FI904035A0 - Menetelmä valmistaa terapeuttisesti aktiivisia 4-substituoituja 17 -(syklopropyyliamino)androst-5-eenijohdannaisia, jotka ovat hyödyllisiä C17-20-lyaasi-inhibiittoreina - Google Patents
Menetelmä valmistaa terapeuttisesti aktiivisia 4-substituoituja 17 -(syklopropyyliamino)androst-5-eenijohdannaisia, jotka ovat hyödyllisiä C17-20-lyaasi-inhibiittoreinaInfo
- Publication number
- FI904035A0 FI904035A0 FI904035A FI904035A FI904035A0 FI 904035 A0 FI904035 A0 FI 904035A0 FI 904035 A FI904035 A FI 904035A FI 904035 A FI904035 A FI 904035A FI 904035 A0 FI904035 A0 FI 904035A0
- Authority
- FI
- Finland
- Prior art keywords
- androst
- substituted
- cyclopropyloxy
- preparation
- therapeutically active
- Prior art date
Links
- 150000001434 androst-5-enes Chemical class 0.000 title 1
- 125000000131 cyclopropyloxy group Chemical group C1(CC1)O* 0.000 title 1
- 239000002697 lyase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- LYFPAZBMEUSVNA-UHFFFAOYSA-N (10R)-3c-Hydroxy-10r.13c-dimethyl-(8cH.9tH.14tH)-Delta5-tetradecahydro-1H-cyclopenta[a]phenanthren Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCCC1(C)CC2 LYFPAZBMEUSVNA-UHFFFAOYSA-N 0.000 abstract 1
- LYFPAZBMEUSVNA-DYKIIFRCSA-N (3s,8s,9s,10r,13s,14s)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 LYFPAZBMEUSVNA-DYKIIFRCSA-N 0.000 abstract 1
- 239000003098 androgen Substances 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 150000002081 enamines Chemical class 0.000 abstract 1
- 150000004678 hydrides Chemical class 0.000 abstract 1
- 150000002466 imines Chemical class 0.000 abstract 1
- 230000003637 steroidlike Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/394,025 US4966898A (en) | 1989-08-15 | 1989-08-15 | 4-substituted 17β-(cyclopropylamino)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
| US39402589 | 1989-08-15 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| FI904035A0 true FI904035A0 (fi) | 1990-08-15 |
| FI95804B FI95804B (fi) | 1995-12-15 |
| FI95804C FI95804C (fi) | 1996-03-25 |
Family
ID=23557240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI904035A FI95804C (fi) | 1989-08-15 | 1990-08-15 | Menetelmä valmistaa terapeuttisesti aktiivisia 4-substituoituja 17 -(syklopropyyliamino)androst-5-eenijohdannaisia, jotka ovat hyödyllisiä C17-20-lyaasi-inhibiittoreina |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4966898A (fi) |
| EP (1) | EP0413270B1 (fi) |
| JP (1) | JP2879703B2 (fi) |
| KR (1) | KR910004649A (fi) |
| CN (1) | CN1050196A (fi) |
| AT (1) | ATE137761T1 (fi) |
| AU (1) | AU628209B2 (fi) |
| CA (1) | CA2023012C (fi) |
| DD (1) | DD299650A5 (fi) |
| DE (1) | DE69026881T2 (fi) |
| ES (1) | ES2088928T3 (fi) |
| FI (1) | FI95804C (fi) |
| HU (1) | HUT55029A (fi) |
| IE (1) | IE72516B1 (fi) |
| IL (1) | IL95358A (fi) |
| NO (1) | NO903564L (fi) |
| NZ (1) | NZ234856A (fi) |
| PH (1) | PH27098A (fi) |
| PT (1) | PT94993B (fi) |
