ES2088928T3 - 17beta-(ciclopropilamino)androst-5-en-3beta-ol 4-sustituido y compuestos relacionados que son inhibidores de liasa c17-20. - Google Patents

17beta-(ciclopropilamino)androst-5-en-3beta-ol 4-sustituido y compuestos relacionados que son inhibidores de liasa c17-20.

Info

Publication number
ES2088928T3
ES2088928T3 ES90115391T ES90115391T ES2088928T3 ES 2088928 T3 ES2088928 T3 ES 2088928T3 ES 90115391 T ES90115391 T ES 90115391T ES 90115391 T ES90115391 T ES 90115391T ES 2088928 T3 ES2088928 T3 ES 2088928T3
Authority
ES
Spain
Prior art keywords
androst
substituted
ciclopropilamino
liasa
17beta
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90115391T
Other languages
English (en)
Inventor
Michael R Angelastro
Thomas R Blohm
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2088928T3 publication Critical patent/ES2088928T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

ESTA INVENCION CONCIERNE A 4-SUSTITUIDOS 17(BETA)-(CICLOPROPILAMINO) ANDROST-5-EN-3(BETA)-OLES Y A COMPUESTOS RELACIONADOS Y TAMBIEN A UN METODO PARA USAR TALES COMPUESTOS EN EL TRATAMIENTO DE DESORDENES DEPENDIENTES DE ANDROGENOS. LOS COMPUESTOS SE PREPARAN POR LA REDUCCION HIBRIDA DE UNA APROPIADA IMINA ESTEROIDE O ENAMINA.
ES90115391T 1989-08-15 1990-08-10 17beta-(ciclopropilamino)androst-5-en-3beta-ol 4-sustituido y compuestos relacionados que son inhibidores de liasa c17-20. Expired - Lifetime ES2088928T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/394,025 US4966898A (en) 1989-08-15 1989-08-15 4-substituted 17β-(cyclopropylamino)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors

Publications (1)

Publication Number Publication Date
ES2088928T3 true ES2088928T3 (es) 1996-10-01

Family

ID=23557240

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90115391T Expired - Lifetime ES2088928T3 (es) 1989-08-15 1990-08-10 17beta-(ciclopropilamino)androst-5-en-3beta-ol 4-sustituido y compuestos relacionados que son inhibidores de liasa c17-20.

Country Status (20)

