherichia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/104—Pseudomonadales, e.g. Pseudomonas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

ES OBJETO DEL INVENTO UN PROCEDIMIENTO PARA PREPARAR UNA VACUNA CONJUGADA NO TOXICA CONTRA INFECCIONES POR BACTERIAS GRAM-NEGATIVAS, QUE CONSTA DE UN POLISACARIDO, ESPECIFICO DE UNA ESPECIE, Y DE UNA PROTEINA, QUE ESTAN UNIDOS CONVALENTEMENTE UNO CON OTRA, ESTANDO CARACTERIZADA LA VACUNA PORQUE EL POLISACARIDO PROCEDE DE LA ENDOTOXINA DE LA BACTERIA Y LA PROTEINA ES UNA EXOPROTEINA. ESTAS VACUNAS SON ESPECIALMENTE VACUNAS CONTRA INFECCIONES POR PSEUDOMONAS AERUGINOSA O ESCHERICHIA COLI. LA EXOPROTEINA ES ESPECIALMENTE UNA EXOTIXINA O UN EXOTOXOIDE, PREFERIBLEMENTE LA TOXINA A PROCEDENTE DE PSEUDOMONAS AERUGINOSA O TAMBIEN UN TOXOIDE DE TETANOS O TOXOIDE DE DIFTERIA. LA PREPARACION DE LA NUEVA VACUNA SE LLEVA A CABO UNIENDO COVALENTEMENTE UN CORRESPONDIENTE POLISACARIDO, PROCEDENTE DE LA ENDOTOXINA DE LA BACTERIA, CON UNA EXOPROTEINA.
ES8601006A 1985-09-27 1986-08-11 Procedimiento para preparar vacunas conjugadas no toxicas contra infecciones por bacterias gram-negativas Expired ES2000140A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH419985 1985-09-27

Publications (1)

Publication Number Publication Date
ES2000140A6 true ES2000140A6 (es) 1987-12-16

Family

ID=4271640

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8601006A Expired ES2000140A6 (es) 1985-09-27 1986-08-11 Procedimiento para preparar vacunas conjugadas no toxicas contra infecciones por bacterias gram-negativas

Country Status (11)

Country Link
US (1) US4771127A (es)
EP (1) EP0220387B1 (es)
JP (1) JPH0662434B2 (es)
AT (1) ATE56615T1 (es)
AU (1) AU587865B2 (es)
CA (1) CA1276552C (es)
DE (1) DE3674328D1 (es)
DK (1) DK163176C (es)
ES (1) ES2000140A6 (es)
PT (1) PT83096B (es)
ZA (1) ZA866564B (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5360897A (en) * 1981-08-31 1994-11-01 The University Of Rochester Immunogenic conjugates of streptococcus pneumonial capsular polymer and toxin or in toxiad
US5057301A (en) * 1988-04-06 1991-10-15 Neorx Corporation Modified cellular substrates used as linkers for increased cell retention of diagnostic and therapeutic agents
JP2639416B2 (ja) * 1988-04-23 1997-08-13 財団法人化学及血清療法研究所 真珠生産用二枚貝の血球活性化製剤および該製剤を用いる真珠の生産方法
NZ239643A (en) * 1990-09-17 1996-05-28 North American Vaccine Inc Vaccine containing bacterial polysaccharide protein conjugate and adjuvant (c-nd-che-a-co-b-r) with a long chain alkyl group.
US6139843A (en) * 1991-04-02 2000-10-31 Albert Einstein College Of Medicine Of Yeshiva University Peptide compositions for the treatment of HIV
US5370872A (en) * 1991-08-12 1994-12-06 Swiss Serum And Vaccine Institute Berne Escherichia coliO-polysaccharide-protein conjugate vaccine
US5554730A (en) * 1993-03-09 1996-09-10 Middlesex Sciences, Inc. Method and kit for making a polysaccharide-protein conjugate
US5866132A (en) * 1995-06-07 1999-02-02 Alberta Research Council Immunogenic oligosaccharide compositions
US5695768A (en) * 1995-06-07 1997-12-09 Alberta Research Council Immunostimulating activity of Streptococcus pneumoniae serotype 8 oligosaccharides
US6749831B1 (en) * 1997-05-16 2004-06-15 Medical Defense Technology, Llc Vaccine against lipopolysaccharide core
IL135148A0 (en) * 1997-10-03 2001-05-20 Galenica Pharmaceuticals Inc A polysaccharide conjugate and pharmaceutical compositions containing the same
US6573245B1 (en) 1998-04-28 2003-06-03 Galenica Pharmaceuticals, Inc. Modified polysaccharide adjuvant-protein antigen conjugates, the preparation thereof and the use thereof
US7749511B2 (en) * 2000-04-18 2010-07-06 Endobiologics, Incorporated Anti-sepsis conjugate vaccine
CA2406229C (en) * 2000-04-18 2010-09-07 Endobiologics, Incorporated Anti-sepsis conjugate vaccine
EP1651261B1 (en) * 2003-08-06 2014-10-08 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES Polysaccharide-protein conjugate vaccines
US8048432B2 (en) 2003-08-06 2011-11-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Polysaccharide-protein conjugate vaccines
WO2005117965A1 (en) * 2004-06-04 2005-12-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods for preparing immunogenic conjugates
US7625736B2 (en) * 2004-06-04 2009-12-01 The United States Of America As Represented By The Department Of Health And Human Services Methods for preparing immunogenic conjugates
KR101700972B1 (ko) * 2008-10-21 2017-01-31 국제백신연구소 신규한 시겔라 단백질 항원 및 방법
CN101912609B (zh) * 2009-08-20 2012-02-01 成都蓉生药业有限责任公司 防治绿脓杆菌感染的组合物及其制备方法
EP2699257A4 (en) 2011-04-21 2014-10-15 Univ Louisiana State PEPTIDE AND CONJUGATED VACCINES FOR FUNGAL INFECTIONS