| ZA (1) | ZA906308B (fi) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4966897A (en) * | 1989-08-15 | 1990-10-30 | Merrell Dow Pharmaceuticals Inc. | 4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
| DK0633893T3 (da) * | 1992-03-31 | 2000-04-17 | Btg Int Ltd | 17-Substituerede steroider, der er nyttige ved cancerbehandling |
| US5604213A (en) * | 1992-03-31 | 1997-02-18 | British Technology Group Limited | 17-substituted steroids useful in cancer treatment |
| TW369521B (en) * | 1993-09-17 | 1999-09-11 | Smithkline Beecham Corp | Androstenone derivative |
| US5541322A (en) * | 1994-10-14 | 1996-07-30 | Glaxo Wellcome Inc. | Synthesis of 6-azaandrostenones |
| US6365597B1 (en) | 1996-02-14 | 2002-04-02 | Aventis Pharmaceuticals Inc. | 4-aza steroids |
| DE60142962D1 (de) * | 2000-06-09 | 2010-10-14 | Merial Ltd | Verfahren zur herstellung von pestiziden verbindungen |
| CN100572363C (zh) | 2000-11-17 | 2009-12-23 | 武田药品工业株式会社 | 咪唑衍生物、其制备方法及其用途 |
| ATE502030T1 (de) | 2000-11-20 | 2011-04-15 | Takeda Pharmaceutical | Imidazolderivate, verfahren zu deren herstellung und deren verwendung |
| DE60139639D1 (de) | 2000-12-08 | 2009-10-01 | Takeda Pharmaceutical | Substituierte thiazolderivate mit 3-pyridylgruppen, verfahren zu deren herstellung und deren verwendung |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| UA105794C2 (uk) | 2009-06-26 | 2014-06-25 | Новартіс Аг | 1,3-ДИЗАМІЩЕНІ ПОХІДНІ ІМІДАЗОЛІДИН-2-ОНУ ЯК ІНГІБІТОРИ Cyp17 |
| JP2011098893A (ja) * | 2009-11-04 | 2011-05-19 | Sumitomo Chemical Co Ltd | テストステロンの生合成を抑制するための化合物の使用およびその化合物 |
| US9132105B2 (en) | 2010-08-04 | 2015-09-15 | Pellficure Pharmaceuticals, Inc. | Treatment of prostate carcinoma |
| US8946260B2 (en) | 2010-09-16 | 2015-02-03 | Novartis Ag | 17α-hydroxylase/C17,20-lyase inhibitors |
| ES2656218T3 (es) | 2011-04-28 | 2018-02-26 | Novartis Ag | Inhibidores de 17 alfa-hidroxilasa/C17,20-liasa |
| CA2902335C (en) | 2013-03-14 | 2021-09-14 | Pellficure Pharmaceuticals, Inc. | Novel therapy for prostate carcinoma |
| US10093620B2 (en) | 2014-09-12 | 2018-10-09 | Pellficure Pharmaceuticals, Inc. | Compositions and methods for treatment of prostate carcinoma |
| CN109640991A (zh) | 2016-07-29 | 2019-04-16 | 詹森药业有限公司 | 治疗前列腺癌的方法 |
| EP3528799A1 (en) | 2016-10-24 | 2019-08-28 | Pellficure Pharmaceuticals, Inc. | Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1, 4-dione |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3107254A (en) * | 1960-10-05 | 1963-10-15 | Upjohn Co | 17beta-dialkylamino-17-cyanosteroids and their 17alpha-alkyl, alkylene and alkyne derivatives |
| US3097200A (en) * | 1962-01-03 | 1963-07-09 | Syntex Corp | 17-aminoandrostanes |
| NL302932A (fi) * | 1962-12-31 | |||
| NZ224288A (en) * | 1987-04-22 | 1989-12-21 | Merrell Dow Pharma | 17b-(cyclopropylamino)androst-5-en-3b-ol and related compounds and methods using these for treatment of non-humans |
