ES2003197A6 - Procedimiento de despolimerizacion de la heparina para la obtencion de una heparina de bajo peso molecular dotada de actividad antitrombotica - Google Patents
Procedimiento de despolimerizacion de la heparina para la obtencion de una heparina de bajo peso molecular dotada de actividad antitromboticaInfo
- Publication number
- ES2003197A6 ES2003197A6 ES8700020A ES8700020A ES2003197A6 ES 2003197 A6 ES2003197 A6 ES 2003197A6 ES 8700020 A ES8700020 A ES 8700020A ES 8700020 A ES8700020 A ES 8700020A ES 2003197 A6 ES2003197 A6 ES 2003197A6
- Authority
- ES
- Spain
- Prior art keywords
- heparin
- ammonium hydroxide
- depolymerization
- molecular weight
- low molecular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
- C08B37/0078—Degradation products
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
PROCEDIMIENTO DE DESPOLIMERIZACION DE LA HEPARINA PARA LA OBTENCION DE UNA HEPARINA DE BAJO PESO MOLECULAR DOTADA DE ACTIVIDAD ANTITROMBOTICA, EN EL QUE SE PARTE DE UNA SAL DE AMONIO CUATERNARIO DE HEPARINA QUE SE TRATA CON UN HIDROXIDO DE AMONIO CUATERNARIO, EN UN DISOLVENTE HIDROXILADO, EFECTUANDO LA REACCION A TEMPERATURA ENTRE 10J Y 60JC, HASTA OBTENER UNA HEPARINA DE PESO MOLECULAR MEDIO COMPRENDIDO ENTRE
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES8700020A ES2003197A6 (es) | 1987-01-05 | 1987-01-05 | Procedimiento de despolimerizacion de la heparina para la obtencion de una heparina de bajo peso molecular dotada de actividad antitrombotica |
AT87500051T ATE106901T1 (de) | 1987-01-05 | 1987-07-22 | Verfahren zur depolymerisierung von heparin zum erhalten eines heparins mit niedrigem molekulargewicht und einer antithrombotischen aktivität. |
DE3750036T DE3750036T2 (de) | 1987-01-05 | 1987-07-22 | Verfahren zur Depolymerisierung von Heparin zum Erhalten eines Heparins mit niedrigem Molekulargewicht und einer antithrombotischen Aktivität. |
EP87500051A EP0293539B1 (fr) | 1987-01-05 | 1987-07-22 | Procédé pour la dépolymérisation de l'héparine pour l'obtention d'une héparine de bas poids moléculaire dotée d'une activité antithrombotique |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES8700020A ES2003197A6 (es) | 1987-01-05 | 1987-01-05 | Procedimiento de despolimerizacion de la heparina para la obtencion de una heparina de bajo peso molecular dotada de actividad antitrombotica |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2003197A6 true ES2003197A6 (es) | 1988-10-16 |
Family
ID=8249032
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8700020A Expired ES2003197A6 (es) | 1987-01-05 | 1987-01-05 | Procedimiento de despolimerizacion de la heparina para la obtencion de una heparina de bajo peso molecular dotada de actividad antitrombotica |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0293539B1 (es) |
AT (1) | ATE106901T1 (es) |
DE (1) | DE3750036T2 (es) |
ES (1) | ES2003197A6 (es) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2161615A1 (es) * | 1999-07-23 | 2001-12-01 | Rovi Lab Farmaceut Sa | Composiciones de heparinas de muy bajo peso molecular. |
CN103012621A (zh) * | 2011-09-26 | 2013-04-03 | 徐美英 | 一种高纯度肝素苄酯盐及其制法和应用 |
WO2014020227A1 (es) | 2012-08-02 | 2014-02-06 | Laboratorios Farmaceuticos Rovi, S.A. | Procedimiento de obtención de heparinas de bajo y muy bajo peso molecular |
WO2021219902A1 (es) * | 2020-04-27 | 2021-11-04 | Laboratorios Farmacéuticos Rovi, S.A. | Procedimiento para la obtención de heparinas de bajo peso molecular y heparinas de bajo peso molecular obtenidas por el mismo |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1234508B (it) * | 1988-06-10 | 1992-05-19 | Alfa Wassermann Spa | Derivati eparinici e procedimento per la loro preparazione |
USRE38743E1 (en) | 1990-06-26 | 2005-06-14 | Aventis Pharma S.A. | Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events |
US6001820A (en) * | 1995-03-31 | 1999-12-14 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
US5744457A (en) * | 1995-03-31 | 1998-04-28 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
US5763427A (en) * | 1995-03-31 | 1998-06-09 | Hamilton Civic Hospitals Research Development Inc. | Compositions and methods for inhibiting thrombogenesis |
