DE69026881D1 - 4-Substituiertes 17-beta-(Cyclopropyl-amino)-androst-5-en-3-beta-ol und seine Derivate, verwendbar als Inhibitoren der C17-20-Lyase - Google Patents
4-Substituiertes 17-beta-(Cyclopropyl-amino)-androst-5-en-3-beta-ol und seine Derivate, verwendbar als Inhibitoren der C17-20-LyaseInfo
- Publication number
- DE69026881D1 DE69026881D1 DE69026881T DE69026881T DE69026881D1 DE 69026881 D1 DE69026881 D1 DE 69026881D1 DE 69026881 T DE69026881 T DE 69026881T DE 69026881 T DE69026881 T DE 69026881T DE 69026881 D1 DE69026881 D1 DE 69026881D1
- Authority
- DE
- Germany
- Prior art keywords
- beta
- androst
- cyclopropylamino
- substituted
- lyase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- LYFPAZBMEUSVNA-UHFFFAOYSA-N (10R)-3c-Hydroxy-10r.13c-dimethyl-(8cH.9tH.14tH)-Delta5-tetradecahydro-1H-cyclopenta[a]phenanthren Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCCC1(C)CC2 LYFPAZBMEUSVNA-UHFFFAOYSA-N 0.000 title abstract 2
- LYFPAZBMEUSVNA-DYKIIFRCSA-N (3s,8s,9s,10r,13s,14s)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 LYFPAZBMEUSVNA-DYKIIFRCSA-N 0.000 title abstract 2
- 102000004317 Lyases Human genes 0.000 title 1
- 108090000856 Lyases Proteins 0.000 title 1
- 125000006317 cyclopropyl amino group Chemical group 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000003098 androgen Substances 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 150000002081 enamines Chemical class 0.000 abstract 1
- 150000004678 hydrides Chemical class 0.000 abstract 1
- 150000002466 imines Chemical class 0.000 abstract 1
- 230000003637 steroidlike Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/394,025 US4966898A (en) | 1989-08-15 | 1989-08-15 | 4-substituted 17β-(cyclopropylamino)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69026881D1 true DE69026881D1 (de) | 1996-06-13 |
| DE69026881T2 DE69026881T2 (de) | 1996-09-12 |
Family
ID=23557240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69026881T Expired - Fee Related DE69026881T2 (de) | 1989-08-15 | 1990-08-10 | 4-Substituiertes 17-beta-(Cyclopropyl-amino)-androst-5-en-3-beta-ol und seine Derivate, verwendbar als Inhibitoren der C17-20-Lyase |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4966898A (de) |
| EP (1) | EP0413270B1 (de) |
| JP (1) | JP2879703B2 (de) |
| KR (1) | KR910004649A (de) |
| CN (1) | CN1050196A (de) |
| AT (1) | ATE137761T1 (de) |
| AU (1) | AU628209B2 (de) |
| CA (1) | CA2023012C (de) |
| DD (1) | DD299650A5 (de) |
| DE (1) | DE69026881T2 (de) |
| ES (1) | ES2088928T3 (de) |
| FI (1) | FI95804C (de) |
| HU (1) | HUT55029A (de) |
| IE (1) | IE72516B1 (de) |
| IL (1) | IL95358A (de) |
| NO (1) | NO903564L (de) |
| NZ (1) | NZ234856A (de) |
| PH (1) | PH27098A (de) |
| PT (1) | PT94993B (de) |
| ZA (1) | ZA906308B (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4966897A (en) * | 1989-08-15 | 1990-10-30 | Merrell Dow Pharmaceuticals Inc. | 4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
| US5604213A (en) * | 1992-03-31 | 1997-02-18 | British Technology Group Limited | 17-substituted steroids useful in cancer treatment |
| NZ249911A (en) * | 1992-03-31 | 1996-06-25 | British Tech Group | 17-(3-pyridyl) substituted steroids and use in pharmaceutical compositions |
| TW369521B (en) * | 1993-09-17 | 1999-09-11 | Smithkline Beecham Corp | Androstenone derivative |
| US5541322A (en) * | 1994-10-14 | 1996-07-30 | Glaxo Wellcome Inc. | Synthesis of 6-azaandrostenones |
| US6365597B1 (en) | 1996-02-14 | 2002-04-02 | Aventis Pharmaceuticals Inc. | 4-aza steroids |
| IL152696A0 (en) * | 2000-06-09 | 2003-06-24 | Bayer Cropscience Sa | Process for the preparation of pesticidal compounds |
| SI1334106T1 (sl) | 2000-11-17 | 2006-10-31 | Takeda Pharmaceutical | Imidazolni derivati, njihov proizvodni postopek in njihova uporaba |
| US6960586B2 (en) | 2000-11-20 | 2005-11-01 | Takeda Pharmaceutical Company Limited | Imidazole derivatives, process for their preparation and their use |
| CA2431171A1 (en) | 2000-12-08 | 2002-06-13 | Takeda Chemical Industries, Ltd. | Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| JO2892B1 (en) | 2009-06-26 | 2015-09-15 | نوفارتيس ايه جي | CYP inhibitors 17 |
| JP2011098893A (ja) * | 2009-11-04 | 2011-05-19 | Sumitomo Chemical Co Ltd | テストステロンの生合成を抑制するための化合物の使用およびその化合物 |
| WO2012018948A2 (en) | 2010-08-04 | 2012-02-09 | Pellficure Pharmaceuticals, Inc. | Novel treatment of prostate carcinoma |
