ES2059438T3 - Tioalquilamidas fenolicas inhibidoras de 5-lipoxigenasa. - Google Patents

Tioalquilamidas fenolicas inhibidoras de 5-lipoxigenasa.

Info

Publication number
ES2059438T3
ES2059438T3 ES88108873T ES88108873T ES2059438T3 ES 2059438 T3 ES2059438 T3 ES 2059438T3 ES 88108873 T ES88108873 T ES 88108873T ES 88108873 T ES88108873 T ES 88108873T ES 2059438 T3 ES2059438 T3 ES 2059438T3
Authority
ES
Spain
Prior art keywords
thioalkylamides
phenolic
lipoxigenase inhibitors
lipoxygenase
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88108873T
Other languages
English (en)
Inventor
Richard August Mueller
Richard Allen Partis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of ES2059438T3 publication Critical patent/ES2059438T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

LOS COMPUESTOS DE LA PRESENTE INVENCION COMPRENDEN TIOALQUILAMIDAS FENOLICAS SUSTITUIDAS QUE SON INHIBIDORES ESPECIFICOS DE 5-LIPOXIGENASA Y QUE POR ELLO SON UTILES EN EL TRATAMIENTO DE INFLAMACION LOCAL Y SISTEMICA, ALERGIA Y REACCIONES DE HIPERSENSIBILIDAD Y OTRAS ALTERACIONES EN LAS QUE ESTEN IMPLICADOS AGENTES FORMADORES EN EL METABOLISMO DE 5-LIPOXIGENASA.
ES88108873T 1987-06-05 1988-06-03 Tioalquilamidas fenolicas inhibidoras de 5-lipoxigenasa. Expired - Lifetime ES2059438T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/058,431 US4835189A (en) 1987-06-05 1987-06-05 Phenolic thioalkylamides as inhibitors of 5-lipoxygenase

Publications (1)

Publication Number Publication Date
ES2059438T3 true ES2059438T3 (es) 1994-11-16

Family

ID=22016767

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88108873T Expired - Lifetime ES2059438T3 (es) 1987-06-05 1988-06-03 Tioalquilamidas fenolicas inhibidoras de 5-lipoxigenasa.

Country Status (7)

Country Link
US (1) US4835189A (es)
EP (1) EP0293899B1 (es)
JP (1) JPS63310820A (es)
AT (1) ATE95692T1 (es)
CA (1) CA1330446C (es)
DE (1) DE3884858T2 (es)
ES (1) ES2059438T3 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5071876A (en) * 1985-02-04 1991-12-10 G. D. Searle & Co. Novel disubstituted 4-hydroxyphenylthio anilides
DE3920616A1 (de) * 1989-06-23 1991-01-03 Boehringer Mannheim Gmbh Arzneimittel, enthaltend di-tert.-butylhydroxyphenyl-derivate sowie neue derivate
DE4204405A1 (de) * 1991-08-02 1993-02-04 Boehringer Mannheim Gmbh Verwendung von di-tert.-butylhydroxyphenyl-derivaten zur therapie von entzuendlichen erkrankungen des magen-darm-traktes
US6737448B2 (en) * 2002-06-03 2004-05-18 Staar Surgical Company High refractive index, optically clear and soft hydrophobic acrylamide copolymers
NZ789295A (en) 2009-04-29 2024-02-23 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
WO2016040331A1 (en) 2014-09-09 2016-03-17 Staar Surgical Company Ophthalmic implants with extended depth of field and enhanced distance visual acuity
US10881504B2 (en) 2016-03-09 2021-01-05 Staar Surgical Company Ophthalmic implants with extended depth of field and enhanced distance visual acuity
CN112867944A (zh) 2018-08-17 2021-05-28 斯塔尔外科有限公司 呈现折射率纳米梯度的聚合物组合物
CN113200894A (zh) * 2020-03-16 2021-08-03 北京中美红格科技有限公司 双硫双丁酚及类似物的合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1064252A (en) * 1963-09-19 1967-04-05 Ici Ltd Amides and pharmaceutical compositions containing them
GB1121722A (en) * 1966-03-31 1968-07-31 Ici Ltd New carboxylic acid derivatives
US3624143A (en) * 1968-05-10 1971-11-30 Merck & Co Inc Compounds of the class {62 -aralkylthio-substituted-{60 -amino acids
DE1936463A1 (de) * 1969-07-17 1971-02-04 Boehringer Sohn Ingelheim Substituierte Phenole
AT353776B (de) * 1973-12-27 1979-12-10 Siegfried Ag Verfahren zur herstellung von neuen alkan- saeuren, deren estern und salzen
US4029812A (en) * 1976-02-18 1977-06-14 The Dow Chemical Company Novel hypolipidemic 2-(3,5-di-tert-butyl-4-hydroxyphenyl)thio carboxamides
JPS52125170A (en) * 1976-04-12 1977-10-20 Yoshitomi Pharmaceut Ind Ltd Pyridine derivatives
JPS5758663A (en) * 1980-09-24 1982-04-08 Otsuka Pharmaceut Co Ltd Alkanoic acid derivative
DE3121072A1 (de) * 1981-05-27 1982-12-16 Henkel Kgaa "aryl- und heteroarylmercapto-alkansaeure-derivate als antiseborrhoische zusaetze fuer kosmetische mittel"
US4534874A (en) * 1983-11-21 1985-08-13 Ciba-Geigy Corporation Anti-oxidative, anti-thermal, and anti-actinic degradation amides of hydroxyphenylalkylthio alkanoic acids, compositions, and method of use therefor
DE3685829T2 (de) * 1985-02-04 1992-12-17 Searle & Co Heterocyclische amide.
CA1332057C (en) * 1985-02-04 1994-09-20 Richard August Mueller Bicycloalkyl, tricycloalkyl, azabicycloalkyl and azatricycloalkyl amides
EP0190682B1 (en) * 1985-02-04 1990-09-12 G.D. Searle & Co. Novel disubstituted 4-hydroxyphenylthio anilides

Also Published As

Publication number Publication date
EP0293899A1 (en) 1988-12-07
CA1330446C (en) 1994-06-28
DE3884858T2 (de) 1994-03-03
US4835189A (en) 1989-05-30
ATE95692T1 (de) 1993-10-15
EP0293899B1 (en) 1993-10-13
JPS63310820A (ja) 1988-12-19
DE3884858D1 (de) 1993-11-18

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