JPS5758663A - Alkanoic acid derivative - Google Patents

Alkanoic acid derivative

Info

Publication number
JPS5758663A
JPS5758663A JP13346380A JP13346380A JPS5758663A JP S5758663 A JPS5758663 A JP S5758663A JP 13346380 A JP13346380 A JP 13346380A JP 13346380 A JP13346380 A JP 13346380A JP S5758663 A JPS5758663 A JP S5758663A
Authority
JP
Japan
Prior art keywords
formula
amine
alkanoic acid
group
acid derivative
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP13346380A
Other languages
Japanese (ja)
Other versions
JPS6338026B2 (en
Inventor
Minoru Uchida
Takao Nishi
Kazuyuki Nakagawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Priority to JP13346380A priority Critical patent/JPS5758663A/en
Publication of JPS5758663A publication Critical patent/JPS5758663A/en
Publication of JPS6338026B2 publication Critical patent/JPS6338026B2/ja
Granted legal-status Critical Current

Links

Landscapes

  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

NEW MATERIAL:An alkanoic acid derivative of formulaI[R1 is phenyl, naphthyl; R2 is hydroxyl, lower alkoxy, group of formula IV (R3, R4 are H, lower alkyl, cycloalkyl); A is lower alkylene]and its salt.
EXAMPLE: Methyl 4-phenylthiobutyrate.
USE: Antiulcerative and anti-inflammatory: it suppresses the quantity of gastic juice excreted and its total acidity.
PREPARATION: The amidation reaction between a carboxylic acid of formula II or its reactive derivative and an amine of formula III or its reactive derivative gives a compound of formulaIwhere R2 is group of formula IV (formula Ia). For example, the reaction between a carboxylic acid of formula II and a halocarboxylic alkyl ester such as methyl chloroformate is conducted in the presence of a base such as triethylamine to form a mixed carboxylic anhydride and the product is made to react with an amine of formula III at 10W50°C for 5minW10hr, thus effecting amidation reaction.
COPYRIGHT: (C)1982,JPO&Japio
JP13346380A 1980-09-24 1980-09-24 Alkanoic acid derivative Granted JPS5758663A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP13346380A JPS5758663A (en) 1980-09-24 1980-09-24 Alkanoic acid derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP13346380A JPS5758663A (en) 1980-09-24 1980-09-24 Alkanoic acid derivative

Publications (2)

Publication Number Publication Date
JPS5758663A true JPS5758663A (en) 1982-04-08
JPS6338026B2 JPS6338026B2 (en) 1988-07-28

Family

ID=15105366

Family Applications (1)

Application Number Title Priority Date Filing Date
JP13346380A Granted JPS5758663A (en) 1980-09-24 1980-09-24 Alkanoic acid derivative

Country Status (1)

Country Link
JP (1) JPS5758663A (en)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4835189A (en) * 1987-06-05 1989-05-30 G. D. Searle & Co. Phenolic thioalkylamides as inhibitors of 5-lipoxygenase
US5002967A (en) * 1987-06-05 1991-03-26 G. D. Searle & Co. Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase
US5019597A (en) * 1985-02-04 1991-05-28 G. D. Searle & Co. Bicycloalkyl tricycloalkyl, azabicycloalkyl and azatricycoalkyl amides
US5071876A (en) * 1985-02-04 1991-12-10 G. D. Searle & Co. Novel disubstituted 4-hydroxyphenylthio anilides
US5157053A (en) * 1985-02-04 1992-10-20 G. D. Searle & Co. Bicycloalky, tricycloalkyl, azabicycloalkyl, and azatricycloalkyl thio amides used to treat inflammation, allergy, asthma and skin disorders
US5244899A (en) * 1985-02-04 1993-09-14 G. D. Searle And Co. Azabicycloalkyl and azatricycloalkyl amides used to treat inflammation, allergy, asthma and skin disorders
JP2007532678A (en) * 2004-04-13 2007-11-15 セフアロン・インコーポレーテツド Bicyclic aromatic sulfinyl derivatives
US9670236B2 (en) 2012-10-31 2017-06-06 University of Pittsburgh—of the Commonwealth System of Higher Education Class of HDAC inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury
US9682919B2 (en) 2009-03-20 2017-06-20 University of Pittsburgh—of the Commonwealth System of Higher Education Small molecule inhibitors of Dusp6 and uses therefor
US10160705B2 (en) 2011-02-10 2018-12-25 University of Pittsburgh—of the Commonwealth System of Higher Education Class of HDAC inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020065717A1 (en) * 2018-09-25 2020-04-02 株式会社ソニー・インタラクティブエンタテインメント Information processing device, information processing system, and object information acquiring method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4124723A (en) * 1975-03-13 1978-11-07 Carter-Wallace, Inc. Method for suppressing histamine release
JPS54100335A (en) * 1978-01-24 1979-08-08 Nippon Shinyaku Co Ltd Preparation of p-tolyl mercaptopropionic acid

