BR0112612A - Misturas de polissacarìdeos sulfatados, processo de preparação das mesmas e composições farmacêuticas - Google Patents

Misturas de polissacarìdeos sulfatados, processo de preparação das mesmas e composições farmacêuticas

Info

Publication number
BR0112612A
BR0112612A BR0112612-1A BR0112612A BR0112612A BR 0112612 A BR0112612 A BR 0112612A BR 0112612 A BR0112612 A BR 0112612A BR 0112612 A BR0112612 A BR 0112612A
Authority
BR
Brazil
Prior art keywords
pharmaceutical compositions
preparation process
sulfated polysaccharide
polysaccharide mixtures
mixtures
Prior art date
Application number
BR0112612-1A
Other languages
English (en)
Other versions
BR0112612B1 (pt
Inventor
Jacques Diaz
Christelle Pecquet
Elisabeth Perrin
Christian Viskov
Original Assignee
Aventis Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8852768&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR0112612(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aventis Pharma Sa filed Critical Aventis Pharma Sa
Publication of BR0112612A publication Critical patent/BR0112612A/pt
Publication of BR0112612B1 publication Critical patent/BR0112612B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/727—Heparin; Heparan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Polymers & Plastics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

"MISTURAS DE POLISSACARìDEOS SULFATADOS, PROCESSO DE PREPARAçãO DAS MESMAS E COMPOSIçõES FARMACêUTICAS". A presente invenção refere-se a misturas de polissacarídeos derivadas da heparina, a seu processo de preparação e às composições farmacêuticas contendo as mesmas.
BRPI0112612-1A 2000-07-21 2001-07-18 misturas de polissacarìdeos sulfatados, processo de preparação das mesmas e composições farmacêuticas. BR0112612B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
FR0009572A FR2811992B1 (fr) 2000-07-21 2000-07-21 Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
FR00/09572 2000-07-21
PCT/FR2001/002332 WO2002008295A1 (fr) 2000-07-21 2001-07-18 Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant

Publications (2)

Publication Number Publication Date
BR0112612A true BR0112612A (pt) 2003-07-29
BR0112612B1 BR0112612B1 (pt) 2011-07-12

Family

ID=8852768

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0112612-1A BR0112612B1 (pt) 2000-07-21 2001-07-18 misturas de polissacarìdeos sulfatados, processo de preparação das mesmas e composições farmacêuticas.

Country Status (36)

Country Link
EP (1) EP1307491B2 (pt)
JP (1) JP5279160B2 (pt)
KR (1) KR100853585B1 (pt)
CN (1) CN1230449C (pt)
AP (1) AP1703A (pt)
AR (1) AR029865A1 (pt)
AT (1) ATE470679T1 (pt)
AU (2) AU2001277602B2 (pt)
BR (1) BR0112612B1 (pt)
CA (1) CA2416673C (pt)
CL (1) CL2004001154A1 (pt)
CY (1) CY1110774T1 (pt)
DE (1) DE60142340D1 (pt)
DK (1) DK1307491T3 (pt)
DZ (1) DZ3411A1 (pt)
EA (1) EA005995B1 (pt)
EC (1) ECSP034442A (pt)
ES (1) ES2347134T5 (pt)
FR (1) FR2811992B1 (pt)
HK (1) HK1059273A1 (pt)
HR (1) HRP20030019A2 (pt)
HU (1) HUP0300755A3 (pt)
IL (2) IL153922A0 (pt)
MA (1) MA26928A1 (pt)
MX (1) MXPA03000579A (pt)
NO (1) NO20030296D0 (pt)
NZ (1) NZ524028A (pt)
OA (1) OA12340A (pt)
PL (1) PL202471B1 (pt)
PT (1) PT1307491E (pt)
SI (1) SI1307491T1 (pt)
TW (1) TWI307278B (pt)
UA (1) UA74836C2 (pt)
WO (1) WO2002008295A1 (pt)
YU (1) YU2903A (pt)
ZA (1) ZA200300898B (pt)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6969705B2 (en) 2000-07-21 2005-11-29 Aventis Pharma S.A. Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
DE60218642T2 (de) * 2002-06-20 2007-11-29 Chemi S.P.A., Cinisello Balsamo Verfahren zur Herstellung von Heparinestern
AR041555A1 (es) 2002-10-10 2005-05-18 Aventis Pharma Sa Mezclas de polisacaridos derivados de heparina, su preparacion y las composiciones farmaceuticas que las contienen
US20040171819A1 (en) 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
FR2845686B1 (fr) * 2002-10-10 2013-08-30 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
US7956046B2 (en) * 2003-07-24 2011-06-07 Aventis Pharma S.A. Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them
FR2857971B1 (fr) * 2003-07-24 2005-08-26 Aventis Pharma Sa Melanges d'oligosaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
DE102004059134B4 (de) 2004-12-08 2011-12-15 Siemens Ag Expansionsvorrichtung für ein Röntgengerät und Röntgenstrahler
AU2007267561B2 (en) * 2006-05-25 2012-05-17 Momenta Pharmaceuticals, Inc. Low molecular weight heparin composition and uses thereof
CN101824099B (zh) * 2010-02-12 2011-11-30 淮安麦德森化学有限公司 一种粗品肝素钠的纯化方法
CN101824446B (zh) * 2010-02-24 2012-12-12 淮安麦德森化学有限公司 反向沉淀生产硫酸软骨素的方法
EP2399591A1 (en) 2010-06-25 2011-12-28 Aventis Pharma S.A. Semuloparin for the extended prevention of a mortality and/or morbidity event in a patient having undergone hip fracture surgery
EP2399590A1 (en) 2010-06-25 2011-12-28 Aventis Pharma S.A. Semuloparin for the prevention of a mortality and/or morbidity event in a patient undergoing major orthopaedic surgery
EP2399592A1 (en) 2010-06-25 2011-12-28 Aventis Pharma S.A. Semuloparin for use as an antithrombotic treatment in hip replacement surgery with improved safety in terms of clinically relevant bleedings and major bleedings
EP2399593A1 (en) 2010-06-28 2011-12-28 Aventis Pharma S.A. Semuloparin for use as an antithrombotic treatment in orthopaedic surgery with improved benefit-risk profile
CN102399379B (zh) * 2010-09-09 2016-08-31 上海喜恩医药科技发展有限公司 一种肝素衍生的多糖混合物及其制备方法和药物组合物
KR101794877B1 (ko) * 2010-09-14 2017-11-07 고쿠리츠 다이가쿠 호징 미야자키 다이가쿠 고순도 헤파린 및 그 제조방법
EP2446891A1 (en) 2010-10-28 2012-05-02 Aventis Pharma S.A. Semuloparin for use as an antithrombotic treatment in major abdominal surgery with improved safety in terms of clinically relevant bleedings and major bleedings
WO2012055843A1 (en) 2010-10-28 2012-05-03 Aventis Pharma S.A. Semuloparin for the prevention of major venous thromboembolism in a patient undergoing major abdominal surgery
EP2548561A1 (en) 2011-07-22 2013-01-23 Aventis Pharma S.A. Semuloparin for improving the survival of patients with locally advanced cancer
ES2445494B1 (es) * 2012-08-02 2015-03-06 Rovi Lab Farmaceut Sa Procedimiento de obtención de heparinas de bajo y muy bajo peso molecular
CN103175925B (zh) * 2013-03-20 2014-12-03 山东辰中生物制药有限公司 依诺肝素钠生产过程中肝素苄基酯的酯化率的检测方法
FR3016632A1 (fr) * 2014-01-21 2015-07-24 IFP Energies Nouvelles Procede de transformation de polysaccharides en molecules oxygenees en presence de superbases organiques neutres
CZ306662B6 (cs) * 2015-06-26 2017-04-26 Contipro A.S. Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2478646A2 (fr) * 1980-03-20 1981-09-25 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
IL61201A (en) * 1979-10-05 1984-09-30 Choay Sa Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
FR2482611B1 (fr) * 1980-05-14 1986-03-07 Pharmindustrie Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments
US4916219A (en) * 1985-03-28 1990-04-10 University Of Iowa Research Foundation Oligosaccharide heparin fragments as inhibitors of complement cascade
EP0337327A1 (en) * 1988-04-09 1989-10-18 Bioiberica, S.A. Process for the preparation of new oligosaccharide fractions by controlled chemical depolimerization of heparin
ES2077533B1 (es) * 1994-02-28 1996-07-01 Bioiberica Procedimiento de obtencion de fracciones de oligosacaridos por despolimerizacion quimica de heparina.
ES2161615B1 (es) * 1999-07-23 2003-03-16 Rovi Lab Farmaceut Sa Composiciones de heparinas de muy bajo peso molecular.
JP4897991B2 (ja) * 1999-07-23 2012-03-14 ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ 超低分子量ヘパリン組成物

