ATE137758T1 - Verfahren zur herstellung von nojirimycin- verbindungen - Google Patents

Verfahren zur herstellung von nojirimycin- verbindungen

Info

Publication number
ATE137758T1
ATE137758T1 AT90124580T AT90124580T ATE137758T1 AT E137758 T1 ATE137758 T1 AT E137758T1 AT 90124580 T AT90124580 T AT 90124580T AT 90124580 T AT90124580 T AT 90124580T AT E137758 T1 ATE137758 T1 AT E137758T1
Authority
AT
Austria
Prior art keywords
nojirimycin
compounds
producing
reductive amination
oxo
Prior art date
Application number
AT90124580T
Other languages
English (en)
Inventor
Peter B Anzeveno
Laura J Creemer
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Application granted granted Critical
Publication of ATE137758T1 publication Critical patent/ATE137758T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/12—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by acids having the group -X-C(=X)-X-, or halides thereof, in which each X means nitrogen, oxygen, sulfur, selenium or tellurium, e.g. carbonic acid, carbamic acid

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hydrogenated Pyridines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
AT90124580T 1989-12-20 1990-12-18 Verfahren zur herstellung von nojirimycin- verbindungen ATE137758T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US45364789A 1989-12-20 1989-12-20

Publications (1)

Publication Number Publication Date
ATE137758T1 true ATE137758T1 (de) 1996-05-15

Family

ID=23801471

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90124580T ATE137758T1 (de) 1989-12-20 1990-12-18 Verfahren zur herstellung von nojirimycin- verbindungen

Country Status (14)

Country Link
US (1) US5227479A (de)
EP (1) EP0433978B1 (de)
JP (1) JP2938193B2 (de)
KR (1) KR0147819B1 (de)
AT (1) ATE137758T1 (de)
AU (1) AU632191B2 (de)
DE (1) DE69026912T2 (de)
DK (1) DK0433978T3 (de)
ES (1) ES2088948T3 (de)
GR (1) GR3020492T3 (de)
HU (1) HU207866B (de)
IE (1) IE72513B1 (de)
IL (1) IL96694A (de)
ZA (1) ZA9010083B (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5066807A (en) * 1990-03-12 1991-11-19 Merrell Dow Pharmaceuticals Inc. Process for the preparation of castanospermine
EP1181277A4 (de) 2000-03-31 2005-08-10 Univ Michigan State Verfahren zur herstellung von 1,5-dideoxy-1,5-imino-hexitolen aus oximen oder iminen

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4634765A (en) * 1984-12-18 1987-01-06 Merrell Dow Pharmaceuticals Inc. Homodisaccharide hypoglycemic agents
DE3628486A1 (de) * 1986-08-22 1988-02-25 Bayer Ag Piperidinderivate
US4880917A (en) * 1988-07-01 1989-11-14 Merrell Dow Pharmaceuticals Inc. Process for hydrolyzing 2,6-dideoxy-2,6-iminoheptononitrile derivatives using trifluoroacetic acid and dinitrogen tetroxide
US4908439A (en) * 1988-09-16 1990-03-13 Merrell Dow Pharmaceuticals Inc. Synthesis of intermediate useful in the preparation of nojirimycin and related compounds

Also Published As

Publication number Publication date
IL96694A0 (en) 1991-09-16
HU908300D0 (en) 1991-06-28
AU632191B2 (en) 1992-12-17
KR910011882A (ko) 1991-08-07
JP2938193B2 (ja) 1999-08-23
GR3020492T3 (en) 1996-10-31
EP0433978A2 (de) 1991-06-26
DK0433978T3 (da) 1996-05-28
AU6808490A (en) 1991-06-27
HUT57224A (en) 1991-11-28
IL96694A (en) 1994-12-29
US5227479A (en) 1993-07-13
JPH0418072A (ja) 1992-01-22
EP0433978A3 (en) 1992-09-09
ES2088948T3 (es) 1996-10-01
DE69026912D1 (de) 1996-06-13
DE69026912T2 (de) 1996-10-02
EP0433978B1 (de) 1996-05-08
ZA9010083B (en) 1991-10-30
KR0147819B1 (ko) 1998-08-01
IE72513B1 (en) 1997-04-23
HU207866B (en) 1993-06-28
IE904598A1 (en) 1991-07-03

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee