ATE137761T1 - 4-substituiertes 17-beta-(cyclopropyl-amino)- androst-5-en-3-beta-ol und seine derivate, verwendbar als inhibitoren der c17-20-lyase - Google Patents
4-substituiertes 17-beta-(cyclopropyl-amino)- androst-5-en-3-beta-ol und seine derivate, verwendbar als inhibitoren der c17-20-lyaseInfo
- Publication number
- ATE137761T1 ATE137761T1 AT90115391T AT90115391T ATE137761T1 AT E137761 T1 ATE137761 T1 AT E137761T1 AT 90115391 T AT90115391 T AT 90115391T AT 90115391 T AT90115391 T AT 90115391T AT E137761 T1 ATE137761 T1 AT E137761T1
- Authority
- AT
- Austria
- Prior art keywords
- beta
- androst
- substituted
- lyase
- cyclopropyl
- Prior art date
Links
- 102000004317 Lyases Human genes 0.000 title 1
- 108090000856 Lyases Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- LYFPAZBMEUSVNA-UHFFFAOYSA-N (10R)-3c-Hydroxy-10r.13c-dimethyl-(8cH.9tH.14tH)-Delta5-tetradecahydro-1H-cyclopenta[a]phenanthren Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCCC1(C)CC2 LYFPAZBMEUSVNA-UHFFFAOYSA-N 0.000 abstract 1
- LYFPAZBMEUSVNA-DYKIIFRCSA-N (3s,8s,9s,10r,13s,14s)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1h-cyclopenta[a]phenanthren-3-ol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CCC[C@@]1(C)CC2 LYFPAZBMEUSVNA-DYKIIFRCSA-N 0.000 abstract 1
- 239000003098 androgen Substances 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 150000002081 enamines Chemical class 0.000 abstract 1
- 150000004678 hydrides Chemical class 0.000 abstract 1
- 150000002466 imines Chemical class 0.000 abstract 1
- 230000003637 steroidlike Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/394,025 US4966898A (en) | 1989-08-15 | 1989-08-15 | 4-substituted 17β-(cyclopropylamino)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE137761T1 true ATE137761T1 (de) | 1996-05-15 |
Family
ID=23557240
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90115391T ATE137761T1 (de) | 1989-08-15 | 1990-08-10 | 4-substituiertes 17-beta-(cyclopropyl-amino)- androst-5-en-3-beta-ol und seine derivate, verwendbar als inhibitoren der c17-20-lyase |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US4966898A (es) |
| EP (1) | EP0413270B1 (es) |
| JP (1) | JP2879703B2 (es) |
| KR (1) | KR910004649A (es) |
| CN (1) | CN1050196A (es) |
| AT (1) | ATE137761T1 (es) |
| AU (1) | AU628209B2 (es) |
| CA (1) | CA2023012C (es) |
| DD (1) | DD299650A5 (es) |
| DE (1) | DE69026881T2 (es) |
| ES (1) | ES2088928T3 (es) |
| FI (1) | FI95804C (es) |
| HU (1) | HUT55029A (es) |
| IE (1) | IE72516B1 (es) |
| IL (1) | IL95358A (es) |
| NO (1) | NO903564L (es) |
| NZ (1) | NZ234856A (es) |
| PH (1) | PH27098A (es) |
| PT (1) | PT94993B (es) |
| ZA (1) | ZA906308B (es) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4966897A (en) * | 1989-08-15 | 1990-10-30 | Merrell Dow Pharmaceuticals Inc. | 4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
| CA2132449C (en) * | 1992-03-31 | 2002-09-10 | Susan E. Barrie | 17 - substituted steroids useful in cancer treatment |
| US5604213A (en) * | 1992-03-31 | 1997-02-18 | British Technology Group Limited | 17-substituted steroids useful in cancer treatment |
| TW369521B (en) * | 1993-09-17 | 1999-09-11 | Smithkline Beecham Corp | Androstenone derivative |
| US5541322A (en) * | 1994-10-14 | 1996-07-30 | Glaxo Wellcome Inc. | Synthesis of 6-azaandrostenones |
| US6365597B1 (en) | 1996-02-14 | 2002-04-02 | Aventis Pharmaceuticals Inc. | 4-aza steroids |
| BR0111654A (pt) * | 2000-06-09 | 2003-05-20 | Bayer Cropscience Sa | Processo de preparação de compostos pesticidas |
| CN1329394C (zh) | 2000-11-17 | 2007-08-01 | 武田药品工业株式会社 | 新咪唑衍生物、其制备方法及其用途 |
| ATE502030T1 (de) | 2000-11-20 | 2011-04-15 | Takeda Pharmaceutical | Imidazolderivate, verfahren zu deren herstellung und deren verwendung |
| EP1348706B1 (en) | 2000-12-08 | 2009-08-19 | Takeda Pharmaceutical Company Limited | Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| ES2475945T3 (es) | 2009-06-26 | 2014-07-11 | Novartis Ag | Derivados imidazolidin-2 -ona 1,3-disustituida como inhibidores de CYP 17 |
| JP2011098893A (ja) * | 2009-11-04 | 2011-05-19 | Sumitomo Chemical Co Ltd | テストステロンの生合成を抑制するための化合物の使用およびその化合物 |
