PT94993A - Processo para a preparacao de 17 beta-(ciclopropilamino)-androst-5-en beta-ol 4 substituido e de compostos afins uteis como inibidores de liase c17-c20 - Google Patents
Processo para a preparacao de 17 beta-(ciclopropilamino)-androst-5-en beta-ol 4 substituido e de compostos afins uteis como inibidores de liase c17-c20Info
- Publication number
- PT94993A PT94993A PT94993A PT9499390A PT94993A PT 94993 A PT94993 A PT 94993A PT 94993 A PT94993 A PT 94993A PT 9499390 A PT9499390 A PT 9499390A PT 94993 A PT94993 A PT 94993A
- Authority
- PT
- Portugal
- Prior art keywords
- beta
- utilized
- compounds
- androst
- cyclopropylamino
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 title 1
- LYFPAZBMEUSVNA-UHFFFAOYSA-N (10R)-3c-Hydroxy-10r.13c-dimethyl-(8cH.9tH.14tH)-Delta5-tetradecahydro-1H-cyclopenta[a]phenanthren Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCCC1(C)CC2 LYFPAZBMEUSVNA-UHFFFAOYSA-N 0.000 abstract 1
- LYFPAZBMEUSVNA-DYKIIFRCSA-N (3s,8s,9s,10r,13s,14s)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 LYFPAZBMEUSVNA-DYKIIFRCSA-N 0.000 abstract 1
- 239000003098 androgen Substances 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 150000002081 enamines Chemical class 0.000 abstract 1
- 150000004678 hydrides Chemical class 0.000 abstract 1
- 150000002466 imines Chemical class 0.000 abstract 1
- 230000003637 steroidlike Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/394,025 US4966898A (en) | 1989-08-15 | 1989-08-15 | 4-substituted 17β-(cyclopropylamino)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT94993A true PT94993A (pt) | 1991-04-18 |
| PT94993B PT94993B (pt) | 1997-07-31 |
Family
ID=23557240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT94993A PT94993B (pt) | 1989-08-15 | 1990-08-14 | Processo para a preparacao de 17 beta-(ciclopropilamino)-androst-5-en beta-ol 4 substituido e de compostos afins uteis como inibidores de liase c17-c20 |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4966898A (pt) |
| EP (1) | EP0413270B1 (pt) |
| JP (1) | JP2879703B2 (pt) |
| KR (1) | KR910004649A (pt) |
| CN (1) | CN1050196A (pt) |
| AT (1) | ATE137761T1 (pt) |
| AU (1) | AU628209B2 (pt) |
| CA (1) | CA2023012C (pt) |
| DD (1) | DD299650A5 (pt) |
| DE (1) | DE69026881T2 (pt) |
| ES (1) | ES2088928T3 (pt) |
| FI (1) | FI95804C (pt) |
| HU (1) | HUT55029A (pt) |
| IE (1) | IE72516B1 (pt) |
| IL (1) | IL95358A (pt) |
| NO (1) | NO903564L (pt) |
| NZ (1) | NZ234856A (pt) |
| PH (1) | PH27098A (pt) |
| PT (1) | PT94993B (pt) |
| ZA (1) | ZA906308B (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4966897A (en) * | 1989-08-15 | 1990-10-30 | Merrell Dow Pharmaceuticals Inc. | 4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
| US5604213A (en) * | 1992-03-31 | 1997-02-18 | British Technology Group Limited | 17-substituted steroids useful in cancer treatment |
| JP2742331B2 (ja) * | 1992-03-31 | 1998-04-22 | ブリテイツシユ・テクノロジー・グループ・リミテツド | 癌治療に有用な１７位置換ステロイド |
| TW369521B (en) * | 1993-09-17 | 1999-09-11 | Smithkline Beecham Corp | Androstenone derivative |
| US5541322A (en) * | 1994-10-14 | 1996-07-30 | Glaxo Wellcome Inc. | Synthesis of 6-azaandrostenones |