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4124723A (en) * 1975-03-13 1978-11-07 Carter-Wallace, Inc. Method for suppressing histamine release
JPS54100335A (en) * 1978-01-24 1979-08-08 Nippon Shinyaku Co Ltd Preparation of p-tolyl mercaptopropionic acid

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5019597A (en) * 1985-02-04 1991-05-28 G. D. Searle & Co. Bicycloalkyl tricycloalkyl, azabicycloalkyl and azatricycoalkyl amides
US5071876A (en) * 1985-02-04 1991-12-10 G. D. Searle & Co. Novel disubstituted 4-hydroxyphenylthio anilides
US5157053A (en) * 1985-02-04 1992-10-20 G. D. Searle & Co. Bicycloalky, tricycloalkyl, azabicycloalkyl, and azatricycloalkyl thio amides used to treat inflammation, allergy, asthma and skin disorders
US5244899A (en) * 1985-02-04 1993-09-14 G. D. Searle And Co. Azabicycloalkyl and azatricycloalkyl amides used to treat inflammation, allergy, asthma and skin disorders
US4835189A (en) * 1987-06-05 1989-05-30 G. D. Searle & Co. Phenolic thioalkylamides as inhibitors of 5-lipoxygenase
US5002967A (en) * 1987-06-05 1991-03-26 G. D. Searle & Co. Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase
JP2007532678A (en) * 2004-04-13 2007-11-15 セフアロン・インコーポレーテツド Bicyclic aromatic sulfinyl derivatives
US9682919B2 (en) 2009-03-20 2017-06-20 University of Pittsburgh—of the Commonwealth System of Higher Education Small molecule inhibitors of Dusp6 and uses therefor
US10160705B2 (en) 2011-02-10 2018-12-25 University of Pittsburgh—of the Commonwealth System of Higher Education Class of HDAC inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury
US9670236B2 (en) 2012-10-31 2017-06-06 University of Pittsburgh—of the Commonwealth System of Higher Education Class of HDAC inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury
US10233201B2 (en) 2012-10-31 2019-03-19 University of Pittsburg—Of the Commonwealth System of Higher Education Class of HDAC inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury

Also Published As

Publication number Publication date
JPS6338026B2 (en) 1988-07-28

Similar Documents

Publication Publication Date Title
JPS5758663A (en) Alkanoic acid derivative
JPS57183738A (en) Aromatic carboxylic acid derivative
JPS57108066A (en) 4-substituted-2-oxoazetidine derivative and its preparation
JPS57198098A (en) Preparation of optically active monoester monocarboxylic acid
JPS5758666A (en) Alkanoic acid derivative
JPS5750980A (en) Tetrazole derivative
JPS5758664A (en) Alkanoic acid derivative
JPS5589245A (en) 9,10-dihydroanthracene-2-alkanoic acid derivative
JPS5562082A (en) Tetrahydroxanthone derivative
JPS55143973A (en) Phenylacetic acid derivative
JPS579784A (en) Production of penem-3-carboxylic derivative
JPS56122362A (en) Tetrazole derivative, its preparation, and antiulcer agent containing the same
JPS5764695A (en) Novel cephalotaxine derivative
JPS57114549A (en) Preparation of cyclopentenediol monoester
JPS57193468A (en) Sulfur-containing compound
JPS57139066A (en) Isoquinoline derivative and its preparation
JPS54109974A (en) Novel imidazolecarboxylic ester derivative
JPS5767537A (en) Carboxylic ester, its preparation and insecticide containing the same as active constituent
JPS55104275A (en) Sulfur-containing compound
JPS5466653A (en) Novel p-aminophenylacetic acid derivative, its preparation, and pharmaceurtical composition containing said derivative as effective component
JPS57109742A (en) Butanediol derivative and its preparation
JPS5738767A (en) Preparation of polyhydric alcohol partial ester with mercaptocarboxylic acid
JPS56138150A (en) Novel benzyl alcohol derivative and its preparation
JPS57144254A (en) 2-substituted-2-oxoazetidine derivative and its preparation
JPS55130944A (en) 1-(o-(2',6'-dichloroanilino)phenyl)-2,2-dimethoxyethylene, and its preparation