| US4966897A (en) * | 1989-08-15 | 1990-10-30 | Merrell Dow Pharmaceuticals Inc. | 4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
-
1989
- 1989-08-15 US US07/394,025 patent/US4966898A/en not_active Expired - Fee Related
-
1990
- 1990-08-09 JP JP2209389A patent/JP2879703B2/ja not_active Expired - Fee Related
- 1990-08-09 AU AU60877/90A patent/AU628209B2/en not_active Ceased
- 1990-08-09 ZA ZA906308A patent/ZA906308B/xx unknown
- 1990-08-09 CA CA002023012A patent/CA2023012C/en not_active Expired - Fee Related
- 1990-08-10 AT AT90115391T patent/ATE137761T1/de not_active IP Right Cessation
- 1990-08-10 NZ NZ234856A patent/NZ234856A/en unknown
- 1990-08-10 DE DE69026881T patent/DE69026881T2/de not_active Expired - Fee Related
- 1990-08-10 EP EP90115391A patent/EP0413270B1/en not_active Expired - Lifetime
- 1990-08-10 ES ES90115391T patent/ES2088928T3/es not_active Expired - Lifetime
- 1990-08-13 IL IL9535890A patent/IL95358A/en not_active IP Right Cessation
- 1990-08-14 NO NO90903564A patent/NO903564L/no unknown
- 1990-08-14 KR KR1019900012533A patent/KR910004649A/ko not_active Application Discontinuation
- 1990-08-14 HU HU905004A patent/HUT55029A/hu unknown
- 1990-08-14 IE IE294290A patent/IE72516B1/en not_active IP Right Cessation
- 1990-08-14 PT PT94993A patent/PT94993B/pt not_active IP Right Cessation
- 1990-08-15 DD DD90343476A patent/DD299650A5/de unknown
- 1990-08-15 CN CN90107580A patent/CN1050196A/zh active Pending
- 1990-08-15 FI FI904035A patent/FI95804C/fi not_active IP Right Cessation
- 1990-08-15 PH PH41034A patent/PH27098A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU905004D0 (en) | 1991-01-28 |
| IE72516B1 (en) | 1997-04-23 |
| FI95804B (fi) | 1995-12-15 |
| EP0413270B1 (en) | 1996-05-08 |
| NO903564D0 (no) | 1990-08-14 |
| PT94993A (pt) | 1991-04-18 |
| CA2023012C (en) | 2001-07-03 |
| NO903564L (no) | 1991-02-18 |
| IL95358A (en) | 1995-03-30 |
| JPH0383998A (ja) | 1991-04-09 |
| KR910004649A (ko) | 1991-03-29 |
| ZA906308B (en) | 1991-06-26 |
| PT94993B (pt) | 1997-07-31 |
| IE902942A1 (en) | 1991-02-27 |
| ES2088928T3 (es) | 1996-10-01 |
| ATE137761T1 (de) | 1996-05-15 |
| DD299650A5 (de) | 1992-04-30 |
| EP0413270A2 (en) | 1991-02-20 |
| DE69026881T2 (de) | 1996-09-12 |
| DE69026881D1 (de) | 1996-06-13 |
| AU6087790A (en) | 1991-02-21 |
| EP0413270A3 (en) | 1992-05-20 |
| US4966898A (en) | 1990-10-30 |
| IL95358A0 (en) | 1991-06-30 |
| NZ234856A (en) | 1992-08-26 |
| JP2879703B2 (ja) | 1999-04-05 |
| FI95804C (fi) | 1996-03-25 |
| CN1050196A (zh) | 1991-03-27 |
| AU628209B2 (en) | 1992-09-10 |
| CA2023012A1 (en) | 1991-02-16 |
| HUT55029A (en) | 1991-04-29 |
| PH27098A (en) | 1993-02-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Patent granted |
Owner name: MERRELL DOW PHARMACEUTICALS INC. |
|
| BB | Publication of examined application | ||
| MM | Patent lapsed |
Owner name: MERRELL DOW PHARMACEUTICALS INC. |