| US6365597B1 (en) | 1996-02-14 | 2002-04-02 | Aventis Pharmaceuticals Inc. | 4-aza steroids |
| BR0111654A (pt) * | 2000-06-09 | 2003-05-20 | Bayer Cropscience Sa | Processo de preparação de compostos pesticidas |
| AU2002214296C1 (en) | 2000-11-17 | 2006-04-13 | Takeda Pharmaceutical Company Limited | Novel imidazole derivatives, production method thereof and use thereof |
| AU2002214320A1 (en) | 2000-11-20 | 2002-05-27 | Takeda Chemical Industries Ltd. | Imidazole derivatives, process for their preparation and their use |
| ATE440096T1 (de) | 2000-12-08 | 2009-09-15 | Takeda Pharmaceutical | Substituierte thiazolderivate mit 3- pyridylgruppen, verfahren zu deren herstellung und deren verwendung |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| UA105794C2 (uk) | 2009-06-26 | 2014-06-25 | Новартіс Аг | 1,3-ДИЗАМІЩЕНІ ПОХІДНІ ІМІДАЗОЛІДИН-2-ОНУ ЯК ІНГІБІТОРИ Cyp17 |
| JP2011098893A (ja) * | 2009-11-04 | 2011-05-19 | Sumitomo Chemical Co Ltd | テストステロンの生合成を抑制するための化合物の使用およびその化合物 |
| EP2600855A2 (en) | 2010-08-04 | 2013-06-12 | Pellficure Pharmaceuticals, Inc. | Combination therapy for the treatment of prostate carcinoma |
| EP2627648A1 (en) | 2010-09-16 | 2013-08-21 | Novartis AG | 17aHYDROXYLASE/C17,20-LYASE INHIBITORS |
| MX359399B (es) | 2011-04-28 | 2018-09-27 | Novartis Ag | Inhibidores de 17alfa-hidroxilasa/c17-20-liasa. |
| AU2014241816B9 (en) | 2013-03-14 | 2019-02-14 | Pellficure Pharmaceuticals Inc. | Novel therapy for prostate carcinoma |
| CA2960750A1 (en) | 2014-09-12 | 2016-03-17 | Pellficure Pharmaceuticals, Inc. | Compositions and methods for treatment of prostate carcinoma |
| UA124972C2 (uk) | 2016-07-29 | 2021-12-22 | Янссен Фармацевтика Нв | Способи лікування раку передміхурової залози |
| AU2017350690A1 (en) | 2016-10-24 | 2019-06-13 | Pellficure Pharmaceuticals Inc. | Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1, 4-dione |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3107254A (en) * | 1960-10-05 | 1963-10-15 | Upjohn Co | 17beta-dialkylamino-17-cyanosteroids and their 17alpha-alkyl, alkylene and alkyne derivatives |
| US3097200A (en) * | 1962-01-03 | 1963-07-09 | Syntex Corp | 17-aminoandrostanes |
| NL302932A (pt) * | 1962-12-31 | |||
| CA1326234C (en) * | 1987-04-22 | 1994-01-18 | Michael R. Angelastro | 17.beta.-(cyclopropylamino)androst-5-en-3.beta.-ol and related compoundsuseful as_c__-__ lyase inhibitors |
| US4966897A (en) * | 1989-08-15 | 1990-10-30 | Merrell Dow Pharmaceuticals Inc. | 4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
-
1989
- 1989-08-15 US US07/394,025 patent/US4966898A/en not_active Expired - Fee Related
-
1990
- 1990-08-09 JP JP2209389A patent/JP2879703B2/ja not_active Expired - Fee Related
- 1990-08-09 AU AU60877/90A patent/AU628209B2/en not_active Ceased
- 1990-08-09 ZA ZA906308A patent/ZA906308B/xx unknown
- 1990-08-09 CA CA002023012A patent/CA2023012C/en not_active Expired - Fee Related
- 1990-08-10 NZ NZ234856A patent/NZ234856A/en unknown
- 1990-08-10 AT AT90115391T patent/ATE137761T1/de not_active IP Right Cessation
- 1990-08-10 DE DE69026881T patent/DE69026881T2/de not_active Expired - Fee Related