| US8946260B2 (en) | 2010-09-16 | 2015-02-03 | Novartis Ag | 17α-hydroxylase/C17,20-lyase inhibitors |
| US9029399B2 (en) | 2011-04-28 | 2015-05-12 | Novartis Ag | 17α-hydroxylase/C17,20-lyase inhibitors |
| EP2968219B1 (de) | 2013-03-14 | 2019-04-24 | Pellficure Pharmaceuticals, Inc. | Neuartige therapie gegen prostatakarzinome |
| CA2960750A1 (en) | 2014-09-12 | 2016-03-17 | Pellficure Pharmaceuticals, Inc. | Compositions and methods for treatment of prostate carcinoma |
| MA45780A (fr) | 2016-07-29 | 2019-06-05 | Janssen Pharmaceutica Nv | Méthodes de traitement du cancer de la prostate |
| EP3528799A1 (de) | 2016-10-24 | 2019-08-28 | Pellficure Pharmaceuticals, Inc. | Pharmazeutische zusammensetzungen aus 5-hydroxy-2-methylnaphthalen-1,4-dion |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3107254A (en) * | 1960-10-05 | 1963-10-15 | Upjohn Co | 17beta-dialkylamino-17-cyanosteroids and their 17alpha-alkyl, alkylene and alkyne derivatives |
| US3097200A (en) * | 1962-01-03 | 1963-07-09 | Syntex Corp | 17-aminoandrostanes |
| NL302932A (de) * | 1962-12-31 | |||
| NZ224288A (en) * | 1987-04-22 | 1989-12-21 | Merrell Dow Pharma | 17b-(cyclopropylamino)androst-5-en-3b-ol and related compounds and methods using these for treatment of non-humans |
| US4966897A (en) * | 1989-08-15 | 1990-10-30 | Merrell Dow Pharmaceuticals Inc. | 4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
-
1989
- 1989-08-15 US US07/394,025 patent/US4966898A/en not_active Expired - Fee Related
-
1990
- 1990-08-09 ZA ZA906308A patent/ZA906308B/xx unknown
- 1990-08-09 JP JP2209389A patent/JP2879703B2/ja not_active Expired - Fee Related
- 1990-08-09 CA CA002023012A patent/CA2023012C/en not_active Expired - Fee Related
- 1990-08-09 AU AU60877/90A patent/AU628209B2/en not_active Ceased
- 1990-08-10 AT AT90115391T patent/ATE137761T1/de not_active IP Right Cessation
- 1990-08-10 NZ NZ234856A patent/NZ234856A/en unknown
- 1990-08-10 ES ES90115391T patent/ES2088928T3/es not_active Expired - Lifetime
- 1990-08-10 DE DE69026881T patent/DE69026881T2/de not_active Expired - Fee Related
- 1990-08-10 EP EP90115391A patent/EP0413270B1/de not_active Expired - Lifetime
- 1990-08-13 IL IL9535890A patent/IL95358A/en not_active IP Right Cessation
- 1990-08-14 KR KR1019900012533A patent/KR910004649A/ko not_active Application Discontinuation
- 1990-08-14 PT PT94993A patent/PT94993B/pt not_active IP Right Cessation
- 1990-08-14 NO NO90903564A patent/NO903564L/no unknown
- 1990-08-14 HU HU905004A patent/HUT55029A/hu unknown
- 1990-08-14 IE IE294290A patent/IE72516B1/en not_active IP Right Cessation
- 1990-08-15 DD DD90343476A patent/DD299650A5/de unknown
- 1990-08-15 PH PH41034A patent/PH27098A/en unknown
- 1990-08-15 FI FI904035A patent/FI95804C/fi not_active IP Right Cessation
- 1990-08-15 CN CN90107580A patent/CN1050196A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR910004649A (ko) | 1991-03-29 |
| EP0413270A3 (en) | 1992-05-20 |
| PH27098A (en) | 1993-02-26 |
| IL95358A (en) | 1995-03-30 |
| IE72516B1 (en) | 1997-04-23 |
| PT94993B (pt) | 1997-07-31 |
| DD299650A5 (de) | 1992-04-30 |
| EP0413270B1 (de) | 1996-05-08 |
| IE902942A1 (en) | 1991-02-27 |
| US4966898A (en) | 1990-10-30 |
| ATE137761T1 (de) | 1996-05-15 |
| JP2879703B2 (ja) | 1999-04-05 |
| JPH0383998A (ja) | 1991-04-09 |
| ES2088928T3 (es) | 1996-10-01 |
| FI904035A0 (fi) | 1990-08-15 |
| NZ234856A (en) | 1992-08-26 |
| PT94993A (pt) | 1991-04-18 |
| HU905004D0 (en) | 1991-01-28 |
| IL95358A0 (en) | 1991-06-30 |
| ZA906308B (en) | 1991-06-26 |
| CA2023012A1 (en) | 1991-02-16 |
| CN1050196A (zh) | 1991-03-27 |
| AU628209B2 (en) | 1992-09-10 |
| EP0413270A2 (de) | 1991-02-20 |
| HUT55029A (en) | 1991-04-29 |
| FI95804B (fi) | 1995-12-15 |
| AU6087790A (en) | 1991-02-21 |
| NO903564D0 (no) | 1990-08-14 |
| DE69026881T2 (de) | 1996-09-12 |
| FI95804C (fi) | 1996-03-25 |
| CA2023012C (en) | 2001-07-03 |
| NO903564L (no) | 1991-02-18 |
Similar Documents
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| DE69026881D1 (de) | 4-Substituiertes 17-beta-(Cyclopropyl-amino)-androst-5-en-3-beta-ol und seine Derivate, verwendbar als Inhibitoren der C17-20-Lyase | |
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| DE69027262T2 (de) | 4-Substitutiertes 17-beta-(Cyclopropyloxy)androst-5-en-3-beta-ol und seine Derivate, verwendbar als Inhibitoren der C17-20-Lyase | |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |