JPS57198098A - Preparation of optically active monoester monocarboxylic acid - Google Patents
Preparation of optically active monoester monocarboxylic acidInfo
- Publication number
- JPS57198098A JPS57198098A JP8112881A JP8112881A JPS57198098A JP S57198098 A JPS57198098 A JP S57198098A JP 8112881 A JP8112881 A JP 8112881A JP 8112881 A JP8112881 A JP 8112881A JP S57198098 A JPS57198098 A JP S57198098A
- Authority
- JP
- Japan
- Prior art keywords
- esterase
- monocarboxylic acid
- reaction
- optically active
- monoester monocarboxylic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
PURPOSE: To prepare the titled monoester monocarboxylic acid useful as a raw material of d-biotin, by the asymmetric hydrolysis of a diester with an esterase.
CONSTITUTION: The optically active monoester monocarboxylic acid or formulaI(X is aminlprotecting group; R is alkyl, substituted alkyl or aryl) is obtained by the asymmetric hydrolysis of the diester of formula II in a buffer solution containing e.g. sodium phosphate, sodium citrate, etc., using an esterase. Any esterase e.g. swine liver esterase can be used for the above purpose provided that the estrase has the capability of asymmetrically hydrolyzing an ester. The pH of the reaction mixture is preferably 7W8 at the initiation of the reaction and ≥4W5 in the course of the reaction. The reaction is carried out at 5W 40°C under agitation or shaking.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8112881A JPS57198098A (en) | 1981-05-29 | 1981-05-29 | Preparation of optically active monoester monocarboxylic acid |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8112881A JPS57198098A (en) | 1981-05-29 | 1981-05-29 | Preparation of optically active monoester monocarboxylic acid |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS57198098A true JPS57198098A (en) | 1982-12-04 |
Family
ID=13737749
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP8112881A Pending JPS57198098A (en) | 1981-05-29 | 1981-05-29 | Preparation of optically active monoester monocarboxylic acid |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS57198098A (en) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58180472A (en) * | 1982-04-16 | 1983-10-21 | Sumitomo Chem Co Ltd | Separation of optical active half ester |
JPS58222068A (en) * | 1982-06-16 | 1983-12-23 | Sumitomo Chem Co Ltd | Preparation of optically active cis-1,3-dibenzyl-5- ethoxycarbonyl-2-oxoimidazolidine-4-carboxylic acid |
US4496739A (en) * | 1982-01-27 | 1985-01-29 | Sumitomo Chemical Company, Limited | Intermediates to optically active cis-1,3-dibenzyl-hexahydro-1H-furo[3,4-d]imidazole-2,4-dione |
JPH01225489A (en) * | 1988-03-07 | 1989-09-08 | Dai Ichi Seiyaku Co Ltd | Production of optically active bisacetic acid monoester |
US5247095A (en) * | 1991-08-27 | 1993-09-21 | Takeda Chemical Industries, Ltd. | Intermediates for d-biotin synthesis and their production |
WO1999041405A1 (en) * | 1998-02-17 | 1999-08-19 | G.D. Searle & Co. | Process for the enzymatic resolution of lactams |
CN108164466A (en) * | 2017-12-12 | 2018-06-15 | 浙江工业大学 | A kind of preparation method of cis- 1,3- dibenzyl imidazoles -2- ketone -4,5- dicarboxylic acids |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5327279A (en) * | 1976-08-25 | 1978-03-14 | Yutaka Terashita | Electric source device for electronic flash |
-
1981
- 1981-05-29 JP JP8112881A patent/JPS57198098A/en active Pending
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5327279A (en) * | 1976-08-25 | 1978-03-14 | Yutaka Terashita | Electric source device for electronic flash |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4496739A (en) * | 1982-01-27 | 1985-01-29 | Sumitomo Chemical Company, Limited | Intermediates to optically active cis-1,3-dibenzyl-hexahydro-1H-furo[3,4-d]imidazole-2,4-dione |
US4544635A (en) * | 1982-01-27 | 1985-10-01 | Sumitomo Chemical Co., Ltd. | Preparation of optically active cis-1,3-dibenzyl-hexahydro-1H-furo[3,4-d]imidazole-2,4-dione and its intermediates |
JPS58180472A (en) * | 1982-04-16 | 1983-10-21 | Sumitomo Chem Co Ltd | Separation of optical active half ester |
JPH0456028B2 (en) * | 1982-04-16 | 1992-09-07 | Sumitomo Chemical Co | |
JPS58222068A (en) * | 1982-06-16 | 1983-12-23 | Sumitomo Chem Co Ltd | Preparation of optically active cis-1,3-dibenzyl-5- ethoxycarbonyl-2-oxoimidazolidine-4-carboxylic acid |
JPH0435463B2 (en) * | 1982-06-16 | 1992-06-11 | Sumitomo Chemical Co | |
JPH01225489A (en) * | 1988-03-07 | 1989-09-08 | Dai Ichi Seiyaku Co Ltd | Production of optically active bisacetic acid monoester |
US5247095A (en) * | 1991-08-27 | 1993-09-21 | Takeda Chemical Industries, Ltd. | Intermediates for d-biotin synthesis and their production |
WO1999041405A1 (en) * | 1998-02-17 | 1999-08-19 | G.D. Searle & Co. | Process for the enzymatic resolution of lactams |
US6277626B1 (en) | 1998-02-17 | 2001-08-21 | G.D. Searle & Co. | Process for the enzymatic resolution of lactams |
US6638758B2 (en) | 1998-02-17 | 2003-10-28 | G.D. Searle & Co. | Process for the enzymatic resolution of lactams |
CN108164466A (en) * | 2017-12-12 | 2018-06-15 | 浙江工业大学 | A kind of preparation method of cis- 1,3- dibenzyl imidazoles -2- ketone -4,5- dicarboxylic acids |
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