- 1990-08-10 ES ES90115391T patent/ES2088928T3/es not_active Expired - Lifetime
- 1990-08-10 EP EP90115391A patent/EP0413270B1/en not_active Expired - Lifetime
- 1990-08-13 IL IL9535890A patent/IL95358A/en not_active IP Right Cessation
- 1990-08-14 PT PT94993A patent/PT94993B/pt not_active IP Right Cessation
- 1990-08-14 HU HU905004A patent/HUT55029A/hu unknown
- 1990-08-14 IE IE294290A patent/IE72516B1/en not_active IP Right Cessation
- 1990-08-14 NO NO90903564A patent/NO903564L/no unknown
- 1990-08-14 KR KR1019900012533A patent/KR910004649A/ko not_active Application Discontinuation
- 1990-08-15 DD DD90343476A patent/DD299650A5/de unknown
- 1990-08-15 CN CN90107580A patent/CN1050196A/zh active Pending
- 1990-08-15 PH PH41034A patent/PH27098A/en unknown
- 1990-08-15 FI FI904035A patent/FI95804C/fi not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| CA2023012C (en) | 2001-07-03 |
| PH27098A (en) | 1993-02-26 |
| KR910004649A (ko) | 1991-03-29 |
| PT94993B (pt) | 1997-07-31 |
| JP2879703B2 (ja) | 1999-04-05 |
| CN1050196A (zh) | 1991-03-27 |
| IL95358A (en) | 1995-03-30 |
| DE69026881T2 (de) | 1996-09-12 |
| ZA906308B (en) | 1991-06-26 |
| AU628209B2 (en) | 1992-09-10 |
| FI904035A0 (fi) | 1990-08-15 |
| IE902942A1 (en) | 1991-02-27 |
| JPH0383998A (ja) | 1991-04-09 |
| HU905004D0 (en) | 1991-01-28 |
| IE72516B1 (en) | 1997-04-23 |
| ES2088928T3 (es) | 1996-10-01 |
| ATE137761T1 (de) | 1996-05-15 |
| NO903564D0 (no) | 1990-08-14 |
| US4966898A (en) | 1990-10-30 |
| HUT55029A (en) | 1991-04-29 |
| CA2023012A1 (en) | 1991-02-16 |
| EP0413270B1 (en) | 1996-05-08 |
| FI95804B (fi) | 1995-12-15 |
| IL95358A0 (en) | 1991-06-30 |
| NO903564L (no) | 1991-02-18 |
| AU6087790A (en) | 1991-02-21 |
| DD299650A5 (de) | 1992-04-30 |
| NZ234856A (en) | 1992-08-26 |
| FI95804C (fi) | 1996-03-25 |
| EP0413270A3 (en) | 1992-05-20 |
| DE69026881D1 (de) | 1996-06-13 |
| EP0413270A2 (en) | 1991-02-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT94993A (pt) | Processo para a preparacao de 17 beta-(ciclopropilamino)-androst-5-en beta-ol 4 substituido e de compostos afins uteis como inibidores de liase c17-c20 | |
| ES2038712T3 (es) | Un procedimiento para preparar un compuesto util como inhibidor de esteroide c17-20 liasa. | |
| LTIP919A (en) | Drugs and process for preparing thereof | |
| PT94994A (pt) | Processo para a preparacao de 17 beta-(ciclopropiloxi)-androst-5-en-3-beta-ol substituido na posicao 4 e de compostos afins como inibidores do esteroide c17-20liase | |
| NZ224287A (en) | 17b-(cyclopropyloxy)androst-5-en-3b-ol and related compounds useful as c 17-20 lyase inhibitors for treating androgen-dependent disorders | |
| DE69432626D1 (de) | Melatonin-Derivate zur Verwendung in der Behandlung von Desynchronisierungs-Erkankungen | |
| ATE114468T1 (de) | Ethyl-(+)-apovincaminat zur behandlung der demyelinisierung klinischer erscheinungen autoimmunen ursprungs. | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| BB1A | Laying open of patent application |
Effective date: 19901113 |
|
| FG3A | Patent granted, date of granting |
Effective date: 19970430 |
|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 20031031 |