Country Link
US (1) US4966898A (es)
EP (1) EP0413270B1 (es)
JP (1) JP2879703B2 (es)
KR (1) KR910004649A (es)
CN (1) CN1050196A (es)
AT (1) ATE137761T1 (es)
AU (1) AU628209B2 (es)
CA (1) CA2023012C (es)
DD (1) DD299650A5 (es)
DE (1) DE69026881T2 (es)
ES (1) ES2088928T3 (es)
FI (1) FI95804C (es)
HU (1) HUT55029A (es)
IE (1) IE72516B1 (es)
IL (1) IL95358A (es)
NO (1) NO903564L (es)
NZ (1) NZ234856A (es)
PH (1) PH27098A (es)
PT (1) PT94993B (es)
ZA (1) ZA906308B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4966897A (en) * 1989-08-15 1990-10-30 Merrell Dow Pharmaceuticals Inc. 4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors
DK0633893T3 (da) * 1992-03-31 2000-04-17 Btg Int Ltd 17-Substituerede steroider, der er nyttige ved cancerbehandling
US5604213A (en) * 1992-03-31 1997-02-18 British Technology Group Limited 17-substituted steroids useful in cancer treatment
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US6365597B1 (en) 1996-02-14 2002-04-02 Aventis Pharmaceuticals Inc. 4-aza steroids
WO2001094315A2 (en) * 2000-06-09 2001-12-13 Bayer Cropscience S.A. Process for the preparation of pesticidal compounds
MY134929A (en) 2000-11-17 2008-01-31 Takeda Pharmaceutical Novel imidazole derivatives, production method thereof and use thereof
EP1344777B1 (en) 2000-11-20 2011-03-16 Takeda Pharmaceutical Company Limited Imidazole derivatives, process for their preparation and their use
EP1348706B1 (en) 2000-12-08 2009-08-19 Takeda Pharmaceutical Company Limited Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
DK2445903T3 (da) 2009-06-26 2014-06-23 Novartis Ag 1,3-Disubstituerede imidazolidin-2-on-derivater som CYP17-inhibitorer
JP2011098893A (ja) * 2009-11-04 2011-05-19 Sumitomo Chemical Co Ltd テストステロンの生合成を抑制するための化合物の使用およびその化合物
KR101594660B1 (ko) 2010-08-04 2016-02-16 펠피큐어 파마슈티걸즈 아이엔씨 전립선 암종의 치료를 위한 병용 요법
WO2012035078A1 (en) 2010-09-16 2012-03-22 Novartis Ag 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS
CN103649073B (zh) 2011-04-28 2016-04-13 诺瓦提斯公司 17α-羟化酶/C17,20-裂合酶抑制剂
US20160022606A1 (en) 2013-03-14 2016-01-28 Pellficure Pharmaceuticals Inc. Novel therapy for prostate carcinoma
WO2016040896A1 (en) 2014-09-12 2016-03-17 Pellficure Pharmaceuticals, Inc. Compositions and methods for treatment of prostate carcinoma
CA3031705A1 (en) 2016-07-29 2018-02-01 Janssen Pharmaceutica Nv Treatment of prostate cancer with niraparib
CA3044812A1 (en) 2016-10-24 2018-05-03 Pellficure Pharmaceuticals Inc. Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1,4-dione

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3107254A (en) * 1960-10-05 1963-10-15 Upjohn Co 17beta-dialkylamino-17-cyanosteroids and their 17alpha-alkyl, alkylene and alkyne derivatives
US3097200A (en) * 1962-01-03 1963-07-09 Syntex Corp 17-aminoandrostanes
NL302932A (es) * 1962-12-31
NZ224288A (en) * 1987-04-22 1989-12-21 Merrell Dow Pharma 17b-(cyclopropylamino)androst-5-en-3b-ol and related compounds and methods using these for treatment of non-humans
US4966897A (en) * 1989-08-15 1990-10-30 Merrell Dow Pharmaceuticals Inc. 4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors

Also Published As

Publication number Publication date
HU905004D0 (en) 1991-01-28
HUT55029A (en) 1991-04-29
PH27098A (en) 1993-02-26
KR910004649A (ko) 1991-03-29
EP0413270A2 (en) 1991-02-20
NZ234856A (en) 1992-08-26
DE69026881T2 (de) 1996-09-12
FI95804B (fi) 1995-12-15
NO903564D0 (no) 1990-08-14
DE69026881D1 (de) 1996-06-13
IE902942A1 (en) 1991-02-27
ZA906308B (en) 1991-06-26
CA2023012C (en) 2001-07-03
IL95358A0 (en) 1991-06-30
PT94993B (pt) 1997-07-31
EP0413270A3 (en) 1992-05-20
AU6087790A (en) 1991-02-21
IL95358A (en) 1995-03-30
US4966898A (en) 1990-10-30
IE72516B1 (en) 1997-04-23
CA2023012A1 (en) 1991-02-16
JP2879703B2 (ja) 1999-04-05
FI904035A0 (fi) 1990-08-15
NO903564L (no) 1991-02-18
ATE137761T1 (de) 1996-05-15
DD299650A5 (de) 1992-04-30
AU628209B2 (en) 1992-09-10
EP0413270B1 (en) 1996-05-08
JPH0383998A (ja) 1991-04-09
FI95804C (fi) 1996-03-25
CN1050196A (zh) 1991-03-27
PT94993A (pt) 1991-04-18

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