US5767269A (en) * | 1996-10-01 | 1998-06-16 | Hamilton Civic Hospitals Research Development Inc. | Processes for the preparation of low-affinity, low molecular weight heparins useful as antithrombotics |
JP4897991B2 (ja) * | 1999-07-23 | 2012-03-14 | ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ | 超低分子量ヘパリン組成物 |
US6969705B2 (en) | 2000-07-21 | 2005-11-29 | Aventis Pharma S.A. | Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them |
JP4828795B2 (ja) | 2002-03-11 | 2011-11-30 | モメンタ ファーマシューティカルズ インコーポレイテッド | 硫酸化多糖類の分析 |
US20040171819A1 (en) | 2002-10-10 | 2004-09-02 | Aventis Pharma S.A. | Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them |
US7956046B2 (en) | 2003-07-24 | 2011-06-07 | Aventis Pharma S.A. | Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them |
ITMI20031679A1 (it) * | 2003-08-29 | 2005-02-28 | Opocrin Spa | Processo per la produzione di eparine a basso peso |
US9139876B1 (en) | 2007-05-03 | 2015-09-22 | Momenta Pharmacueticals, Inc. | Method of analyzing a preparation of a low molecular weight heparin |
US9068957B2 (en) | 2011-02-21 | 2015-06-30 | Momenta Pharmaceuticals, Inc. | Evaluating heparin preparations |
CN103012620B (zh) * | 2011-09-26 | 2017-09-19 | 徐美英 | 一种高纯度肝素苄酯盐及其制法和应用 |
CN107759712B (zh) * | 2016-08-19 | 2020-03-24 | 苏州融析生物科技有限公司 | 羊来源的低分子肝素及其制备方法与应用 |
WO2018032502A1 (zh) * | 2016-08-19 | 2018-02-22 | 苏州融析生物科技有限公司 | 羊来源的低分子肝素及其制备方法与应用 |
WO2022015794A1 (en) | 2020-07-14 | 2022-01-20 | Optimvia, Llc | Methods for synthesizing non-anticoagulant heparan sulfate |
CN110092848A (zh) * | 2019-05-14 | 2019-08-06 | 山东辰龙药业有限公司 | 一种贝米肝素钠的制备方法 |
EP3997238A1 (en) | 2019-07-09 | 2022-05-18 | Optimvia, LLC | Methods for synthesizing anticoagulant polysaccharides |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2482611B1 (fr) * | 1980-05-14 | 1986-03-07 | Pharmindustrie | Nouveaux polysaccharides sulfates, procedes pour leur preparation et leur utilisation comme medicaments |
-
1987
- 1987-01-05 ES ES8700020A patent/ES2003197A6/es not_active Expired
- 1987-07-22 EP EP87500051A patent/EP0293539B1/fr not_active Expired - Lifetime
- 1987-07-22 AT AT87500051T patent/ATE106901T1/de not_active IP Right Cessation
- 1987-07-22 DE DE3750036T patent/DE3750036T2/de not_active Expired - Lifetime
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2161615A1 (es) * | 1999-07-23 | 2001-12-01 | Rovi Lab Farmaceut Sa | Composiciones de heparinas de muy bajo peso molecular. |
CN103012621A (zh) * | 2011-09-26 | 2013-04-03 | 徐美英 | 一种高纯度肝素苄酯盐及其制法和应用 |
CN103012621B (zh) * | 2011-09-26 | 2017-09-19 | 徐美英 | 一种高纯度肝素苄酯盐及其制法和应用 |
WO2014020227A1 (es) | 2012-08-02 | 2014-02-06 | Laboratorios Farmaceuticos Rovi, S.A. | Procedimiento de obtención de heparinas de bajo y muy bajo peso molecular |
ES2445494A1 (es) * | 2012-08-02 | 2014-03-03 | Laboratorios Farmacéuticos Rovi, S.A. | Procedimiento de obtención de heparinas de bajo y muy bajo peso molecular |
CN104507972A (zh) * | 2012-08-02 | 2015-04-08 | 罗维药品实验室有限公司 | 低分子量和极低分子量肝素获取工艺 |
CN108102007A (zh) * | 2012-08-02 | 2018-06-01 | 罗维药品实验室有限公司 | 低分子量和极低分子量肝素获取工艺 |
WO2021219902A1 (es) * | 2020-04-27 | 2021-11-04 | Laboratorios Farmacéuticos Rovi, S.A. | Procedimiento para la obtención de heparinas de bajo peso molecular y heparinas de bajo peso molecular obtenidas por el mismo |
WO2021219907A1 (es) * | 2020-04-27 | 2021-11-04 | Laboratorios Farmacéuticos Rovi, S.A. | Procedimiento para la obtención de heparinas de bajo peso molecular y heparinas de bajo peso molecular obtenidas por el mismo |
CN114072430A (zh) * | 2020-04-27 | 2022-02-18 | 罗威制药股份有限公司 | 低分子量肝素获取程序以及由此获得的低分子量肝素 |
Also Published As
Publication number | Publication date |
---|---|
DE3750036T2 (de) | 1995-01-26 |
EP0293539A2 (fr) | 1988-12-07 |
EP0293539A3 (en) | 1989-04-12 |
DE3750036D1 (de) | 1994-07-14 |
EP0293539B1 (fr) | 1994-06-08 |
ATE106901T1 (de) | 1994-06-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
SA6 | Expiration date (snapshot 920101) |
Free format text: 2007-01-05 |
|
SPCD | Supplementary protection certificate rejected |
Free format text: HIBOR MOTIVOS: SUBSISTEN DEFECTOR QUE NO HAN SIDO DEBIDAMENTE SUBSANADOS EN EL PLAZO PREVISTO AL EFECTO SEGUN LO ESTABLECIDO EN EL ARTICULO 10.4 DEL REGLAMENTO (CEE) NO1768/92. Spc suppl protection certif: C9900016 Filing date: 19990409 Effective date: 20001027 |
|
FD1A | Patent lapsed |
Effective date: 20070108 |