ES2445494B1 - Procedimiento de obtención de heparinas de bajo y muy bajo peso molecular - Google Patents

Procedimiento de obtención de heparinas de bajo y muy bajo peso molecular Download PDF

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Publication number
ES2445494B1
ES2445494B1 ES201231257A ES201231257A ES2445494B1 ES 2445494 B1 ES2445494 B1 ES 2445494B1 ES 201231257 A ES201231257 A ES 201231257A ES 201231257 A ES201231257 A ES 201231257A ES 2445494 B1 ES2445494 B1 ES 2445494B1
Authority
ES
Spain
Prior art keywords
low
procedure
molecular weight
weight heparins
obtaining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES201231257A
Other languages
English (en)
Other versions
ES2445494A1 (es
Inventor
Rodriguez Guillermo Franco
Aduriz Ibón Gutierro
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Farmaceuticos Rovi SA
Original Assignee
Laboratorios Farmaceuticos Rovi SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES201231257A priority Critical patent/ES2445494B1/es
Application filed by Laboratorios Farmaceuticos Rovi SA filed Critical Laboratorios Farmaceuticos Rovi SA
Priority to CN201380041068.8A priority patent/CN104507972A/zh
Priority to LTEP13825506.2T priority patent/LT2881404T/lt
Priority to BR112015002358A priority patent/BR112015002358A2/pt
Priority to SI201331031T priority patent/SI2881404T1/sl
Priority to CN201810042059.5A priority patent/CN108102007A/zh
Priority to DK13825506.2T priority patent/DK2881404T3/en
Priority to PCT/ES2013/070575 priority patent/WO2014020227A1/es
Priority to IN435MUN2015 priority patent/IN2015MN00435A/en
Priority to HUE13825506A priority patent/HUE037251T2/hu
Priority to PT138255062T priority patent/PT2881404T/pt
Priority to EP13825506.2A priority patent/EP2881404B1/en
Priority to PL13825506T priority patent/PL2881404T3/pl
Priority to ES13825506.2T priority patent/ES2669727T3/es
Priority to JP2015524817A priority patent/JP6298052B2/ja
Publication of ES2445494A1 publication Critical patent/ES2445494A1/es
Application granted granted Critical
Publication of ES2445494B1 publication Critical patent/ES2445494B1/es
Priority to HK15106635.1A priority patent/HK1206042A1/xx
Priority to HRP20180777TT priority patent/HRP20180777T1/hr
Priority to CY181100525T priority patent/CY1120872T1/el
Priority to HK18110851.7A priority patent/HK1252082A1/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
ES201231257A 2012-08-02 2012-08-02 Procedimiento de obtención de heparinas de bajo y muy bajo peso molecular Expired - Fee Related ES2445494B1 (es)

Priority Applications (19)

Application Number Priority Date Filing Date Title
ES201231257A ES2445494B1 (es) 2012-08-02 2012-08-02 Procedimiento de obtención de heparinas de bajo y muy bajo peso molecular
BR112015002358A BR112015002358A2 (pt) 2012-08-02 2013-08-02 processo para obtenção de heparinas de baixo e muito baixo peso molecular
EP13825506.2A EP2881404B1 (en) 2012-08-02 2013-08-02 Method for obtaining low molecular weight and very low molecular weight heparins
SI201331031T SI2881404T1 (sl) 2012-08-02 2013-08-02 Metode za pridobivanje heparinov z nizko molekularno težo in zelo nizko molekularno težo
CN201810042059.5A CN108102007A (zh) 2012-08-02 2013-08-02 低分子量和极低分子量肝素获取工艺
DK13825506.2T DK2881404T3 (en) 2012-08-02 2013-08-02 Process for obtaining low molecular weight and very low molecular weight heparin
PCT/ES2013/070575 WO2014020227A1 (es) 2012-08-02 2013-08-02 Procedimiento de obtención de heparinas de bajo y muy bajo peso molecular
IN435MUN2015 IN2015MN00435A (es) 2012-08-02 2013-08-02
HUE13825506A HUE037251T2 (hu) 2012-08-02 2013-08-02 Eljárás alacsony és rendkívül alacsony molekulatömegû heparinok elõállítására
ES13825506.2T ES2669727T3 (es) 2012-08-02 2013-08-02 Procedimiento de obtención de heparinas de bajo y muy bajo peso molecular
CN201380041068.8A CN104507972A (zh) 2012-08-02 2013-08-02 低分子量和极低分子量肝素获取工艺
PL13825506T PL2881404T3 (pl) 2012-08-02 2013-08-02 Metoda otrzymywania heparyn drobnocząsteczkowych (HDCz) i heparyn ultra-drobnocząsteczkowych (ultra-HDCz)
LTEP13825506.2T LT2881404T (lt) 2012-08-02 2013-08-02 Mažos molekulinės masės ir labai mažos molekulinės masės heparinų gavimo būdas
JP2015524817A JP6298052B2 (ja) 2012-08-02 2013-08-02 低分子量および超低分子量ヘパリンの製造方法
PT138255062T PT2881404T (pt) 2012-08-02 2013-08-02 Método para obter heparinas de baixo peso molecular e de muito baixo peso molecular
HK15106635.1A HK1206042A1 (en) 2012-08-02 2015-07-10 Method for obtaining low molecular weight and very low molecular weight heparins
HRP20180777TT HRP20180777T1 (hr) 2012-08-02 2018-05-18 Postupak za dobivanje heparina niske molekularne mase i vrlo niske molekularne mase
CY181100525T CY1120872T1 (el) 2012-08-02 2018-05-21 Μεθοδος για τη ληψη ηπαρινων χαμηλου μοριακου βαρους και πολυ χαμηλου μοριακου βαρους
HK18110851.7A HK1252082A1 (zh) 2012-08-02 2018-08-23 低分子量和極低分子量肝素獲取工藝

