ES2077533A1 - Procedimiento de obtencion de fracciones de oligosacaridos por despolimerizacion quimica de heparina. - Google Patents

Procedimiento de obtencion de fracciones de oligosacaridos por despolimerizacion quimica de heparina.

Info

Publication number
ES2077533A1
ES2077533A1 ES09400395A ES9400395A ES2077533A1 ES 2077533 A1 ES2077533 A1 ES 2077533A1 ES 09400395 A ES09400395 A ES 09400395A ES 9400395 A ES9400395 A ES 9400395A ES 2077533 A1 ES2077533 A1 ES 2077533A1
Authority
ES
Spain
Prior art keywords
heparin
chemical depolymerization
fractions
oligosaccharide fractions
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES09400395A
Other languages
English (en)
Other versions
ES2077533B1 (es
Inventor
Pahi F Javier Vila
Gallemt Carles Farrerons
Ravetllat Luis Salvador
Torne Pedro Gomis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bioiberica SA
Original Assignee
Bioiberica SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioiberica SA filed Critical Bioiberica SA
Priority to ES9400395A priority Critical patent/ES2077533B1/es
Publication of ES2077533A1 publication Critical patent/ES2077533A1/es
Application granted granted Critical
Publication of ES2077533B1 publication Critical patent/ES2077533B1/es
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

PROCEDIMIENTO DE DESPOLIMERIZACION QUIMICA DE HEPARINA CARACTERIZADO PORQUE SE SOMETEN A UNA REACCION DE BE-ELIMINACION UNOS DERIVADOS DE HEPARINA EN LOS QUE SE HA SUSTITUIDO PARCIALMENTE GRUPOS CARBOXILATO POR GRUPOS ANHIDRIDO. DICHA REACCION SE EFECTUA EN UN MEDIO ORGANICO COMO LA N-METIL-2-PIRROLIDONA POR LA ACCION DE UNA BASE DEL TIPO HIDROXIDO DE AMONIO CUATERNARIO. SE OBTIENEN DE ESTE MODO UNAS FRACCIONES DE OLIGOSACARIDOS QUE OFRECEN CIERTAS MEJORAS DE LAS PROPIEDADES FARMACOLOGICAS CON RESPECTO A OTRAS FRACCIONES CONOCIDAS Y QUE SON UTILES EN EL TRATAMIENTO DE LOS TRASTORNOS TROMBOEMBOLICOS.
ES9400395A 1994-02-28 1994-02-28 Procedimiento de obtencion de fracciones de oligosacaridos por despolimerizacion quimica de heparina. Expired - Fee Related ES2077533B1 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES9400395A ES2077533B1 (es) 1994-02-28 1994-02-28 Procedimiento de obtencion de fracciones de oligosacaridos por despolimerizacion quimica de heparina.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES9400395A ES2077533B1 (es) 1994-02-28 1994-02-28 Procedimiento de obtencion de fracciones de oligosacaridos por despolimerizacion quimica de heparina.

Publications (2)

Publication Number Publication Date
ES2077533A1 true ES2077533A1 (es) 1995-11-16
ES2077533B1 ES2077533B1 (es) 1996-07-01

Family

ID=8285378

Family Applications (1)

Application Number Title Priority Date Filing Date
ES9400395A Expired - Fee Related ES2077533B1 (es) 1994-02-28 1994-02-28 Procedimiento de obtencion de fracciones de oligosacaridos por despolimerizacion quimica de heparina.

Country Status (1)

Country Link
ES (1) ES2077533B1 (es)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2811992A1 (fr) * 2000-07-21 2002-01-25 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
US7812007B2 (en) 2000-07-21 2010-10-12 Aventis Pharma S.A. Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
US7956046B2 (en) 2003-07-24 2011-06-07 Aventis Pharma S.A. Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them
US8003623B2 (en) 2002-10-10 2011-08-23 Aventis Pharma S.A. Mixtures of sulfated oligosaccharides

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0040144A1 (fr) * 1980-05-14 1981-11-18 Pharmuka Laboratoires Nouveaux polysaccharides sulfatés, procédés pour leur préparation et leur utilisation comme médicaments
WO1992011294A1 (en) * 1990-12-20 1992-07-09 Fidia S.P.A. Heparin derivatives

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0040144A1 (fr) * 1980-05-14 1981-11-18 Pharmuka Laboratoires Nouveaux polysaccharides sulfatés, procédés pour leur préparation et leur utilisation comme médicaments
WO1992011294A1 (en) * 1990-12-20 1992-07-09 Fidia S.P.A. Heparin derivatives

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2811992A1 (fr) * 2000-07-21 2002-01-25 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
WO2002008295A1 (fr) * 2000-07-21 2002-01-31 Aventis Pharma S.A. Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
US7812007B2 (en) 2000-07-21 2010-10-12 Aventis Pharma S.A. Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
US8003623B2 (en) 2002-10-10 2011-08-23 Aventis Pharma S.A. Mixtures of sulfated oligosaccharides
US7956046B2 (en) 2003-07-24 2011-06-07 Aventis Pharma S.A. Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
ES2077533B1 (es) 1996-07-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20040601