JPS57198098A - Preparation of optically active monoester monocarboxylic acid - Google Patents

Preparation of optically active monoester monocarboxylic acid

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Publication number
JPS57198098A
JPS57198098A JP8112881A JP8112881A JPS57198098A JP S57198098 A JPS57198098 A JP S57198098A JP 8112881 A JP8112881 A JP 8112881A JP 8112881 A JP8112881 A JP 8112881A JP S57198098 A JPS57198098 A JP S57198098A
Authority
JP
Japan
Prior art keywords
esterase
monocarboxylic acid
reaction
optically active
monoester monocarboxylic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP8112881A
Other languages
Japanese (ja)
Inventor
Shinobu Iriuchijima
Genichi Dobashi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sagami Chemical Research Institute
Original Assignee
Sagami Chemical Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sagami Chemical Research Institute filed Critical Sagami Chemical Research Institute
Priority to JP8112881A priority Critical patent/JPS57198098A/en
Publication of JPS57198098A publication Critical patent/JPS57198098A/en
Pending legal-status Critical Current

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  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

PURPOSE: To prepare the titled monoester monocarboxylic acid useful as a raw material of d-biotin, by the asymmetric hydrolysis of a diester with an esterase.
CONSTITUTION: The optically active monoester monocarboxylic acid or formulaI(X is aminlprotecting group; R is alkyl, substituted alkyl or aryl) is obtained by the asymmetric hydrolysis of the diester of formula II in a buffer solution containing e.g. sodium phosphate, sodium citrate, etc., using an esterase. Any esterase e.g. swine liver esterase can be used for the above purpose provided that the estrase has the capability of asymmetrically hydrolyzing an ester. The pH of the reaction mixture is preferably 7W8 at the initiation of the reaction and ≥4W5 in the course of the reaction. The reaction is carried out at 5W 40°C under agitation or shaking.
COPYRIGHT: (C)1982,JPO&Japio
JP8112881A 1981-05-29 1981-05-29 Preparation of optically active monoester monocarboxylic acid Pending JPS57198098A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP8112881A JPS57198098A (en) 1981-05-29 1981-05-29 Preparation of optically active monoester monocarboxylic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP8112881A JPS57198098A (en) 1981-05-29 1981-05-29 Preparation of optically active monoester monocarboxylic acid

Publications (1)

Publication Number Publication Date
JPS57198098A true JPS57198098A (en) 1982-12-04

Family

ID=13737749

Family Applications (1)

Application Number Title Priority Date Filing Date
JP8112881A Pending JPS57198098A (en) 1981-05-29 1981-05-29 Preparation of optically active monoester monocarboxylic acid

Country Status (1)

Country Link
JP (1) JPS57198098A (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58180472A (en) * 1982-04-16 1983-10-21 Sumitomo Chem Co Ltd Separation of optical active half ester
JPS58222068A (en) * 1982-06-16 1983-12-23 Sumitomo Chem Co Ltd Preparation of optically active cis-1,3-dibenzyl-5- ethoxycarbonyl-2-oxoimidazolidine-4-carboxylic acid
US4496739A (en) * 1982-01-27 1985-01-29 Sumitomo Chemical Company, Limited Intermediates to optically active cis-1,3-dibenzyl-hexahydro-1H-furo[3,4-d]imidazole-2,4-dione
JPH01225489A (en) * 1988-03-07 1989-09-08 Dai Ichi Seiyaku Co Ltd Production of optically active bisacetic acid monoester
US5247095A (en) * 1991-08-27 1993-09-21 Takeda Chemical Industries, Ltd. Intermediates for d-biotin synthesis and their production
WO1999041405A1 (en) * 1998-02-17 1999-08-19 G.D. Searle & Co. Process for the enzymatic resolution of lactams
CN108164466A (en) * 2017-12-12 2018-06-15 浙江工业大学 A kind of preparation method of cis- 1,3- dibenzyl imidazoles -2- ketone -4,5- dicarboxylic acids

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5327279A (en) * 1976-08-25 1978-03-14 Yutaka Terashita Electric source device for electronic flash

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5327279A (en) * 1976-08-25 1978-03-14 Yutaka Terashita Electric source device for electronic flash

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4496739A (en) * 1982-01-27 1985-01-29 Sumitomo Chemical Company, Limited Intermediates to optically active cis-1,3-dibenzyl-hexahydro-1H-furo[3,4-d]imidazole-2,4-dione
US4544635A (en) * 1982-01-27 1985-10-01 Sumitomo Chemical Co., Ltd. Preparation of optically active cis-1,3-dibenzyl-hexahydro-1H-furo[3,4-d]imidazole-2,4-dione and its intermediates
JPS58180472A (en) * 1982-04-16 1983-10-21 Sumitomo Chem Co Ltd Separation of optical active half ester
JPH0456028B2 (en) * 1982-04-16 1992-09-07 Sumitomo Chemical Co
JPS58222068A (en) * 1982-06-16 1983-12-23 Sumitomo Chem Co Ltd Preparation of optically active cis-1,3-dibenzyl-5- ethoxycarbonyl-2-oxoimidazolidine-4-carboxylic acid
JPH0435463B2 (en) * 1982-06-16 1992-06-11 Sumitomo Chemical Co
JPH01225489A (en) * 1988-03-07 1989-09-08 Dai Ichi Seiyaku Co Ltd Production of optically active bisacetic acid monoester
US5247095A (en) * 1991-08-27 1993-09-21 Takeda Chemical Industries, Ltd. Intermediates for d-biotin synthesis and their production
WO1999041405A1 (en) * 1998-02-17 1999-08-19 G.D. Searle & Co. Process for the enzymatic resolution of lactams
US6277626B1 (en) 1998-02-17 2001-08-21 G.D. Searle & Co. Process for the enzymatic resolution of lactams
US6638758B2 (en) 1998-02-17 2003-10-28 G.D. Searle & Co. Process for the enzymatic resolution of lactams
CN108164466A (en) * 2017-12-12 2018-06-15 浙江工业大学 A kind of preparation method of cis- 1,3- dibenzyl imidazoles -2- ketone -4,5- dicarboxylic acids

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