JPS5758663A - Alkanoic acid derivative - Google Patents
Alkanoic acid derivativeInfo
- Publication number
- JPS5758663A JPS5758663A JP13346380A JP13346380A JPS5758663A JP S5758663 A JPS5758663 A JP S5758663A JP 13346380 A JP13346380 A JP 13346380A JP 13346380 A JP13346380 A JP 13346380A JP S5758663 A JPS5758663 A JP S5758663A
- Authority
- JP
- Japan
- Prior art keywords
- formula
- amine
- alkanoic acid
- group
- acid derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
NEW MATERIAL:An alkanoic acid derivative of formulaI[R1 is phenyl, naphthyl; R2 is hydroxyl, lower alkoxy, group of formula IV (R3, R4 are H, lower alkyl, cycloalkyl); A is lower alkylene]and its salt.
EXAMPLE: Methyl 4-phenylthiobutyrate.
USE: Antiulcerative and anti-inflammatory: it suppresses the quantity of gastic juice excreted and its total acidity.
PREPARATION: The amidation reaction between a carboxylic acid of formula II or its reactive derivative and an amine of formula III or its reactive derivative gives a compound of formulaIwhere R2 is group of formula IV (formula Ia). For example, the reaction between a carboxylic acid of formula II and a halocarboxylic alkyl ester such as methyl chloroformate is conducted in the presence of a base such as triethylamine to form a mixed carboxylic anhydride and the product is made to react with an amine of formula III at 10W50°C for 5minW10hr, thus effecting amidation reaction.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13346380A JPS5758663A (en) | 1980-09-24 | 1980-09-24 | Alkanoic acid derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13346380A JPS5758663A (en) | 1980-09-24 | 1980-09-24 | Alkanoic acid derivative |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS5758663A true JPS5758663A (en) | 1982-04-08 |
JPS6338026B2 JPS6338026B2 (en) | 1988-07-28 |
Family
ID=15105366
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP13346380A Granted JPS5758663A (en) | 1980-09-24 | 1980-09-24 | Alkanoic acid derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5758663A (en) |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4835189A (en) * | 1987-06-05 | 1989-05-30 | G. D. Searle & Co. | Phenolic thioalkylamides as inhibitors of 5-lipoxygenase |
US5002967A (en) * | 1987-06-05 | 1991-03-26 | G. D. Searle & Co. | Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase |
US5019597A (en) * | 1985-02-04 | 1991-05-28 | G. D. Searle & Co. | Bicycloalkyl tricycloalkyl, azabicycloalkyl and azatricycoalkyl amides |
US5071876A (en) * | 1985-02-04 | 1991-12-10 | G. D. Searle & Co. | Novel disubstituted 4-hydroxyphenylthio anilides |
US5157053A (en) * | 1985-02-04 | 1992-10-20 | G. D. Searle & Co. | Bicycloalky, tricycloalkyl, azabicycloalkyl, and azatricycloalkyl thio amides used to treat inflammation, allergy, asthma and skin disorders |
US5244899A (en) * | 1985-02-04 | 1993-09-14 | G. D. Searle And Co. | Azabicycloalkyl and azatricycloalkyl amides used to treat inflammation, allergy, asthma and skin disorders |
JP2007532678A (en) * | 2004-04-13 | 2007-11-15 | セフアロン・インコーポレーテツド | Bicyclic aromatic sulfinyl derivatives |
US9670236B2 (en) | 2012-10-31 | 2017-06-06 | University of Pittsburgh—of the Commonwealth System of Higher Education | Class of HDAC inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury |
US9682919B2 (en) | 2009-03-20 | 2017-06-20 | University of Pittsburgh—of the Commonwealth System of Higher Education | Small molecule inhibitors of Dusp6 and uses therefor |
US10160705B2 (en) | 2011-02-10 | 2018-12-25 | University of Pittsburgh—of the Commonwealth System of Higher Education | Class of HDAC inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020065717A1 (en) * | 2018-09-25 | 2020-04-02 | 株式会社ソニー・インタラクティブエンタテインメント | Information processing device, information processing system, and object information acquiring method |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4124723A (en) * | 1975-03-13 | 1978-11-07 | Carter-Wallace, Inc. | Method for suppressing histamine release |
JPS54100335A (en) * | 1978-01-24 | 1979-08-08 | Nippon Shinyaku Co Ltd | Preparation of p-tolyl mercaptopropionic acid |
-
1980
- 1980-09-24 JP JP13346380A patent/JPS5758663A/en active Granted
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4124723A (en) * | 1975-03-13 | 1978-11-07 | Carter-Wallace, Inc. | Method for suppressing histamine release |
JPS54100335A (en) * | 1978-01-24 | 1979-08-08 | Nippon Shinyaku Co Ltd | Preparation of p-tolyl mercaptopropionic acid |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5019597A (en) * | 1985-02-04 | 1991-05-28 | G. D. Searle & Co. | Bicycloalkyl tricycloalkyl, azabicycloalkyl and azatricycoalkyl amides |
US5071876A (en) * | 1985-02-04 | 1991-12-10 | G. D. Searle & Co. | Novel disubstituted 4-hydroxyphenylthio anilides |
US5157053A (en) * | 1985-02-04 | 1992-10-20 | G. D. Searle & Co. | Bicycloalky, tricycloalkyl, azabicycloalkyl, and azatricycloalkyl thio amides used to treat inflammation, allergy, asthma and skin disorders |
US5244899A (en) * | 1985-02-04 | 1993-09-14 | G. D. Searle And Co. | Azabicycloalkyl and azatricycloalkyl amides used to treat inflammation, allergy, asthma and skin disorders |
US4835189A (en) * | 1987-06-05 | 1989-05-30 | G. D. Searle & Co. | Phenolic thioalkylamides as inhibitors of 5-lipoxygenase |
US5002967A (en) * | 1987-06-05 | 1991-03-26 | G. D. Searle & Co. | Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase |
JP2007532678A (en) * | 2004-04-13 | 2007-11-15 | セフアロン・インコーポレーテツド | Bicyclic aromatic sulfinyl derivatives |
US9682919B2 (en) | 2009-03-20 | 2017-06-20 | University of Pittsburgh—of the Commonwealth System of Higher Education | Small molecule inhibitors of Dusp6 and uses therefor |
US10160705B2 (en) | 2011-02-10 | 2018-12-25 | University of Pittsburgh—of the Commonwealth System of Higher Education | Class of HDAC inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury |
US9670236B2 (en) | 2012-10-31 | 2017-06-06 | University of Pittsburgh—of the Commonwealth System of Higher Education | Class of HDAC inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury |
US10233201B2 (en) | 2012-10-31 | 2019-03-19 | University of Pittsburg—Of the Commonwealth System of Higher Education | Class of HDAC inhibitors expands the renal progenitor cells population and improves the rate of recovery from acute kidney injury |
Also Published As
Publication number | Publication date |
---|---|
JPS6338026B2 (en) | 1988-07-28 |
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