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4356170A (en) * 1981-05-27 1982-10-26 Canadian Patents & Development Ltd. Immunogenic polysaccharide-protein conjugates
US4619828A (en) * 1982-07-06 1986-10-28 Connaught Laboratories, Inc. Polysaccharide exotoxoid conjugate vaccines
US4663160A (en) * 1983-03-14 1987-05-05 Miles Laboratories, Inc. Vaccines for gram-negative bacteria
US4693891A (en) * 1985-09-09 1987-09-15 Miles Laboratories, Inc. Vaccine for Pseudomonas aeruginosa
US4707543A (en) * 1985-09-17 1987-11-17 The United States Of America As Represented By The Secretary Of The Army Process for the preparation of detoxified polysaccharide-outer membrane protein complexes, and their use as antibacterial vaccines

Also Published As

Publication number Publication date
JPH0662434B2 (ja) 1994-08-17
EP0220387A3 (en) 1989-03-22
JPS6289632A (ja) 1987-04-24
PT83096B (pt) 1988-07-01
DK320786A (da) 1987-03-28
CA1276552C (en) 1990-11-20
ATE56615T1 (de) 1990-10-15
PT83096A (en) 1986-08-01
US4771127A (en) 1988-09-13
DK163176B (da) 1992-02-03
ZA866564B (en) 1987-05-27
EP0220387A2 (de) 1987-05-06
DE3674328D1 (de) 1990-10-25
DK163176C (da) 1992-06-22
AU6322986A (en) 1987-04-02
DK320786D0 (da) 1986-07-04
AU587865B2 (en) 1989-08-31
EP0220387B1 (de) 1990-09-19

Similar Documents

Publication Publication Date Title
ES2000140A6 (es) Procedimiento para preparar vacunas conjugadas no toxicas contra infecciones por bacterias gram-negativas
CA1336308C (en) Polysaccharide-protein conjugates
KR920003982A (ko) 면역원성 콘쥬게이트 및 이를 함유하는 백신 조성물
CA2246760C (en) Polysaccharide-peptide-conjugates
ATE19734T1 (de) Heamophilus influenzae b polysaccharid exotoxoid konjugat-impfstoff.
LU91924I2 (fr) Composition vaccinale comprenant le polysaccharidecapsulaire et Haemophilus influenzae type b coupl é à l'anatoxine tétanique, l'antigène diphtérique,l'antigène tétanique, des antigènes de la polio, des antigènes de la coqueluche et du phosphate d'aluminium
AU2464192A (en) Escherichia coli o-polysaccharide-protein conjugate vaccine
CA2071811A1 (en) Improved meningococcal polysaccharide conjugate vaccine
EP1846025A2 (en) Glycoconjugate vaccines containing peptidoglycan
CA2340692A1 (en) Immunogenic .beta.-propionamido-linked polysaccharide protein conjugate useful as a vaccine produced using an n-acryloylated polysaccharide
YU8192A (sh) Postupak za izradu pneumokoknog polisaharidnog imunogenog proteinskog konjugata
WO1993017712A3 (en) Conjugates formed from heat shock proteins and oligo- or polysaccharides
CA2145397A1 (en) Group b streptococcus type ii and type v polysaccharide-protein conjugate vaccines
WO1994010317A3 (en) Conjugate vaccine against group b streptococcus
US6165468A (en) Antigenic carbohydrate linked to an immunogenic carrier
Tsay et al. Preparation and characterization of a nontoxic polysaccharide-protein conjugate that induces active immunity and passively protective antibody against Pseudomonas aeruginosa immunotype 1 in mice
Singh et al. Protective efficacy and immunogenicity of Vi-porin conjugate against Salmonella typhi
US20210401960A1 (en) Multivalent glycoconjugates immunogenic compositions

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040812