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201231257A ES2445494B1 (es) 2012-08-02 2012-08-02 Procedimiento de obtención de heparinas de bajo y muy bajo peso molecular

Publications (2)

Publication Number Publication Date
ES2445494A1 ES2445494A1 (es) 2014-03-03
ES2445494B1 true ES2445494B1 (es) 2015-03-06

Family

ID=50027324

Family Applications (2)

Application Number Title Priority Date Filing Date
ES201231257A Expired - Fee Related ES2445494B1 (es) 2012-08-02 2012-08-02 Procedimiento de obtención de heparinas de bajo y muy bajo peso molecular
ES13825506.2T Active ES2669727T3 (es) 2012-08-02 2013-08-02 Procedimiento de obtención de heparinas de bajo y muy bajo peso molecular

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES13825506.2T Active ES2669727T3 (es) 2012-08-02 2013-08-02 Procedimiento de obtención de heparinas de bajo y muy bajo peso molecular

Country Status (16)

Country Link
EP (1) EP2881404B1 (es)
JP (1) JP6298052B2 (es)
CN (2) CN104507972A (es)
BR (1) BR112015002358A2 (es)
CY (1) CY1120872T1 (es)
DK (1) DK2881404T3 (es)
ES (2) ES2445494B1 (es)
HK (2) HK1206042A1 (es)
HR (1) HRP20180777T1 (es)
HU (1) HUE037251T2 (es)
IN (1) IN2015MN00435A (es)
LT (1) LT2881404T (es)
PL (1) PL2881404T3 (es)
PT (1) PT2881404T (es)
SI (1) SI2881404T1 (es)
WO (1) WO2014020227A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114072430B (zh) 2020-04-27 2023-07-28 罗威制药股份有限公司 低分子量肝素获取程序以及由此获得的低分子量肝素
CN111393542B (zh) * 2020-05-16 2021-11-05 青岛科技大学 一种粗品肝素钠精制新方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2003197A6 (es) * 1987-01-05 1988-10-16 Rovi Lab Farmaceut Sa Procedimiento de despolimerizacion de la heparina para la obtencion de una heparina de bajo peso molecular dotada de actividad antitrombotica
US4981955A (en) * 1988-06-28 1991-01-01 Lopez Lorenzo L Depolymerization method of heparin
US5707973A (en) * 1991-04-23 1998-01-13 Rhone-Poulenc Rorer S.A. Sulfated polysaccharids for treatment or prevention of thromboses
JP4897991B2 (ja) * 1999-07-23 2012-03-14 ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ 超低分子量ヘパリン組成物
ES2161615B1 (es) * 1999-07-23 2003-03-16 Rovi Lab Farmaceut Sa Composiciones de heparinas de muy bajo peso molecular.
FR2811992B1 (fr) * 2000-07-21 2003-07-04 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
EP1319183B1 (en) * 2000-09-12 2009-03-25 Massachusetts Institute Of Technology Methods and products related to low molecular weight heparin
FR2845686B1 (fr) * 2002-10-10 2013-08-30 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
US7904036B2 (en) 2005-12-02 2011-03-08 Telefonaktiebolaget Lm Ericsson (Publ) Modulation method and apparatus
EP2399592A1 (en) * 2010-06-25 2011-12-28 Aventis Pharma S.A. Semuloparin for use as an antithrombotic treatment in hip replacement surgery with improved safety in terms of clinically relevant bleedings and major bleedings
EP2399590A1 (en) * 2010-06-25 2011-12-28 Aventis Pharma S.A. Semuloparin for the prevention of a mortality and/or morbidity event in a patient undergoing major orthopaedic surgery
EP2548561A1 (en) * 2011-07-22 2013-01-23 Aventis Pharma S.A. Semuloparin for improving the survival of patients with locally advanced cancer
CN102603925B (zh) * 2012-03-21 2013-12-11 东营天东制药有限公司 一种由粗品肝素钠直接生产依诺肝素钠的方法

Also Published As

Publication number Publication date
HK1252082A1 (zh) 2019-05-17
PL2881404T3 (pl) 2018-08-31
ES2445494A1 (es) 2014-03-03
HRP20180777T1 (hr) 2018-08-10
JP2015523451A (ja) 2015-08-13
DK2881404T3 (en) 2018-06-06
HUE037251T2 (hu) 2018-08-28
EP2881404A4 (en) 2016-04-20
CY1120872T1 (el) 2019-12-11
SI2881404T1 (sl) 2018-10-30
LT2881404T (lt) 2018-08-10
ES2669727T3 (es) 2018-05-29
PT2881404T (pt) 2018-05-23
WO2014020227A1 (es) 2014-02-06
CN104507972A (zh) 2015-04-08
IN2015MN00435A (es) 2015-09-04
CN108102007A (zh) 2018-06-01
EP2881404B1 (en) 2018-02-28
BR112015002358A2 (pt) 2017-07-04
HK1206042A1 (en) 2015-12-31
JP6298052B2 (ja) 2018-03-20
EP2881404A1 (en) 2015-06-10

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