Also Published As

Publication number Publication date
OA12340A (fr) 2006-05-15
AU2001277602B2 (en) 2007-07-19
ECSP034442A (es) 2003-03-10
UA74836C2 (en) 2006-02-15
AP1703A (en) 2007-02-26
NO20030296L (no) 2003-01-20
NO20030296D0 (no) 2003-01-20
EA005995B1 (ru) 2005-08-25
PT1307491E (pt) 2010-09-10
SI1307491T1 (sl) 2010-10-29
HRP20030019A2 (en) 2005-10-31
DZ3411A1 (fr) 2002-01-31
EA200300178A1 (ru) 2003-06-26
KR100853585B1 (ko) 2008-08-21
CL2004001154A1 (es) 2005-05-27
KR20030040364A (ko) 2003-05-22
PL365561A1 (en) 2005-01-10
JP2004504451A (ja) 2004-02-12
CN1447820A (zh) 2003-10-08
ZA200300898B (en) 2004-04-30
FR2811992A1 (fr) 2002-01-25
EP1307491B2 (fr) 2014-05-07
MA26928A1 (fr) 2004-12-20
ATE470679T1 (de) 2010-06-15
AR029865A1 (es) 2003-07-16
IL153922A0 (en) 2003-07-31
HK1059273A1 (en) 2004-06-25
BR0112612B1 (pt) 2011-07-12
PL202471B1 (pl) 2009-06-30
DE60142340D1 (de) 2010-07-22
EP1307491A1 (fr) 2003-05-07
AU7760201A (en) 2002-02-05
HUP0300755A3 (en) 2004-03-01
WO2002008295A1 (fr) 2002-01-31
CN1230449C (zh) 2005-12-07
DK1307491T3 (da) 2010-10-11
CA2416673A1 (fr) 2002-01-31
ES2347134T3 (es) 2010-10-26
YU2903A (sh) 2006-03-03
AP2003002744A0 (en) 2003-03-31
TWI307278B (en) 2009-03-11
CY1110774T1 (el) 2015-06-10
CA2416673C (fr) 2011-06-14
MXPA03000579A (es) 2003-06-06
NZ524028A (en) 2004-12-24
FR2811992B1 (fr) 2003-07-04
JP5279160B2 (ja) 2013-09-04
HUP0300755A2 (hu) 2003-12-29
IL153922A (en) 2010-05-17
ES2347134T5 (es) 2014-06-24
EP1307491B1 (fr) 2010-06-09

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 18/07/2001, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time
B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2471 DE 15-05-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.