| KR101926320B1 (ko) | 2010-08-04 | 2018-12-06 | 펠피큐어 파마슈티걸즈 아이엔씨 | 전립선 암종의 치료를 위한 병용 요법 |
| WO2012035078A1 (en) | 2010-09-16 | 2012-03-22 | Novartis Ag | 17α-HYDROXYLASE/C17,20-LYASE INHIBITORS |
| CA2834224A1 (en) | 2011-04-28 | 2012-11-01 | Novartis Ag | 17.alpha.-hydroxylase/c17,20-lyase inhibitors |
| AU2014241816B9 (en) | 2013-03-14 | 2019-02-14 | Pellficure Pharmaceuticals Inc. | Novel therapy for prostate carcinoma |
| US10093620B2 (en) | 2014-09-12 | 2018-10-09 | Pellficure Pharmaceuticals, Inc. | Compositions and methods for treatment of prostate carcinoma |
| KR20240115925A (ko) | 2016-07-29 | 2024-07-26 | 얀센 파마슈티카 엔브이 | 전립선암의 치료 방법 |
| WO2018080933A1 (en) | 2016-10-24 | 2018-05-03 | Pellficure Pharmaceuticals Inc. | Pharmaceutical compositions of 5-hydroxy-2-methylnaphthalene-1, 4-dione |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3107254A (en) * | 1960-10-05 | 1963-10-15 | Upjohn Co | 17beta-dialkylamino-17-cyanosteroids and their 17alpha-alkyl, alkylene and alkyne derivatives |
| US3097200A (en) * | 1962-01-03 | 1963-07-09 | Syntex Corp | 17-aminoandrostanes |
| NL302932A (es) * | 1962-12-31 | |||
| ZA882717B (en) * | 1987-04-22 | 1988-10-17 | Merrell Dow Pharmaceuticals Inc. | 17beta-(cyclopropylamino)-androst-5-eb-3beta-ol and related compounds useful as c17-20 lyase inhibitors |
| US4966897A (en) * | 1989-08-15 | 1990-10-30 | Merrell Dow Pharmaceuticals Inc. | 4-substituted 17β-(cyclopropyloxy)androst-5-en-3β-ol and related compounds useful as C17-20 lyase inhibitors |
-
1989
- 1989-08-15 US US07/394,025 patent/US4966898A/en not_active Expired - Fee Related
-
1990
- 1990-08-09 AU AU60877/90A patent/AU628209B2/en not_active Ceased
- 1990-08-09 ZA ZA906308A patent/ZA906308B/xx unknown
- 1990-08-09 JP JP2209389A patent/JP2879703B2/ja not_active Expired - Fee Related
- 1990-08-09 CA CA002023012A patent/CA2023012C/en not_active Expired - Fee Related
- 1990-08-10 NZ NZ234856A patent/NZ234856A/en unknown
- 1990-08-10 ES ES90115391T patent/ES2088928T3/es not_active Expired - Lifetime
- 1990-08-10 DE DE69026881T patent/DE69026881T2/de not_active Expired - Fee Related
- 1990-08-10 AT AT90115391T patent/ATE137761T1/de not_active IP Right Cessation
- 1990-08-10 EP EP90115391A patent/EP0413270B1/en not_active Expired - Lifetime
- 1990-08-13 IL IL9535890A patent/IL95358A/en not_active IP Right Cessation
- 1990-08-14 HU HU905004A patent/HUT55029A/hu unknown
- 1990-08-14 PT PT94993A patent/PT94993B/pt not_active IP Right Cessation
- 1990-08-14 KR KR1019900012533A patent/KR910004649A/ko not_active Application Discontinuation
- 1990-08-14 NO NO90903564A patent/NO903564L/no unknown
- 1990-08-14 IE IE294290A patent/IE72516B1/en not_active IP Right Cessation
- 1990-08-15 DD DD90343476A patent/DD299650A5/de unknown
- 1990-08-15 PH PH41034A patent/PH27098A/en unknown
- 1990-08-15 FI FI904035A patent/FI95804C/fi not_active IP Right Cessation
- 1990-08-15 CN CN90107580A patent/CN1050196A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR910004649A (ko) | 1991-03-29 |
| HUT55029A (en) | 1991-04-29 |
| IL95358A0 (en) | 1991-06-30 |
| ES2088928T3 (es) | 1996-10-01 |
| FI904035A0 (fi) | 1990-08-15 |
| FI95804B (fi) | 1995-12-15 |
| AU628209B2 (en) | 1992-09-10 |
| DE69026881D1 (de) | 1996-06-13 |
| PH27098A (en) | 1993-02-26 |
| NZ234856A (en) | 1992-08-26 |
| EP0413270A3 (en) | 1992-05-20 |
| EP0413270B1 (en) | 1996-05-08 |
| PT94993B (pt) | 1997-07-31 |
| JP2879703B2 (ja) | 1999-04-05 |
| CN1050196A (zh) | 1991-03-27 |
| NO903564L (no) | 1991-02-18 |
| HU905004D0 (en) | 1991-01-28 |
| ZA906308B (en) | 1991-06-26 |
| JPH0383998A (ja) | 1991-04-09 |
| CA2023012C (en) | 2001-07-03 |
| IE902942A1 (en) | 1991-02-27 |
| IL95358A (en) | 1995-03-30 |
| FI95804C (fi) | 1996-03-25 |
| IE72516B1 (en) | 1997-04-23 |
| DD299650A5 (de) | 1992-04-30 |
| PT94993A (pt) | 1991-04-18 |
| AU6087790A (en) | 1991-02-21 |
| DE69026881T2 (de) | 1996-09-12 |
| US4966898A (en) | 1990-10-30 |
| EP0413270A2 (en) | 1991-02-20 |
| NO903564D0 (no) | 1990-08-14 |
| CA2023012A1 (en) | 1991-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| REN | Ceased due to non-payment of the annual fee |