HK1252082A1 - 低分子量和極低分子量肝素獲取工藝 - Google Patents

低分子量和極低分子量肝素獲取工藝

Info

Publication number
HK1252082A1
HK1252082A1 HK18110851.7A HK18110851A HK1252082A1 HK 1252082 A1 HK1252082 A1 HK 1252082A1 HK 18110851 A HK18110851 A HK 18110851A HK 1252082 A1 HK1252082 A1 HK 1252082A1
Authority
HK
Hong Kong
Prior art keywords
molecular weight
low molecular
heparins
obtaining
obtaining low
Prior art date
Application number
HK18110851.7A
Other languages
English (en)
Inventor
古伊萊莫‧弗蘭科羅德里格斯
伊本‧古蒂耶羅阿杜里斯
Original Assignee
羅維藥品實驗室有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 羅維藥品實驗室有限公司 filed Critical 羅維藥品實驗室有限公司
Publication of HK1252082A1 publication Critical patent/HK1252082A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • C08B37/0078—Degradation products
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Polymers & Plastics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Materials Engineering (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Materials For Medical Uses (AREA)
HK18110851.7A 2012-08-02 2018-08-23 低分子量和極低分子量肝素獲取工藝 HK1252082A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201231257A ES2445494B1 (es) 2012-08-02 2012-08-02 Procedimiento de obtención de heparinas de bajo y muy bajo peso molecular

Publications (1)

Publication Number Publication Date
HK1252082A1 true HK1252082A1 (zh) 2019-05-17

Family

ID=50027324

Family Applications (2)

Application Number Title Priority Date Filing Date
HK15106635.1A HK1206042A1 (zh) 2012-08-02 2015-07-10 低分子量和極低分子量肝素獲取工藝
HK18110851.7A HK1252082A1 (zh) 2012-08-02 2018-08-23 低分子量和極低分子量肝素獲取工藝

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK15106635.1A HK1206042A1 (zh) 2012-08-02 2015-07-10 低分子量和極低分子量肝素獲取工藝

Country Status (16)

Country Link
EP (1) EP2881404B1 (zh)
JP (1) JP6298052B2 (zh)
CN (2) CN104507972A (zh)
BR (1) BR112015002358A2 (zh)
CY (1) CY1120872T1 (zh)
DK (1) DK2881404T3 (zh)
ES (2) ES2445494B1 (zh)
HK (2) HK1206042A1 (zh)
HR (1) HRP20180777T1 (zh)
HU (1) HUE037251T2 (zh)
IN (1) IN2015MN00435A (zh)
LT (1) LT2881404T (zh)
PL (1) PL2881404T3 (zh)
PT (1) PT2881404T (zh)
SI (1) SI2881404T1 (zh)
WO (1) WO2014020227A1 (zh)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114072430B (zh) 2020-04-27 2023-07-28 罗威制药股份有限公司 低分子量肝素获取程序以及由此获得的低分子量肝素
CN111393542B (zh) * 2020-05-16 2021-11-05 青岛科技大学 一种粗品肝素钠精制新方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2003197A6 (es) * 1987-01-05 1988-10-16 Rovi Lab Farmaceut Sa Procedimiento de despolimerizacion de la heparina para la obtencion de una heparina de bajo peso molecular dotada de actividad antitrombotica
US4981955A (en) * 1988-06-28 1991-01-01 Lopez Lorenzo L Depolymerization method of heparin
US5707973A (en) * 1991-04-23 1998-01-13 Rhone-Poulenc Rorer S.A. Sulfated polysaccharids for treatment or prevention of thromboses
JP4897991B2 (ja) * 1999-07-23 2012-03-14 ラボラトリオス ファルマセウティコス ロビ ソシエダッド アノニマ 超低分子量ヘパリン組成物
ES2161615B1 (es) * 1999-07-23 2003-03-16 Rovi Lab Farmaceut Sa Composiciones de heparinas de muy bajo peso molecular.
FR2811992B1 (fr) * 2000-07-21 2003-07-04 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
EP1319183B1 (en) * 2000-09-12 2009-03-25 Massachusetts Institute Of Technology Methods and products related to low molecular weight heparin
FR2845686B1 (fr) * 2002-10-10 2013-08-30 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
US7904036B2 (en) 2005-12-02 2011-03-08 Telefonaktiebolaget Lm Ericsson (Publ) Modulation method and apparatus
EP2399592A1 (en) * 2010-06-25 2011-12-28 Aventis Pharma S.A. Semuloparin for use as an antithrombotic treatment in hip replacement surgery with improved safety in terms of clinically relevant bleedings and major bleedings
EP2399590A1 (en) * 2010-06-25 2011-12-28 Aventis Pharma S.A. Semuloparin for the prevention of a mortality and/or morbidity event in a patient undergoing major orthopaedic surgery
EP2548561A1 (en) * 2011-07-22 2013-01-23 Aventis Pharma S.A. Semuloparin for improving the survival of patients with locally advanced cancer
CN102603925B (zh) * 2012-03-21 2013-12-11 东营天东制药有限公司 一种由粗品肝素钠直接生产依诺肝素钠的方法

Also Published As

Publication number Publication date
PL2881404T3 (pl) 2018-08-31
ES2445494A1 (es) 2014-03-03
ES2445494B1 (es) 2015-03-06
HRP20180777T1 (hr) 2018-08-10
JP2015523451A (ja) 2015-08-13
DK2881404T3 (en) 2018-06-06
HUE037251T2 (hu) 2018-08-28
EP2881404A4 (en) 2016-04-20
CY1120872T1 (el) 2019-12-11
SI2881404T1 (sl) 2018-10-30
LT2881404T (lt) 2018-08-10
ES2669727T3 (es) 2018-05-29
PT2881404T (pt) 2018-05-23
WO2014020227A1 (es) 2014-02-06
CN104507972A (zh) 2015-04-08
IN2015MN00435A (zh) 2015-09-04
CN108102007A (zh) 2018-06-01
EP2881404B1 (en) 2018-02-28
BR112015002358A2 (pt) 2017-07-04
HK1206042A1 (zh) 2015-12-31
JP6298052B2 (ja) 2018-03-20
EP2881404A1 (en) 2015-06-10

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